KEGG   PATHWAY: mmu04640Help
Entry
mmu04640                    Pathway                                

Name
Hematopoietic cell lineage - Mus musculus (mouse)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Hematopoietic cell lineage
mmu04640

All organismsOrtholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
17311  
Kitl; kit ligand [KO:K05461]
16196  
Il7; interleukin 7 [KO:K05431]
16189  
Il4; interleukin 4 [KO:K05430]
12981  
Csf2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
14256  
Flt3l; FMS-like tyrosine kinase 3 ligand [KO:K05454]
16191  
Il5; interleukin 5 [KO:K05428]
12985  
Csf3; colony stimulating factor 3 (granulocyte) [KO:K05423]
16187  
Il3; interleukin 3 [KO:K04736]
16193  
Il6; interleukin 6 [KO:K05405]
16156  
Il11; interleukin 11 [KO:K05417]
16175  
Il1a; interleukin 1 alpha [KO:K04383]
16176  
Il1b; interleukin 1 beta [KO:K04519]
21926  
Tnf; tumor necrosis factor [KO:K03156]
12977  
Csf1; colony stimulating factor 1 (macrophage) [KO:K05453]
13856  
Epo; erythropoietin [KO:K05437]
21832  
Thpo; thrombopoietin [KO:K06854]
12490  
Cd34; CD34 antigen [KO:K06474]
14255  
Flt3; FMS-like tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
21673  
Dntt; deoxynucleotidyltransferase, terminal [KO:K00977] [EC:2.7.7.31]
12505  
Cd44; CD44 antigen [KO:K06256]
16590  
Kit; kit oncogene [KO:K05091] [EC:2.7.10.1]
16184  
Il2ra; interleukin 2 receptor, alpha chain [KO:K05068]
16197  
Il7r; interleukin 7 receptor [KO:K05072]
22042  
Tfrc; transferrin receptor [KO:K06503]
12516  
Cd7; CD7 antigen [KO:K06457]
12481  
Cd2; CD2 antigen [KO:K06449]
12507  
Cd5; CD5 antigen [KO:K06455]
12479  
Cd1d1; CD1d1 antigen [KO:K06448]
12480  
Cd1d2; CD1d2 antigen [KO:K06448]
12504  
Cd4; CD4 antigen [KO:K06454]
12525  
Cd8a; CD8 antigen, alpha chain [KO:K06458]
12526  
Cd8b1; CD8 antigen, beta chain 1 [KO:K06459]
12500  
Cd3d; CD3 antigen, delta polypeptide [KO:K06450]
12501  
Cd3e; CD3 antigen, epsilon polypeptide [KO:K06451]
12502  
Cd3g; CD3 antigen, gamma polypeptide [KO:K06452]
17380  
Mme; membrane metallo endopeptidase [KO:K01389] [EC:3.4.24.11]
12527  
Cd9; CD9 antigen [KO:K06460]
12478  
Cd19; CD19 antigen [KO:K06465]
12483  
Cd22; CD22 antigen [KO:K06467]
12484  
Cd24a; CD24a antigen [KO:K06469]
12482  
Ms4a1; membrane-spanning 4-domains, subfamily A, member 1 [KO:K06466]
12902  
Cr2; complement receptor 2 [KO:K04012]
12493  
Cd37; CD37 antigen [KO:K06475]
IgH; uncharacterized LOC102642252 [KO:K06856]
IgH; Ig heavy chain Mem5-like [KO:K06856]
14128  
Fcer2a; Fc receptor, IgE, low affinity II, alpha polypeptide [KO:K06468]
12982  
Csf2ra; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [KO:K05066]
16188  
Il3ra; interleukin 3 receptor, alpha chain [KO:K04737]
12489  
Cd33; CD33 antigen [KO:K06473]
233274  
Siglech; sialic acid binding Ig-like lectin H [KO:K06473]
16190  
Il4ra; interleukin 4 receptor, alpha [KO:K05071]
16194  
Il6ra; interleukin 6 receptor, alpha [KO:K05055]
14129  
Fcgr1; Fc receptor, IgG, high affinity I [KO:K06498]
12978  
Csf1r; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
16790  
Anpep; alanyl (membrane) aminopeptidase [KO:K11140] [EC:3.4.11.2]
16409  
Itgam; integrin alpha M [KO:K06461]
12475  
Cd14; CD14 antigen [KO:K04391]
16199  
Il9r; interleukin 9 receptor [KO:K05073]
16177  
Il1r1; interleukin 1 receptor, type I [KO:K04386]
16178  
Il1r2; interleukin 1 receptor, type II [KO:K04387]
12986  
Csf3r; colony stimulating factor 3 receptor (granulocyte) [KO:K05061]
16192  
Il5ra; interleukin 5 receptor, alpha [KO:K05067]
13857  
Epor; erythropoietin receptor [KO:K05079]
12491  
Cd36; CD36 antigen [KO:K06259]
13136  
Cd55; CD55 molecule, decay accelerating factor for complement [KO:K04006]
13137  
Cd55b; CD55 molecule, decay accelerating factor for complement B [KO:K04006]
12509  
Cd59a; CD59a antigen [KO:K04008]
333883  
Cd59b; CD59b antigen [KO:K04008]
16157  
Il11ra1; interleukin 11 receptor, alpha chain 1 [KO:K05056]
16158  
Il11ra2; interleukin 11 receptor, alpha chain 2 [KO:K05056]
interleukin-11 receptor subunit alpha-2-like; K05056 interleukin 11 receptor alpha [KO:K05056]
Gm13305; predicted gene 13305 [KO:K05056]
Gm2002; predicted gene 2002 [KO:K05056]
16416  
Itgb3; integrin beta 3 [KO:K06493]
16399  
Itga2b; integrin alpha 2b [KO:K06476]
54368  
Gp9; glycoprotein 9 (platelet) [KO:K06263]
14723  
Gp1ba; glycoprotein 1b, alpha polypeptide [KO:K06261]
14724  
Gp1bb; glycoprotein Ib, beta polypeptide [KO:K06262]
14729  
Gp5; glycoprotein 5 (platelet) [KO:K06260]
109700  
Itga1; integrin alpha 1 [KO:K06480]
16398  
Itga2; integrin alpha 2 [KO:K06481]
16400  
Itga3; integrin alpha 3 [KO:K06482]
16401  
Itga4; integrin alpha 4 [KO:K06483]
16402  
Itga5; integrin alpha 5 (fibronectin receptor alpha) [KO:K06484]
16403  
Itga6; integrin alpha 6 [KO:K06485]
12494  
Cd38; CD38 antigen [KO:K01242] [EC:2.4.99.20 3.2.2.6]
14968  
 
14969  
H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
Compound
G01078  
Lewis x-sulfated
G01493  
Lewis x-sulfated
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
(Japanese)
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
Reference
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
Reference
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
Reference
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
Reference
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
Reference
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
Reference
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
Reference
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
Reference
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
KO pathway
 

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