KEGG   PATHWAY: mmu05330Help
Entry
mmu05330                    Pathway                                

Name
Allograft rejection - Mus musculus (mouse)
Description
Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class
Human Diseases; Immune diseases
BRITE hierarchy
Pathway map
Allograft rejection
mmu05330

All organismsOrtholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
14990  
H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991  
H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997  
H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
15006  
H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007  
H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013  
H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15018  
H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15019  
H2-Q8; histocompatibility 2, Q region locus 8 [KO:K06751]
15039  
H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040  
H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042  
H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043  
H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15051  
H2-T9; histocompatibility 2, T region locus 9 [KO:K06751]
224753  
H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754  
H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756  
H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761  
H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
333715  
H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
399549  
H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
15024  
H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
110557  
H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110696  
H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
14963  
H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  
H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14972  
H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14985  
H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
547349  
MHC class I family member; K06751 major histocompatibility complex, class I [KO:K06751]
15033  
H2-T18; histocompatibility 2, T region locus 18 [KO:K06751]
110558  
H2-Q9; histocompatibility 2, Q region locus 9 [KO:K06751]
667977  
Gm8909; predicted gene 8909 [KO:K06751]
14980  
H2-L; histocompatibility 2, D region locus L [KO:K06751]
69717  
Gm10499; predicted gene 10499 [KO:K06751]
15015  
H2-Q4; histocompatibility 2, Q region locus 4 [KO:K06751]
667803  
H2-T-ps; histocompatibility 2, T region locus, pseudogene [KO:K06751]
Gm11127; predicted gene 11127 [KO:K06751]
240095  
H2-M5; histocompatibility 2, M region locus 5 [KO:K06751]
630294  
Gm7030; predicted gene 7030 [KO:K06751]
12519  
Cd80; CD80 antigen [KO:K05412]
12524  
Cd86; CD86 antigen [KO:K05413]
12487  
Cd28; CD28 antigen [KO:K06470]
16159  
Il12a; interleukin 12a [KO:K05406]
16160  
Il12b; interleukin 12b [KO:K05425]
14103  
Fasl; Fas ligand (TNF superfamily, member 6) [KO:K04389]
14102  
Fas; Fas (TNF receptor superfamily member 6) [KO:K04390]
18646  
Prf1; perforin 1 (pore forming protein) [KO:K07818]
14939  
Gzmb; granzyme B [KO:K01353] [EC:3.4.21.79]
14960  
H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  
H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14969  
H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14998  
H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  
H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  
H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  
H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  
H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
H2-Ea-ps; histocompatibility 2, class II antigen E alpha, pseudogene [KO:K06752]
16183  
Il2; interleukin 2 [KO:K05429]
21947  
Cd40lg; CD40 ligand [KO:K03161]
21939  
Cd40; CD40 antigen [KO:K03160]
15978  
Ifng; interferon gamma [KO:K04687]
21926  
Tnf; tumor necrosis factor [KO:K03156]
16189  
Il4; interleukin 4 [KO:K05430]
16191  
Il5; interleukin 5 [KO:K05428]
16153  
Il10; interleukin 10 [KO:K05443]
Compound
C00533  
Nitric oxide
Reference
  Authors
Arakelov A, Lakkis FG.
  Title
The alloimmune response and effector mechanisms of allograft rejection.
  Journal
Semin Nephrol 20:95-102 (2000)
Reference
  Authors
Le Moine A, Goldman M, Abramowicz D.
  Title
Multiple pathways to allograft rejection.
  Journal
Transplantation 73:1373-81 (2002)
Reference
  Authors
Trivedi HL.
  Title
Immunobiology of rejection and adaptation.
  Journal
Transplant Proc 39:647-52 (2007)
Reference
  Authors
Pietra BA.
  Title
Transplantation immunology 2003: simplified approach.
  Journal
Pediatr Clin North Am 50:1233-59 (2003)
Reference
PMID:8835634
  Authors
Oka T, Yoshimura N.
  Title
Immunosuppression in organ transplantation.
  Journal
Jpn J Pharmacol 71:89-100 (1996)
Reference
  Authors
Sayegh MH.
  Title
Why do we reject a graft? Role of indirect allorecognition in graft rejection.
  Journal
Kidney Int 56:1967-79 (1999)
Reference
  Authors
Benichou G.
  Title
Direct and indirect antigen recognition: the pathways to allograft immune rejection.
  Journal
Front Biosci 4:D476-80 (1999)
Reference
  Authors
Turvey SE, Wood KJ.
  Title
Immunobiology of solid organ transplantation.
  Journal
Int Surg 84:279-90 (1999)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Game DS, Lechler RI.
  Title
Pathways of allorecognition: implications for transplantation tolerance.
  Journal
Transpl Immunol 10:101-8 (2002)
Reference
  Authors
Lechler RI, Garden OA, Turka LA.
  Title
The complementary roles of deletion and regulation in transplantation tolerance.
  Journal
Nat Rev Immunol 3:147-58 (2003)
KO pathway
 

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