KEGG   PATHWAY: mmu05320Help
Entry
mmu05320                    Pathway                                

Name
Autoimmune thyroid disease - Mus musculus (mouse)
Description
The classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants,  Graves' disease (GD) and autoimmune atrophic thyroiditis or primary myxedema. HT is characterized by the presence of goitre, thyroid autoantibodies against thyroid peroxidase (TPO) and thyroglobulin (Tg) in serum and varying degrees of thyroid dysfunction. During HT, self-reactive CD4+ T lymphocytes (Th) recruit B cells and CD8+ T cells (CTL) into the thyroid. Disease progression leads to the death of thyroid cells and hypothyroidism. Both autoantibodies and thyroid-specific cytotoxic T lymphocytes (CTLs) have been proposed to be responsible for autoimmune thyrocyte depletion. In GD, the TSH-R is the most important autoantigen. Antibodies directed against it mimic the effects of the hormone on thyroid cells, TSH, stimulating autonomous production of thyroxine and triiodothyronine and causing hyperthyroidism. The presence of  TSH-R-blocking antibodies that bind the TSH receptor in a similar fashion to the antibodies in patients with Grave's disease but that block rather than activate the receptor explains some cases of atrophic hypothyroidism.
Class
Human Diseases; Immune diseases
BRITE hierarchy
Pathway map
Autoimmune thyroid disease
mmu05320

All organismsOrtholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
15962  
Ifna1; interferon alpha 1 [KO:K05414]
15965  
Ifna2; interferon alpha 2 [KO:K05414]
15967  
Ifna4; interferon alpha 4 [KO:K05414]
15968  
Ifna5; interferon alpha 5 [KO:K05414]
15969  
Ifna6; interferon alpha 6 [KO:K05414]
15970  
Ifna7; interferon alpha 7 [KO:K05414]
15972  
Ifna9; interferon alpha 9 [KO:K05414]
15964  
Ifna11; interferon alpha 11 [KO:K05414]
242519  
Ifna12; interferon alpha 12 [KO:K05414]
230396  
Ifna13; interferon alpha 13 [KO:K05414]
404549  
Ifna14; interferon alpha 14 [KO:K05414]
15974  
Ifnab; interferon alpha B [KO:K05414]
242517  
Ifna15; interferon alpha 15 [KO:K05414]
12477  
Ctla4; cytotoxic T-lymphocyte-associated protein 4 [KO:K06538]
22018  
Tpo; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
21819  
Tg; thyroglobulin [KO:K10809]
14960  
H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  
H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14969  
H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14998  
H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  
H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  
H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  
H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  
H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
H2-Ea-ps; histocompatibility 2, class II antigen E alpha, pseudogene [KO:K06752]
12519  
Cd80; CD80 antigen [KO:K05412]
12524  
Cd86; CD86 antigen [KO:K05413]
12487  
Cd28; CD28 antigen [KO:K06470]
16183  
Il2; interleukin 2 [KO:K05429]
14990  
H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991  
H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997  
H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
15006  
H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007  
H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013  
H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15018  
H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15019  
H2-Q8; histocompatibility 2, Q region locus 8 [KO:K06751]
15039  
H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040  
H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042  
H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043  
H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15051  
H2-T9; histocompatibility 2, T region locus 9 [KO:K06751]
224753  
H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754  
H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756  
H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761  
H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
333715  
H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
399549  
H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
15024  
H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
110557  
H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110696  
H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
14963  
H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  
H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14972  
H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14985  
H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
547349  
MHC class I family member; K06751 major histocompatibility complex, class I [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
15033  
H2-T18; histocompatibility 2, T region locus 18 [KO:K06751]
110558  
H2-Q9; histocompatibility 2, Q region locus 9 [KO:K06751]
667977  
Gm8909; predicted gene 8909 [KO:K06751]
14980  
H2-L; histocompatibility 2, D region locus L [KO:K06751]
69717  
Gm10499; predicted gene 10499 [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
15015  
H2-Q4; histocompatibility 2, Q region locus 4 [KO:K06751]
667803  
C920025E04Rik; RIKEN cDNA C920025E04 gene [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
Gm11127; predicted gene 11127 [KO:K06751]
240095  
H2-M5; histocompatibility 2, M region locus 5 [KO:K06751]
630294  
Gm7030; predicted gene 7030 [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
HLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
14103  
Fasl; Fas ligand (TNF superfamily, member 6) [KO:K04389]
14102  
Fas; Fas (TNF receptor superfamily member 6) [KO:K04390]
18646  
Prf1; perforin 1 (pore forming protein) [KO:K07818]
14939  
Gzmb; granzyme B [KO:K01353] [EC:3.4.21.79]
21947  
Cd40lg; CD40 ligand [KO:K03161]
21939  
Cd40; CD40 antigen [KO:K03160]
16189  
Il4; interleukin 4 [KO:K05430]
16191  
Il5; interleukin 5 [KO:K05428]
16153  
Il10; interleukin 10 [KO:K05443]
IgH; uncharacterized LOC102642252 [KO:K06856]
IgH; Ig heavy chain Mem5-like [KO:K06856]
22095  
Tshr; thyroid stimulating hormone receptor [KO:K04249]
12640  
Cga; glycoprotein hormones, alpha subunit [KO:K08522]
22094  
Tshb; thyroid stimulating hormone, beta subunit [KO:K05251]
Compound
C01382  
Iodine
C01829  
Thyroxine
C02465  
Triiodothyronine
D00636  
Amiodarone hydrochloride (JP17/USAN)
Reference
  Authors
Fountoulakis S, Tsatsoulis A.
  Title
On the pathogenesis of autoimmune thyroid disease: a unifying hypothesis.
  Journal
Clin Endocrinol (Oxf) 60:397-409 (2004)
Reference
  Authors
Chistiakov DA.
  Title
Immunogenetics of Hashimoto's thyroiditis.
  Journal
J Autoimmune Dis 2:1 (2005)
Reference
PMID:9534029
  Authors
McIver B, Morris JC.
  Title
The pathogenesis of Graves' disease.
  Journal
Endocrinol Metab Clin North Am 27:73-89 (1998)
Reference
  Authors
Stassi G, De Maria R.
  Title
Autoimmune thyroid disease: new models of cell death in autoimmunity.
  Journal
Nat Rev Immunol 2:195-204 (2002)
Reference
  Authors
Collins J, Gough S.
  Title
Autoimmunity in thyroid disease.
  Journal
Eur J Nucl Med Mol Imaging 29 Suppl 2:S417-24 (2002)
Reference
  Authors
Ruwhof C, Drexhage HA.
  Title
Iodine and thyroid autoimmune disease in animal models.
  Journal
Thyroid 11:427-36 (2001)
Reference
  Authors
Tsatsoulis A.
  Title
The role of stress in the clinical expression of thyroid autoimmunity.
  Journal
Ann N Y Acad Sci 1088:382-95 (2006)
Reference
  Authors
Prummel MF, Strieder T, Wiersinga WM.
  Title
The environment and autoimmune thyroid diseases.
  Journal
Eur J Endocrinol 150:605-18 (2004)
Reference
  Authors
Kopp P.
  Title
The TSH receptor and its role in thyroid disease.
  Journal
Cell Mol Life Sci 58:1301-22 (2001)
KO pathway
 

DBGET integrated database retrieval system