KEGG PATHWAY: mmu04145

PATHWAY: mmu04145

Entry

mmu04145 Pathway

Name

Phagosome - Mus musculus (mouse)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

mmu04145

Phagosome

Module

mmu_M00401

Sec61 complex [PATH:mmu04145]

Other DBs

BSID:

153914

GO:

0045335

Organism

Mus musculus (mouse) [GN:mmu]

Gene

22319	Vamp3; vesicle-associated membrane protein 3 [KO:K13505]
100226	Stx12; syntaxin 12 [KO:K13813]
53331	Stx7; syntaxin 7 [KO:K08488]
11461	Actb; actin, beta [KO:K05692]
11465	Actg1; actin, gamma, cytoplasmic 1 [KO:K05692]
12721	Coro1a; coronin, actin binding protein 1A [KO:K13882]
71116	Stx18; syntaxin 18 [KO:K08492]
20333	Sec22b; SEC22 vesicle trafficking protein homolog B (S. cerevisiae) [KO:K08517]
14990	H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991	H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997	H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
15006	H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007	H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013	H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15018	H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15019	H2-Q8; histocompatibility 2, Q region locus 8 [KO:K06751]
15039	H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040	H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042	H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043	H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15051	H2-T9; histocompatibility 2, T region locus 9 [KO:K06751]
224753	H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754	H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756	H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761	H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
333715	H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
399549	H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
15024	H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
110557	H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110696	H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
14963	H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964	H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14972	H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14985	H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
547349	MHC class I family member; K06751 major histocompatibility complex, class I [KO:K06751]
100862435	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
676708	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
101056305	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
101056446	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
14960	H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961	H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14969	H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14998	H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999	H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000	H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001	H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002	H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
100504404	H2-Ea-ps; histocompatibility 2, class II antigen E alpha, pseudogene [KO:K06752]
271457	Rab5a; RAB5A, member RAS oncogene family [KO:K07887]
19344	Rab5b; RAB5B, member RAS oncogene family [KO:K07888]
19345	Rab5c; RAB5C, member RAS oncogene family [KO:K07889]
216238	Eea1; early endosome antigen 1 [KO:K12478]
225326	Pik3c3; phosphoinositide-3-kinase, class 3 [KO:K00914] [EC:2.7.1.137]
22042	Tfrc; transferrin receptor [KO:K06503]
15239	Hgs; HGF-regulated tyrosine kinase substrate [KO:K12182]
11964	Atp6v1a; ATPase, H+ transporting, lysosomal V1 subunit A [KO:K02145] [EC:3.6.3.14]
11966	Atp6v1b2; ATPase, H+ transporting, lysosomal V1 subunit B2 [KO:K02147] [EC:3.6.3.14]
110935	Atp6v1b1; ATPase, H+ transporting, lysosomal V1 subunit B1 [KO:K02147] [EC:3.6.3.14]
66335	Atp6v1c1; ATPase, H+ transporting, lysosomal V1 subunit C1 [KO:K02148] [EC:3.6.3.14]
68775	Atp6v1c2; ATPase, H+ transporting, lysosomal V1 subunit C2 [KO:K02148] [EC:3.6.3.14]
73834	Atp6v1d; ATPase, H+ transporting, lysosomal V1 subunit D [KO:K02149] [EC:3.6.3.14]
11973	Atp6v1e1; ATPase, H+ transporting, lysosomal V1 subunit E1 [KO:K02150] [EC:3.6.3.14]
74915	Atp6v1e2; ATPase, H+ transporting, lysosomal V1 subunit E2 [KO:K02150] [EC:3.6.3.14]
66144	Atp6v1f; ATPase, H+ transporting, lysosomal V1 subunit F [KO:K02151] [EC:3.6.3.14]
66237	Atp6v1g2; ATPase, H+ transporting, lysosomal V1 subunit G2 [KO:K02152] [EC:3.6.3.14]
66290	Atp6v1g1; ATPase, H+ transporting, lysosomal V1 subunit G1 [KO:K02152] [EC:3.6.3.14]
338375	Atp6v1g3; ATPase, H+ transporting, lysosomal V1 subunit G3 [KO:K02152] [EC:3.6.3.14]
11974	Atp6v0e; ATPase, H+ transporting, lysosomal V0 subunit E [KO:K02153] [EC:3.6.3.14]
76252	Atp6v0e2; ATPase, H+ transporting, lysosomal V0 subunit E2 [KO:K02153] [EC:3.6.3.14]
11975	Atp6v0a1; ATPase, H+ transporting, lysosomal V0 subunit A1 [KO:K02154] [EC:3.6.3.14]
21871	Atp6v0a2; ATPase, H+ transporting, lysosomal V0 subunit A2 [KO:K02154] [EC:3.6.3.14]
27060	Tcirg1; T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 [KO:K02154] [EC:3.6.3.14]
140494	Atp6v0a4; ATPase, H+ transporting, lysosomal V0 subunit A4 [KO:K02154] [EC:3.6.3.14]
11972	Atp6v0d1; ATPase, H+ transporting, lysosomal V0 subunit D1 [KO:K02146] [EC:3.6.3.14]
242341	Atp6v0d2; ATPase, H+ transporting, lysosomal V0 subunit D2 [KO:K02146] [EC:3.6.3.14]
108664	Atp6v1h; ATPase, H+ transporting, lysosomal V1 subunit H [KO:K02144] [EC:3.6.3.14]
11984	Atp6v0c; ATPase, H+ transporting, lysosomal V0 subunit C [KO:K02155] [EC:3.6.3.14]
114143	Atp6v0b; ATPase, H+ transporting, lysosomal V0 subunit B [KO:K03661] [EC:3.6.3.14]
54411	Atp6ap1; ATPase, H+ transporting, lysosomal accessory protein 1 [KO:K03662] [EC:3.6.3.14]
19349	Rab7; RAB7, member RAS oncogene family [KO:K07897]
226421	5430435G22Rik; RIKEN cDNA 5430435G22 gene [KO:K07898]
280408	Rilp; Rab interacting lysosomal protein [KO:K13883]
13424	Dync1h1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
110350	Dync2h1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
13426	Dync1i1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415]
13427	Dync1i2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
234663	Dync1li2; dynein, cytoplasmic 1 light intermediate chain 2 [KO:K10416]
235661	Dync1li1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
22145	Tuba4a; tubulin, alpha 4A [KO:K07374]
22144	Tuba3a; tubulin, alpha 3A [KO:K07374]
22142	Tuba1a; tubulin, alpha 1A [KO:K07374]
22146	Tuba1c; tubulin, alpha 1C [KO:K07374]
22147	Tuba3b; tubulin, alpha 3B [KO:K07374]
22143	Tuba1b; tubulin, alpha 1B [KO:K07374]
53857	Tuba8; tubulin, alpha 8 [KO:K07374]
238463	Tubal3; tubulin, alpha-like 3 [KO:K07374]
434428	Gm5620; tubulin, alpha 1B pseudogene [KO:K07374]
227613	Tubb4b; tubulin, beta 4B class IVB [KO:K07375]
22151	Tubb2a; tubulin, beta 2A class IIA [KO:K07375]
22152	Tubb3; tubulin, beta 3 class III [KO:K07375]
22153	Tubb4a; tubulin, beta 4A class IVA [KO:K07375]
67951	Tubb6; tubulin, beta 6 class V [KO:K07375]
22154	Tubb5; tubulin, beta 5 class I [KO:K07375]
545486	Tubb1; tubulin, beta 1 class VI [KO:K07375]
73710	Tubb2b; tubulin, beta 2B class IIB [KO:K07375]
16783	Lamp1; lysosomal-associated membrane protein 1 [KO:K06528]
16784	Lamp2; lysosomal-associated membrane protein 2 [KO:K06528]
18711	Pikfyve; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
17113	M6pr; mannose-6-phosphate receptor, cation dependent [KO:K10089]
18125	Nos1; nitric oxide synthase 1, neuronal [KO:K13240] [EC:1.14.13.39]
17523	Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
13039	Ctsl; cathepsin L [KO:K01365] [EC:3.4.22.15]
13040	Ctss; cathepsin S [KO:K01368] [EC:3.4.22.27]
53421	Sec61a1; Sec61 alpha 1 subunit (S. cerevisiae) [KO:K10956]
57743	Sec61a2; Sec61, alpha subunit 2 (S. cerevisiae) [KO:K10956]
66212	Sec61b; Sec61 beta subunit [KO:K09481]
20335	Sec61g; SEC61, gamma subunit [KO:K07342]
100042561	Gm10177; predicted gene 10177 [KO:K07342]
100041121	Gm10144; predicted pseudogene 10144 [KO:K07342]
100043027	Gm11575; predicted gene 11575 [KO:K07342]
100046078	Gm15266; predicted gene 15266 [KO:K07342]
21354	Tap1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05653]
21355	Tap2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05654]
12317	Calr; calreticulin [KO:K08057]
12330	Canx; calnexin [KO:K08054]
14129	Fcgr1; Fc receptor, IgG, high affinity I [KO:K06498]
14130	Fcgr2b; Fc receptor, IgG, low affinity IIb [KO:K12560]
14131	Fcgr3; Fc receptor, IgG, low affinity III [KO:K16824]
246256	Fcgr4; Fc receptor, IgG, low affinity IV [KO:K06463]
16061	Igh-VJ558; immunoglobulin heavy chain (J558 family) [KO:K06856]
50909	C1ra; complement component 1, r subcomponent A [KO:K01330] [EC:3.4.21.41]
16409	Itgam; integrin alpha M [KO:K06461]
16414	Itgb2; integrin beta 2 [KO:K06464]
16415	Itgb2l; integrin beta 2-like [KO:K06464]
12266	C3; complement component 3 [KO:K03990]
71693	Colec11; collectin sub-family member 11 [KO:K10066]
140792	Colec12; collectin sub-family member 12 [KO:K10062]
17194	Mbl1; mannose-binding lectin (protein A) 1 [KO:K03991]
17195	Mbl2; mannose-binding lectin (protein C) 2 [KO:K03991]
20387	Sftpa1; surfactant associated protein A1 [KO:K10067]
20390	Sftpd; surfactant associated protein D [KO:K10068]
16410	Itgav; integrin alpha V [KO:K06487]
16398	Itga2; integrin alpha 2 [KO:K06481]
16402	Itga5; integrin alpha 5 (fibronectin receptor alpha) [KO:K06484]
16412	Itgb1; integrin beta 1 (fibronectin receptor beta) [KO:K05719]
16416	Itgb3; integrin beta 3 [KO:K06493]
16419	Itgb5; integrin beta 5 [KO:K06588]
21825	Thbs1; thrombospondin 1 [KO:K16857]
12845	Comp; cartilage oligomeric matrix protein [KO:K04659]
21826	Thbs2; thrombospondin 2 [KO:K04659]
21827	Thbs3; thrombospondin 3 [KO:K04659]
21828	Thbs4; thrombospondin 4 [KO:K04659]
24088	Tlr2; toll-like receptor 2 [KO:K10159]
21899	Tlr6; toll-like receptor 6 [KO:K10169]
21898	Tlr4; toll-like receptor 4 [KO:K10160]
12475	Cd14; CD14 antigen [KO:K04391]
17533	Mrc1; mannose receptor, C type 1 [KO:K06560]
17534	Mrc2; mannose receptor, C type 2 [KO:K06560]
18779	Pla2r1; phospholipase A2 receptor 1 [KO:K06560]
170776	Cd209c; CD209c antigen [KO:K06563]
170779	Cd209d; CD209d antigen [KO:K06563]
170780	Cd209e; CD209e antigen [KO:K06563]
170786	Cd209a; CD209a antigen [KO:K06563]
69165	Cd209b; CD209b antigen [KO:K06563]
69142	Cd209f; CD209f antigen [KO:K06563]
70192	Cd209g; CD209g antigen [KO:K06563]
56644	Clec7a; C-type lectin domain family 7, member a [KO:K10074]
20288	Msr1; macrophage scavenger receptor 1 [KO:K06558]
17167	Marco; macrophage receptor with collagenous structure [KO:K13884]
108078	Olr1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763]
20778	Scarb1; scavenger receptor class B, member 1 [KO:K13885]
12491	Cd36; CD36 antigen [KO:K06259]
13057	Cyba; cytochrome b-245, alpha polypeptide [KO:K08009]
13058	Cybb; cytochrome b-245, beta polypeptide [KO:K08008]
224480	Nox3; NADPH oxidase 3 [KO:K08008]
237038	Nox1; NADPH oxidase 1 [KO:K08008]
19353	Rac1; RAS-related C3 botulinum substrate 1 [KO:K04392]
17969	Ncf1; neutrophil cytosolic factor 1 [KO:K08011]
17970	Ncf2; neutrophil cytosolic factor 2 [KO:K08010]
17972	Ncf4; neutrophil cytosolic factor 4 [KO:K08012]

Compound

C00007	Oxygen
C00027	Hydrogen peroxide
C00533	Nitric oxide
C00704	O2.-
C04549	1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

PMID:15894272

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)

Reference

PMID:10684585

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)

Reference

PMID:18492791

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)

Reference

PMID:15036145

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)

Reference

PMID:17245426

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)

Reference

PMID:17637737

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)

Reference

PMID:18513324

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)

KO pathway

ko04145

All links

Pathway (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (180)   
   KEGG GENES (180)   
All databases (183)   

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