KEGG   PATHWAY: mmu04115Help
Entry
mmu04115                    Pathway                                

Name
p53 signaling pathway - Mus musculus (mouse)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
p53 signaling pathway
mmu04115

All organismsOrtholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
11920  
Atm; ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
50883  
Chek2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
245000  
Atr; ataxia telangiectasia and Rad3 related [KO:K06640] [EC:2.7.11.1]
12649  
Chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
98376  
Gorab; golgin, RAB6-interacting [KO:K19748]
12578  
Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621]
17246  
Mdm2; transformed mouse 3T3 cell double minute 2 [KO:K06643] [EC:2.3.2.27]
17248  
Mdm4; transformed mouse 3T3 cell double minute 4 [KO:K10127]
22059  
Trp53; transformation related protein 53 [KO:K04451]
12575  
Cdkn1a; cyclin-dependent kinase inhibitor 1A (P21) [KO:K06625]
12443  
Ccnd1; cyclin D1 [KO:K04503]
12444  
Ccnd2; cyclin D2 [KO:K10151]
12445  
Ccnd3; cyclin D3 [KO:K10152]
12567  
Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
12571  
Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
12447  
Ccne1; cyclin E1 [KO:K06626]
12448  
Ccne2; cyclin E2 [KO:K06626]
12566  
Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
55948  
Sfn; stratifin [KO:K06644]
67874  
Rprm; reprimo, TP53 dependent G2 arrest mediator candidate [KO:K10128]
268697  
Ccnb1; cyclin B1 [KO:K05868]
12442  
Ccnb2; cyclin B2 [KO:K05868]
209091  
Ccnb3; cyclin B3 [KO:K05868]
12534  
Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.23 2.7.11.22]
13197  
Gadd45a; growth arrest and DNA-damage-inducible 45 alpha [KO:K04402]
17873  
Gadd45b; growth arrest and DNA-damage-inducible 45 beta [KO:K04402]
23882  
Gadd45g; growth arrest and DNA-damage-inducible 45 gamma [KO:K04402]
29870  
Gtse1; G two S phase expressed protein 1 [KO:K10129]
14102  
Fas; Fas (TNF receptor superfamily member 6) [KO:K04390]
57913  
Pidd1; p53 induced death domain protein 1 [KO:K10130]
12370  
Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
12122  
Bid; BH3 interacting domain death agonist [KO:K04726]
12028  
Bax; BCL2-associated X protein [KO:K02159]
58801  
Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
170770  
Bbc3; BCL2 binding component 3 [KO:K10132]
13663  
Ei24; etoposide induced 2.4 mRNA [KO:K10134]
66940  
Shisa5; shisa family member 5 [KO:K10135]
64058  
Perp; PERP, TP53 apoptosis effector [KO:K10136]
22401  
Zmat3; zinc finger matrin type 3 [KO:K10137]
20437  
Siah1a; seven in absentia 1A [KO:K04506] [EC:2.3.2.27]
20438  
Siah1b; seven in absentia 1B [KO:K04506] [EC:2.3.2.27]
13063  
Cycs; cytochrome c, somatic [KO:K08738]
13067  
Cyct; cytochrome c, testis [KO:K08738]
11783  
Apaf1; apoptotic peptidase activating factor 1 [KO:K02084]
12371  
Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
12367  
Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
16009  
Igfbp3; insulin-like growth factor binding protein 3 [KO:K10138]
16000  
Igf1; insulin-like growth factor 1 [KO:K05459]
18787  
Serpine1; serine (or cysteine) peptidase inhibitor, clade E, member 1 [KO:K03982]
107831  
Adgrb1; adhesion G protein-coupled receptor B1 [KO:K04596]
12521  
Cd82; CD82 antigen [KO:K06509]
21825  
Thbs1; thrombospondin 1 [KO:K16857]
20724  
Serpinb5; serine (or cysteine) peptidase inhibitor, clade B, member 5 [KO:K10139]
107986  
Ddb2; damage specific DNA binding protein 2 [KO:K10140]
382985  
Rrm2b; ribonucleotide reductase M2 B (TP53 inducible) [KO:K10808] [EC:1.17.4.1]
20135  
Rrm2; ribonucleotide reductase M2 [KO:K10808] [EC:1.17.4.1]
140742  
Sesn1; sestrin 1 [KO:K10141]
75747  
Sesn3; sestrin 3 [KO:K10141]
230784  
Sesn2; sestrin 2 [KO:K20394]
19211  
Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
22084  
Tsc2; tuberous sclerosis 2 [KO:K07207]
68428  
Steap3; STEAP family member 3 [KO:K10142] [EC:1.16.1.-]
26374  
Rfwd2; ring finger and WD repeat domain 2 [KO:K10143] [EC:2.3.2.27]
68098  
Rchy1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:2.3.2.27]
12450  
Ccng1; cyclin G1 [KO:K10145]
12452  
Ccng2; cyclin G2 [KO:K10146]
53892  
Ppm1d; protein phosphatase 1D magnesium-dependent, delta isoform [KO:K10147] [EC:3.1.3.16]
22062  
Trp73; transformation related protein 73 [KO:K10148]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
KO pathway
 

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