KEGG PATHWAY: mmu05169

PATHWAY: mmu05169

Entry

mmu05169 Pathway

Name

Epstein-Barr virus infection - Mus musculus (mouse)

Description

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxic T cells, causing infectious mononucleosis during adolescence. Primary infection with EBV is followed by latent infection in which the reservoir B cells are immortalized. EBV tumorigenic potential in Burkitt lymphoma, nasopharyngeal carcinoma, Hodgkin lymphoma, and post-transplant B cell lymphomas has been well-documented. Distinct forms of EBV latency and patterns of latent gene expression can contribute to the different tumours.

Class

Human Diseases; Infectious diseases

Pathway map

mmu05169

Epstein-Barr virus infection

Organism

Mus musculus (mouse) [GN:mmu]

Gene

12902	Cr2; complement receptor 2 [KO:K04012]
20020	Polr2a; polymerase (RNA) II (DNA directed) polypeptide A [KO:K03006] [EC:2.7.7.6]
231329	Polr2b; polymerase (RNA) II (DNA directed) polypeptide B [KO:K03010] [EC:2.7.7.6]
20021	Polr2c; polymerase (RNA) II (DNA directed) polypeptide C [KO:K03011]
20022	Polr2j; polymerase (RNA) II (DNA directed) polypeptide J [KO:K03008]
69241	Polr2d; polymerase (RNA) II (DNA directed) polypeptide D [KO:K03012]
67710	Polr2g; polymerase (RNA) II (DNA directed) polypeptide G [KO:K03015]
69920	Polr2i; polymerase (RNA) II (DNA directed) polypeptide I [KO:K03017]
66420	Polr2e; polymerase (RNA) II (DNA directed) polypeptide E [KO:K03013]
69833	Polr2f; polymerase (RNA) II (DNA directed) polypeptide F [KO:K03014]
245841	Polr2h; polymerase (RNA) II (DNA directed) polypeptide H [KO:K03016]
100862456	DNA-directed RNA polymerases I; K03009 DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009]
66491	Polr2l; polymerase (RNA) II (DNA directed) polypeptide L [KO:K03007]
218832	Polr3a; polymerase (RNA) III (DNA directed) polypeptide A [KO:K03018] [EC:2.7.7.6]
70428	Polr3b; polymerase (RNA) III (DNA directed) polypeptide B [KO:K03021] [EC:2.7.7.6]
20016	Polr1c; polymerase (RNA) I polypeptide C [KO:K03027]
20018	Polr1d; polymerase (RNA) I polypeptide D [KO:K03020]
74414	Polr3c; polymerase (RNA) III (DNA directed) polypeptide C [KO:K03023]
67065	Polr3d; polymerase (RNA) III (DNA directed) polypeptide D [KO:K03026]
26939	Polr3e; polymerase (RNA) III (DNA directed) polypeptide E [KO:K14721]
70408	Polr3f; polymerase (RNA) III (DNA directed) polypeptide F [KO:K03025]
67486	Polr3g; polymerase (RNA) III (DNA directed) polypeptide G [KO:K03024]
69870	Polr3gl; polymerase (RNA) III (DNA directed) polypeptide G like [KO:K03024]
78929	Polr3h; polymerase (RNA) III (DNA directed) polypeptide H [KO:K03022]
67005	Polr3k; polymerase (RNA) III (DNA directed) polypeptide K [KO:K03019]
103573	Xpo1; exportin 1, CRM1 homolog (yeast) [KO:K14290]
19384	Ran; RAN, member RAS oncogene family [KO:K07936]
19428	Rasl2-9; RAS-like, family 2, locus 9 [KO:K07936]
75471	1700009N14Rik; RIKEN cDNA 1700009N14 gene [KO:K07936]
100045999	GTP-binding nuclear protein Ran-like; K07936 GTP-binding nuclear protein Ran [KO:K07936]
227720	Nup214; nucleoporin 214 [KO:K14317]
14990	H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991	H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997	H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
15006	H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007	H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013	H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15018	H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15019	H2-Q8; histocompatibility 2, Q region locus 8 [KO:K06751]
15039	H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040	H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042	H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043	H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15051	H2-T9; histocompatibility 2, T region locus 9 [KO:K06751]
224753	H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754	H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756	H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761	H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
333715	H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
399549	H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
15024	H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
110557	H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110696	H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
14963	H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964	H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14972	H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14985	H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
547349	MHC class I family member; K06751 major histocompatibility complex, class I [KO:K06751]
100862435	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
676708	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
101056305	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
101056446	h-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
12182	Bst1; bone marrow stromal cell antigen 1 [KO:K01242] [EC:3.2.2.5]
12494	Cd38; CD38 antigen [KO:K01242] [EC:3.2.2.5]
20737	Spn; sialophorin [KO:K06477]
12534	Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.23 2.7.11.22]
54194	Akap8l; A kinase (PRKA) anchor protein 8-like [KO:K15978]
15481	Hspa8; heat shock protein 8 [KO:K03283]
15482	Hspa1l; heat shock protein 1-like [KO:K03283]
193740	Hspa1a; heat shock protein 1A [KO:K03283]
15512	Hspa2; heat shock protein 2 [KO:K03283]
15511	Hspa1b; heat shock protein 1B [KO:K03283]
15507	Hspb1; heat shock protein 1 [KO:K04455]
69253	Hspb2; heat shock protein 2 [KO:K09543]
22631	Ywhaz; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [KO:K16197]
54401	Ywhab; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [KO:K16197]
22630	Ywhaq; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide [KO:K16197]
22627	Ywhae; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [KO:K06630]
100039786	Gm2423; predicted gene 2423 [KO:K06630]
22629	Ywhah; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [KO:K16198]
22628	Ywhag; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide [KO:K16198]
229906	Gtf2b; general transcription factor IIB [KO:K03124]
56463	Snd1; staphylococcal nuclease and tudor domain containing 1 [KO:K15979]
74197	Gtf2e1; general transcription factor II E, polypeptide 1 (alpha subunit) [KO:K03136]
99169	expressed sequence AU015228; K03136 transcription initiation factor TFIIE subunit alpha [KO:K03136]
68153	Gtf2e2; general transcription factor II E, polypeptide 2 (beta subunit) [KO:K03137]
208727	Hdac4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
15184	Hdac5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
66354	Snw1; SNW domain containing 1 [KO:K06063]
20602	Ncor2; nuclear receptor co-repressor 2 [KO:K06065]
19664	Rbpj; recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
19668	Rbpjl; recombination signal binding protein for immunoglobulin kappa J region-like [KO:K06053]
20375	Sfpi1; SFFV proviral integration 1 [KO:K09438]
15182	Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
433759	Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
12914	Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
328572	Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
19231	Ptma; prothymosin alpha [KO:K13784]
14128	Fcer2a; Fc receptor, IgE, low affinity II, alpha polypeptide [KO:K06468]
14191	Fgr; Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog [KO:K08891] [EC:2.7.10.2]
17869	Myc; myelocytomatosis oncogene [KO:K04377]
22059	Trp53; transformation related protein 53 [KO:K04451]
21374	Tbp; TATA box binding protein [KO:K03120]
237336	Tbpl1; TATA box binding protein-like 1 [KO:K03120]
227606	Tbpl2; TATA box binding protein like 2 [KO:K03120]
12575	Cdkn1a; cyclin-dependent kinase inhibitor 1A (P21) [KO:K06625]
17246	Mdm2; transformed mouse 3T3 cell double minute 2 [KO:K06643] [EC:6.3.2.19]
19181	Psmc2; proteasome (prosome, macropain) 26S subunit, ATPase 2 [KO:K03061]
19179	Psmc1; protease (prosome, macropain) 26S subunit, ATPase 1 [KO:K03062]
23996	Psmc4; proteasome (prosome, macropain) 26S subunit, ATPase, 4 [KO:K03063]
67089	Psmc6; proteasome (prosome, macropain) 26S subunit, ATPase, 6 [KO:K03064]
19182	Psmc3; proteasome (prosome, macropain) 26S subunit, ATPase 3 [KO:K03065]
19184	Psmc5; protease (prosome, macropain) 26S subunit, ATPase 5 [KO:K03066]
21762	Psmd2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [KO:K03028]
70247	Psmd1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 [KO:K03032]
22123	Psmd3; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [KO:K03033]
66997	Psmd12; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [KO:K03035]
69077	Psmd11; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [KO:K03036]
66413	Psmd6; proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [KO:K03037]
17463	Psmd7; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 [KO:K03038]
23997	Psmd13; proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 [KO:K03039]
19185	Psmd4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [KO:K03029]
59029	Psmd14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [KO:K03030]
57296	Psmd8; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 [KO:K03031]
20422	Shfm1; split hand/foot malformation (ectrodactyly) type 1 [KO:K10881]
252870	Usp7; ubiquitin specific peptidase 7 [KO:K11838] [EC:3.1.2.15]
18747	Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749	Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
19108	Prkx; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
12995	Csnk2a1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
13000	Csnk2a2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
100047957	casein kinase II subunit alpha-like; K03097 casein kinase II subunit alpha [EC:2.7.11.1] [KO:K03097] [EC:2.7.11.1]
13001	Csnk2b; casein kinase 2, beta polypeptide [KO:K03115]
12576	Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
12428	Ccna2; cyclin A2 [KO:K06627]
12427	Ccna1; cyclin A1 [KO:K06627]
12566	Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
19645	Rb1; retinoblastoma 1 [KO:K06618]
27401	Skp2; S-phase kinase-associated protein 2 (p45) [KO:K03875]
30955	Pik3cg; phosphoinositide-3-kinase, catalytic, gamma polypeptide [KO:K00922] [EC:2.7.1.153]
18706	Pik3ca; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide [KO:K00922] [EC:2.7.1.153]
18707	Pik3cd; phosphatidylinositol 3-kinase catalytic delta polypeptide [KO:K00922] [EC:2.7.1.153]
74769	Pik3cb; phosphatidylinositol 3-kinase, catalytic, beta polypeptide [KO:K00922] [EC:2.7.1.153]
18709	Pik3r2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [KO:K02649]
18708	Pik3r1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) [KO:K02649]
320207	Pik3r5; phosphoinositide-3-kinase, regulatory subunit 5, p101 [KO:K02649]
18710	Pik3r3; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) [KO:K02649]
11651	Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652	Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797	Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
56637	Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
22029	Traf1; TNF receptor-associated factor 1 [KO:K03172]
22030	Traf2; TNF receptor-associated factor 2 [KO:K03173]
22031	Traf3; TNF receptor-associated factor 3 [KO:K03174]
22033	Traf5; TNF receptor-associated factor 5 [KO:K09849]
53859	Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
12675	Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
19698	Relb; avian reticuloendotheliosis viral (v-rel) oncogene related B [KO:K09253]
18034	Nfkb2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [KO:K04469]
71609	Tradd; TNFRSF1A-associated via death domain [KO:K03171]
19766	Ripk1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
16151	Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
16150	Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
18036	Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581]
18035	Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18037	Nfkbie; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon [KO:K05872]
18033	Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697	Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
16179	Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
22034	Traf6; TNF receptor-associated factor 6 [KO:K03175]
66513	Tab1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
68652	Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
26409	Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
26397	Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
26399	Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
26416	Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
19094	Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
29857	Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
26415	Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
26398	Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
26400	Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
26419	Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420	Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26414	Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
16476	Jun; Jun oncogene [KO:K04448]
11909	Atf2; activating transcription factor 2 [KO:K04450]
100047997	cyclic AMP-dependent transcription factor ATF-2-like; K04450 cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
16453	Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
12495	Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
215446	Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
72090	Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
21939	Cd40; CD40 antigen [KO:K03160]
12505	Cd44; CD44 antigen [KO:K06256]
16408	Itgal; integrin alpha L [KO:K05718]
15894	Icam1; intercellular adhesion molecule 1 [KO:K06490]
22352	Vim; vimentin [KO:K07606]
21929	Tnfaip3; tumor necrosis factor, alpha-induced protein 3 [KO:K11859] [EC:3.-.-.-]
12043	Bcl2; B cell leukemia/lymphoma 2 [KO:K02161]
16061	Igh-VJ558; immunoglobulin heavy chain (J558 family) [KO:K06856]
17096	Lyn; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog [KO:K05854] [EC:2.7.10.2]
666513	Gm11787; predicted gene 11787 [KO:K05854] [EC:2.7.10.2]
20963	Syk; spleen tyrosine kinase [KO:K05855] [EC:2.7.10.2]
18803	Plcg1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
234779	Plcg2; phospholipase C, gamma 2 [KO:K05859] [EC:3.1.4.11]
12478	Cd19; CD19 antigen [KO:K06465]
17999	Nedd4; neural precursor cell expressed, developmentally down-regulated 4 [KO:K10591] [EC:6.3.2.19]
230073	Ddx58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:3.6.3.14]
15978	Ifng; interferon gamma [KO:K04687]
56480	Tbk1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
54131	Irf3; interferon regulatory factor 3 [KO:K05411]
16153	Il10; interleukin 10 [KO:K05443]
15467	Eif2ak1; eukaryotic translation initiation factor 2 alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
19106	Eif2ak2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
13666	Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
27103	Eif2ak4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
16154	Il10ra; interleukin 10 receptor, alpha [KO:K05134]
16155	Il10rb; interleukin 10 receptor, beta [KO:K05135]
16451	Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
54721	Tyk2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
20848	Stat3; signal transducer and activator of transcription 3 [KO:K04692]

Compound

C00076	Calcium cation
C01245	D-myo-Inositol 1,4,5-trisphosphate
C05981	Phosphatidylinositol-3,4,5-trisphosphate

Reference

Authors

Kieff E, Rickinson AB.

Title

Epstein-Barr virus and its replication.

Journal

Fields Virology. New York, Lippincott-Raven

Reference

PMID:15510157

Authors

Young LS, Rickinson AB.

Title

Epstein-Barr virus: 40 years on.

Journal

Nat Rev Cancer 4:757-68 (2004)

Reference

PMID:12910248

Authors

Young LS, Murray PG

Title

Epstein-Barr virus and oncogenesis: from latent genes to tumours.

Journal

Oncogene 22:5108-21 (2003)

Reference

PMID:10666279

Authors

Haan KM, Kwok WW, Longnecker R, Speck P

Title

Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor.

Journal

J Virol 74:2451-4 (2000)

Reference

PMID:16352731

Authors

Knight JS, Sharma N, Robertson ES

Title

Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase.

Journal

Proc Natl Acad Sci U S A 102:18562-6 (2005)

Reference

PMID:15542638

Authors

Knight JS, Sharma N, Kalman DE, Robertson ES

Title

A cyclin-binding motif within the amino-terminal homology domain of EBNA3C binds cyclin A and modulates cyclin A-dependent kinase activity in Epstein-Barr virus-infected cells.

Journal

J Virol 78:12857-67 (2004)

Reference

PMID:10891508

Authors

Cotter MA 2nd, Robertson ES

Title

Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha.

Journal

Mol Cell Biol 20:5722-35 (2000)

Reference

PMID:14576817

Authors

Eliopoulos AG, Caamano JH, Flavell J, Reynolds GM, Murray PG, Poyet JL, Young LS

Title

Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway.

Journal

Oncogene 22:7557-69 (2003)

Reference

PMID:10683340

Authors

Ikeda M, Ikeda A, Longan LC, Longnecker R

Title

The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.

Journal

Virology 268:178-91 (2000)

Reference

PMID:15021898

Authors

Masucci MG

Title

Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system.

Journal

Oncogene 23:2107-15 (2004)

Reference

PMID:14673102

Authors

Luftig M, Prinarakis E, Yasui T, Tsichritzis T, Cahir-McFarland E, Inoue J, Nakano H, Mak TW, Yeh WC, Li X, Akira S, Suzuki N, Suzuki S, Mosialos G, Kieff E

Title

Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.

Journal

Proc Natl Acad Sci U S A 100:15595-600 (2003)

Reference

PMID:16007144

Authors

Mainou BA, Everly DN Jr, Raab-Traub N

Title

Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K.

Journal

Oncogene 24:6917-24 (2005)

Reference

PMID:18786993

Authors

Young KA, Herbert AP, Barlow PN, Holers VM, Hannan JP

Title

Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.

Journal

J Virol 82:11217-27 (2008)

Reference

PMID:17159145

Authors

Portal D, Rosendorff A, Kieff E

Title

Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4.

Journal

Proc Natl Acad Sci U S A 103:19278-83 (2006)

Reference

PMID:21518914

Authors

Portal D, Zhao B, Calderwood MA, Sommermann T, Johannsen E, Kieff E

Title

EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.

Journal

Proc Natl Acad Sci U S A 108:7808-13 (2011)

Reference

PMID:10644367

Authors

Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD

Title

A role for SKIP in EBNA2 activation of CBF1-repressed promoters.

Journal

J Virol 74:1939-47 (2000)

Reference

PMID:16603506

Authors

Brinkmann MM, Schulz TF

Title

Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae.

Journal

J Gen Virol 87:1047-74 (2006)

Reference

PMID:18559925

Authors

Anderson LJ, Longnecker R

Title

EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway.

Journal

J Gen Virol 89:1563-8 (2008)

Reference

PMID:1658397

Authors

Flemington EK, Goldfeld AE, Speck SH

Title

Efficient transcription of the Epstein-Barr virus immediate-early BZLF1 and BRLF1 genes requires protein synthesis.

Journal

J Virol 65:7073-7 (1991)

Reference

PMID:12438576

Authors

Mauser A, Saito S, Appella E, Anderson CW, Seaman WT, Kenney S

Title

The Epstein-Barr virus immediate-early protein BZLF1 regulates p53 function through multiple mechanisms.

Journal

J Virol 76:12503-12 (2002)

Reference

PMID:19375142

Authors

Sato Y, Shirata N, Kudoh A, Iwahori S, Nakayama S, Murata T, Isomura H, Nishiyama Y, Tsurumi T

Title

Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription.

Journal

Virology 388:204-11 (2009)

Reference

PMID:7895172

Authors

Miller CL, Burkhardt AL, Lee JH, Stealey B, Longnecker R, Bolen JB, Kieff E

Title

Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases.

Journal

Immunity 2:155-66 (1995)

Reference

PMID:10400785

Authors

Boyle SM, Ruvolo V, Gupta AK, Swaminathan S

Title

Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene expression.

Journal

J Virol 73:6872-81 (1999)

Reference

PMID:9565632

Authors

Callan MF, Tan L, Annels N, Ogg GS, Wilson JD, O'Callaghan CA, Steven N, McMichael AJ, Rickinson AB

Title

Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo.

Journal

J Exp Med 187:1395-402 (1998)

Reference

Authors

Isobe Y.

Title

EB virus and oncogenesis. [Japanese]

Journal

Genomu Igaku. Tokyo, Medical Review Co. Ltd.

KO pathway

ko05169

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