KEGG   PATHWAY: mmu05166Help
Entry
mmu05166                    Pathway                                

Name
HTLV-I infection - Mus musculus (mouse)
Description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
HTLV-I infection
mmu05166

All organismsOrtholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
21803  
Tgfb1; transforming growth factor, beta 1 [KO:K13375]
21808  
Tgfb2; transforming growth factor, beta 2 [KO:K13376]
21809  
Tgfb3; transforming growth factor, beta 3 [KO:K13377]
20525  
Slc2a1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO:K07299]
18186  
Nrp1; neuropilin 1 [KO:K06724]
22329  
Vcam1; vascular cell adhesion molecule 1 [KO:K06527]
12500  
Cd3d; CD3 antigen, delta polypeptide [KO:K06450]
12501  
Cd3e; CD3 antigen, epsilon polypeptide [KO:K06451]
12502  
Cd3g; CD3 antigen, gamma polypeptide [KO:K06452]
15894  
Icam1; intercellular adhesion molecule 1 [KO:K06490]
16408  
Itgal; integrin alpha L [KO:K05718]
16414  
Itgb2; integrin beta 2 [KO:K06464]
16415  
Itgb2l; integrin beta 2-like [KO:K06464]
21894  
Tln1; talin 1 [KO:K06271]
70549  
Tln2; talin 2 [KO:K06271]
17869  
Myc; myelocytomatosis oncogene [KO:K04377]
100683  
Trrap; transformation/transcription domain-associated protein [KO:K08874]
81601  
Kat5; K(lysine) acetyltransferase 5 [KO:K11304] [EC:2.3.1.48]
12444  
Ccnd2; cyclin D2 [KO:K10151]
71810  
Ranbp3; RAN binding protein 3 [KO:K15304]
19384  
Ran; RAN, member RAS oncogene family [KO:K07936]
19428  
Rasl2-9; RAS-like, family 2, locus 9 [KO:K07936]
75471  
1700009N14Rik; RIKEN cDNA 1700009N14 gene [KO:K07936]
103573  
Xpo1; exportin 1, CRM1 homolog (yeast) [KO:K14290]
14990  
H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991  
H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997  
H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
15006  
H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007  
H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013  
H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15018  
H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15019  
H2-Q8; histocompatibility 2, Q region locus 8 [KO:K06751]
15039  
H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040  
H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042  
H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043  
H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15051  
H2-T9; histocompatibility 2, T region locus 9 [KO:K06751]
224753  
H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754  
H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756  
H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761  
H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
333715  
H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
399549  
H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
15024  
H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
110557  
H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110696  
H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
14963  
H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  
H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14972  
H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14985  
H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
547349  
MHC class I family member; K06751 major histocompatibility complex, class I [KO:K06751]
h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
12317  
Calr; calreticulin [KO:K08057]
19057  
Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19055  
Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  
Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19058  
Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  
Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
18018  
Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446]
18019  
Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332]
18021  
Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333]
73181  
Nfatc4; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 [KO:K17334]
12330  
Canx; calnexin [KO:K08054]
16185  
Il2rb; interleukin 2 receptor, beta chain [KO:K05069]
16186  
Il2rg; interleukin 2 receptor, gamma chain [KO:K05070]
16451  
Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
16453  
Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
20850  
Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
20851  
Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
110196  
Fdps; farnesyl diphosphate synthetase [KO:K00787] [EC:2.5.1.10 2.5.1.1]
15461  
Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16653  
Kras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
18176  
Nras; neuroblastoma ras oncogene [KO:K07828]
20130  
Rras; Harvey rat sarcoma oncogene, subgroup R [KO:K07829]
66922  
Rras2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
17532  
Mras; muscle and microspikes RAS [KO:K07831]
22333  
Vdac1; voltage-dependent anion channel 1 [KO:K05862]
11739  
Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863]
11740  
Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863]
73333  
Slc25a31; solute carrier family 25 (mitochondrial carrier [KO:K05863]
22334  
Vdac2; voltage-dependent anion channel 2 [KO:K15040]
22335  
Vdac3; voltage-dependent anion channel 3 [KO:K15041]
12257  
Tspo; translocator protein [KO:K05770]
234729  
Vac14; Vac14 homolog (S. cerevisiae) [KO:K15305]
19385  
Ranbp1; RAN binding protein 1 [KO:K15306]
56150  
Mad2l1; MAD2 mitotic arrest deficient-like 1 [KO:K02537]
12236  
Bub1b; budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) [KO:K06637] [EC:2.7.11.1]
12237  
Bub3; budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) [KO:K02180]
107995  
Cdc20; cell division cycle 20 [KO:K03363]
17222  
Anapc1; anaphase promoting complex subunit 1 [KO:K03348]
99152  
Anapc2; anaphase promoting complex subunit 2 [KO:K03349]
217232  
Cdc27; cell division cycle 27 [KO:K03350]
52206  
Anapc4; anaphase promoting complex subunit 4 [KO:K03351]
59008  
Anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
69957  
Cdc16; CDC16 cell division cycle 16 [KO:K03353]
56317  
Anapc7; anaphase promoting complex subunit 7 [KO:K03354]
52563  
Cdc23; CDC23 cell division cycle 23 [KO:K03355]
68999  
Anapc10; anaphase promoting complex subunit 10 [KO:K03357]
66156  
Anapc11; anaphase promoting complex subunit 11 [KO:K03358]
66440  
Cdc26; cell division cycle 26 [KO:K03359]
30939  
Pttg1; pituitary tumor-transforming gene 1 [KO:K06635]
12575  
Cdkn1a; cyclin-dependent kinase inhibitor 1A (P21) [KO:K06625]
18538  
Pcna; proliferating cell nuclear antigen [KO:K04802]
18971  
Pold1; polymerase (DNA directed), delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
18972  
Pold2; polymerase (DNA directed), delta 2, regulatory subunit [KO:K02328]
67967  
Pold3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
69745  
Pold4; polymerase (DNA-directed), delta 4 [KO:K03505]
18973  
Pole; polymerase (DNA directed), epsilon [KO:K02324] [EC:2.7.7.7]
18974  
Pole2; polymerase (DNA directed), epsilon 2 (p59 subunit) [KO:K02325] [EC:2.7.7.7]
59001  
Pole3; polymerase (DNA directed), epsilon 3 (p17 subunit) [KO:K02326] [EC:2.7.7.7]
66979  
Pole4; polymerase (DNA-directed), epsilon 4 (p12 subunit) [KO:K03506] [EC:2.7.7.7]
12443  
Ccnd1; cyclin D1 [KO:K04503]
12445  
Ccnd3; cyclin D3 [KO:K10152]
12567  
Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
19645  
Rb1; retinoblastoma 1 [KO:K06618]
13555  
E2f1; E2F transcription factor 1 [KO:K17454]
242705  
E2f2; E2F transcription factor 2 [KO:K09389]
13557  
E2f3; E2F transcription factor 3 [KO:K06620]
12578  
Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621]
12579  
Cdkn2b; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [KO:K04685]
22408  
Wnt1; wingless-type MMTV integration site family, member 1 [KO:K03209]
22413  
Wnt2; wingless-type MMTV integration site family, member 2 [KO:K00182]
22414  
Wnt2b; wingless-type MMTV integration site family, member 2B [KO:K00182]
22415  
Wnt3; wingless-type MMTV integration site family, member 3 [KO:K00312]
22416  
Wnt3a; wingless-type MMTV integration site family, member 3A [KO:K00312]
22417  
Wnt4; wingless-type MMTV integration site family, member 4 [KO:K00408]
22418  
Wnt5a; wingless-type MMTV integration site family, member 5A [KO:K00444]
22419  
Wnt5b; wingless-type MMTV integration site family, member 5B [KO:K00444]
22420  
Wnt6; wingless-type MMTV integration site family, member 6 [KO:K00445]
22421  
Wnt7a; wingless-type MMTV integration site family, member 7A [KO:K00572]
22422  
Wnt7b; wingless-type MMTV integration site family, member 7B [KO:K00572]
20890  
Wnt8a; wingless-type MMTV integration site family, member 8A [KO:K00714]
22423  
Wnt8b; wingless-type MMTV integration site family, member 8B [KO:K00714]
216795  
Wnt9a; wingless-type MMTV integration site family, member 9A [KO:K01064]
22412  
Wnt9b; wingless-type MMTV integration site family, member 9B [KO:K01064]
22410  
Wnt10b; wingless-type MMTV integration site family, member 10B [KO:K01357]
22409  
Wnt10a; wingless-type MMTV integration site family, member 10A [KO:K01357]
22411  
Wnt11; wingless-type MMTV integration site family, member 11 [KO:K01384]
93735  
Wnt16; wingless-type MMTV integration site family, member 16 [KO:K01558]
14362  
Fzd1; frizzled homolog 1 (Drosophila) [KO:K02432]
14369  
Fzd7; frizzled homolog 7 (Drosophila) [KO:K02432]
57265  
Fzd2; frizzled homolog 2 (Drosophila) [KO:K02235]
14365  
Fzd3; frizzled homolog 3 (Drosophila) [KO:K02329]
14366  
Fzd4; frizzled homolog 4 (Drosophila) [KO:K02354]
14367  
Fzd5; frizzled homolog 5 (Drosophila) [KO:K02375]
14370  
Fzd8; frizzled homolog 8 (Drosophila) [KO:K02375]
14368  
Fzd6; frizzled homolog 6 (Drosophila) [KO:K02376]
93897  
Fzd10; frizzled homolog 10 (Drosophila) [KO:K02842]
14371  
Fzd9; frizzled homolog 9 (Drosophila) [KO:K02842]
13544  
Dvl3; dishevelled 3, dsh homolog (Drosophila) [KO:K02353]
13542  
Dvl1; dishevelled, dsh homolog 1 (Drosophila) [KO:K02353]
13543  
Dvl2; dishevelled 2, dsh homolog (Drosophila) [KO:K02353]
56637  
Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
12387  
Ctnnb1; catenin (cadherin associated protein), beta 1 [KO:K02105]
11789  
Apc; adenomatosis polyposis coli [KO:K02085]
23805  
Apc2; adenomatosis polyposis coli 2 [KO:K02085]
13383  
Dlg1; discs, large homolog 1 (Drosophila) [KO:K12076]
18590  
Pdgfa; platelet derived growth factor, alpha [KO:K04359]
18591  
Pdgfb; platelet derived growth factor, B polypeptide [KO:K17386]
18595  
Pdgfra; platelet derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
18596  
Pdgfrb; platelet derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
18709  
Pik3r2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [KO:K02649]
18708  
Pik3r1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) [KO:K02649]
320207  
Pik3r5; phosphoinositide-3-kinase, regulatory subunit 5, p101 [KO:K02649]
18710  
Pik3r3; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) [KO:K02649]
30955  
Pik3cg; phosphoinositide-3-kinase, catalytic, gamma polypeptide [KO:K00922] [EC:2.7.1.153]
18706  
Pik3ca; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide [KO:K00922] [EC:2.7.1.153]
18707  
Pik3cd; phosphatidylinositol 3-kinase catalytic delta polypeptide [KO:K00922] [EC:2.7.1.153]
74769  
Pik3cb; phosphatidylinositol 3-kinase, catalytic, beta polypeptide [KO:K00922] [EC:2.7.1.153]
11651  
Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  
Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797  
Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
21926  
Tnf; tumor necrosis factor [KO:K03156]
21937  
Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
26401  
Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
26398  
Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
16476  
Jun; jun proto-oncogene [KO:K04448]
56310  
Gps2; G protein pathway suppressor 2 [KO:K15307]
16177  
Il1r1; interleukin 1 receptor, type I [KO:K04386]
16178  
Il1r2; interleukin 1 receptor, type II [KO:K04387]
26406  
Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
12675  
Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
16150  
Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  
Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
18035  
Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18033  
Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697  
Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
17000  
Ltbr; lymphotoxin B receptor [KO:K03159]
21939  
Cd40; CD40 antigen [KO:K03160]
72049  
Tnfrsf13c; tumor necrosis factor receptor superfamily, member 13c [KO:K05151]
53859  
Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
19698  
Relb; avian reticuloendotheliosis viral (v-rel) oncogene related B [KO:K09253]
18034  
Nfkb2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [KO:K04469]
16183  
Il2; interleukin 2 [KO:K05429]
16184  
Il2ra; interleukin 2 receptor, alpha chain [KO:K05068]
16168  
Il15; interleukin 15 [KO:K05433]
16169  
Il15ra; interleukin 15 receptor, alpha chain [KO:K05074]
16193  
Il6; interleukin 6 [KO:K05405]
12981  
Csf2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
16992  
Lta; lymphotoxin A [KO:K05468]
12048  
Bcl2l1; BCL2-like 1 [KO:K04570]
11798  
Xiap; X-linked inhibitor of apoptosis [KO:K04725]
22695  
Zfp36; zinc finger protein 36 [KO:K15308]
18045  
Nfyb; nuclear transcription factor-Y beta [KO:K08065]
14960  
H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  
H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14969  
H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14998  
H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  
H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  
H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  
H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  
H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
H2-Ea-ps; histocompatibility 2, class II antigen E alpha, pseudogene [KO:K06752]
20807  
Srf; serum response factor [KO:K04378]
13714  
Elk4; ELK4, member of ETS oncogene family [KO:K04376]
13712  
Elk1; ELK1, member of ETS oncogene family [KO:K04375]
20375  
Spi1; spleen focus forming virus (SFFV) proviral integration oncogene [KO:K09438]
23871  
Ets1; E26 avian leukemia oncogene 1, 5' domain [KO:K02678]
23872  
Ets2; E26 avian leukemia oncogene 2, 3' domain [KO:K02678]
21374  
Tbp; TATA box binding protein [KO:K03120]
237336  
Tbpl1; TATA box binding protein-like 1 [KO:K03120]
227606  
Tbpl2; TATA box binding protein like 2 [KO:K03120]
14281  
Fos; FBJ osteosarcoma oncogene [KO:K04379]
13653  
Egr1; early growth response 1 [KO:K09203]
13654  
Egr2; early growth response 2 [KO:K12496]
14283  
Fosl1; fos-like antigen 1 [KO:K04502]
432530  
Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
210044  
Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
104111  
Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
104110  
Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
224129  
Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
11512  
Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  
Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  
Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  
Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
18747  
Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  
Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
19108  
Prkx; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
12912  
Creb1; cAMP responsive element binding protein 1 [KO:K05870]
12916  
Crem; cAMP responsive element modulator [KO:K09052]
11908  
Atf1; activating transcription factor 1 [KO:K09053]
11909  
Atf2; activating transcription factor 2 [KO:K04450]
11910  
Atf3; activating transcription factor 3 [KO:K09032]
11911  
Atf4; activating transcription factor 4 [KO:K04374]
22433  
Xbp1; X-box binding protein 1 [KO:K09027]
382056  
Crtc1; CREB regulated transcription coactivator 1 [KO:K15309]
74343  
Crtc2; CREB regulated transcription coactivator 2 [KO:K16333]
70461  
Crtc3; CREB regulated transcription coactivator 3 [KO:K16334]
12914  
Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
328572  
Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
14534  
Kat2a; K(lysine) acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
18519  
Kat2b; K(lysine) acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
21423  
Tcf3; transcription factor 3 [KO:K09063]
18970  
Polb; polymerase (DNA directed), beta [KO:K02330] [EC:4.2.99.- 2.7.7.7]
12580  
Cdkn2c; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) [KO:K06622]
16818  
Lck; lymphocyte protein tyrosine kinase [KO:K05856] [EC:2.7.10.2]
21752  
Tert; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
17863  
Myb; myeloblastosis oncogene [KO:K09420]
17864  
Mybl1; myeloblastosis oncogene-like 1 [KO:K09421]
17865  
Mybl2; myeloblastosis oncogene-like 2 [KO:K09421]
21812  
Tgfbr1; transforming growth factor, beta receptor I [KO:K04674] [EC:2.7.11.30]
21813  
Tgfbr2; transforming growth factor, beta receptor II [KO:K04388] [EC:2.7.11.30]
17126  
Smad2; SMAD family member 2 [KO:K04500]
17127  
Smad3; SMAD family member 3 [KO:K04500]
17128  
Smad4; SMAD family member 4 [KO:K04501]
11920  
Atm; ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
245000  
Atr; ataxia telangiectasia and Rad3 related [KO:K06640] [EC:2.7.11.1]
12649  
Chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
50883  
Chek2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
22059  
Trp53; transformation related protein 53 [KO:K04451]
12028  
Bax; BCL2-associated X protein [KO:K02159]
60599  
Trp53inp1; transformation related protein 53 inducible nuclear protein 1 [KO:K15310]
17701  
Msx1; msh homeobox 1 [KO:K09341]
17702  
Msx2; msh homeobox 2 [KO:K09341]
17703  
Msx3; msh homeobox 3 [KO:K09341]
12442  
Ccnb2; cyclin B2 [KO:K05868]
26419  
Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
Compound
C00027  
Hydrogen peroxide
C00076  
Calcium cation
C00238  
Potassium cation
C00575  
3',5'-Cyclic AMP
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C18994  
Accessory protein p12I
C18995  
P13 protein
C18996  
Accessory protein p30II
C19313  
HTLV-1 basic zipper factor
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
Reference
  Authors
Gatza ML, Watt JC, Marriott SJ
  Title
Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades.
  Journal
Oncogene 22:5141-9 (2003)
Reference
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
Reference
  Authors
Boxus M, Willems L
  Title
Mechanisms of HTLV-1 persistence and transformation.
  Journal
Br J Cancer 101:1497-501 (2009)
Reference
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
Reference
  Authors
Yasunaga J, Matsuoka M
  Title
[HTLV-I and leukemogenesis].
  Journal
Uirusu 56:241-9 (2006)
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
Reference
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
Reference
  Authors
Peloponese JM Jr, Jeang KT
  Title
Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein.
  Journal
J Biol Chem 281:8927-38 (2006)
Reference
  Authors
Marriott SJ, Semmes OJ
  Title
Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response.
  Journal
Oncogene 24:5986-95 (2005)
Reference
  Authors
Jeang KT
  Title
Functional activities of the human T-cell leukemia virus type I Tax oncoprotein:  cellular signaling through NF-kappa B.
  Journal
Cytokine Growth Factor Rev 12:207-17 (2001)
Reference
  Authors
Bouzar AB, Willems L
  Title
How HTLV-1 may subvert miRNAs for persistence and transformation.
  Journal
Retrovirology 5:101 (2008)
Reference
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
Reference
  Authors
Manel N, Battini JL, Taylor N, Sitbon M
  Title
HTLV-1 tropism and envelope receptor.
  Journal
Oncogene 24:6016-25 (2005)
Reference
  Authors
Sun SC, Ballard DW
  Title
Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.
  Journal
Oncogene 18:6948-58 (1999)
Reference
  Authors
Taylor GP, Matsuoka M
  Title
Natural history of adult T-cell leukemia/lymphoma and approaches to therapy.
  Journal
Oncogene 24:6047-57 (2005)
Reference
  Authors
Franchini G, Fukumoto R, Fullen JR
  Title
T-cell control by human T-cell leukemia/lymphoma virus type 1.
  Journal
Int J Hematol 78:280-96 (2003)
Reference
  Authors
Baydoun HH, Bellon M, Nicot C
  Title
HTLV-1 Yin and Yang: Rex and p30 master regulators of viral mRNA trafficking.
  Journal
AIDS Rev 10:195-204 (2008)
Reference
PMID:9325311
  Authors
Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT
  Title
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.
  Journal
J Biol Chem 272:25816-23 (1997)
Reference
  Authors
Pise-Masison CA, Brady JN
  Title
Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.
  Journal
Front Biosci 10:919-30 (2005)
KO pathway
 

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