KEGG   PATHWAY: mmu05169Help
Entry
mmu05169                    Pathway                                

Name
Epstein-Barr virus infection - Mus musculus (mouse)
Description
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxic T cells, causing infectious mononucleosis during adolescence. Primary infection with EBV is followed by latent infection in which the reservoir B cells are immortalized. EBV tumorigenic potential in Burkitt lymphoma, nasopharyngeal carcinoma, Hodgkin lymphoma, and post-transplant B cell lymphomas has been well-documented. Distinct forms of EBV latency and patterns of latent gene expression can contribute to the different tumours.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Epstein-Barr virus infection
mmu05169

All organismsOrtholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
12902  
Cr2; complement receptor 2 [KO:K04012]
20020  
Polr2a; polymerase (RNA) II (DNA directed) polypeptide A [KO:K03006] [EC:2.7.7.6]
231329  
Polr2b; polymerase (RNA) II (DNA directed) polypeptide B [KO:K03010] [EC:2.7.7.6]
20021  
Polr2c; polymerase (RNA) II (DNA directed) polypeptide C [KO:K03011]
20022  
Polr2j; polymerase (RNA) II (DNA directed) polypeptide J [KO:K03008]
69241  
Polr2d; polymerase (RNA) II (DNA directed) polypeptide D [KO:K03012]
67710  
Polr2g; polymerase (RNA) II (DNA directed) polypeptide G [KO:K03015]
69920  
Polr2i; polymerase (RNA) II (DNA directed) polypeptide I [KO:K03017]
66420  
Polr2e; polymerase (RNA) II (DNA directed) polypeptide E [KO:K03013]
69833  
Polr2f; polymerase (RNA) II (DNA directed) polypeptide F [KO:K03014]
245841  
Polr2h; polymerase (RNA) II (DNA directed) polypeptide H [KO:K03016]
DNA-directed RNA polymerases I; K03009 DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009]
66491  
Polr2l; polymerase (RNA) II (DNA directed) polypeptide L [KO:K03007]
218832  
Polr3a; polymerase (RNA) III (DNA directed) polypeptide A [KO:K03018] [EC:2.7.7.6]
70428  
Polr3b; polymerase (RNA) III (DNA directed) polypeptide B [KO:K03021] [EC:2.7.7.6]
20016  
Polr1c; polymerase (RNA) I polypeptide C [KO:K03027]
20018  
Polr1d; polymerase (RNA) I polypeptide D [KO:K03020]
74414  
Polr3c; polymerase (RNA) III (DNA directed) polypeptide C [KO:K03023]
67065  
Polr3d; polymerase (RNA) III (DNA directed) polypeptide D [KO:K03026]
26939  
Polr3e; polymerase (RNA) III (DNA directed) polypeptide E [KO:K14721]
70408  
Polr3f; polymerase (RNA) III (DNA directed) polypeptide F [KO:K03025]
67486  
Polr3g; polymerase (RNA) III (DNA directed) polypeptide G [KO:K03024]
69870  
Polr3gl; polymerase (RNA) III (DNA directed) polypeptide G like [KO:K03024]
78929  
Polr3h; polymerase (RNA) III (DNA directed) polypeptide H [KO:K03022]
67005  
Polr3k; polymerase (RNA) III (DNA directed) polypeptide K [KO:K03019]
103573  
Xpo1; exportin 1, CRM1 homolog (yeast) [KO:K14290]
19384  
Ran; RAN, member RAS oncogene family [KO:K07936]
19428  
Rasl2-9; RAS-like, family 2, locus 9 [KO:K07936]
75471  
1700009N14Rik; RIKEN cDNA 1700009N14 gene [KO:K07936]
227720  
Nup214; nucleoporin 214 [KO:K14317]
14990  
H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991  
H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997  
H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
15006  
H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007  
H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013  
H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15018  
H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15019  
H2-Q8; histocompatibility 2, Q region locus 8 [KO:K06751]
15039  
H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040  
H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042  
H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043  
H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15051  
H2-T9; histocompatibility 2, T region locus 9 [KO:K06751]
224753  
H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754  
H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756  
H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761  
H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
333715  
H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
399549  
H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
15024  
H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
110557  
H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110696  
H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
14963  
H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  
H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14972  
H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14985  
H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
547349  
MHC class I family member; K06751 major histocompatibility complex, class I [KO:K06751]
h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
12494  
Cd38; CD38 antigen [KO:K01242] [EC:2.4.99.20 3.2.2.6]
20737  
Spn; sialophorin [KO:K06477]
12534  
Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.23 2.7.11.22]
54194  
Akap8l; A kinase (PRKA) anchor protein 8-like [KO:K15978]
15481  
Hspa8; heat shock protein 8 [KO:K03283]
15482  
Hspa1l; heat shock protein 1-like [KO:K03283]
193740  
Hspa1a; heat shock protein 1A [KO:K03283]
15512  
Hspa2; heat shock protein 2 [KO:K03283]
15511  
Hspa1b; heat shock protein 1B [KO:K03283]
15507  
Hspb1; heat shock protein 1 [KO:K04455]
69253  
Hspb2; heat shock protein 2 [KO:K09543]
22631  
Ywhaz; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [KO:K16197]
54401  
Ywhab; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [KO:K16197]
22630  
Ywhaq; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide [KO:K16197]
22627  
Ywhae; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [KO:K06630]
Gm2423; predicted gene 2423 [KO:K06630]
22629  
Ywhah; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [KO:K16198]
22628  
Ywhag; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide [KO:K16198]
229906  
Gtf2b; general transcription factor IIB [KO:K03124]
56463  
Snd1; staphylococcal nuclease and tudor domain containing 1 [KO:K15979]
74197  
Gtf2e1; general transcription factor II E, polypeptide 1 (alpha subunit) [KO:K03136]
99169  
expressed sequence AU015228; K03136 transcription initiation factor TFIIE subunit alpha [KO:K03136]
68153  
Gtf2e2; general transcription factor II E, polypeptide 2 (beta subunit) [KO:K03137]
208727  
Hdac4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
15184  
Hdac5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
66354  
Snw1; SNW domain containing 1 [KO:K06063]
20602  
Ncor2; nuclear receptor co-repressor 2 [KO:K06065]
19664  
Rbpj; recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
19668  
Rbpjl; recombination signal binding protein for immunoglobulin kappa J region-like [KO:K06053]
20375  
Spi1; spleen focus forming virus (SFFV) proviral integration oncogene [KO:K09438]
15182  
Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
433759  
Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
12914  
Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
328572  
Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
19231  
Ptma; prothymosin alpha [KO:K13784]
14128  
Fcer2a; Fc receptor, IgE, low affinity II, alpha polypeptide [KO:K06468]
14191  
Fgr; Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog [KO:K08891] [EC:2.7.10.2]
17869  
Myc; myelocytomatosis oncogene [KO:K04377]
22059  
Trp53; transformation related protein 53 [KO:K04451]
21374  
Tbp; TATA box binding protein [KO:K03120]
237336  
Tbpl1; TATA box binding protein-like 1 [KO:K03120]
227606  
Tbpl2; TATA box binding protein like 2 [KO:K03120]
12575  
Cdkn1a; cyclin-dependent kinase inhibitor 1A (P21) [KO:K06625]
17246  
Mdm2; transformed mouse 3T3 cell double minute 2 [KO:K06643] [EC:6.3.2.19]
19181  
Psmc2; proteasome (prosome, macropain) 26S subunit, ATPase 2 [KO:K03061]
19179  
Psmc1; protease (prosome, macropain) 26S subunit, ATPase 1 [KO:K03062]
23996  
Psmc4; proteasome (prosome, macropain) 26S subunit, ATPase, 4 [KO:K03063]
67089  
Psmc6; proteasome (prosome, macropain) 26S subunit, ATPase, 6 [KO:K03064]
19182  
Psmc3; proteasome (prosome, macropain) 26S subunit, ATPase 3 [KO:K03065]
19184  
Psmc5; protease (prosome, macropain) 26S subunit, ATPase 5 [KO:K03066]
21762  
Psmd2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [KO:K03028]
70247  
Psmd1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 [KO:K03032]
22123  
Psmd3; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [KO:K03033]
66997  
Psmd12; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [KO:K03035]
69077  
Psmd11; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [KO:K03036]
66413  
Psmd6; proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [KO:K03037]
17463  
Psmd7; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 [KO:K03038]
23997  
Psmd13; proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 [KO:K03039]
19185  
Psmd4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [KO:K03029]
59029  
Psmd14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [KO:K03030]
57296  
Psmd8; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 [KO:K03031]
20422  
Shfm1; split hand/foot malformation (ectrodactyly) type 1 [KO:K10881]
252870  
Usp7; ubiquitin specific peptidase 7 [KO:K11838] [EC:3.1.2.15]
18747  
Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  
Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
19108  
Prkx; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
12995  
Csnk2a1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
13000  
Csnk2a2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
13001  
Csnk2b; casein kinase 2, beta polypeptide [KO:K03115]
12576  
Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
12428  
Ccna2; cyclin A2 [KO:K06627]
12427  
Ccna1; cyclin A1 [KO:K06627]
12566  
Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
19645  
Rb1; retinoblastoma 1 [KO:K06618]
27401  
Skp2; S-phase kinase-associated protein 2 (p45) [KO:K03875]
30955  
Pik3cg; phosphoinositide-3-kinase, catalytic, gamma polypeptide [KO:K00922] [EC:2.7.1.153]
18706  
Pik3ca; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide [KO:K00922] [EC:2.7.1.153]
18707  
Pik3cd; phosphatidylinositol 3-kinase catalytic delta polypeptide [KO:K00922] [EC:2.7.1.153]
74769  
Pik3cb; phosphatidylinositol 3-kinase, catalytic, beta polypeptide [KO:K00922] [EC:2.7.1.153]
18709  
Pik3r2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [KO:K02649]
18708  
Pik3r1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) [KO:K02649]
320207  
Pik3r5; phosphoinositide-3-kinase, regulatory subunit 5, p101 [KO:K02649]
18710  
Pik3r3; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) [KO:K02649]
11651  
Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  
Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797  
Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
56637  
Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
22029  
Traf1; TNF receptor-associated factor 1 [KO:K03172]
22030  
Traf2; TNF receptor-associated factor 2 [KO:K03173]
22031  
Traf3; TNF receptor-associated factor 3 [KO:K03174]
22033  
Traf5; TNF receptor-associated factor 5 [KO:K09849]
53859  
Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
12675  
Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
19698  
Relb; avian reticuloendotheliosis viral (v-rel) oncogene related B [KO:K09253]
18034  
Nfkb2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [KO:K04469]
71609  
Tradd; TNFRSF1A-associated via death domain [KO:K03171]
19766  
Ripk1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
16151  
Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
16150  
Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
18036  
Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581]
18035  
Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18037  
Nfkbie; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon [KO:K05872]
18033  
Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697  
Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
16179  
Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
22034  
Traf6; TNF receptor-associated factor 6 [KO:K03175]
66513  
Tab1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
68652  
Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
26409  
Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
26397  
Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
26399  
Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
26416  
Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
19094  
Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
29857  
Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
26415  
Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
26398  
Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
26400  
Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
26419  
Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  
Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26414  
Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
16476  
Jun; jun proto-oncogene [KO:K04448]
11909  
Atf2; activating transcription factor 2 [KO:K04450]
16453  
Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
12495  
Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
215446  
Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
72090  
Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
21939  
Cd40; CD40 antigen [KO:K03160]
12505  
Cd44; CD44 antigen [KO:K06256]
16408  
Itgal; integrin alpha L [KO:K05718]
15894  
Icam1; intercellular adhesion molecule 1 [KO:K06490]
22352  
Vim; vimentin [KO:K07606]
21929  
Tnfaip3; tumor necrosis factor, alpha-induced protein 3 [KO:K11859] [EC:3.-.-.-]
12043  
Bcl2; B cell leukemia/lymphoma 2 [KO:K02161]
16061  
Igh-VJ558; immunoglobulin heavy chain (J558 family) [KO:K06856]
17096  
Lyn; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog [KO:K05854] [EC:2.7.10.2]
666513  
Gm11787; predicted gene 11787 [KO:K05854] [EC:2.7.10.2]
20963  
Syk; spleen tyrosine kinase [KO:K05855] [EC:2.7.10.2]
18803  
Plcg1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
234779  
Plcg2; phospholipase C, gamma 2 [KO:K05859] [EC:3.1.4.11]
12478  
Cd19; CD19 antigen [KO:K06465]
17999  
Nedd4; neural precursor cell expressed, developmentally down-regulated 4 [KO:K10591] [EC:6.3.2.19]
230073  
Ddx58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:3.6.3.14]
15978  
Ifng; interferon gamma [KO:K04687]
56480  
Tbk1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
54131  
Irf3; interferon regulatory factor 3 [KO:K05411]
16153  
Il10; interleukin 10 [KO:K05443]
15467  
Eif2ak1; eukaryotic translation initiation factor 2 alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
19106  
Eif2ak2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
13666  
Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
27103  
Eif2ak4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
16154  
Il10ra; interleukin 10 receptor, alpha [KO:K05134]
16155  
Il10rb; interleukin 10 receptor, beta [KO:K05135]
16451  
Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
54721  
Tyk2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
20848  
Stat3; signal transducer and activator of transcription 3 [KO:K04692]
Compound
C00076  
Calcium cation
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kieff E, Rickinson AB.
  Title
Epstein-Barr virus and its replication.
  Journal
Fields Virology. New York, Lippincott-Raven
Reference
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
Reference
  Authors
Young LS, Murray PG
  Title
Epstein-Barr virus and oncogenesis: from latent genes to tumours.
  Journal
Oncogene 22:5108-21 (2003)
Reference
  Authors
Haan KM, Kwok WW, Longnecker R, Speck P
  Title
Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor.
  Journal
J Virol 74:2451-4 (2000)
Reference
  Authors
Knight JS, Sharma N, Robertson ES
  Title
Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase.
  Journal
Proc Natl Acad Sci U S A 102:18562-6 (2005)
Reference
  Authors
Knight JS, Sharma N, Kalman DE, Robertson ES
  Title
A cyclin-binding motif within the amino-terminal homology domain of EBNA3C binds  cyclin A and modulates cyclin A-dependent kinase activity in Epstein-Barr virus-infected cells.
  Journal
J Virol 78:12857-67 (2004)
Reference
  Authors
Cotter MA 2nd, Robertson ES
  Title
Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha.
  Journal
Mol Cell Biol 20:5722-35 (2000)
Reference
  Authors
Eliopoulos AG, Caamano JH, Flavell J, Reynolds GM, Murray PG, Poyet JL, Young LS
  Title
Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling  pathway.
  Journal
Oncogene 22:7557-69 (2003)
Reference
  Authors
Ikeda M, Ikeda A, Longan LC, Longnecker R
  Title
The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.
  Journal
Virology 268:178-91 (2000)
Reference
  Authors
Masucci MG
  Title
Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system.
  Journal
Oncogene 23:2107-15 (2004)
Reference
  Authors
Luftig M, Prinarakis E, Yasui T, Tsichritzis T, Cahir-McFarland E, Inoue J, Nakano H, Mak TW, Yeh WC, Li X, Akira S, Suzuki N, Suzuki S, Mosialos G, Kieff E
  Title
Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.
  Journal
Proc Natl Acad Sci U S A 100:15595-600 (2003)
Reference
  Authors
Mainou BA, Everly DN Jr, Raab-Traub N
  Title
Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K.
  Journal
Oncogene 24:6917-24 (2005)
Reference
  Authors
Young KA, Herbert AP, Barlow PN, Holers VM, Hannan JP
  Title
Molecular basis of the interaction between complement receptor type 2 (CR2/CD21)  and Epstein-Barr virus glycoprotein gp350.
  Journal
J Virol 82:11217-27 (2008)
Reference
  Authors
Portal D, Rosendorff A, Kieff E
  Title
Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4.
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Proc Natl Acad Sci U S A 103:19278-83 (2006)
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Portal D, Zhao B, Calderwood MA, Sommermann T, Johannsen E, Kieff E
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EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from  enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.
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Proc Natl Acad Sci U S A 108:7808-13 (2011)
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A role for SKIP in EBNA2 activation of CBF1-repressed promoters.
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J Virol 74:1939-47 (2000)
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Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae.
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J Gen Virol 87:1047-74 (2006)
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Anderson LJ, Longnecker R
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EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway.
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J Gen Virol 89:1563-8 (2008)
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PMID:1658397
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Flemington EK, Goldfeld AE, Speck SH
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Efficient transcription of the Epstein-Barr virus immediate-early BZLF1 and BRLF1 genes requires protein synthesis.
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J Virol 65:7073-7 (1991)
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Mauser A, Saito S, Appella E, Anderson CW, Seaman WT, Kenney S
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The Epstein-Barr virus immediate-early protein BZLF1 regulates p53 function through multiple mechanisms.
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J Virol 76:12503-12 (2002)
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Sato Y, Shirata N, Kudoh A, Iwahori S, Nakayama S, Murata T, Isomura H, Nishiyama Y, Tsurumi T
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Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription.
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Virology 388:204-11 (2009)
Reference
PMID:7895172
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Miller CL, Burkhardt AL, Lee JH, Stealey B, Longnecker R, Bolen JB, Kieff E
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Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases.
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Immunity 2:155-66 (1995)
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Boyle SM, Ruvolo V, Gupta AK, Swaminathan S
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Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene  expression.
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J Virol 73:6872-81 (1999)
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Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo.
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J Exp Med 187:1395-402 (1998)
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EB virus and oncogenesis. [Japanese]
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Genomu Igaku. Tokyo, Medical Review Co. Ltd.
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