KEGG   PATHWAY: mpu03440Help
Entry
mpu03440                    Pathway                                

Name
Homologous recombination - Mycoplasma pulmonis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
mpu03440  Homologous recombination
mpu03440

Ortholog table
Module
mpu_M00260  DNA polymerase III complex, bacteria [PATH:mpu03440]
Other DBs
BSID: 5511
GO: 0000724
Organism
Mycoplasma pulmonis [GN:mpu]
Gene
MYPU_6100  MYPU_6100; SINGLE-STRAND BINDING PROTEIN (SSB) (HELIX-DESTABILIZING PROTEIN) [KO:K03111]
MYPU_1590  MYPU_1590; unknown; predicted coding region [KO:K03584]
MYPU_0510  MYPU_0510; RECOMBINATION PROTEIN RECR [KO:K06187]
MYPU_2520  MYPU_2520; RECOMBINATION PROTEIN RECA [KO:K03553]
MYPU_7200  MYPU_7200; DNA POLYMERASE I (POL I) [KO:K02335] [EC:2.7.7.7]
MYPU_6570  MYPU_6570; HOLLIDAY JUNCTION DNA HELICASE RUVA [KO:K03550] [EC:3.6.4.12]
MYPU_6580  MYPU_6580; HOLLIDAY JUNCTION DNA HELICASE RUVB [KO:K03551] [EC:3.6.4.12]
MYPU_7820  MYPU_7820; EXODEOXYRIBONUCLEASE V ALPHA CHAIN [KO:K03581] [EC:3.1.11.5]
MYPU_7190  MYPU_7190; DNA POLYMERASE III, ALPHA CHAIN [KO:K02337] [EC:2.7.7.7]
MYPU_6750  MYPU_6750; DNA POLYMERASE III, ALPHA CHAIN POLC-TYPE (POLIII) [KO:K03763] [EC:2.7.7.7]
MYPU_0020  MYPU_0020; DNA POLYMERASE III, BETA CHAIN [KO:K02338] [EC:2.7.7.7]
MYPU_0490  MYPU_0490; DNA POLYMERASE III SUBUNIT GAMMA AND TAU [KO:K02343] [EC:2.7.7.7]
MYPU_4620  MYPU_4620; conserved hypothetical protein [KO:K02340] [EC:2.7.7.7]
MYPU_0530  MYPU_0530; DNA POLYMERASE III SUBUNITS GAMMA AND TAU [KO:K02341] [EC:2.7.7.7]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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