KEGG PATHWAY: mmu04144

PATHWAY: mmu04144

Entry

mmu04144 Pathway

Name

Endocytosis - Mus musculus (mouse)

Description

Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.

Class

Cellular Processes; Transport and catabolism

Pathway map

mmu04144

Endocytosis

Module

mmu_M00408	ESCRT-0 complex [PATH:mmu04144]
mmu_M00409	ESCRT-I complex [PATH:mmu04144]
mmu_M00410	ESCRT-II complex [PATH:mmu04144]
mmu_M00412	ESCRT-III complex [PATH:mmu04144]

Other DBs

BSID:

102286

GO:

0006897

Organism

Mus musculus (mouse) [GN:mmu]

Gene

21803	Tgfb1; transforming growth factor, beta 1 [KO:K13375]
21808	Tgfb2; transforming growth factor, beta 2 [KO:K13376]
21809	Tgfb3; transforming growth factor, beta 3 [KO:K13377]
21812	Tgfbr1; transforming growth factor, beta receptor I [KO:K04674] [EC:2.7.11.30]
21813	Tgfbr2; transforming growth factor, beta receptor II [KO:K04388] [EC:2.7.11.30]
218441	Zfyve16; zinc finger, FYVE domain containing 16 [KO:K04679]
230597	Zfyve9; zinc finger, FYVE domain containing 9 [KO:K04679]
18854	Pml; promyelocytic leukemia [KO:K10054]
17126	Smad2; SMAD family member 2 [KO:K04500]
17127	Smad3; SMAD family member 3 [KO:K04500]
22042	Tfrc; transferrin receptor [KO:K06503]
13649	Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
14254	Flt1; FMS-like tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
16542	Kdr; kinase insert domain protein receptor [KO:K05098] [EC:2.7.10.1]
18595	Pdgfra; platelet derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
14183	Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
14184	Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
14186	Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
16001	Igf1r; insulin-like growth factor I receptor [KO:K05087] [EC:2.7.10.1]
17295	Met; met proto-oncogene [KO:K05099] [EC:2.7.10.1]
18211	Ntrk1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
13867	Erbb3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [KO:K05084] [EC:2.7.10.1]
13869	Erbb4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) [KO:K05085] [EC:2.7.10.1]
16590	Kit; kit oncogene [KO:K05091] [EC:2.7.10.1]
19713	Ret; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
12978	Csf1r; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
13645	Egf; epidermal growth factor [KO:K04357]
13430	Dnm2; dynamin 2 [KO:K01528] [EC:3.6.5.5]
13429	Dnm1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
103967	Dnm3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
11845	Arf6; ADP-ribosylation factor 6 [KO:K07941]
18717	Pip5k1c; phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma [KO:K00889] [EC:2.7.1.68]
18719	Pip5k1b; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta [KO:K00889] [EC:2.7.1.68]
18720	Pip5k1a; phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha [KO:K00889] [EC:2.7.1.68]
227733	Pip5kl1; phosphatidylinositol-4-phosphate 5-kinase-like 1 [KO:K13712] [EC:2.7.1.68]
18806	Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
18805	Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
12757	Clta; clathrin, light polypeptide (Lca) [KO:K04644]
74325	Cltb; clathrin, light polypeptide (Lcb) [KO:K04645]
67300	Cltc; clathrin, heavy polypeptide (Hc) [KO:K04646]
11772	Ap2a2; adaptor-related protein complex 2, alpha 2 subunit [KO:K11824]
11771	Ap2a1; adaptor-related protein complex 2, alpha 1 subunit [KO:K11824]
71770	Ap2b1; adaptor-related protein complex 2, beta 1 subunit [KO:K11825]
11773	Ap2m1; adaptor-related protein complex 2, mu 1 subunit [KO:K11826]
232910	Ap2s1; adaptor-related protein complex 2, sigma 1 subunit [KO:K11827]
259300	Ehd2; EH-domain containing 2 [KO:K12469]
12402	Cbl; Casitas B-lineage lymphoma [KO:K04707] [EC:6.3.2.19]
208650	Cblb; Casitas B-lineage lymphoma b [KO:K04707] [EC:6.3.2.19]
80794	Cblc; Casitas B-lineage lymphoma c [KO:K04707] [EC:6.3.2.19]
17999	Nedd4; neural precursor cell expressed, developmentally down-regulated 4 [KO:K10591] [EC:6.3.2.19]
83814	Nedd4l; neural precursor cell expressed, developmentally down-regulated gene 4-like [KO:K13305] [EC:6.3.2.19]
17246	Mdm2; transformed mouse 3T3 cell double minute 2 [KO:K06643] [EC:6.3.2.19]
22034	Traf6; TNF receptor-associated factor 6 [KO:K03175]
67588	Rnf41; ring finger protein 41 [KO:K11981] [EC:6.3.2.19]
16396	Itch; itchy, E3 ubiquitin protein ligase [KO:K05632] [EC:6.3.2.19]
66313	Smurf2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:6.3.2.19]
75788	Smurf1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:6.3.2.19]
107568	Wwp1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:6.3.2.19]
58194	Sh3kbp1; SH3-domain kinase binding protein 1 [KO:K12470]
20408	Sh3gl3; SH3-domain GRB2-like 3 [KO:K11247]
20404	Sh3gl2; SH3-domain GRB2-like 2 [KO:K11247]
20405	Sh3gl1; SH3-domain GRB2-like 1 [KO:K11247]
54673	Sh3glb1; SH3-domain GRB2-like B1 (endophilin) [KO:K11248]
227700	Sh3glb2; SH3-domain GRB2-like endophilin B2 [KO:K11248]
13854	Epn1; epsin 1 [KO:K12471]
13855	Epn2; epsin 2 [KO:K12471]
71889	Epn3; epsin 3 [KO:K12471]
13858	Eps15; epidermal growth factor receptor pathway substrate 15 [KO:K12472]
16835	Ldlr; low density lipoprotein receptor [KO:K12473]
100017	Ldlrap1; low density lipoprotein receptor adaptor protein 1 [KO:K12474]
13132	Dab2; disabled 2, mitogen-responsive phosphoprotein [KO:K12475]
12774	Ccr5; chemokine (C-C motif) receptor 5 [KO:K04180]
227288	Cxcr1; chemokine (C-X-C motif) receptor 1 [KO:K04175]
12765	Cxcr2; chemokine (C-X-C motif) receptor 2 [KO:K05050]
12767	Cxcr4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
14062	F2r; coagulation factor II (thrombin) receptor [KO:K03914]
11554	Adrb1; adrenergic receptor, beta 1 [KO:K04141]
11555	Adrb2; adrenergic receptor, beta 2 [KO:K04142]
11556	Adrb3; adrenergic receptor, beta 3 [KO:K04143]
24013	Grk1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
110355	Adrbk1; adrenergic receptor kinase, beta 1 [KO:K00910] [EC:2.7.11.15]
14772	Grk4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
14773	Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
26385	Grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
109689	Arrb1; arrestin, beta 1 [KO:K04439]
216869	Arrb2; arrestin, beta 2 [KO:K04439]
17130	Smad6; SMAD family member 6 [KO:K04677]
17131	Smad7; SMAD family member 7 [KO:K04677]
14275	Folr1; folate receptor 1 (adult) [KO:K13649]
14276	Folr2; folate receptor 2 (fetal) [KO:K13649]
64931	Folr4; folate receptor 4 (delta) [KO:K13649]
12389	Cav1; caveolin 1, caveolae protein [KO:K06278]
12390	Cav2; caveolin 2 [KO:K12958]
12391	Cav3; caveolin 3 [KO:K12959]
14990	H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991	H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997	H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
15006	H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007	H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013	H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15018	H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15019	H2-Q8; histocompatibility 2, Q region locus 8 [KO:K06751]
15039	H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040	H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042	H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043	H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15051	H2-T9; histocompatibility 2, T region locus 9 [KO:K06751]
224753	H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754	H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756	H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761	H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
333715	H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
399549	H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
15024	H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
110557	H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110696	H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
14963	H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964	H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14972	H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14985	H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
547349	MHC class I family member; K06751 major histocompatibility complex, class I [KO:K06751]
100862435	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
676708	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
101056305	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
101056446	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
16184	Il2ra; interleukin 2 receptor, alpha chain [KO:K05068]
16185	Il2rb; interleukin 2 receptor, beta chain [KO:K05069]
16186	Il2rg; interleukin 2 receptor, gamma chain [KO:K05070]
20779	Src; Rous sarcoma oncogene [KO:K05704] [EC:2.7.10.2]
15461	Hras1; Harvey rat sarcoma virus oncogene 1 [KO:K02833]
11848	Rhoa; ras homolog gene family, member A [KO:K04513]
67653	4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513]
15481	Hspa8; heat shock protein 8 [KO:K03283]
15482	Hspa1l; heat shock protein 1-like [KO:K03283]
193740	Hspa1a; heat shock protein 1A [KO:K03283]
15512	Hspa2; heat shock protein 2 [KO:K03283]
15511	Hspa1b; heat shock protein 1B [KO:K03283]
72685	Dnajc6; DnaJ (Hsp40) homolog, subfamily C, member 6 [KO:K09526]
84092	Usp8; ubiquitin specific peptidase 8 [KO:K11839] [EC:3.1.2.15]
70527	Stambp; STAM binding protein [KO:K11866] [EC:3.1.2.15]
19349	Rab7; RAB7, member RAS oncogene family [KO:K07897]
15239	Hgs; HGF-regulated tyrosine kinase substrate [KO:K12182]
20844	Stam; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [KO:K04705]
56324	Stam2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [KO:K04705]
22088	Tsg101; tumor susceptibility gene 101 [KO:K12183]
73711	Mvb12a; multivesicular body subunit 12A [KO:K12186]
72543	Mvb12b; multivesicular body subunit 12B [KO:K12186]
66914	Vps28; vacuolar protein sorting 28 (yeast) [KO:K12184]
194309	Vps37d; vacuolar protein sorting 37D (yeast) [KO:K12185]
330192	Vps37b; vacuolar protein sorting 37B (yeast) [KO:K12185]
107305	Vps37c; vacuolar protein sorting 37C (yeast) [KO:K12185]
52348	Vps37a; vacuolar protein sorting 37A (yeast) [KO:K12185]
27681	Snf8; SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) [KO:K12188]
70160	Vps36; vacuolar protein sorting 36 (yeast) [KO:K12190]
28084	Vps25; vacuolar protein sorting 25 (yeast) [KO:K12189]
208092	Chmp6; charged multivesicular body protein 6 [KO:K12195]
66371	Chmp4c; charged multivesicular body protein 4C [KO:K12194]
75608	Chmp4b; charged multivesicular body protein 4B [KO:K12194]
66700	Chmp3; charged multivesicular body protein 3 [KO:K12193]
68953	Chmp2a; charged multivesicular body protein 2A [KO:K12191]
68942	Chmp2b; charged multivesicular body protein 2B [KO:K12192]
105513	Chmp7; charged multivesicular body protein 7 [KO:K15053]
20479	Vps4b; vacuolar protein sorting 4b (yeast) [KO:K12196]
116733	Vps4a; vacuolar protein sorting 4a (yeast) [KO:K12196]
66201	Vta1; Vps20-associated 1 homolog (S. cerevisiae) [KO:K12199]
67028	2610002M06Rik; RIKEN cDNA 2610002M06 gene [KO:K12197]
67064	Chmp1b; charged multivesicular body protein 1B [KO:K12197]
234852	Chmp1a; charged multivesicular body protein 1A [KO:K12197]
76959	Chmp5; charged multivesicular body protein 5 [KO:K12198]
18571	Pdcd6ip; programmed cell death 6 interacting protein [KO:K12200]
57440	Ehd3; EH-domain containing 3 [KO:K12476]
98878	Ehd4; EH-domain containing 4 [KO:K12477]
216238	Eea1; early endosome antigen 1 [KO:K12478]
271457	Rab5a; RAB5A, member RAS oncogene family [KO:K07887]
19344	Rab5b; RAB5B, member RAS oncogene family [KO:K07888]
19345	Rab5c; RAB5C, member RAS oncogene family [KO:K07889]
22365	Vps45; vacuolar protein sorting 45 (yeast) [KO:K12479]
54189	Rabep1; rabaptin, RAB GTPase binding effector protein 1 [KO:K12480]
78287	Zfyve20; zinc finger, FYVE domain containing 20 [KO:K12481]
19341	Rab4a; RAB4A, member RAS oncogene family [KO:K07879]
216724	Rufy1; RUN and FYVE domain containing 1 [KO:K12482]
13660	Ehd1; EH-domain containing 1 [KO:K12483]
53869	Rab11a; RAB11a, member RAS oncogene family [KO:K07904]
19326	Rab11b; RAB11B, member RAS oncogene family [KO:K07905]
74998	Rab11fip2; RAB11 family interacting protein 2 (class I) [KO:K12484]
75767	Rab11fip1; RAB11 family interacting protein 1 (class I) [KO:K12484]
52055	Rab11fip5; RAB11 family interacting protein 5 (class I) [KO:K12484]
268451	Rab11fip4; RAB11 family interacting protein 4 (class II) [KO:K12485]
215445	Rab11fip3; RAB11 family interacting protein 3 (class II) [KO:K12485]
19334	Rab22a; RAB22A, member RAS oncogene family [KO:K07891]
106572	Rab31; RAB31, member RAS oncogene family [KO:K07892]
93742	Pard3; par-3 (partitioning defective 3) homolog (C. elegans) [KO:K04237]
56513	Pard6a; par-6 (partitioning defective 6,) homolog alpha (C. elegans) [KO:K06093]
58220	Pard6b; par-6 (partitioning defective 6) homolog beta (C. elegans) [KO:K06093]
93737	Pard6g; par-6 partitioning defective 6 homolog gamma (C. elegans) [KO:K06093]
18759	Prkci; protein kinase C, iota [KO:K06069] [EC:2.7.11.13]
18762	Prkcz; protein kinase C, zeta [KO:K06069] [EC:2.7.11.13]
12540	Cdc42; cell division cycle 42 [KO:K04393]
69780	Smap2; stromal membrane-associated GTPase-activating protein 2 [KO:K12486]
98366	Smap1; stromal membrane-associated protein 1 [KO:K12486]
216963	Git1; G protein-coupled receptor kinase-interactor 1 [KO:K05737]
26431	Git2; G protein-coupled receptor kinase-interactor 2 [KO:K12487]
230837	Asap3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [KO:K12488]
211914	Asap2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [KO:K12488]
13196	Asap1; ArfGAP with SH3 domain, ankyrin repeat and PH domain1 [KO:K12488]
140500	Acap3; ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [KO:K12489]
216859	Acap1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [KO:K12489]
78618	Acap2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [KO:K12489]
69710	Arap1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [KO:K12490]
212285	Arap2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [KO:K12490]
106952	Arap3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
213990	Agap3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [KO:K12491]
216439	Agap2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [KO:K12491]
347722	Agap1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [KO:K12491]
228998	Arfgap1; ADP-ribosylation factor GTPase activating protein 1 [KO:K12492]
66251	Arfgap3; ADP-ribosylation factor GTPase activating protein 3 [KO:K12493]
77038	Arfgap2; ADP-ribosylation factor GTPase activating protein 2 [KO:K12493]
215632	Psd4; pleckstrin and Sec7 domain containing 4 [KO:K12494]
234353	Psd3; pleckstrin and Sec7 domain containing 3 [KO:K12494]
73728	Psd; pleckstrin and Sec7 domain containing [KO:K12494]
74002	Psd2; pleckstrin and Sec7 domain containing 2 [KO:K12494]
245666	Iqsec2; IQ motif and Sec7 domain 2 [KO:K12495]
232227	Iqsec1; IQ motif and Sec7 domain 1 [KO:K12495]
243621	Iqsec3; IQ motif and Sec7 domain 3 [KO:K12495]

Compound

C00002	ATP
C00008	ADP
C00504	Folate
C04549	1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637	1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981	Phosphatidylinositol-3,4,5-trisphosphate
G00110	GM1

Reference

PMID:19007773

Authors

Acconcia F, Sigismund S, Polo S

Title

Ubiquitin in trafficking: the network at work.

Journal

Exp Cell Res 315:1610-8 (2009)

Reference

PMID:18647649

Authors

Donaldson JG, Porat-Shliom N, Cohen LA

Title

Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.

Journal

Cell Signal 21:1-6 (2009)

Reference

PMID:15261671

Authors

Sorkin A

Title

Cargo recognition during clathrin-mediated endocytosis: a team effort.

Journal

Curr Opin Cell Biol 16:392-9 (2004)

Reference

PMID:19325624

Authors

Raiborg C, Stenmark H

Title

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.

Journal

Nature 458:445-52 (2009)

Reference

(Japanese)

Authors

Ohno H, Yoshimori T (eds).

Title

[Current Stream in Membrane Traffic] (in Japanese)

Journal

Tanpakushitsu Kakusan Koso 53 (2008)

Reference

PMID:20110990

Authors

Scita G, Di Fiore PP

Title

The endocytic matrix.

Journal

Nature 463:464-73 (2010)

Reference

PMID:15687999

Authors

Le Roy C, Wrana JL

Title

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.

Journal

Nat Rev Mol Cell Biol 6:112-26 (2005)

Reference

PMID:19924646

Authors

Jovic M, Sharma M, Rahajeng J, Caplan S

Title

The early endosome: a busy sorting station for proteins at the crossroads.

Journal

Histol Histopathol 25:99-112 (2010)

Reference

PMID:16203612

Authors

Pietiainen VM, Marjomaki V, Heino J, Hyypia T

Title

Viral entry, lipid rafts and caveosomes.

Journal

Ann Med 37:394-403 (2005)

KO pathway

ko04144

All links

Pathway (5)   
   KEGG MODULE (4)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (225)   
   KEGG GENES (225)   
All databases (231)   

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