KEGG   PATHWAY: mmu05166Help
Entry
mmu05166                    Pathway                                

Name
HTLV-I infection - Mus musculus (mouse)
Description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
mmu05166  HTLV-I infection
mmu05166

Ortholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
21803  Tgfb1; transforming growth factor, beta 1 [KO:K13375]
21808  Tgfb2; transforming growth factor, beta 2 [KO:K13376]
21809  Tgfb3; transforming growth factor, beta 3 [KO:K13377]
20525  Slc2a1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO:K07299]
18186  Nrp1; neuropilin 1 [KO:K06724]
22329  Vcam1; vascular cell adhesion molecule 1 [KO:K06527]
12500  Cd3d; CD3 antigen, delta polypeptide [KO:K06450]
12501  Cd3e; CD3 antigen, epsilon polypeptide [KO:K06451]
12502  Cd3g; CD3 antigen, gamma polypeptide [KO:K06452]
15894  Icam1; intercellular adhesion molecule 1 [KO:K06490]
16408  Itgal; integrin alpha L [KO:K05718]
16414  Itgb2; integrin beta 2 [KO:K06464]
16415  Itgb2l; integrin beta 2-like [KO:K06464]
21894  Tln1; talin 1 [KO:K06271]
70549  Tln2; talin 2 [KO:K06271]
17869  Myc; myelocytomatosis oncogene [KO:K04377]
100683  Trrap; transformation/transcription domain-associated protein [KO:K08874]
81601  Kat5; K(lysine) acetyltransferase 5 [KO:K11304] [EC:2.3.1.48]
12444  Ccnd2; cyclin D2 [KO:K10151]
71810  Ranbp3; RAN binding protein 3 [KO:K15304]
19384  Ran; RAN, member RAS oncogene family [KO:K07936]
19428  Rasl2-9; RAS-like, family 2, locus 9 [KO:K07936]
75471  1700009N14Rik; RIKEN cDNA 1700009N14 gene [KO:K07936]
103573  Xpo1; exportin 1 [KO:K14290]
14990  H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991  H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997  H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
15006  H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007  H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013  H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15018  H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15019  H2-Q8; histocompatibility 2, Q region locus 8 [KO:K06751]
15039  H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040  H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042  H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043  H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15051  H2-T9; histocompatibility 2, T region locus 9 [KO:K06751]
224753  H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754  H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756  H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761  H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
333715  H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
399549  H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
15024  H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
110557  H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110696  H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
14963  H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14972  H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14985  H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
547349  MHC class I family member [KO:K06751]
15033  H2-T18; histocompatibility 2, T region locus 18 [KO:K06751]
110558  H2-Q9; histocompatibility 2, Q region locus 9 [KO:K06751]
667977  Gm8909; predicted gene 8909 [KO:K06751]
14980  H2-L; histocompatibility 2, D region locus L [KO:K06751]
69717  Gm10499; predicted gene 10499 [KO:K06751]
15015  H2-Q4; histocompatibility 2, Q region locus 4 [KO:K06751]
667803  H2-T-ps; histocompatibility 2, T region locus, pseudogene [KO:K06751]
100529082  Gm11127; predicted gene 11127 [KO:K06751]
240095  H2-M5; histocompatibility 2, M region locus 5 [KO:K06751]
630294  Gm7030; predicted gene 7030 [KO:K06751]
12317  Calr; calreticulin [KO:K08057]
19057  Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19055  Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19058  Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
18018  Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446]
18019  Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332]
18021  Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333]
73181  Nfatc4; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 [KO:K17334]
12330  Canx; calnexin [KO:K08054]
16185  Il2rb; interleukin 2 receptor, beta chain [KO:K05069]
16186  Il2rg; interleukin 2 receptor, gamma chain [KO:K05070]
16451  Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
16453  Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
20850  Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
20851  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
110196  Fdps; farnesyl diphosphate synthetase [KO:K00787] [EC:2.5.1.10 2.5.1.1]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
20130  Rras; related RAS viral (r-ras) oncogene [KO:K07829]
66922  Rras2; related RAS viral (r-ras) oncogene 2 [KO:K07830]
17532  Mras; muscle and microspikes RAS [KO:K07831]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
11739  Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863]
11740  Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863]
73333  Slc25a31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [KO:K05863]
22334  Vdac2; voltage-dependent anion channel 2 [KO:K15040]
22335  Vdac3; voltage-dependent anion channel 3 [KO:K15041]
12257  Tspo; translocator protein [KO:K05770]
234729  Vac14; Vac14 homolog (S. cerevisiae) [KO:K15305]
19385  Ranbp1; RAN binding protein 1 [KO:K15306]
56150  Mad2l1; MAD2 mitotic arrest deficient-like 1 [KO:K02537]
12236  Bub1b; BUB1B, mitotic checkpoint serine/threonine kinase [KO:K06637] [EC:2.7.11.1]
12237  Bub3; BUB3 mitotic checkpoint protein [KO:K02180]
107995  Cdc20; cell division cycle 20 [KO:K03363]
17222  Anapc1; anaphase promoting complex subunit 1 [KO:K03348]
99152  Anapc2; anaphase promoting complex subunit 2 [KO:K03349]
217232  Cdc27; cell division cycle 27 [KO:K03350]
52206  Anapc4; anaphase promoting complex subunit 4 [KO:K03351]
59008  Anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
69957  Cdc16; CDC16 cell division cycle 16 [KO:K03353]
56317  Anapc7; anaphase promoting complex subunit 7 [KO:K03354]
52563  Cdc23; CDC23 cell division cycle 23 [KO:K03355]
68999  Anapc10; anaphase promoting complex subunit 10 [KO:K03357]
66156  Anapc11; anaphase promoting complex subunit 11 [KO:K03358]
66440  Cdc26; cell division cycle 26 [KO:K03359]
30939  Pttg1; pituitary tumor-transforming gene 1 [KO:K06635]
12442  Ccnb2; cyclin B2 [KO:K21770]
12575  Cdkn1a; cyclin-dependent kinase inhibitor 1A (P21) [KO:K06625]
18538  Pcna; proliferating cell nuclear antigen [KO:K04802]
18971  Pold1; polymerase (DNA directed), delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
18972  Pold2; polymerase (DNA directed), delta 2, regulatory subunit [KO:K02328]
67967  Pold3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
69745  Pold4; polymerase (DNA-directed), delta 4 [KO:K03505]
18973  Pole; polymerase (DNA directed), epsilon [KO:K02324] [EC:2.7.7.7]
18974  Pole2; polymerase (DNA directed), epsilon 2 (p59 subunit) [KO:K02325] [EC:2.7.7.7]
59001  Pole3; polymerase (DNA directed), epsilon 3 (p17 subunit) [KO:K02326] [EC:2.7.7.7]
66979  Pole4; polymerase (DNA-directed), epsilon 4 (p12 subunit) [KO:K03506] [EC:2.7.7.7]
12443  Ccnd1; cyclin D1 [KO:K04503]
12445  Ccnd3; cyclin D3 [KO:K10152]
12567  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
19645  Rb1; RB transcriptional corepressor 1 [KO:K06618]
13555  E2f1; E2F transcription factor 1 [KO:K17454]
242705  E2f2; E2F transcription factor 2 [KO:K09389]
13557  E2f3; E2F transcription factor 3 [KO:K06620]
12578  Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621]
12579  Cdkn2b; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [KO:K04685]
22408  Wnt1; wingless-type MMTV integration site family, member 1 [KO:K03209]
22413  Wnt2; wingless-type MMTV integration site family, member 2 [KO:K00182]
22414  Wnt2b; wingless-type MMTV integration site family, member 2B [KO:K00182]
22415  Wnt3; wingless-type MMTV integration site family, member 3 [KO:K00312]
22416  Wnt3a; wingless-type MMTV integration site family, member 3A [KO:K00312]
22417  Wnt4; wingless-type MMTV integration site family, member 4 [KO:K00408]
22418  Wnt5a; wingless-type MMTV integration site family, member 5A [KO:K00444]
22419  Wnt5b; wingless-type MMTV integration site family, member 5B [KO:K00444]
22420  Wnt6; wingless-type MMTV integration site family, member 6 [KO:K00445]
22421  Wnt7a; wingless-type MMTV integration site family, member 7A [KO:K00572]
22422  Wnt7b; wingless-type MMTV integration site family, member 7B [KO:K00572]
20890  Wnt8a; wingless-type MMTV integration site family, member 8A [KO:K00714]
22423  Wnt8b; wingless-type MMTV integration site family, member 8B [KO:K00714]
216795  Wnt9a; wingless-type MMTV integration site family, member 9A [KO:K01064]
22412  Wnt9b; wingless-type MMTV integration site family, member 9B [KO:K01064]
22410  Wnt10b; wingless-type MMTV integration site family, member 10B [KO:K01357]
22409  Wnt10a; wingless-type MMTV integration site family, member 10A [KO:K01357]
22411  Wnt11; wingless-type MMTV integration site family, member 11 [KO:K01384]
93735  Wnt16; wingless-type MMTV integration site family, member 16 [KO:K01558]
14362  Fzd1; frizzled class receptor 1 [KO:K02432]
14369  Fzd7; frizzled class receptor 7 [KO:K02432]
57265  Fzd2; frizzled class receptor 2 [KO:K02235]
14365  Fzd3; frizzled class receptor 3 [KO:K02329]
14366  Fzd4; frizzled class receptor 4 [KO:K02354]
14367  Fzd5; frizzled class receptor 5 [KO:K02375]
14370  Fzd8; frizzled class receptor 8 [KO:K02375]
14368  Fzd6; frizzled class receptor 6 [KO:K02376]
93897  Fzd10; frizzled class receptor 10 [KO:K02842]
14371  Fzd9; frizzled class receptor 9 [KO:K02842]
13544  Dvl3; dishevelled segment polarity protein 3 [KO:K02353]
13542  Dvl1; dishevelled segment polarity protein 1 [KO:K02353]
13543  Dvl2; dishevelled segment polarity protein 2 [KO:K02353]
56637  Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
12387  Ctnnb1; catenin (cadherin associated protein), beta 1 [KO:K02105]
11789  Apc; adenomatosis polyposis coli [KO:K02085]
23805  Apc2; adenomatosis polyposis coli 2 [KO:K02085]
13383  Dlg1; discs large MAGUK scaffold protein 1 [KO:K12076]
18590  Pdgfa; platelet derived growth factor, alpha [KO:K04359]
18591  Pdgfb; platelet derived growth factor, B polypeptide [KO:K17386]
18595  Pdgfra; platelet derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
18596  Pdgfrb; platelet derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
21926  Tnf; tumor necrosis factor [KO:K03156]
21937  Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
26401  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
26398  Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
16476  Jun; jun proto-oncogene [KO:K04448]
56310  Gps2; G protein pathway suppressor 2 [KO:K15307]
16177  Il1r1; interleukin 1 receptor, type I [KO:K04386]
16178  Il1r2; interleukin 1 receptor, type II [KO:K04387]
26406  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
12675  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
16150  Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
18035  Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
17000  Ltbr; lymphotoxin B receptor [KO:K03159]
21939  Cd40; CD40 antigen [KO:K03160]
72049  Tnfrsf13c; tumor necrosis factor receptor superfamily, member 13c [KO:K05151]
53859  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
19698  Relb; avian reticuloendotheliosis viral (v-rel) oncogene related B [KO:K09253]
18034  Nfkb2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [KO:K04469]
16183  Il2; interleukin 2 [KO:K05429]
16184  Il2ra; interleukin 2 receptor, alpha chain [KO:K05068]
16168  Il15; interleukin 15 [KO:K05433]
16169  Il15ra; interleukin 15 receptor, alpha chain [KO:K05074]
16193  Il6; interleukin 6 [KO:K05405]
12981  Csf2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
16992  Lta; lymphotoxin A [KO:K05468]
12048  Bcl2l1; BCL2-like 1 [KO:K04570]
11798  Xiap; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27]
22695  Zfp36; zinc finger protein 36 [KO:K15308]
18045  Nfyb; nuclear transcription factor-Y beta [KO:K08065]
14960  H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14969  H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14998  H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
100504404  H2-Ea-ps; histocompatibility 2, class II antigen E alpha, pseudogene [KO:K06752]
20807  Srf; serum response factor [KO:K04378]
13714  Elk4; ELK4, member of ETS oncogene family [KO:K04376]
13712  Elk1; ELK1, member of ETS oncogene family [KO:K04375]
20375  Spi1; spleen focus forming virus (SFFV) proviral integration oncogene [KO:K09438]
23871  Ets1; E26 avian leukemia oncogene 1, 5' domain [KO:K02678]
23872  Ets2; E26 avian leukemia oncogene 2, 3' domain [KO:K21932]
21374  Tbp; TATA box binding protein [KO:K03120]
237336  Tbpl1; TATA box binding protein-like 1 [KO:K03120]
227606  Tbpl2; TATA box binding protein like 2 [KO:K03120]
14281  Fos; FBJ osteosarcoma oncogene [KO:K04379]
13653  Egr1; early growth response 1 [KO:K09203]
13654  Egr2; early growth response 2 [KO:K12496]
14283  Fosl1; fos-like antigen 1 [KO:K04502]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
11512  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
12912  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
12916  Crem; cAMP responsive element modulator [KO:K09052]
11908  Atf1; activating transcription factor 1 [KO:K09053]
11909  Atf2; activating transcription factor 2 [KO:K04450]
11910  Atf3; activating transcription factor 3 [KO:K09032]
11911  Atf4; activating transcription factor 4 [KO:K04374]
22433  Xbp1; X-box binding protein 1 [KO:K09027]
382056  Crtc1; CREB regulated transcription coactivator 1 [KO:K15309]
74343  Crtc2; CREB regulated transcription coactivator 2 [KO:K16333]
70461  Crtc3; CREB regulated transcription coactivator 3 [KO:K16334]
12914  Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
328572  Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
14534  Kat2a; K(lysine) acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
18519  Kat2b; K(lysine) acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
21423  Tcf3; transcription factor 3 [KO:K09063]
18970  Polb; polymerase (DNA directed), beta [KO:K02330] [EC:4.2.99.- 2.7.7.7]
12580  Cdkn2c; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) [KO:K06622]
16818  Lck; lymphocyte protein tyrosine kinase [KO:K05856] [EC:2.7.10.2]
21752  Tert; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
17863  Myb; myeloblastosis oncogene [KO:K09420]
17865  Mybl2; myeloblastosis oncogene-like 2 [KO:K21769]
21812  Tgfbr1; transforming growth factor, beta receptor I [KO:K04674] [EC:2.7.11.30]
21813  Tgfbr2; transforming growth factor, beta receptor II [KO:K04388] [EC:2.7.11.30]
17126  Smad2; SMAD family member 2 [KO:K04500]
17127  Smad3; SMAD family member 3 [KO:K04500]
17128  Smad4; SMAD family member 4 [KO:K04501]
11920  Atm; ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
245000  Atr; ataxia telangiectasia and Rad3 related [KO:K06640] [EC:2.7.11.1]
12649  Chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
50883  Chek2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
22059  Trp53; transformation related protein 53 [KO:K04451]
12028  Bax; BCL2-associated X protein [KO:K02159]
60599  Trp53inp1; transformation related protein 53 inducible nuclear protein 1 [KO:K15310]
17701  Msx1; msh homeobox 1 [KO:K09341]
17702  Msx2; msh homeobox 2 [KO:K09341]
17703  Msx3; msh homeobox 3 [KO:K09341]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C18994  Accessory protein p12I
C18995  P13 protein
C18996  Accessory protein p30II
C19313  HTLV-1 basic zipper factor
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
  Authors
Gatza ML, Watt JC, Marriott SJ
  Title
Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades.
  Journal
Oncogene 22:5141-9 (2003)
DOI:10.1038/sj.onc.1206549
Reference
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Boxus M, Willems L
  Title
Mechanisms of HTLV-1 persistence and transformation.
  Journal
Br J Cancer 101:1497-501 (2009)
DOI:10.1038/sj.bjc.6605345
Reference
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
  Authors
Yasunaga J, Matsuoka M
  Title
[HTLV-I and leukemogenesis].
  Journal
Uirusu 56:241-9 (2006)
DOI:10.2222/jsv.56.241
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
  Authors
Peloponese JM Jr, Jeang KT
  Title
Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein.
  Journal
J Biol Chem 281:8927-38 (2006)
DOI:10.1074/jbc.M510598200
Reference
  Authors
Marriott SJ, Semmes OJ
  Title
Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response.
  Journal
Oncogene 24:5986-95 (2005)
DOI:10.1038/sj.onc.1208976
Reference
  Authors
Jeang KT
  Title
Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B.
  Journal
Cytokine Growth Factor Rev 12:207-17 (2001)
DOI:10.1016/S1359-6101(00)00028-9
Reference
  Authors
Bouzar AB, Willems L
  Title
How HTLV-1 may subvert miRNAs for persistence and transformation.
  Journal
Retrovirology 5:101 (2008)
DOI:10.1186/1742-4690-5-101
Reference
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
  Authors
Manel N, Battini JL, Taylor N, Sitbon M
  Title
HTLV-1 tropism and envelope receptor.
  Journal
Oncogene 24:6016-25 (2005)
DOI:10.1038/sj.onc.1208972
Reference
  Authors
Sun SC, Ballard DW
  Title
Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.
  Journal
Oncogene 18:6948-58 (1999)
DOI:10.1038/sj.onc.1203220
Reference
  Authors
Taylor GP, Matsuoka M
  Title
Natural history of adult T-cell leukemia/lymphoma and approaches to therapy.
  Journal
Oncogene 24:6047-57 (2005)
DOI:10.1038/sj.onc.1208979
Reference
  Authors
Franchini G, Fukumoto R, Fullen JR
  Title
T-cell control by human T-cell leukemia/lymphoma virus type 1.
  Journal
Int J Hematol 78:280-96 (2003)
DOI:10.1007/BF02983552
Reference
  Authors
Baydoun HH, Bellon M, Nicot C
  Title
HTLV-1 Yin and Yang: Rex and p30 master regulators of viral mRNA trafficking.
  Journal
AIDS Rev 10:195-204 (2008)
Reference
PMID:9325311
  Authors
Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT
  Title
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.
  Journal
J Biol Chem 272:25816-23 (1997)
DOI:10.1074/jbc.272.41.25816
Reference
  Authors
Pise-Masison CA, Brady JN
  Title
Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.
  Journal
Front Biosci 10:919-30 (2005)
KO pathway
ko05166   

DBGET integrated database retrieval system