KEGG   PATHWAY: mmu04010Help
Entry
mmu04010                    Pathway                                

Name
MAPK signaling pathway - Mus musculus (mouse)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
MAPK signaling pathway
mmu04010

All organismsOrtholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
12286  
Cacna1a; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344]
12287  
Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
12288  
Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
12289  
Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
12290  
Cacna1e; calcium channel, voltage-dependent, R type, alpha 1E subunit [KO:K04852]
54652  
Cacna1f; calcium channel, voltage-dependent, alpha 1F subunit [KO:K04853]
12291  
Cacna1g; calcium channel, voltage-dependent, T type, alpha 1G subunit [KO:K04854]
58226  
Cacna1h; calcium channel, voltage-dependent, T type, alpha 1H subunit [KO:K04855]
239556  
Cacna1i; calcium channel, voltage-dependent, alpha 1I subunit [KO:K04856]
12292  
Cacna1s; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
12293  
Cacna2d1; calcium channel, voltage-dependent, alpha2/delta subunit 1 [KO:K04858]
56808  
Cacna2d2; calcium channel, voltage-dependent, alpha 2/delta subunit 2 [KO:K04859]
12294  
Cacna2d3; calcium channel, voltage-dependent, alpha2/delta subunit 3 [KO:K04860]
319734  
Cacna2d4; calcium channel, voltage-dependent, alpha 2/delta subunit 4 [KO:K04861]
12295  
Cacnb1; calcium channel, voltage-dependent, beta 1 subunit [KO:K04862]
12296  
Cacnb2; calcium channel, voltage-dependent, beta 2 subunit [KO:K04863]
12297  
Cacnb3; calcium channel, voltage-dependent, beta 3 subunit [KO:K04864]
12298  
Cacnb4; calcium channel, voltage-dependent, beta 4 subunit [KO:K04865]
12299  
Cacng1; calcium channel, voltage-dependent, gamma subunit 1 [KO:K04866]
12300  
Cacng2; calcium channel, voltage-dependent, gamma subunit 2 [KO:K04867]
54376  
Cacng3; calcium channel, voltage-dependent, gamma subunit 3 [KO:K04868]
54377  
Cacng4; calcium channel, voltage-dependent, gamma subunit 4 [KO:K04869]
140723  
Cacng5; calcium channel, voltage-dependent, gamma subunit 5 [KO:K04870]
54378  
Cacng6; calcium channel, voltage-dependent, gamma subunit 6 [KO:K04871]
81904  
Cacng7; calcium channel, voltage-dependent, gamma subunit 7 [KO:K04872]
81905  
Cacng8; calcium channel, voltage-dependent, gamma subunit 8 [KO:K04873]
18747  
Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  
Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
19108  
Prkx; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
18750  
Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18751  
Prkcb; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
18752  
Prkcg; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
14673  
Gna12; guanine nucleotide binding protein, alpha 12 [KO:K04346]
14701  
Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
Gm5741; predicted gene 5741 [KO:K04347]
19057  
Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19055  
Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  
Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19058  
Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  
Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
19417  
Rasgrf1; RAS protein-specific guanine nucleotide-releasing factor 1 [KO:K04349]
19418  
Rasgrf2; RAS protein-specific guanine nucleotide-releasing factor 2 [KO:K12326]
19419  
Rasgrp1; RAS guanyl releasing protein 1 [KO:K04350]
19395  
Rasgrp2; RAS, guanyl releasing protein 2 [KO:K12361]
240168  
Rasgrp3; RAS, guanyl releasing protein 3 [KO:K12362]
233046  
Rasgrp4; RAS guanyl releasing protein 4 [KO:K12363]
76089  
Rapgef2; Rap guanine nucleotide exchange factor (GEF) 2 [KO:K08018]
18015  
Nf1; neurofibromatosis 1 [KO:K08052]
218397  
Rasa1; RAS p21 protein activator 1 [KO:K04352]
114713  
Rasa2; RAS p21 protein activator 2 [KO:K08053]
109905  
Rap1a; RAS-related protein-1a [KO:K04353]
215449  
Rap1b; RAS related protein 1b [KO:K07836]
18049  
Ngf; nerve growth factor [KO:K02582]
12064  
Bdnf; brain derived neurotrophic factor [KO:K04355]
18205  
Ntf3; neurotrophin 3 [KO:K04356]
78405  
Ntf5; neurotrophin 5 [KO:K12457]
13645  
Egf; epidermal growth factor [KO:K04357]
14164  
Fgf1; fibroblast growth factor 1 [KO:K04358]
14173  
Fgf2; fibroblast growth factor 2 [KO:K04358]
14174  
Fgf3; fibroblast growth factor 3 [KO:K04358]
14175  
Fgf4; fibroblast growth factor 4 [KO:K04358]
14176  
Fgf5; fibroblast growth factor 5 [KO:K04358]
14178  
Fgf7; fibroblast growth factor 7 [KO:K04358]
14179  
Fgf8; fibroblast growth factor 8 [KO:K04358]
14180  
Fgf9; fibroblast growth factor 9 [KO:K04358]
14165  
Fgf10; fibroblast growth factor 10 [KO:K04358]
14166  
Fgf11; fibroblast growth factor 11 [KO:K04358]
14167  
Fgf12; fibroblast growth factor 12 [KO:K04358]
14168  
Fgf13; fibroblast growth factor 13 [KO:K04358]
14169  
Fgf14; fibroblast growth factor 14 [KO:K04358]
80903  
Fgf16; fibroblast growth factor 16 [KO:K04358]
14171  
Fgf17; fibroblast growth factor 17 [KO:K04358]
14172  
Fgf18; fibroblast growth factor 18 [KO:K04358]
14170  
Fgf15; fibroblast growth factor 15 [KO:K04358]
80857  
Fgf20; fibroblast growth factor 20 [KO:K04358]
56636  
Fgf21; fibroblast growth factor 21 [KO:K04358]
67112  
Fgf22; fibroblast growth factor 22 [KO:K04358]
64654  
Fgf23; fibroblast growth factor 23 [KO:K04358]
14177  
Fgf6; fibroblast growth factor 6 [KO:K04358]
18590  
Pdgfa; platelet derived growth factor, alpha [KO:K04359]
18591  
Pdgfb; platelet derived growth factor, B polypeptide [KO:K17386]
18211  
Ntrk1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
18212  
Ntrk2; neurotrophic tyrosine kinase, receptor, type 2 [KO:K04360] [EC:2.7.10.1]
13649  
Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
14182  
Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
14183  
Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
14184  
Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
14186  
Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
18595  
Pdgfra; platelet derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
18596  
Pdgfrb; platelet derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
14784  
Grb2; growth factor receptor bound protein 2 [KO:K04364]
20662  
Sos1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
20663  
Sos2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
15461  
Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16653  
Kras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
18176  
Nras; neuroblastoma ras oncogene [KO:K07828]
20130  
Rras; Harvey rat sarcoma oncogene, subgroup R [KO:K07829]
66922  
Rras2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
17532  
Mras; muscle and microspikes RAS [KO:K07831]
109880  
Braf; Braf transforming gene [KO:K04365] [EC:2.7.11.1]
110157  
Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
17451  
Mos; Moloney sarcoma oncogene [KO:K04367] [EC:2.7.11.1]
26395  
Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  
Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
56692  
Lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
26413  
Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  
Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
17346  
Mknk1; MAP kinase-interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
17347  
Mknk2; MAP kinase-interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
110651  
Rps6ka3; ribosomal protein S6 kinase polypeptide 3 [KO:K04373] [EC:2.7.11.1]
20111  
Rps6ka1; ribosomal protein S6 kinase polypeptide 1 [KO:K04373] [EC:2.7.11.1]
20112  
Rps6ka2; ribosomal protein S6 kinase, polypeptide 2 [KO:K04373] [EC:2.7.11.1]
67071  
Rps6ka6; ribosomal protein S6 kinase polypeptide 6 [KO:K04373] [EC:2.7.11.1]
11911  
Atf4; activating transcription factor 4 [KO:K04374]
13712  
Elk1; ELK1, member of ETS oncogene family [KO:K04375]
13714  
Elk4; ELK4, member of ETS oncogene family [KO:K04376]
17869  
Myc; myelocytomatosis oncogene [KO:K04377]
20807  
Srf; serum response factor [KO:K04378]
14281  
Fos; FBJ osteosarcoma oncogene [KO:K04379]
17762  
Mapt; microtubule-associated protein tau [KO:K04380]
16765  
Stmn1; stathmin 1 [KO:K04381]
329502  
Pla2g4e; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
18783  
Pla2g4a; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
211429  
Pla2g4b; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
232889  
Pla2g4c; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
78390  
Pla2g4d; phospholipase A2, group IVD [KO:K16342] [EC:3.1.1.4]
271844  
Pla2g4f; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
21926  
Tnf; tumor necrosis factor [KO:K03156]
16175  
Il1a; interleukin 1 alpha [KO:K04383]
16176  
Il1b; interleukin 1 beta [KO:K04519]
21803  
Tgfb1; transforming growth factor, beta 1 [KO:K13375]
21808  
Tgfb2; transforming growth factor, beta 2 [KO:K13376]
21809  
Tgfb3; transforming growth factor, beta 3 [KO:K13377]
21937  
Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
16177  
Il1r1; interleukin 1 receptor, type I [KO:K04386]
16178  
Il1r2; interleukin 1 receptor, type II [KO:K04387]
21812  
Tgfbr1; transforming growth factor, beta receptor I [KO:K04674] [EC:2.7.11.30]
21813  
Tgfbr2; transforming growth factor, beta receptor II [KO:K04388] [EC:2.7.11.30]
14103  
Fasl; Fas ligand (TNF superfamily, member 6) [KO:K04389]
14102  
Fas; Fas (TNF receptor superfamily member 6) [KO:K04390]
12475  
Cd14; CD14 antigen [KO:K04391]
19353  
Rac1; RAS-related C3 botulinum substrate 1 [KO:K04392]
19354  
Rac2; RAS-related C3 botulinum substrate 2 [KO:K07860]
170758  
Rac3; RAS-related C3 botulinum substrate 3 [KO:K07861]
12540  
Cdc42; cell division cycle 42 [KO:K04393]
12367  
Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
22030  
Traf2; TNF receptor-associated factor 2 [KO:K03173]
13163  
Daxx; Fas death domain-associated protein [KO:K02308]
22034  
Traf6; TNF receptor-associated factor 6 [KO:K03175]
13197  
Gadd45a; growth arrest and DNA-damage-inducible 45 alpha [KO:K04402]
17873  
Gadd45b; growth arrest and DNA-damage-inducible 45 beta [KO:K04402]
23882  
Gadd45g; growth arrest and DNA-damage-inducible 45 gamma [KO:K04402]
66513  
Tab1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
68652  
Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
26940  
Ecsit; ECSIT homolog (Drosophila) [KO:K04405]
225028  
Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
26921  
Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
26411  
Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
18479  
Pak1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
224105  
Pak2; p21 protein (Cdc42/Rac)-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
58231  
Stk4; serine/threonine kinase 4 [KO:K04411]
56274  
Stk3; serine/threonine kinase 3 [KO:K04412]
26412  
Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
26410  
Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
26401  
Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
26403  
Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
26405  
Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
26406  
Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
71751  
Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
26404  
Map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
65964  
Zak; sterile alpha motif and leucine zipper containing kinase AZK [KO:K04424] [EC:2.7.11.25]
53608  
Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
26408  
Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
26409  
Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
26407  
Map3k4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
330177  
Taok3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
216965  
Taok1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
381921  
Taok2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
26398  
Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
26400  
Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
26397  
Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
26399  
Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
19099  
Mapk8ip1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
60597  
Mapk8ip2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
30957  
Mapk8ip3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
192176  
Flna; filamin, alpha [KO:K04437]
286940  
Flnb; filamin, beta [KO:K04437]
68794  
Flnc; filamin C, gamma [KO:K04437]
12928  
Crk; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO:K04438]
12929  
Crkl; v-crk sarcoma virus CT10 oncogene homolog (avian)-like [KO:K04438]
109689  
Arrb1; arrestin, beta 1 [KO:K04439]
216869  
Arrb2; arrestin, beta 2 [KO:K04439]
26419  
Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  
Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26414  
Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26416  
Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
19094  
Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
29857  
Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
26415  
Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
17165  
Mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
17164  
Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102626  
Mapkapk3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
73086  
Rps6ka5; ribosomal protein S6 kinase, polypeptide 5 [KO:K04445] [EC:2.7.11.1]
56613  
Rps6ka4; ribosomal protein S6 kinase, polypeptide 4 [KO:K16510] [EC:2.7.11.1]
12531  
Cdc25b; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
18018  
Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446]
18021  
Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333]
16476  
Jun; jun proto-oncogene [KO:K04448]
16478  
Jund; jun D proto-oncogene [KO:K04449]
11909  
Atf2; activating transcription factor 2 [KO:K04450]
22059  
Trp53; transformation related protein 53 [KO:K04451]
13198  
Ddit3; DNA-damage inducible transcript 3 [KO:K04452]
17187  
Max; Max protein [KO:K04453]
17260  
Mef2c; myocyte enhancer factor 2C [KO:K04454]
15507  
Hspb1; heat shock protein 1 [KO:K04455]
11651  
Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  
Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797  
Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
19042  
Ppm1a; protein phosphatase 1A, magnesium dependent, alpha isoform [KO:K04457] [EC:3.1.3.16]
19279  
Ptprr; protein tyrosine phosphatase, receptor type, R [KO:K04458] [EC:3.1.3.48]
19259  
Ptpn5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
320139  
Ptpn7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
19252  
Dusp1; dual specificity phosphatase 1 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
319520  
Dusp4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
235584  
Dusp7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
18218  
Dusp8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
240672  
Dusp5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
67603  
Dusp6; dual specificity phosphatase 6 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
75590  
Dusp9; dual specificity phosphatase 9 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
63953  
Dusp10; dual specificity phosphatase 10 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
13537  
Dusp2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
70686  
Dusp16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
72349  
Dusp3; dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) [KO:K17614] [EC:3.1.3.48 3.1.3.16]
19060  
Ppp5c; protein phosphatase 5, catalytic subunit [KO:K04460] [EC:3.1.3.16]
19043  
Ppm1b; protein phosphatase 1B, magnesium dependent, beta isoform [KO:K04461] [EC:3.1.3.16]
15481  
Hspa8; heat shock protein 8 [KO:K03283]
15482  
Hspa1l; heat shock protein 1-like [KO:K03283]
193740  
Hspa1a; heat shock protein 1A [KO:K03283]
15512  
Hspa2; heat shock protein 2 [KO:K03283]
15511  
Hspa1b; heat shock protein 1B [KO:K03283]
14013  
Mecom; MDS1 and EVI1 complex locus [KO:K04462]
23938  
Map2k5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
23939  
Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
15370  
Nr4a1; nuclear receptor subfamily 4, group A, member 1 [KO:K04465]
53859  
Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
12675  
Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
16150  
Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  
Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
18099  
Nlk; nemo like kinase [KO:K04468] [EC:2.7.11.24]
18033  
Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
18034  
Nfkb2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [KO:K04469]
19697  
Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
19698  
Relb; avian reticuloendotheliosis viral (v-rel) oncogene related B [KO:K09253]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00338  
Lipopolysaccharide
C00575  
3',5'-Cyclic AMP
C01245  
D-myo-Inositol 1,4,5-trisphosphate
Reference
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
Reference
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
Reference
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
Reference
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
Reference
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
Reference
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
Reference
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
Reference
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
Reference
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
KO pathway
 

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