KEGG   PATHWAY: mmu05217Help
Entry
mmu05217                    Pathway                                

Name
Basal cell carcinoma - Mus musculus (mouse)
Description
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC.
Class
Human Diseases; Cancers
BRITE hierarchy
Pathway map
Basal cell carcinoma
mmu05217

All organismsOrtholog table
Module
Hedgehog signaling [PATH:mmu05217]
Organism
Mus musculus (mouse) [GN:mmu]
Gene
22059  
Trp53; transformation related protein 53 [KO:K04451]
20423  
Shh; sonic hedgehog [KO:K11988]
19206  
Ptch1; patched 1 [KO:K06225]
319757  
Smo; smoothened, frizzled class receptor [KO:K06226]
269209  
Stk36; serine/threonine kinase 36 [KO:K06228] [EC:2.7.11.1]
24069  
Sufu; suppressor of fused homolog (Drosophila) [KO:K06229]
14632  
Gli1; GLI-Kruppel family member GLI1 [KO:K16797]
14633  
Gli2; GLI-Kruppel family member GLI2 [KO:K16798]
14634  
Gli3; GLI-Kruppel family member GLI3 [KO:K06230]
12156  
Bmp2; bone morphogenetic protein 2 [KO:K04662]
12159  
Bmp4; bone morphogenetic protein 4 [KO:K04662]
15245  
Hhip; Hedgehog-interacting protein [KO:K06231]
19207  
Ptch2; patched 2 [KO:K11101]
22408  
Wnt1; wingless-type MMTV integration site family, member 1 [KO:K03209]
22413  
Wnt2; wingless-type MMTV integration site family, member 2 [KO:K00182]
22414  
Wnt2b; wingless-type MMTV integration site family, member 2B [KO:K00182]
22415  
Wnt3; wingless-type MMTV integration site family, member 3 [KO:K00312]
22416  
Wnt3a; wingless-type MMTV integration site family, member 3A [KO:K00312]
22417  
Wnt4; wingless-type MMTV integration site family, member 4 [KO:K00408]
22418  
Wnt5a; wingless-type MMTV integration site family, member 5A [KO:K00444]
22419  
Wnt5b; wingless-type MMTV integration site family, member 5B [KO:K00444]
22420  
Wnt6; wingless-type MMTV integration site family, member 6 [KO:K00445]
22421  
Wnt7a; wingless-type MMTV integration site family, member 7A [KO:K00572]
22422  
Wnt7b; wingless-type MMTV integration site family, member 7B [KO:K00572]
20890  
Wnt8a; wingless-type MMTV integration site family, member 8A [KO:K00714]
22423  
Wnt8b; wingless-type MMTV integration site family, member 8B [KO:K00714]
216795  
Wnt9a; wingless-type MMTV integration site family, member 9A [KO:K01064]
22412  
Wnt9b; wingless-type MMTV integration site family, member 9B [KO:K01064]
22410  
Wnt10b; wingless-type MMTV integration site family, member 10B [KO:K01357]
22409  
Wnt10a; wingless-type MMTV integration site family, member 10A [KO:K01357]
22411  
Wnt11; wingless-type MMTV integration site family, member 11 [KO:K01384]
93735  
Wnt16; wingless-type MMTV integration site family, member 16 [KO:K01558]
14362  
Fzd1; frizzled class receptor 1 [KO:K02432]
14369  
Fzd7; frizzled class receptor 7 [KO:K02432]
57265  
Fzd2; frizzled class receptor 2 [KO:K02235]
14365  
Fzd3; frizzled class receptor 3 [KO:K02329]
14366  
Fzd4; frizzled class receptor 4 [KO:K02354]
14367  
Fzd5; frizzled class receptor 5 [KO:K02375]
14370  
Fzd8; frizzled class receptor 8 [KO:K02375]
14368  
Fzd6; frizzled class receptor 6 [KO:K02376]
93897  
Fzd10; frizzled class receptor 10 [KO:K02842]
14371  
Fzd9; frizzled class receptor 9 [KO:K02842]
13544  
Dvl3; dishevelled segment polarity protein 3 [KO:K02353]
13542  
Dvl1; dishevelled segment polarity protein 1 [KO:K02353]
13543  
Dvl2; dishevelled segment polarity protein 2 [KO:K02353]
56637  
Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
12005  
Axin1; axin 1 [KO:K02157]
12006  
Axin2; axin 2 [KO:K04385]
11789  
Apc; adenomatosis polyposis coli [KO:K02085]
23805  
Apc2; adenomatosis polyposis coli 2 [KO:K02085]
12387  
Ctnnb1; catenin (cadherin associated protein), beta 1 [KO:K02105]
21414  
Tcf7; transcription factor 7, T cell specific [KO:K02620]
21415  
Tcf7l1; transcription factor 7 like 1 (T cell specific, HMG box) [KO:K04490]
21416  
Tcf7l2; transcription factor 7 like 2, T cell specific, HMG box [KO:K04491]
16842  
Lef1; lymphoid enhancer binding factor 1 [KO:K04492]
Compound
C00187  
Cholesterol
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
J Pathol 193:427-32 (2001)
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
KO pathway
 

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