KEGG   PATHWAY: mtc03440Help
Entry
mtc03440                    Pathway                                

Name
Homologous recombination - Mycobacterium tuberculosis CDC1551
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
mtc03440

All organismsOrtholog table
Module
DNA polymerase III complex, bacteria [PATH:mtc03440]
Other DBs
BSID: 
GO: 
Organism
Mycobacterium tuberculosis CDC1551 [GN:mtc]
Gene
MT0060  
ssb; single-stranded DNA-binding protein [KO:K03111]
MT2553  
hypothetical protein; K03111 single-strand DNA-binding protein [KO:K03111]
MT0003  
recF; recombination protein F [KO:K03629]
MT2431  
recO; DNA repair protein RecO [KO:K03584]
MT3818  
recR; recombination protein RecR [KO:K06187]
MT2806  
recA; DNA recombination protein RecA [KO:K03553]
MT1665  
polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
MT2670  
ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
MT2669  
ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
MT2671  
ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
MT3051  
recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
MT0658  
recB; exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
MT0659  
recC; exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
MT0657  
recD; exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
MT1598  
dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
MT0002  
dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
MT3824  
dnaZX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
MT2486  
hypothetical protein; K02340 DNA polymerase III subunit delta [EC:2.7.7.7] [KO:K02340] [EC:2.7.7.7]
MT3747  
holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
MT2247  
hypothetical protein; K02342 DNA polymerase III subunit epsilon [EC:2.7.7.7] [KO:K02342] [EC:2.7.7.7]
MT3814  
dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
MT1446  
primosome assembly protein PriA; K04066 primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:3.6.4.-] [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

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