KEGG PATHWAY: mmu04630

PATHWAY: mmu04630

Entry

mmu04630 Pathway

Name

Jak-STAT signaling pathway - Mus musculus (mouse)

Description

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.

Class

Environmental Information Processing; Signal transduction

Pathway map

mmu04630

Jak-STAT signaling pathway

Other DBs

BSID:

83274

GO:

0007259

Organism

Mus musculus (mouse) [GN:mmu]

Gene

22018	Tpo; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
13856	Epo; erythropoietin [KO:K05437]
14599	Gh; growth hormone [KO:K05438]
19109	Prl; prolactin [KO:K05439]
15978	Ifng; interferon gamma [KO:K04687]
15962	Ifna1; interferon alpha 1 [KO:K05414]
15965	Ifna2; interferon alpha 2 [KO:K05414]
15967	Ifna4; interferon alpha 4 [KO:K05414]
15968	Ifna5; interferon alpha 5 [KO:K05414]
15969	Ifna6; interferon alpha 6 [KO:K05414]
15970	Ifna7; interferon alpha 7 [KO:K05414]
15972	Ifna9; interferon alpha 9 [KO:K05414]
15964	Ifna11; interferon alpha 11 [KO:K05414]
242519	Ifna12; interferon alpha 12 [KO:K05414]
230396	Ifna13; interferon alpha 13 [KO:K05414]
404549	Ifna14; interferon, alpha 14 [KO:K05414]
15974	Ifnab; interferon alpha B [KO:K05414]
242517	Gm12597; predicted gene 12597 [KO:K05414]
15977	Ifnb1; interferon beta 1, fibroblast [KO:K05415]
387510	Ifnk; interferon kappa [KO:K05441]
230405	Ifne; interferon epsilon [KO:K05442]
16153	Il10; interleukin 10 [KO:K05443]
329244	Il19; interleukin 19 [KO:K05444]
58181	Il20; interleukin 20 [KO:K05444]
93672	Il24; interleukin 24 [KO:K05444]
50929	Il22; interleukin 22 [KO:K05445]
338374	Ifnl3; interferon lambda 3 [KO:K05447]
330496	Ifnl2; interferon lambda 2 [KO:K05447]
16187	Il3; interleukin 3 [KO:K04736]
12981	Csf2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
16191	Il5; interleukin 5 [KO:K05428]
16183	Il2; interleukin 2 [KO:K05429]
16189	Il4; interleukin 4 [KO:K05430]
16196	Il7; interleukin 7 [KO:K05431]
16198	Il9; interleukin 9 [KO:K05432]
16168	Il15; interleukin 15 [KO:K05433]
60505	Il21; interleukin 21 [KO:K05434]
16163	Il13; interleukin 13 [KO:K05435]
53603	Tslp; thymic stromal lymphopoietin [KO:K05436]
16193	Il6; interleukin 6 [KO:K05405]
16159	Il12a; interleukin 12a [KO:K05406]
16156	Il11; interleukin 11 [KO:K05417]
18413	Osm; oncostatin M [KO:K05418]
16878	Lif; leukemia inhibitory factor [KO:K05419]
12803	Cntf; ciliary neurotrophic factor [KO:K05420]
56708	Clcf1; cardiotrophin-like cytokine factor 1 [KO:K05421]
13019	Ctf1; cardiotrophin 1 [KO:K05422]
12985	Csf3; colony stimulating factor 3 (granulocyte) [KO:K05423]
16846	Lep; leptin [KO:K05424]
16160	Il12b; interleukin 12b [KO:K05425]
83430	Il23a; interleukin 23, alpha subunit p19 [KO:K05426]
16188	Il3ra; interleukin 3 receptor, alpha chain [KO:K04737]
12984	Csf2rb2; colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) [KO:K04738]
12983	Csf2rb; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [KO:K04738]
16194	Il6ra; interleukin 6 receptor, alpha [KO:K05055]
16157	Il11ra1; interleukin 11 receptor, alpha chain 1 [KO:K05056]
16158	Il11ra2; interleukin 11 receptor, alpha chain 2 [KO:K05056]
100861969	interleukin-11 receptor subunit alpha-2-like; K05056 interleukin 11 receptor alpha [KO:K05056]
100042555	Gm13305; predicted gene 13305 [KO:K05056]
100038993	Gm2002; predicted gene 2002 [KO:K05056]
18414	Osmr; oncostatin M receptor [KO:K05057]
16880	Lifr; leukemia inhibitory factor receptor [KO:K05058]
12804	Cntfr; ciliary neurotrophic factor receptor [KO:K05059]
16195	Il6st; interleukin 6 signal transducer [KO:K05060]
12986	Csf3r; colony stimulating factor 3 receptor (granulocyte) [KO:K05061]
16847	Lepr; leptin receptor [KO:K05062]
16161	Il12rb1; interleukin 12 receptor, beta 1 [KO:K05063]
16162	Il12rb2; interleukin 12 receptor, beta 2 [KO:K05064]
209590	Il23r; interleukin 23 receptor [KO:K05065]
12982	Csf2ra; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [KO:K05066]
16192	Il5ra; interleukin 5 receptor, alpha [KO:K05067]
16184	Il2ra; interleukin 2 receptor, alpha chain [KO:K05068]
16185	Il2rb; interleukin 2 receptor, beta chain [KO:K05069]
16186	Il2rg; interleukin 2 receptor, gamma chain [KO:K05070]
16190	Il4ra; interleukin 4 receptor, alpha [KO:K05071]
16197	Il7r; interleukin 7 receptor [KO:K05072]
16199	Il9r; interleukin 9 receptor [KO:K05073]
16169	Il15ra; interleukin 15 receptor, alpha chain [KO:K05074]
60504	Il21r; interleukin 21 receptor [KO:K05075]
16164	Il13ra1; interleukin 13 receptor, alpha 1 [KO:K05076]
16165	Il13ra2; interleukin 13 receptor, alpha 2 [KO:K05077]
57914	Crlf2; cytokine receptor-like factor 2 [KO:K05078]
13857	Epor; erythropoietin receptor [KO:K05079]
14600	Ghr; growth hormone receptor [KO:K05080]
19116	Prlr; prolactin receptor [KO:K05081]
17480	Mpl; myeloproliferative leukemia virus oncogene [KO:K05082]
15975	Ifnar1; interferon (alpha and beta) receptor 1 [KO:K05130]
15976	Ifnar2; interferon (alpha and beta) receptor 2 [KO:K05131]
15979	Ifngr1; interferon gamma receptor 1 [KO:K05132]
15980	Ifngr2; interferon gamma receptor 2 [KO:K05133]
16154	Il10ra; interleukin 10 receptor, alpha [KO:K05134]
16155	Il10rb; interleukin 10 receptor, beta [KO:K05135]
237313	Il20ra; interleukin 20 receptor, alpha [KO:K05136]
213208	Il20rb; interleukin 20 receptor beta [KO:K05137]
230828	Il22ra1; interleukin 22 receptor, alpha 1 [KO:K05138]
237310	Il22ra2; interleukin 22 receptor, alpha 2 [KO:K05139]
242700	Ifnlr1; interferon lambda receptor 1 [KO:K05140]
16451	Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
16452	Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
16453	Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
54721	Tyk2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
20846	Stat1; signal transducer and activator of transcription 1 [KO:K11220]
20847	Stat2; signal transducer and activator of transcription 2 [KO:K11221]
20848	Stat3; signal transducer and activator of transcription 3 [KO:K04692]
20849	Stat4; signal transducer and activator of transcription 4 [KO:K11222]
20850	Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
20851	Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
20852	Stat6; signal transducer and activator of transcription 6 [KO:K11225]
16391	Irf9; interferon regulatory factor 9 [KO:K04693]
12914	Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
328572	Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
12703	Socs1; suppressor of cytokine signaling 1 [KO:K04694]
216233	Socs2; suppressor of cytokine signaling 2 [KO:K04695]
12702	Socs3; suppressor of cytokine signaling 3 [KO:K04696]
67296	Socs4; suppressor of cytokine signaling 4 [KO:K04697]
56468	Socs5; suppressor of cytokine signaling 5 [KO:K04698]
192157	Socs7; suppressor of cytokine signaling 7 [KO:K04699]
12700	Cish; cytokine inducible SH2-containing protein [KO:K04701]
18712	Pim1; proviral integration site 1 [KO:K04702] [EC:2.7.11.1]
17869	Myc; myelocytomatosis oncogene [KO:K04377]
12443	Ccnd1; cyclin D1 [KO:K04503]
12444	Ccnd2; cyclin D2 [KO:K10151]
12445	Ccnd3; cyclin D3 [KO:K10152]
12048	Bcl2l1; BCL2-like 1 [KO:K04570]
101809	Spred3; sprouty-related, EVH1 domain containing 3 [KO:K04703]
114715	Spred1; sprouty protein with EVH-1 domain 1, related sequence [KO:K04703]
114716	Spred2; sprouty-related, EVH1 domain containing 2 [KO:K04703]
236576	Spry3; sprouty homolog 3 (Drosophila) [KO:K04704]
24063	Spry1; sprouty homolog 1 (Drosophila) [KO:K04704]
24064	Spry2; sprouty homolog 2 (Drosophila) [KO:K04704]
24066	Spry4; sprouty homolog 4 (Drosophila) [KO:K04704]
20844	Stam; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [KO:K04705]
56324	Stam2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [KO:K04705]
56469	Pias1; protein inhibitor of activated STAT 1 [KO:K04706] [EC:6.3.2.-]
17344	Pias2; protein inhibitor of activated STAT 2 [KO:K16063] [EC:6.3.2.-]
229615	Pias3; protein inhibitor of activated STAT 3 [KO:K16064] [EC:6.3.2.-]
59004	Pias4; protein inhibitor of activated STAT 4 [KO:K16065] [EC:6.3.2.-]
12402	Cbl; Casitas B-lineage lymphoma [KO:K04707] [EC:6.3.2.19]
208650	Cblb; Casitas B-lineage lymphoma b [KO:K04707] [EC:6.3.2.19]
80794	Cblc; Casitas B-lineage lymphoma c [KO:K04707] [EC:6.3.2.19]
19247	Ptpn11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
14784	Grb2; growth factor receptor bound protein 2 [KO:K04364]
20662	Sos1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
20663	Sos2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
30955	Pik3cg; phosphoinositide-3-kinase, catalytic, gamma polypeptide [KO:K00922] [EC:2.7.1.153]
18706	Pik3ca; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide [KO:K00922] [EC:2.7.1.153]
18707	Pik3cd; phosphatidylinositol 3-kinase catalytic delta polypeptide [KO:K00922] [EC:2.7.1.153]
74769	Pik3cb; phosphatidylinositol 3-kinase, catalytic, beta polypeptide [KO:K00922] [EC:2.7.1.153]
18709	Pik3r2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [KO:K02649]
18708	Pik3r1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) [KO:K02649]
320207	Pik3r5; phosphoinositide-3-kinase, regulatory subunit 5, p101 [KO:K02649]
18710	Pik3r3; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) [KO:K02649]
11651	Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652	Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797	Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
15170	Ptpn6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:3.1.3.48]

Reference

PMID:12039028

Authors

Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW.

Title

Signaling through the JAK/STAT pathway, recent advances and future challenges.

Journal

Gene 285:1-24 (2002)

Reference

PMID:11994400

Authors

Schindler CW.

Title

Series introduction. JAK-STAT signaling in human disease.

Journal

J Clin Invest 109:1133-7 (2002)

Reference

PMID:9716487

Authors

Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L.

Title

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.

Journal

Biochem J 334 ( Pt 2):297-314 (1998)

Reference

PMID:15003245

Authors

Luo C, Laaja P.

Title

Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs.

Journal

Drug Discov Today 9:268-75 (2004)

Reference

PMID:12479803

Authors

Hou SX, Zheng Z, Chen X, Perrimon N.

Title

The Jak/STAT pathway in model organisms: emerging roles in cell movement.

Journal

Dev Cell 3:765-78 (2002)

Reference

PMID:15032587

Authors

Alexander WS, Hilton DJ.

Title

The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response.

Journal

Annu Rev Immunol 22:503-29 (2004)

Reference

PMID:10409724

Authors

Kim H, Baumann H.

Title

Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.

Journal

Mol Cell Biol 19:5326-38 (1999)

KO pathway

ko04630

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (156)   
   KEGG GENES (156)   
All databases (158)   

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