KEGG   PATHWAY: mmu04062Help
Entry
mmu04062                    Pathway                                

Name
Chemokine signaling pathway - Mus musculus (mouse)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Chemokine signaling pathway
mmu04062

All organismsOrtholog table
Other DBs
BSID: 
GO: 
Organism
Mus musculus (mouse) [GN:mmu]
Gene
14825  
Cxcl1; chemokine (C-X-C motif) ligand 1 [KO:K05505]
20310  
Cxcl2; chemokine (C-X-C motif) ligand 2 [KO:K05505]
330122  
Cxcl3; chemokine (C-X-C motif) ligand 3 [KO:K05505]
20311  
Cxcl5; chemokine (C-X-C motif) ligand 5 [KO:K05506]
57349  
Ppbp; pro-platelet basic protein [KO:K10029]
17329  
Cxcl9; chemokine (C-X-C motif) ligand 9 [KO:K05416]
15945  
Cxcl10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
56066  
Cxcl11; chemokine (C-X-C motif) ligand 11 [KO:K12672]
20315  
Cxcl12; chemokine (C-X-C motif) ligand 12 [KO:K10031]
55985  
Cxcl13; chemokine (C-X-C motif) ligand 13 [KO:K10032]
66102  
Cxcl16; chemokine (C-X-C motif) ligand 16 [KO:K10035]
20309  
Cxcl15; chemokine (C-X-C motif) ligand 15 [KO:K10034]
56744  
Pf4; platelet factor 4 [KO:K05407]
57266  
Cxcl14; chemokine (C-X-C motif) ligand 14 [KO:K10033]
16963  
Xcl1; chemokine (C motif) ligand 1 [KO:K05507]
20312  
Cx3cl1; chemokine (C-X3-C motif) ligand 1 [KO:K05508]
20296  
Ccl2; chemokine (C-C motif) ligand 2 [KO:K14624]
20293  
Ccl12; chemokine (C-C motif) ligand 12 [KO:K14624]
20302  
Ccl3; chemokine (C-C motif) ligand 3 [KO:K05408]
20303  
Ccl4; chemokine (C-C motif) ligand 4 [KO:K12964]
20304  
Ccl5; chemokine (C-C motif) ligand 5 [KO:K12499]
20305  
Ccl6; chemokine (C-C motif) ligand 6 [KO:K05510]
20308  
Ccl9; chemokine (C-C motif) ligand 9 [KO:K05510]
20306  
Ccl7; chemokine (C-C motif) ligand 7 [KO:K05509]
20307  
Ccl8; chemokine (C-C motif) ligand 8 [KO:K16596]
20292  
Ccl11; chemokine (C-C motif) ligand 11 [KO:K16597]
24047  
Ccl19; chemokine (C-C motif) ligand 19 [KO:K05512]
Gm2023; predicted gene 2023 [KO:K05512]
20297  
Ccl20; chemokine (C-C motif) ligand 20 [KO:K14625]
Gm21541; predicted gene, 21541 [KO:K16062]
Gm13304; predicted gene 13304 [KO:K16062]
Gm10591; predicted gene 10591 [KO:K16062]
Ccl21b; chemokine (C-C motif) ligand 21B (leucine) [KO:K16062]
c-C motif chemokine 21c-like; K16062 C-C motif chemokine 21 [KO:K16062]
c-C motif chemokine 21c-like; K16062 C-C motif chemokine 21 [KO:K16062]
65956  
Ccl21c; chemokine (C-C motif) ligand 21C (leucine) [KO:K16062]
Gm1987; predicted gene 1987 [KO:K16062]
18829  
Ccl21a; chemokine (C-C motif) ligand 21A (serine) [KO:K16062]
20300  
Ccl25; chemokine (C-C motif) ligand 25 [KO:K13072]
20301  
Ccl27a; chemokine (C-C motif) ligand 27A [KO:K16598]
Ccl27b; chemokine (C-C motif) ligand 27b [KO:K16598]
Gm20878; predicted gene, 20878 [KO:K16598]
Gm13306; predicted gene 13306 [KO:K16598]
c-C motif chemokine 27-like; K16598 C-C motif chemokine 27 [KO:K16598]
Gm2506; predicted gene 2506 [KO:K16598]
Gm21586; predicted gene, 21586 [KO:K16598]
621580  
Gm13308; predicted gene 13308 [KO:K16598]
56838  
Ccl28; chemokine (C-C motif) ligand 28 [KO:K05513]
20290  
Ccl1; chemokine (C-C motif) ligand 1 [KO:K05514]
20299  
Ccl22; chemokine (C-C motif) ligand 22 [KO:K05514]
56221  
Ccl24; chemokine (C-C motif) ligand 24 [KO:K05514]
20295  
Ccl17; chemokine (C-C motif) ligand 17 [KO:K05514]
541307  
Ccl26; chemokine (C-C motif) ligand 26 [KO:K05514]
12765  
Cxcr2; chemokine (C-X-C motif) receptor 2 [KO:K05050]
227288  
Cxcr1; chemokine (C-X-C motif) receptor 1 [KO:K04175]
12766  
Cxcr3; chemokine (C-X-C motif) receptor 3 [KO:K04188]
12767  
Cxcr4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
12145  
Cxcr5; chemokine (C-X-C motif) receptor 5 [KO:K04190]
80901  
Cxcr6; chemokine (C-X-C motif) receptor 6 [KO:K04191]
23832  
Xcr1; chemokine (C motif) receptor 1 [KO:K04193]
13051  
Cx3cr1; chemokine (C-X3-C motif) receptor 1 [KO:K04192]
12776  
Ccr8; chemokine (C-C motif) receptor 8 [KO:K04183]
12458  
Ccr6; chemokine (C-C motif) receptor 6 [KO:K04181]
12769  
Ccr9; chemokine (C-C motif) receptor 9 [KO:K04184]
12773  
Ccr4; chemokine (C-C motif) receptor 4 [KO:K04179]
12775  
Ccr7; chemokine (C-C motif) receptor 7 [KO:K04182]
12772  
Ccr2; chemokine (C-C motif) receptor 2 [KO:K04177]
12774  
Ccr5; chemokine (C-C motif) receptor 5 [KO:K04180]
12768  
Ccr1; chemokine (C-C motif) receptor 1 [KO:K04176]
12770  
Ccr1l1; chemokine (C-C motif) receptor 1-like 1 [KO:K04176]
12771  
Ccr3; chemokine (C-C motif) receptor 3 [KO:K04178]
12777  
Ccr10; chemokine (C-C motif) receptor 10 [KO:K04185]
16452  
Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
16453  
Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
20846  
Stat1; signal transducer and activator of transcription 1 [KO:K11220]
20847  
Stat2; signal transducer and activator of transcription 2 [KO:K11221]
20848  
Stat3; signal transducer and activator of transcription 3 [KO:K04692]
20851  
Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
14677  
Gnai1; guanine nucleotide binding protein (G protein), alpha inhibiting 1 [KO:K04630]
14679  
Gnai3; guanine nucleotide binding protein (G protein), alpha inhibiting 3 [KO:K04630]
14678  
Gnai2; guanine nucleotide binding protein (G protein), alpha inhibiting 2 [KO:K04630]
432530  
Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
210044  
Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
104111  
Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
104110  
Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
224129  
Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
11512  
Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  
Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  
Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  
Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
18747  
Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  
Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
19108  
Prkx; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
17096  
Lyn; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog [KO:K05854] [EC:2.7.10.2]
666513  
Gm11787; predicted gene 11787 [KO:K05854] [EC:2.7.10.2]
15162  
Hck; hemopoietic cell kinase [KO:K08893] [EC:2.7.10.2]
14191  
Fgr; Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog [KO:K08891] [EC:2.7.10.2]
20779  
Src; Rous sarcoma oncogene [KO:K05704] [EC:2.7.10.2]
20416  
Shc1; src homology 2 domain-containing transforming protein C1 [KO:K06279]
216148  
Shc2; SHC (Src homology 2 domain containing) transforming protein 2 [KO:K17447]
20418  
Shc3; src homology 2 domain-containing transforming protein C3 [KO:K17448]
271849  
Shc4; SHC (Src homology 2 domain containing) family, member 4 [KO:K17449]
14784  
Grb2; growth factor receptor bound protein 2 [KO:K04364]
20662  
Sos1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
20663  
Sos2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
15461  
Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16653  
Kras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
18176  
Nras; neuroblastoma ras oncogene [KO:K07828]
110157  
Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
109880  
Braf; Braf transforming gene [KO:K04365] [EC:2.7.11.1]
26395  
Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26413  
Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  
Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
18709  
Pik3r2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [KO:K02649]
18708  
Pik3r1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) [KO:K02649]
320207  
Pik3r5; phosphoinositide-3-kinase, regulatory subunit 5, p101 [KO:K02649]
18710  
Pik3r3; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) [KO:K02649]
30955  
Pik3cg; phosphoinositide-3-kinase, catalytic, gamma polypeptide [KO:K00922] [EC:2.7.1.153]
18706  
Pik3ca; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide [KO:K00922] [EC:2.7.1.153]
18707  
Pik3cd; phosphatidylinositol 3-kinase catalytic delta polypeptide [KO:K00922] [EC:2.7.1.153]
74769  
Pik3cb; phosphatidylinositol 3-kinase, catalytic, beta polypeptide [KO:K00922] [EC:2.7.1.153]
11651  
Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  
Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797  
Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
56484  
Foxo3; forkhead box O3 [KO:K09408]
12675  
Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
16150  
Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  
Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
18035  
Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18036  
Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581]
18033  
Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697  
Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
606496  
Gsk3a; glycogen synthase kinase 3 alpha [KO:K08822] [EC:2.7.11.26]
56637  
Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
16428  
Itk; IL2 inducible T cell kinase [KO:K07363] [EC:2.7.10.2]
22324  
Vav1; vav 1 oncogene [KO:K05730]
22325  
Vav2; vav 2 oncogene [KO:K05730]
57257  
Vav3; vav 3 oncogene [KO:K05730]
19353  
Rac1; RAS-related C3 botulinum substrate 1 [KO:K04392]
19354  
Rac2; RAS-related C3 botulinum substrate 2 [KO:K07860]
18479  
Pak1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
12540  
Cdc42; cell division cycle 42 [KO:K04393]
22376  
Was; Wiskott-Aldrich syndrome homolog (human) [KO:K05747]
73178  
Wasl; Wiskott-Aldrich syndrome-like (human) [KO:K05747]
11848  
Rhoa; ras homolog gene family, member A [KO:K04513]
67653  
4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513]
19877  
Rock1; Rho-associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
19878  
Rock2; Rho-associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
14688  
Gnb1; guanine nucleotide binding protein (G protein), beta 1 [KO:K04536]
14693  
Gnb2; guanine nucleotide binding protein (G protein), beta 2 [KO:K04537]
14695  
Gnb3; guanine nucleotide binding protein (G protein), beta 3 [KO:K07825]
14696  
Gnb4; guanine nucleotide binding protein (G protein), beta 4 [KO:K04538]
14697  
Gnb5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539]
14702  
Gng2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826]
14704  
Gng3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540]
14706  
Gng4; guanine nucleotide binding protein (G protein), gamma 4 [KO:K04541]
14707  
Gng5; guanine nucleotide binding protein (G protein), gamma 5 [KO:K04542]
Gm15776; predicted gene 15776 [KO:K04542]
14708  
Gng7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543]
14709  
Gng8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544]
14700  
Gng10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545]
66066  
Gng11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546]
14701  
Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
Gm5741; predicted gene 5741 [KO:K04347]
64337  
Gng13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547]
14699  
Gngt1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548]
14710  
Gngt2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549]
277360  
Prex1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [KO:K12365]
140580  
Elmo1; engulfment and cell motility 1 [KO:K12366]
94176  
Dock2; dedicator of cyto-kinesis 2 [KO:K12367]
14083  
Ptk2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
19303  
Pxn; paxillin [KO:K05760]
12927  
Bcar1; breast cancer anti-estrogen resistance 1 [KO:K05726]
12928  
Crk; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO:K04438]
12929  
Crkl; v-crk sarcoma virus CT10 oncogene homolog (avian)-like [KO:K04438]
19229  
Ptk2b; PTK2 protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
18795  
Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18797  
Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  
Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18796  
Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
19395  
Rasgrp2; RAS, guanyl releasing protein 2 [KO:K12361]
109905  
Rap1a; RAS-related protein-1a [KO:K04353]
215449  
Rap1b; RAS related protein 1b [KO:K07836]
93742  
Pard3; par-3 family cell polarity regulator [KO:K04237]
21844  
Tiam1; T cell lymphoma invasion and metastasis 1 [KO:K05731]
17969  
Ncf1; neutrophil cytosolic factor 1 [KO:K08011]
24013  
Grk1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
110355  
Adrbk1; adrenergic receptor kinase, beta 1 [KO:K00910] [EC:2.7.11.15]
14772  
Grk4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
14773  
Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
26385  
Grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
109689  
Arrb1; arrestin, beta 1 [KO:K04439]
216869  
Arrb2; arrestin, beta 2 [KO:K04439]
18751  
Prkcb; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
18753  
Prkcd; protein kinase C, delta [KO:K06068] [EC:2.7.11.13]
18762  
Prkcz; protein kinase C, zeta [KO:K06069] [EC:2.7.11.13]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00575  
3',5'-Cyclic AMP
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
Reference
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
Reference
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
Reference
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
Reference
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
Reference
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
Reference
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
Reference
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
Reference
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
Reference
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
Reference
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
Reference
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
Reference
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
Reference
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
Reference
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
Reference
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
Reference
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
Reference
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
Reference
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
Reference
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
KO pathway
 

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