KEGG PATHWAY: mmu05164

PATHWAY: mmu05164

Entry

mmu05164 Pathway

Name

Influenza A - Mus musculus (mouse)

Description

Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B, IRF3 and AP1. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.

Class

Human Diseases; Infectious diseases

Pathway map

mmu05164

Influenza A

Organism

Mus musculus (mouse) [GN:mmu]

Gene

436522	Try10; trypsin 10 [KO:K01312] [EC:3.4.21.4]
22072	Prss2; protease, serine, 2 [KO:K01312] [EC:3.4.21.4]
67373	2210010C04Rik; RIKEN cDNA 2210010C04 gene [KO:K01312] [EC:3.4.21.4]
103964	Try5; trypsin 5 [KO:K01312] [EC:3.4.21.4]
100040233	Gm10334; predicted gene 10334 [KO:K01312] [EC:3.4.21.4]
22074	Try4; trypsin 4 [KO:K01312] [EC:3.4.21.4]
73626	1810009J06Rik; RIKEN cDNA 1810009J06 gene [KO:K01312] [EC:3.4.21.4]
50528	Tmprss2; transmembrane protease, serine 2 [KO:K09633]
214523	Tmprss4; transmembrane protease, serine 4 [KO:K09635]
246730	Oas1a; 2'-5' oligoadenylate synthetase 1A [KO:K14216]
246728	Oas2; 2'-5' oligoadenylate synthetase 2 [KO:K14216]
246727	Oas3; 2'-5' oligoadenylate synthetase 3 [KO:K14216]
23961	Oas1b; 2'-5' oligoadenylate synthetase 1B [KO:K14216]
23960	Oas1g; 2'-5' oligoadenylate synthetase 1G [KO:K14216]
24014	Rnasel; ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) [KO:K01165]
81489	Dnajb1; DnaJ (Hsp40) homolog, subfamily B, member 1 [KO:K09507]
100037258	Dnajc3; DnaJ (Hsp40) homolog, subfamily C, member 3 [KO:K09523]
15481	Hspa8; heat shock protein 8 [KO:K03283]
15482	Hspa1l; heat shock protein 1-like [KO:K03283]
193740	Hspa1a; heat shock protein 1A [KO:K03283]
15512	Hspa2; heat shock protein 2 [KO:K03283]
15511	Hspa1b; heat shock protein 1B [KO:K03283]
15467	Eif2ak1; eukaryotic translation initiation factor 2 alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
19106	Eif2ak2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
13666	Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
27103	Eif2ak4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
13665	Eif2s1; eukaryotic translation initiation factor 2, subunit 1 alpha [KO:K03237]
26397	Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
26399	Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
26416	Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
19094	Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
29857	Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
26415	Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
26398	Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
26400	Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
26419	Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420	Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26414	Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
16476	Jun; Jun oncogene [KO:K04448]
11909	Atf2; activating transcription factor 2 [KO:K04450]
100047997	cyclic AMP-dependent transcription factor ATF-2-like; K04450 cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
230073	Ddx58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:3.6.3.14]
71586	Ifih1; interferon induced with helicase C domain 1 [KO:K12647] [EC:3.6.4.13]
228607	Mavs; mitochondrial antiviral signaling protein [KO:K12648]
270151	Nlrx1; NLR family member X1 [KO:K12653]
16150	Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
18036	Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581]
18035	Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18033	Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697	Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
217069	Trim25; tripartite motif-containing 25 [KO:K10652]
142980	Tlr3; toll-like receptor 3 [KO:K05401]
106759	Ticam1; toll-like receptor adaptor molecule 1 [KO:K05842]
56480	Tbk1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
56489	Ikbke; inhibitor of kappaB kinase epsilon [KO:K07211] [EC:2.7.11.10]
54131	Irf3; interferon regulatory factor 3 [KO:K05411]
12914	Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
328572	Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
18709	Pik3r2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [KO:K02649]
18708	Pik3r1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) [KO:K02649]
320207	Pik3r5; phosphoinositide-3-kinase, regulatory subunit 5, p101 [KO:K02649]
18710	Pik3r3; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) [KO:K02649]
30955	Pik3cg; phosphoinositide-3-kinase, catalytic, gamma polypeptide [KO:K00922] [EC:2.7.1.153]
18706	Pik3ca; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide [KO:K00922] [EC:2.7.1.153]
18707	Pik3cd; phosphatidylinositol 3-kinase catalytic delta polypeptide [KO:K00922] [EC:2.7.1.153]
74769	Pik3cb; phosphatidylinositol 3-kinase, catalytic, beta polypeptide [KO:K00922] [EC:2.7.1.153]
11651	Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652	Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797	Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
21898	Tlr4; toll-like receptor 4 [KO:K10160]
170743	Tlr7; toll-like receptor 7 [KO:K05404]
17874	Myd88; myeloid differentiation primary response gene 88 [KO:K04729]
266632	Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
54123	Irf7; interferon regulatory factor 7 [KO:K09447]
16175	Il1a; interleukin 1 alpha [KO:K04383]
16176	Il1b; interleukin 1 beta [KO:K04519]
16193	Il6; interleukin 6 [KO:K05405]
16159	Il12a; interleukin 12a [KO:K05406]
16160	Il12b; interleukin 12b [KO:K05425]
21926	Tnf; tumor necrosis factor [KO:K03156]
20296	Ccl2; chemokine (C-C motif) ligand 2 [KO:K14624]
20293	Ccl12; chemokine (C-C motif) ligand 12 [KO:K14624]
100862578	c-C motif chemokine 12-like; K14624 C-C motif chemokine 2 [KO:K14624]
20304	Ccl5; chemokine (C-C motif) ligand 5 [KO:K12499]
15945	Cxcl10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
15894	Icam1; intercellular adhesion molecule 1 [KO:K06490]
15962	Ifna1; interferon alpha 1 [KO:K05414]
15965	Ifna2; interferon alpha 2 [KO:K05414]
15967	Ifna4; interferon alpha 4 [KO:K05414]
15968	Ifna5; interferon alpha 5 [KO:K05414]
15969	Ifna6; interferon alpha 6 [KO:K05414]
15970	Ifna7; interferon alpha 7 [KO:K05414]
15972	Ifna9; interferon alpha 9 [KO:K05414]
15964	Ifna11; interferon alpha 11 [KO:K05414]
242519	Ifna12; interferon alpha 12 [KO:K05414]
230396	Ifna13; interferon alpha 13 [KO:K05414]
404549	Ifna14; interferon, alpha 14 [KO:K05414]
15974	Ifnab; interferon alpha B [KO:K05414]
242517	Gm12597; predicted gene 12597 [KO:K05414]
15977	Ifnb1; interferon beta 1, fibroblast [KO:K05415]
15975	Ifnar1; interferon (alpha and beta) receptor 1 [KO:K05130]
15976	Ifnar2; interferon (alpha and beta) receptor 2 [KO:K05131]
16451	Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
54721	Tyk2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
20846	Stat1; signal transducer and activator of transcription 1 [KO:K11220]
20847	Stat2; signal transducer and activator of transcription 2 [KO:K11221]
16391	Irf9; interferon regulatory factor 9 [KO:K04693]
12702	Socs3; suppressor of cytokine signaling 3 [KO:K04696]
17858	Mx2; myxovirus (influenza virus) resistance 2 [KO:K14754]
56417	Adar; adenosine deaminase, RNA-specific [KO:K12968] [EC:3.5.4.-]
18854	Pml; promyelocytic leukemia [KO:K10054]
15978	Ifng; interferon gamma [KO:K04687]
15979	Ifngr1; interferon gamma receptor 1 [KO:K05132]
15980	Ifngr2; interferon gamma receptor 2 [KO:K05133]
16452	Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
12265	Ciita; class II transactivator [KO:K08060]
14960	H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961	H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14969	H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14998	H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999	H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000	H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001	H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002	H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
100504404	H2-Ea-ps; histocompatibility 2, class II antigen E alpha, pseudogene [KO:K06752]
216799	Nlrp3; NLR family, pyrin domain containing 3 [KO:K12800]
66824	Pycard; PYD and CARD domain containing [KO:K12799]
12362	Casp1; caspase 1 [KO:K01370] [EC:3.4.22.36]
16173	Il18; interleukin 18 [KO:K05482]
77125	Il33; interleukin 33 [KO:K12967]
22035	Tnfsf10; tumor necrosis factor (ligand) superfamily, member 10 [KO:K04721]
21933	Tnfrsf10b; tumor necrosis factor receptor superfamily, member 10b [KO:K04722]
14103	Fasl; Fas ligand (TNF superfamily, member 6) [KO:K04389]
14102	Fas; Fas (TNF receptor superfamily member 6) [KO:K04390]
21937	Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
22333	Vdac1; voltage-dependent anion channel 1 [KO:K05862]
13063	Cycs; cytochrome c, somatic [KO:K08738]
13067	Cyct; cytochrome c, testis [KO:K08738]
12371	Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
56637	Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
16646	Kpna1; karyopherin (importin) alpha 1 [KO:K15042]
16647	Kpna2; karyopherin (importin) alpha 2 [KO:K15043]
53817	Ddx39b; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B [KO:K12812] [EC:3.6.4.13]
103573	Xpo1; exportin 1, CRM1 homolog (yeast) [KO:K14290]
15463	Agfg1; ArfGAP with FG repeats 1 [KO:K15044]
110157	Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
26395	Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396	Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
26413	Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417	Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
58185	Rsad2; radical S-adenosyl methionine domain containing 2 [KO:K15045]
110196	Fdps; farnesyl diphosphate synthetase [KO:K00787] [EC:2.5.1.10 2.5.1.1]
11461	Actb; actin, beta [KO:K05692]
11465	Actg1; actin, gamma, cytoplasmic 1 [KO:K05692]
117198	Ivns1abp; influenza virus NS1A binding protein [KO:K15046]
54188	Cpsf4; cleavage and polyadenylation specific factor 4 [KO:K14404]
54196	Pabpn1; poly(A) binding protein, nuclear 1 [KO:K14396]
382035	Pabpn1l; poly(A)binding protein nuclear 1-like [KO:K14396]
53319	Nxf1; nuclear RNA export factor 1 [KO:K14284]
170722	Nxf7; nuclear RNA export factor 7 [KO:K14284]
83454	Nxf2; nuclear RNA export factor 2 [KO:K14284]
245610	Nxf3; nuclear RNA export factor 3 [KO:K14284]
56488	Nxt1; NTF2-related export protein 1 [KO:K14285]
237082	Nxt2; nuclear transport factor 2-like export factor 2 [KO:K14285]
66679	Rae1; RAE1 RNA export 1 homolog (S. pombe) [KO:K14298]
232989	Hnrnpul1; heterogeneous nuclear ribonucleoprotein U-like 1 [KO:K15047]
269966	Nup98; nucleoporin 98 [KO:K14297]
18550	Furin; furin (paired basic amino acid cleaving enzyme) [KO:K01349] [EC:3.4.21.75]
214531	Tmprss13; transmembrane protease, serine 13 [KO:K09643]
18815	Plg; plasminogen [KO:K01315] [EC:3.4.21.7]
18750	Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18751	Prkcb; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]

Compound

C00027	Hydrogen peroxide
C00080	H+
C05981	Phosphatidylinositol-3,4,5-trisphosphate
C18990	PB1-F2

Reference

PMID:19782761

Authors

Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S

Title

Interplay between influenza A virus and the innate immune signaling.

Journal

Microbes Infect 12:81-7 (2010)

Reference

PMID:20020828

Authors

Hale BG, Albrecht RA, Garcia-Sastre A

Title

Innate immune evasion strategies of influenza viruses.

Journal

Future Microbiol 5:23-41 (2010)

Reference

PMID:19420020

Authors

Ludwig S

Title

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy.

Journal

J Antimicrob Chemother 64:1-4 (2009)

Reference

PMID:18049471

Authors

von Itzstein M

Title

The war against influenza: discovery and development of sialidase inhibitors.

Journal

Nat Rev Drug Discov 6:967-74 (2007)

Reference

PMID:16494716

Authors

Garcia-Sastre A

Title

Antiviral response in pandemic influenza viruses.

Journal

Emerg Infect Dis 12:44-7 (2006)

Reference

PMID:18980544

Authors

Ichinohe T, Iwasaki A, Hasegawa H

Title

Innate sensors of influenza virus: clues to developing better intranasal vaccines.

Journal

Expert Rev Vaccines 7:1435-45 (2008)

Reference

PMID:19864182

Authors

Peiris JS, Cheung CY, Leung CY, Nicholls JM

Title

Innate immune responses to influenza A H5N1: friend or foe?

Journal

Trends Immunol 30:574-84 (2009)

Reference

PMID:18588994

Authors

Thanh TT, van Doorn HR, de Jong MD

Title

Human H5N1 influenza: current insight into pathogenesis.

Journal

Int J Biochem Cell Biol 40:2671-4 (2008)

Reference

PMID:17944269

Authors

Neumann G, Shinya K, Kawaoka Y

Title

Molecular pathogenesis of H5N1 influenza virus infections.

Journal

Antivir Ther 12:617-26 (2007)

Reference

PMID:17213831

Authors

La Gruta NL, Kedzierska K, Stambas J, Doherty PC

Title

A question of self-preservation: immunopathology in influenza virus infection.

Journal

Immunol Cell Biol 85:85-92 (2007)

Reference

PMID:19481124

Authors

Nayak DP, Balogun RA, Yamada H, Zhou ZH, Barman S

Title

Influenza virus morphogenesis and budding.

Journal

Virus Res 143:147-61 (2009)

Reference

PMID:17072332

Authors

Hiscott J, Nguyen TL, Arguello M, Nakhaei P, Paz S

Title

Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses.

Journal

Oncogene 25:6844-67 (2006)

Reference

PMID:19290913

Authors

Ehrhardt C, Ludwig S

Title

A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway.

Journal

Cell Microbiol 11:863-71 (2009)

Reference

PMID:21147034

Authors

Pang IK, Iwasaki A

Title

Inflammasomes as mediators of immunity against influenza virus.

Journal

Trends Immunol 32:34-41 (2011)

Reference

PMID:17267598

Authors

Satterly N, Tsai PL, van Deursen J, Nussenzveig DR, Wang Y, Faria PA, Levay A, Levy DE, Fontoura BM

Title

Influenza virus targets the mRNA export machinery and the nuclear pore complex.

Journal

Proc Natl Acad Sci U S A 104:1853-8 (2007)

Reference

PMID:16882036

Authors

Ehrhardt C, Marjuki H, Wolff T, Nurnberg B, Planz O, Pleschka S, Ludwig S

Title

Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence.

Journal

Cell Microbiol 8:1336-48 (2006)

Reference

PMID:15502848

Authors

Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC

Title

Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.

Journal

Nat Struct Mol Biol 11:1060-7 (2004)

Reference

PMID:11907320

Authors

Portela A, Digard P

Title

The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.

Journal

J Gen Virol 83:723-34 (2002)

Reference

PMID:9060654

Authors

Avalos RT, Yu Z, Nayak DP

Title

Association of influenza virus NP and M1 proteins with cellular cytoskeletal elements in influenza virus-infected cells.

Journal

J Virol 71:2947-58 (1997)

Reference

PMID:20629046

Authors

Bertram S, Glowacka I, Steffen I, Kuhl A, Pohlmann S

Title

Novel insights into proteolytic cleavage of influenza virus hemagglutinin.

Journal

Rev Med Virol 20:298-310 (2010)

KO pathway

ko05164

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Genome (1)   
   KEGG GENOME (1)   
Gene (172)   
   KEGG GENES (172)   
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