HTLV-I infection - Mus musculus (mouse)

Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.

Human Diseases; Infectious diseases

Mus musculus (mouse) [GN:mmu]

PMID:11244044

Yoshida M

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Annu Rev Immunol 19:475-96 (2001)

PMID:12910251

Gatza ML, Watt JC, Marriott SJ

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Oncogene 22:5141-9 (2003)

PMID:21114861

Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O

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Retrovirology 7:99 (2010)

PMID:19861996

Boxus M, Willems L

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Br J Cancer 101:1497-501 (2009)

PMID:17384582

Matsuoka M, Jeang KT

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Nat Rev Cancer 7:270-80 (2007)

PMID:17446673

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Uirusu 56:241-9 (2006)

PMID:18702816

Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L

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Retrovirology 5:76 (2008)

PMID:16036567

Harhaj EW, Harhaj NS

Mechanisms of persistent NF-kappaB activation by HTLV-I tax.

IUBMB Life 57:83-91 (2005)

PMID:16436385

Peloponese JM Jr, Jeang KT

Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein.

J Biol Chem 281:8927-38 (2006)

PMID:16155605

Marriott SJ, Semmes OJ

Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response.

Oncogene 24:5986-95 (2005)

PMID:11325603

Jeang KT

Functional activities of the human T-cell leukemia virus type I Tax oncoprotein:  cellular signaling through NF-kappa B.

Cytokine Growth Factor Rev 12:207-17 (2001)

PMID:19014483

Bouzar AB, Willems L

How HTLV-1 may subvert miRNAs for persistence and transformation.

Retrovirology 5:101 (2008)

PMID:16155602

Sun SC, Yamaoka S

Activation of NF-kappaB by HTLV-I and implications for cell transformation.

Oncogene 24:5952-64 (2005)

PMID:16155608

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Oncogene 24:6016-25 (2005)

PMID:10602469

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Oncogene 18:6948-58 (1999)

PMID:16155611

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Oncogene 24:6047-57 (2005)

PMID:14686485

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Int J Hematol 78:280-96 (2003)

PMID:19092975

Baydoun HH, Bellon M, Nicot C

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AIDS Rev 10:195-204 (2008)

PMID:9325311

Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT

A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.

J Biol Chem 272:25816-23 (1997)

PMID:15569630

Pise-Masison CA, Brady JN

Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.

Front Biosci 10:919-30 (2005)