KEGG   PATHWAY: mmu05332Help
Entry
mmu05332                    Pathway                                

Name
Graft-versus-host disease - Mus musculus (mouse)
Description
Graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells. GVHD pathophysiology can be summerized in a three-step process. Step 1 involves the development of an inflammatory milieu resulting from damage in the host tissues induced by the preparative chemotherapy or radiotherapy regimen. Damaged tissues secrete inflammatory cytokines, including interleukin 1 (IL-1), and tumor necrosis factor (TNF-alpha ). During step 2, antigen-presenting cells (APCs) trigger the activation of donor-derived T cells, which induce further T-cell expansion, induce cytotoxic T lymphocytes (CTL) and natural killer (NK) cells responses and prime additional mononuclear phagocytes to produce TNF-alpha and IL-1. Also, nitric oxide (NO) is produced by activated macrophages, and it may contribute to the tissue damage seen during step 3. During step 3, the effector phase, activated CTL and NK cells mediate cytotoxicity against target host cells through Fas-Fas ligand interactions and perforin-granzyme B.
Class
Human Diseases; Immune diseases
BRITE hierarchy
Pathway map
Graft-versus-host disease
mmu05332

All organismsOrtholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
16193  
Il6; interleukin 6 [KO:K05405]
16175  
Il1a; interleukin 1 alpha [KO:K04383]
16176  
Il1b; interleukin 1 beta [KO:K04519]
21926  
Tnf; tumor necrosis factor [KO:K03156]
14960  
H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  
H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14969  
H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14998  
H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  
H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  
H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  
H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  
H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
H2-Ea-ps; histocompatibility 2, class II antigen E alpha, pseudogene [KO:K06752]
12519  
Cd80; CD80 antigen [KO:K05412]
12524  
Cd86; CD86 antigen [KO:K05413]
12487  
Cd28; CD28 antigen [KO:K06470]
16183  
Il2; interleukin 2 [KO:K05429]
14990  
H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991  
H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997  
H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
15006  
H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007  
H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013  
H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15018  
H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15019  
H2-Q8; histocompatibility 2, Q region locus 8 [KO:K06751]
15039  
H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040  
H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042  
H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043  
H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15051  
H2-T9; histocompatibility 2, T region locus 9 [KO:K06751]
224753  
H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754  
H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756  
H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761  
H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
333715  
H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
399549  
H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
15024  
H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
110557  
H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110696  
H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
14963  
H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  
H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14972  
H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14985  
H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
547349  
MHC class I family member; K06751 major histocompatibility complex, class I [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
15033  
H2-T18; histocompatibility 2, T region locus 18 [KO:K06751]
110558  
H2-Q9; histocompatibility 2, Q region locus 9 [KO:K06751]
667977  
Gm8909; predicted gene 8909 [KO:K06751]
14980  
H2-L; histocompatibility 2, D region locus L [KO:K06751]
69717  
Gm10499; predicted gene 10499 [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
15015  
H2-Q4; histocompatibility 2, Q region locus 4 [KO:K06751]
667803  
C920025E04Rik; RIKEN cDNA C920025E04 gene [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
Gm11127; predicted gene 11127 [KO:K06751]
240095  
H2-M5; histocompatibility 2, M region locus 5 [KO:K06751]
630294  
Gm7030; predicted gene 7030 [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
HLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
14103  
Fasl; Fas ligand (TNF superfamily, member 6) [KO:K04389]
14102  
Fas; Fas (TNF receptor superfamily member 6) [KO:K04390]
18646  
Prf1; perforin 1 (pore forming protein) [KO:K07818]
14939  
Gzmb; granzyme B [KO:K01353] [EC:3.4.21.79]
15978  
Ifng; interferon gamma [KO:K04687]
16643  
Klrd1; killer cell lectin-like receptor, subfamily D, member 1 [KO:K06516]
16627  
Klra1; killer cell lectin-like receptor, subfamily A, member 1
16634  
Klra3; killer cell lectin-like receptor, subfamily A, member 3
16638  
Klra7; killer cell lectin-like receptor, subfamily A, member 7
16640  
Klra9; killer cell lectin-like receptor subfamily A, member 9
16641  
Klrc1; killer cell lectin-like receptor subfamily C, member 1 [KO:K06541]
Compound
C00338  
Lipopolysaccharide
C00533  
Nitric oxide
Reference
  Authors
Ferrara JL, Reddy P.
  Title
Pathophysiology of graft-versus-host disease.
  Journal
Semin Hematol 43:3-10 (2006)
Reference
  Authors
Reddy P.
  Title
Pathophysiology of acute graft-versus-host disease.
  Journal
Hematol Oncol 21:149-61 (2003)
Reference
  Authors
Sun Y, Tawara I, Toubai T, Reddy P.
  Title
Pathophysiology of acute graft-versus-host disease: recent advances.
  Journal
Transl Res 150:197-214 (2007)
Reference
  Authors
Jaksch M, Mattsson J.
  Title
The pathophysiology of acute graft-versus-host disease.
  Journal
Scand J Immunol 61:398-409 (2005)
Reference
  Authors
Vogelsang GB, Lee L, Bensen-Kennedy DM.
  Title
Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant.
  Journal
Annu Rev Med 54:29-52 (2003)
Reference
  Authors
Reddy P, Ferrara JL.
  Title
Immunobiology of acute graft-versus-host disease.
  Journal
Blood Rev 17:187-94 (2003)
Reference
  Authors
Blazar BR, Murphy WJ.
  Title
Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD).
  Journal
Philos Trans R Soc Lond B Biol Sci 360:1747-67 (2005)
Reference
  Authors
Couriel D, Caldera H, Champlin R, Komanduri K.
  Title
Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management.
  Journal
Cancer 101:1936-46 (2004)
Reference
  Authors
Jacobsohn DA, Vogelsang GB.
  Title
Acute graft versus host disease.
  Journal
Orphanet J Rare Dis 2:35 (2007)
KO pathway
 

DBGET integrated database retrieval system