Transcriptional misregulation in cancer - Mus musculus (mouse)

Human Diseases; Cancers

Mus musculus (mouse) [GN:mmu]

PMID:11607818

Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG

Common themes in the pathogenesis of acute myeloid leukemia.

Oncogene 20:5680-94 (2001)

PMID:12032780

Scandura JM, Boccuni P, Cammenga J, Nimer SD

Transcription factor fusions in acute leukemia: variations on a theme.

Oncogene 21:3422-44 (2002)

PMID:12529654

Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C

New mechanisms of AML1 gene alteration in hematological malignancies.

Leukemia 17:9-16 (2003)

PMID:10717473

Lutterbach B, Hiebert SW

Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.

Gene 245:223-35 (2000)

PMID:19075268

Koschmieder S, Halmos B, Levantini E, Tenen DG

Dysregulation of the C/EBPalpha differentiation pathway in human cancer.

J Clin Oncol 27:619-28 (2009)

PMID:11340171

Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG

c-Myc is a critical target for c/EBPalpha in granulopoiesis.

Mol Cell Biol 21:3789-806 (2001)

PMID:15985538

Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP

Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in  myeloid leukemia.

Blood 106:2827-36 (2005)

PMID:12393465

Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.

Blood 101:270-7 (2003)

PMID:12130514

Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

Blood 100:998-1007 (2002)

PMID:15160934

Jing Y

The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.

Leuk Lymphoma 45:639-48 (2004)

PMID:15024077

Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H

Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

Mol Cell Biol 24:2890-904 (2004)

PMID:19855079

Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD

Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.

Blood 114:5499-511 (2009)

PMID:10500199

McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C

Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.

Proc Natl Acad Sci U S A 96:11464-9 (1999)

PMID:15156184

Zelent A, Greaves M, Enver T

Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.

Oncogene 23:4275-83 (2004)

PMID:14630078

Sawinska M, Ladon D

Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.

Leuk Res 28:35-42 (2004)

PMID:19141473

Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage  leukemia.

Genes Dev 22:3403-8 (2008)

PMID:16169901

Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ

The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B  (p27kip1) expression.

Proc Natl Acad Sci U S A 102:14028-33 (2005)

PMID:21518926

Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.

Blood 117:6895-905 (2011)

PMID:14701735

Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.

Mol Cell Biol 24:617-28 (2004)

PMID:19133982

Riz I, Hawley TS, Johnston H, Hawley RG

Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.

Br J Haematol 145:140-3 (2009)

PMID:12511414

Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P

Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.

Blood 101:3681-6 (2003)

PMID:11313274

Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C

Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

Blood 97:2798-807 (2001)

PMID:12670461

Zuzel M, Cawley JC.

The biology of hairy cells.

Best Pract Res Clin Haematol 16:1-13 (2003)

PMID:14998494

Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM

Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.

Cancer Cell 5:191-9 (2004)

PMID:20974671

Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

Blood 117:211-20 (2011)

PMID:19059936

Brito JL, Walker B, Jenner M, Dickens NJ, Brown NJ, Ross FM, Avramidou A, Irving JA, Gonzalez D, Davies FE, Morgan GJ

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.

Haematologica 94:78-86 (2009)

PMID:10350329

Iida S, Rao PH, Ueda R, Chaganti RS, Dalla-Favera R

Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).

Leuk Lymphoma 34:25-33 (1999)

PMID:10784387

Ohno H, Ueda C, Akasaka T

The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.

Leuk Lymphoma 36:435-45 (2000)

PMID:19233641

Prensner JR, Chinnaiyan AM

Oncogenic gene fusions in epithelial carcinomas.

Curr Opin Genet Dev 19:82-91 (2009)

PMID:19406209

Brenner JC, Chinnaiyan AM

Translocations in epithelial cancers.

Biochim Biophys Acta 1796:201-15 (2009)

PMID:16946003

Reddi HV, McIver B, Grebe SK, Eberhardt NL.

THE PAX8/PPAR{gamma} ONCOGENE IN THYROID TUMORIGENESIS.

Endocrinology : (2006)

PMID:19422821

Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG

The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.

Exp Cell Res 315:2399-409 (2009)

PMID:18563191

Kumar-Sinha C, Tomlins SA, Chinnaiyan AM

Recurrent gene fusions in prostate cancer.

Nat Rev Cancer 8:497-511 (2008)

PMID:20478527

Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.

Cancer Cell 17:443-54 (2010)

PMID:21747944

Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.

PLoS One 6:e21650 (2011)

PMID:17505060

Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL, Shemshedini L

ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.

Mol Endocrinol 21:1835-46 (2007)

PMID:18172298

Helgeson BE, Tomlins SA, Shah N, Laxman B, Cao Q, Prensner JR, Cao X, Singla N, Montie JE, Varambally S, Mehra R, Chinnaiyan AM

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.

Cancer Res 68:73-80 (2008)

PMID:21849159

Westermark UK, Wilhelm M, Frenzel A, Henriksson MA

The MYCN oncogene and differentiation in neuroblastoma.

Semin Cancer Biol 21:256-66 (2011)

PMID:20153925

Bell E, Chen L, Liu T, Marshall GM, Lunec J, Tweddle DA

MYCN oncoprotein targets and their therapeutic potential.

Cancer Lett 293:144-57 (2010)

PMID:15644444

Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

Proc Natl Acad Sci U S A 102:731-6 (2005)

PMID:20190806

Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T

Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.

Oncogene 29:2681-90 (2010)

PMID:20145147

Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA

p53 is a direct transcriptional target of MYCN in neuroblastoma.

Cancer Res 70:1377-88 (2010)

PMID:17327229

Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM

N-MYC regulates focal adhesion kinase expression in human neuroblastoma.

J Biol Chem 282:12503-16 (2007)

PMID:21123453

Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G

A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.

Cancer Res 71:404-12 (2011)

PMID:17024155

Dreijerink KM, Hoppener JW, Timmers HM, Lips CJ

Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.

Nat Clin Pract Endocrinol Metab 2:562-70 (2006)

PMID:19075677

Wu X, Hua X

Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.

Curr Mol Med 8:805-15 (2008)

PMID:19564705

Sakurai A, Murakami A, Sano K, Uchino S, Fukushima Y

Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.

Endocr J 56:887-95 (2009)

PMID:17222504

Yang Y, Hua X

In search of tumor suppressing functions of menin.

Mol Cell Endocrinol 265-266:34-41 (2007)

PMID:15826838

Aman P

Fusion oncogenes in tumor development.

Semin Cancer Biol 15:236-43 (2005)

PMID:12527902

Fukuma M, Okita H, Hata J, Umezawa A

Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.

Oncogene 22:1-9 (2003)

PMID:18648544

Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.

PLoS One 3:e2634 (2008)

PMID:17250957

Riggi N, Stamenkovic I.

The Biology of Ewing sarcoma.

Cancer Lett 254:1-10 (2007)

PMID:20490326

Jedlicka P

Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.

Int J Clin Exp Pathol 3:338-47 (2010)

PMID:19738075

Ordonez JL, Osuna D, Herrero D, de Alava E, Madoz-Gurpide J

Advances in Ewing's sarcoma research: where are we now and what lies ahead?

Cancer Res 69:7140-50 (2009)

PMID:12527906

Jishage M, Fujino T, Yamazaki Y, Kuroda H, Nakamura T

Identification of target genes for EWS/ATF-1 chimeric transcription factor.

Oncogene 22:41-9 (2003)

PMID:15826834

Gerald WL, Haber DA

The EWS-WT1 gene fusion in desmoplastic small round cell tumor.

Semin Cancer Biol 15:197-205 (2005)

PMID:18855877

Filion C, Motoi T, Olshen AB, Lae M, Emnett RJ, Gutmann DH, Perry A, Ladanyi M, Labelle Y

The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.

J Pathol 217:83-93 (2009)

PMID:18330902

Kim S, Lee HJ, Jun HJ, Kim J

The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.

Int J Cancer 122:2446-53 (2008)

PMID:10537274

Sjogren H, Meis-Kindblom J, Kindblom LG, Aman P, Stenman G

Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.

Cancer Res 59:5064-7 (1999)

PMID:15688424

Goransson M, Elias E, Stahlberg A, Olofsson A, Andersson C, Aman P

Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.

Int J Cancer 115:556-60 (2005)

PMID:18850010

Goransson M, Andersson MK, Forni C, Stahlberg A, Andersson C, Olofsson A, Mantovani R, Aman P

The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target  genes by interaction with NFKBIZ.

Oncogene 28:270-8 (2009)

PMID:20863376

Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovee JV

Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity  and casein kinase II inhibition as a potential treatment option.

Mol Cancer 9:257 (2010)

PMID:18457914

Linardic CM

PAX3-FOXO1 fusion gene in rhabdomyosarcoma.

Cancer Lett 270:10-8 (2008)

PMID:11863357

Barber TD, Barber MC, Tomescu O, Barr FG, Ruben S, Friedman TB

Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.

Genomics 79:278-84 (2002)

PMID:17101797

Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T

The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.

Mol Cell Biol 27:1348-55 (2007)

PMID:19472090

Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Lim do H, Yoo KH, Choi YL

Expression of MET in alveolar soft part sarcoma.

Med Oncol 27:459-65 (2010)

PMID:21779514

Rivlin N, Brosh R, Oren M, Rotter V

Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.

Genes Cancer 2:466-74 (2011)

PMID:21765642

Suzuki K, Matsubara H

Recent advances in p53 research and cancer treatment.

J Biomed Biotechnol 2011:978312 (2011)