KEGG PATHWAY: mmu04062

PATHWAY: mmu04062

Entry

mmu04062 Pathway

Name

Chemokine signaling pathway - Mus musculus (mouse)

Description

Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.

Class

Organismal Systems; Immune system

Pathway map

mmu04062

Chemokine signaling pathway

Other DBs

BSID:

99271

GO:

0070098

Organism

Mus musculus (mouse) [GN:mmu]

Gene

14825	Cxcl1; chemokine (C-X-C motif) ligand 1 [KO:K05505]
20310	Cxcl2; chemokine (C-X-C motif) ligand 2 [KO:K05505]
330122	Cxcl3; chemokine (C-X-C motif) ligand 3 [KO:K05505]
20311	Cxcl5; chemokine (C-X-C motif) ligand 5 [KO:K05506]
57349	Ppbp; pro-platelet basic protein [KO:K10029]
17329	Cxcl9; chemokine (C-X-C motif) ligand 9 [KO:K05416]
15945	Cxcl10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
56066	Cxcl11; chemokine (C-X-C motif) ligand 11 [KO:K12672]
20315	Cxcl12; chemokine (C-X-C motif) ligand 12 [KO:K10031]
55985	Cxcl13; chemokine (C-X-C motif) ligand 13 [KO:K10032]
66102	Cxcl16; chemokine (C-X-C motif) ligand 16 [KO:K10035]
20309	Il8; interleukin 8 [KO:K10034]
56744	Pf4; platelet factor 4 [KO:K05407]
57266	Cxcl14; chemokine (C-X-C motif) ligand 14 [KO:K10033]
16963	Xcl1; chemokine (C motif) ligand 1 [KO:K05507]
20312	Cx3cl1; chemokine (C-X3-C motif) ligand 1 [KO:K05508]
20296	Ccl2; chemokine (C-C motif) ligand 2 [KO:K14624]
20293	Ccl12; chemokine (C-C motif) ligand 12 [KO:K14624]
100862578	c-C motif chemokine 12-like; K14624 C-C motif chemokine 2 [KO:K14624]
20302	Ccl3; chemokine (C-C motif) ligand 3 [KO:K05408]
20303	Ccl4; chemokine (C-C motif) ligand 4 [KO:K12964]
20304	Ccl5; chemokine (C-C motif) ligand 5 [KO:K12499]
20305	Ccl6; chemokine (C-C motif) ligand 6 [KO:K05510]
20308	Ccl9; chemokine (C-C motif) ligand 9 [KO:K05510]
20306	Ccl7; chemokine (C-C motif) ligand 7 [KO:K05509]
20307	Ccl8; chemokine (C-C motif) ligand 8 [KO:K16596]
100503254	c-C motif chemokine 8-like; K16596 C-C motif chemokine 8 [KO:K16596]
20292	Ccl11; chemokine (C-C motif) ligand 11 [KO:K16597]
24047	Ccl19; chemokine (C-C motif) ligand 19 [KO:K05512]
100039053	Gm2023; predicted gene 2023 [KO:K05512]
20297	Ccl20; chemokine (C-C motif) ligand 20 [KO:K14625]
100862177	Gm21541; predicted gene, 21541 [KO:K16062]
100504346	Gm13304; predicted gene 13304 [KO:K16062]
100504239	Gm10591; predicted gene 10591 [KO:K16062]
100042493	Ccl21b; chemokine (C-C motif) ligand 21B (leucine) [KO:K16062]
100041593	c-C motif chemokine 21c-like; K16062 C-C motif chemokine 21 [KO:K16062]
100041504	c-C motif chemokine 21c-like; K16062 C-C motif chemokine 21 [KO:K16062]
65956	Ccl21c; chemokine (C-C motif) ligand 21C (leucine) [KO:K16062]
100504362	Gm1987; predicted gene 1987 [KO:K16062]
18829	Ccl21a; chemokine (C-C motif) ligand 21A (serine) [KO:K16062]
20300	Ccl25; chemokine (C-C motif) ligand 25 [KO:K13072]
20301	Ccl27a; chemokine (C-C motif) ligand 27A [KO:K16598]
100040048	Ccl27b; chemokine (C-C motif) ligand 27b [KO:K16598]
100041579	Gm20878; predicted gene, 20878 [KO:K16598]
100039863	Gm13306; predicted gene 13306 [KO:K16598]
100861978	c-C motif chemokine 27-like; K16598 C-C motif chemokine 27 [KO:K16598]
100039939	Gm2506; predicted gene 2506 [KO:K16598]
100862247	Gm21586; predicted gene, 21586 [KO:K16598]
621580	Gm13308; predicted gene 13308 [KO:K16598]
56838	Ccl28; chemokine (C-C motif) ligand 28 [KO:K05513]
20290	Ccl1; chemokine (C-C motif) ligand 1 [KO:K05514]
20299	Ccl22; chemokine (C-C motif) ligand 22 [KO:K05514]
56221	Ccl24; chemokine (C-C motif) ligand 24 [KO:K05514]
20295	Ccl17; chemokine (C-C motif) ligand 17 [KO:K05514]
541307	Ccl26; chemokine (C-C motif) ligand 26 [KO:K05514]
12765	Cxcr2; chemokine (C-X-C motif) receptor 2 [KO:K05050]
227288	Cxcr1; chemokine (C-X-C motif) receptor 1 [KO:K04175]
12766	Cxcr3; chemokine (C-X-C motif) receptor 3 [KO:K04188]
12767	Cxcr4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
12145	Cxcr5; chemokine (C-X-C motif) receptor 5 [KO:K04190]
80901	Cxcr6; chemokine (C-X-C motif) receptor 6 [KO:K04191]
23832	Xcr1; chemokine (C motif) receptor 1 [KO:K04193]
13051	Cx3cr1; chemokine (C-X3-C) receptor 1 [KO:K04192]
12776	Ccr8; chemokine (C-C motif) receptor 8 [KO:K04183]
12458	Ccr6; chemokine (C-C motif) receptor 6 [KO:K04181]
12769	Ccr9; chemokine (C-C motif) receptor 9 [KO:K04184]
12773	Ccr4; chemokine (C-C motif) receptor 4 [KO:K04179]
12775	Ccr7; chemokine (C-C motif) receptor 7 [KO:K04182]
12772	Ccr2; chemokine (C-C motif) receptor 2 [KO:K04177]
12774	Ccr5; chemokine (C-C motif) receptor 5 [KO:K04180]
12768	Ccr1; chemokine (C-C motif) receptor 1 [KO:K04176]
12770	Ccr1l1; chemokine (C-C motif) receptor 1-like 1 [KO:K04176]
12771	Ccr3; chemokine (C-C motif) receptor 3 [KO:K04178]
12777	Ccr10; chemokine (C-C motif) receptor 10 [KO:K04185]
16452	Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
16453	Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
20846	Stat1; signal transducer and activator of transcription 1 [KO:K11220]
20847	Stat2; signal transducer and activator of transcription 2 [KO:K11221]
20848	Stat3; signal transducer and activator of transcription 3 [KO:K04692]
20851	Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
14677	Gnai1; guanine nucleotide binding protein (G protein), alpha inhibiting 1 [KO:K04630]
14679	Gnai3; guanine nucleotide binding protein (G protein), alpha inhibiting 3 [KO:K04630]
14678	Gnai2; guanine nucleotide binding protein (G protein), alpha inhibiting 2 [KO:K04630]
432530	Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
210044	Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
104111	Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
104110	Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
224129	Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
11512	Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513	Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514	Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515	Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
18747	Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749	Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
19108	Prkx; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
17096	Lyn; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog [KO:K05854] [EC:2.7.10.2]
666513	Gm11787; predicted gene 11787 [KO:K05854] [EC:2.7.10.2]
15162	Hck; hemopoietic cell kinase [KO:K08893] [EC:2.7.10.2]
14191	Fgr; Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog [KO:K08891] [EC:2.7.10.2]
20779	Src; Rous sarcoma oncogene [KO:K05704] [EC:2.7.10.2]
20416	Shc1; src homology 2 domain-containing transforming protein C1 [KO:K06279]
20418	Shc3; src homology 2 domain-containing transforming protein C3 [KO:K06279]
216148	Shc2; SHC (Src homology 2 domain containing) transforming protein 2 [KO:K06279]
271849	Shc4; SHC (Src homology 2 domain containing) family, member 4 [KO:K06279]
14784	Grb2; growth factor receptor bound protein 2 [KO:K04364]
20662	Sos1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
20663	Sos2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
15461	Hras1; Harvey rat sarcoma virus oncogene 1 [KO:K02833]
16653	Kras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
18176	Nras; neuroblastoma ras oncogene [KO:K07828]
110157	Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
109880	Braf; Braf transforming gene [KO:K04365] [EC:2.7.11.1]
26395	Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26413	Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417	Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
18709	Pik3r2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [KO:K02649]
18708	Pik3r1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) [KO:K02649]
320207	Pik3r5; phosphoinositide-3-kinase, regulatory subunit 5, p101 [KO:K02649]
18710	Pik3r3; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) [KO:K02649]
30955	Pik3cg; phosphoinositide-3-kinase, catalytic, gamma polypeptide [KO:K00922] [EC:2.7.1.153]
18706	Pik3ca; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide [KO:K00922] [EC:2.7.1.153]
18707	Pik3cd; phosphatidylinositol 3-kinase catalytic delta polypeptide [KO:K00922] [EC:2.7.1.153]
74769	Pik3cb; phosphatidylinositol 3-kinase, catalytic, beta polypeptide [KO:K00922] [EC:2.7.1.153]
11651	Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652	Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797	Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
56484	Foxo3; forkhead box O3 [KO:K09408]
12675	Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
16150	Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151	Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
18035	Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18036	Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581]
18033	Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697	Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
606496	Gsk3a; glycogen synthase kinase 3 alpha [KO:K08822] [EC:2.7.11.26]
56637	Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
16428	Itk; IL2 inducible T cell kinase [KO:K07363] [EC:2.7.10.2]
22324	Vav1; vav 1 oncogene [KO:K05730]
22325	Vav2; vav 2 oncogene [KO:K05730]
57257	Vav3; vav 3 oncogene [KO:K05730]
19353	Rac1; RAS-related C3 botulinum substrate 1 [KO:K04392]
19354	Rac2; RAS-related C3 botulinum substrate 2 [KO:K07860]
18479	Pak1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
12540	Cdc42; cell division cycle 42 [KO:K04393]
22376	Was; Wiskott-Aldrich syndrome homolog (human) [KO:K05747]
73178	Wasl; Wiskott-Aldrich syndrome-like (human) [KO:K05747]
11848	Rhoa; ras homolog gene family, member A [KO:K04513]
67653	4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513]
19877	Rock1; Rho-associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
19878	Rock2; Rho-associated coiled-coil containing protein kinase 2 [KO:K04514] [EC:2.7.11.1]
14688	Gnb1; guanine nucleotide binding protein (G protein), beta 1 [KO:K04536]
14693	Gnb2; guanine nucleotide binding protein (G protein), beta 2 [KO:K04537]
14695	Gnb3; guanine nucleotide binding protein (G protein), beta 3 [KO:K07825]
14696	Gnb4; guanine nucleotide binding protein (G protein), beta 4 [KO:K04538]
14697	Gnb5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539]
14702	Gng2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826]
14704	Gng3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540]
14706	Gng4; guanine nucleotide binding protein (G protein), gamma 4 [KO:K04541]
14707	Gng5; guanine nucleotide binding protein (G protein), gamma 5 [KO:K04542]
100043507	Gm15776; predicted gene 15776 [KO:K04542]
100048410	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like; K04542 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
14708	Gng7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543]
14709	Gng8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544]
14700	Gng10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545]
66066	Gng11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546]
14701	Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
100503710	Gm5741; predicted gene 5741 [KO:K04347]
64337	Gng13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547]
14699	Gngt1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548]
14710	Gngt2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549]
277360	Prex1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [KO:K12365]
140580	Elmo1; engulfment and cell motility 1 [KO:K12366]
94176	Dock2; dedicator of cyto-kinesis 2 [KO:K12367]
14083	Ptk2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
19303	Pxn; paxillin [KO:K05760]
12927	Bcar1; breast cancer anti-estrogen resistance 1 [KO:K05726]
12928	Crk; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO:K04438]
12929	Crkl; v-crk sarcoma virus CT10 oncogene homolog (avian)-like [KO:K04438]
19229	Ptk2b; PTK2 protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
18795	Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18797	Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798	Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18796	Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
19395	Rasgrp2; RAS, guanyl releasing protein 2 [KO:K12361]
109905	Rap1a; RAS-related protein-1a [KO:K04353]
215449	Rap1b; RAS related protein 1b [KO:K07836]
93742	Pard3; par-3 (partitioning defective 3) homolog (C. elegans) [KO:K04237]
21844	Tiam1; T cell lymphoma invasion and metastasis 1 [KO:K05731]
17969	Ncf1; neutrophil cytosolic factor 1 [KO:K08011]
24013	Grk1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
110355	Adrbk1; adrenergic receptor kinase, beta 1 [KO:K00910] [EC:2.7.11.15]
14772	Grk4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
14773	Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
26385	Grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
109689	Arrb1; arrestin, beta 1 [KO:K04439]
216869	Arrb2; arrestin, beta 2 [KO:K04439]
18751	Prkcb; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
18753	Prkcd; protein kinase C, delta [KO:K06068] [EC:2.7.11.13]
18762	Prkcz; protein kinase C, zeta [KO:K06069] [EC:2.7.11.13]

Compound

C00076	Calcium cation
C00165	Diacylglycerol
C00575	3',5'-Cyclic AMP
C01245	D-myo-Inositol 1,4,5-trisphosphate
C05981	Phosphatidylinositol-3,4,5-trisphosphate

Reference

PMID:12495636

Authors

Wong MM, Fish EN

Title

Chemokines: attractive mediators of the immune response.

Journal

Semin Immunol 15:5-14 (2003)

Reference

PMID:11872087

Authors

Curnock AP, Logan MK, Ward SG

Title

Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.

Journal

Immunology 105:125-36 (2002)

Reference

PMID:12069927

Authors

Olson TS, Ley K

Title

Chemokines and chemokine receptors in leukocyte trafficking.

Journal

Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)

Reference

PMID:17169327

Authors

Busillo JM, Benovic JL

Title

Regulation of CXCR4 signaling.

Journal

Biochim Biophys Acta 1768:952-63 (2007)

Reference

PMID:11244042

Authors

Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C

Title

Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.

Journal

Annu Rev Immunol 19:397-421 (2001)

Reference

PMID:8576262

Authors

Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL

Title

Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.

Journal

J Biol Chem 271:2832-8 (1996)

Reference

PMID:17537990

Authors

Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT

Title

p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.

Journal

Blood 110:1730-8 (2007)

Reference

PMID:18662984

Authors

Sai J, Raman D, Liu Y, Wikswo J, Richmond A

Title

Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.

Journal

J Biol Chem 283:26538-47 (2008)

Reference

PMID:10852130

Authors

Hauck CR, Klingbeil CK, Schlaepfer DD

Title

Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.

Journal

Immunol Res 21:293-303 (2000)

Reference

PMID:14625285

Authors

Chandrasekar B, Bysani S, Mummidi S

Title

CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.

Journal

J Biol Chem 279:3188-96 (2004)

Reference

PMID:17371236

Authors

Smith L, Webb A, Ward SG

Title

T-lymphocyte navigation and migration: beyond the PI3K paradigm.

Journal

Biochem Soc Trans 35:193-8 (2007)

Reference

PMID:16144840

Authors

Huttenrauch F, Pollok-Kopp B, Oppermann M

Title

G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.

Journal

J Biol Chem 280:37503-15 (2005)

Reference

PMID:18711432

Authors

Thelen M, Stein JV

Title

How chemokines invite leukocytes to dance.

Journal

Nat Immunol 9:953-9 (2008)

Reference

PMID:19159344

Authors

Ward SG, Marelli-Berg FM

Title

Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.

Journal

Biochem J 418:13-27 (2009)

Reference

PMID:15803148

Authors

Schwartzberg PL, Finkelstein LD, Readinger JA

Title

TEC-family kinases: regulators of T-helper-cell differentiation.

Journal

Nat Rev Immunol 5:284-95 (2005)

Reference

PMID:15771581

Authors

Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.

Title

Tec family kinases in T lymphocyte development and function.

Journal

Annu Rev Immunol 23:549-600 (2005)

Reference

PMID:17496928

Authors

Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A

Title

Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.

Journal

Oncogene 26:7081-91 (2007)

Reference

PMID:9765254

Authors

Korchak HM, Rossi MW, Kilpatrick LE

Title

Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.

Journal

J Biol Chem 273:27292-9 (1998)

Reference

PMID:15046611

Authors

Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C

Title

Chemokine inhibition--why, when, where, which and how?

Journal

Biochem Soc Trans 32:366-77 (2004)

Reference

PMID:12051620

Authors

Zhelev DV, Alteraifi A

Title

Signaling in the motility responses of the human neutrophil.

Journal

Ann Biomed Eng 30:356-70 (2002)

Reference

PMID:17675482

Authors

Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS

Title

Phospholipase cbeta is critical for T cell chemotaxis.

Journal

J Immunol 179:2223-7 (2007)

Reference

PMID:14607270

Authors

Hornstein I, Alcover A, Katzav S

Title

Vav proteins, masters of the world of cytoskeleton organization.

Journal

Cell Signal 16:1-11 (2004)

KO pathway

ko04062

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (199)   
   KEGG GENES (199)   
All databases (201)   

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