KEGG   PATHWAY: mtu03440
Entry
mtu03440                    Pathway                                
Name
Homologous recombination - Mycobacterium tuberculosis H37Rv
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
mtu03440  Homologous recombination
mtu03440

Other DBs
GO: 0000724
Organism
Mycobacterium tuberculosis H37Rv [GN:mtu]
Gene
Rv0054  ssb; single-strand DNA-binding protein [KO:K03111]
Rv2478c  hypothetical protein [KO:K03111]
Rv0003  recF; DNA replication/repair protein RecF [KO:K03629]
Rv2362c  recO; DNA repair protein RecO [KO:K03584]
Rv3715c  recR; recombination protein RecR [KO:K06187]
Rv2737c  recA; recombinase A [KO:K03553]
Rv1629  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Rv2593c  ruvA; Holliday junction ATP-dependent DNA helicase RuvA [KO:K03550]
Rv2592c  ruvB; Holliday junction ATP-dependent DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Rv2594c  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Rv2973c  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Rv0630c  recB; exonuclease V subunit beta RecB [KO:K03582] [EC:3.1.11.5]
Rv0631c  recC; exonuclease V subunit gamma RecC [KO:K03583] [EC:3.1.11.5]
Rv0629c  recD; exonuclease V subunit alpha RecD [KO:K03581] [EC:3.1.11.5]
Rv1547  dnaE1; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
Rv0002  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
Rv3721c  dnaZX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
Rv2413c  hypothetical protein [KO:K02340] [EC:2.7.7.7]
Rv3644c  DNA polymerase [KO:K02341] [EC:2.7.7.7]
Rv3711c  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
Rv2191  hypothetical protein [KO:K02342] [EC:2.7.7.7]
Rv1402  priA; primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG GENES (22)   
All databases (23)   

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