KEGG PATHWAY: ncr03015

PATHWAY: ncr03015

Entry

ncr03015 Pathway

Name

mRNA surveillance pathway - Neurospora crassa

Description

The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.

Class

Genetic Information Processing; Translation

Pathway map

ncr03015

mRNA surveillance pathway

Module

ncr_M00399	Cap binding complex [PATH:ncr03015]
ncr_M00430	Exon junction complex (EJC) [PATH:ncr03015]

Other DBs

BSID:

193338

GO:

0071028

Organism

Neurospora crassa [GN:ncr]

Gene

NCU04187	similar to snRNA cap binding complex subunit; K12882 nuclear cap-binding protein subunit 1 [KO:K12882]
NCU00210	nuclear cap binding protein subunit 2; K12883 nuclear cap-binding protein subunit 2 [KO:K12883]
NCU03435	hypothetical protein; K14328 regulator of nonsense transcripts 3 [KO:K14328]
NCU03226	hypothetical protein; K12876 RNA-binding protein 8A [KO:K12876]
NCU04405	mago nashi protein; K12877 protein mago nashi [KO:K12877]
NCU01234	eukaryotic initiation factor 4A-12; K13025 ATP-dependent RNA helicase [EC:3.6.4.13] [KO:K13025] [EC:3.6.4.13]
NCU00159	hypothetical protein; K14324 histone deacetylase complex subunit SAP18 [KO:K14324]
NCU09901	hypothetical protein; K14325 RNA-binding protein with serine-rich domain 1 [KO:K14325]
NCU07421	hypothetical protein; K12881 THO complex subunit 4 [KO:K12881]
NCU01793	hypothetical protein; K12881 THO complex subunit 4 [KO:K12881]
NCU09317	hypothetical protein; K14284 nuclear RNA export factor 1/2 [KO:K14284]
NCU03631	hypothetical protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
NCU09076	ATP-dependent RNA helicase; K12812 ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13] [KO:K12812] [EC:3.6.4.13]
NCU03232	hypothetical protein; K14294 partner of Y14 and mago [KO:K14294]
NCU03971	similar to mRNA cap methyltransferase; K00565 mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56] [KO:K00565] [EC:2.1.1.56]
NCU03946	polyadenylate-binding protein 2; K14396 polyadenylate-binding protein 2 [KO:K14396]
NCU09014	similar to cleavage and polyadenylation specific factor 5; K14397 cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
NCU08983	Poly(A) polymerase; K14376 poly(A) polymerase [EC:2.7.7.19] [KO:K14376] [EC:2.7.7.19]
NCU06314	hypothetical protein; K14399 polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78] [KO:K14399] [EC:2.7.1.78]
NCU02082	hypothetical protein; K14401 cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
NCU06869	hypothetical protein; K14402 cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
NCU03479	similar to cleavage and polyadenylation specifity factor; K14403 cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] [KO:K14403] [EC:3.1.27.-]
NCU08353	similar to mRNA cleavage and polyadenylation specificity factor complex subunit; K14404 cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
NCU07654	hypothetical protein; K14405 pre-mRNA 3'-end-processing factor FIP1 [KO:K14405]
NCU06718	hypothetical protein; K15541 protein MPE1 [KO:K15541]
NCU00037	protein PFS2; K15542 polyadenylation factor subunit 2 [KO:K15542]
NCU07885	similar to WD repeat protein; K14962 COMPASS component SWD2 [KO:K14962]
NCU00043	PP1 Serine/threonine protein phosphatase; K06269 protein phosphatase 1, catalytic subunit [EC:3.1.3.16] [KO:K06269] [EC:3.1.3.16]
NCU03114	protein SSU72; K15544 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16] [KO:K15544] [EC:3.1.3.16]
NCU03311	hypothetical protein; K14407 cleavage stimulation factor subunit 2 [KO:K14407]
NCU09435	hypothetical protein; K14408 cleavage stimulation factor subunit 3 [KO:K14408]
NCU11329	hypothetical protein; K06100 symplekin [KO:K06100]
NCU04239	hypothetical protein; K14411 RNA-binding protein Musashi [KO:K14411]
NCU04799	polyadenylate-binding protein; K13126 polyadenylate-binding protein [KO:K13126]
NCU00410	eukaryotic peptide chain release factor subunit 1; K03265 peptide chain release factor subunit 1 [KO:K03265]
NCU04790	eukaryotic peptide chain release factor GTP-binding subunit; K03267 peptide chain release factor subunit 3 [KO:K03267]
NCU04242	ATP-dependent helicase NAM7; K14326 regulator of nonsense transcripts 1 [EC:3.6.4.-] [KO:K14326] [EC:3.6.4.-]
NCU05267	similar to nonsense-mediated mRNA decay factor; K14327 regulator of nonsense transcripts 2 [KO:K14327]
NCU06630	serine/threonine-protein phosphatase PP2A catalytic subunit; K04382 protein phosphatase 2 (formerly 2A), catalytic subunit [EC:3.1.3.16] [KO:K04382] [EC:3.1.3.16]
NCU00488	protein phosphatase PP2A regulatory subunit A; K03456 protein phosphatase 2 (formerly 2A), regulatory subunit A [KO:K03456]
NCU09377	protein phosphatase PP2A regulatory subunit B; K04354 protein phosphatase 2 (formerly 2A), regulatory subunit B [KO:K04354]
NCU03786	serine/threonine protein phosphatase 2A; K11584 protein phosphatase 2 (formerly 2A), regulatory subunit B' [KO:K11584]
NCU03981	similar to translation elongation factor EF-1 subunit; K14416 elongation factor 1 alpha-like protein [KO:K14416]
NCU09161	similar to translation factor pelota; K06965 protein pelota [KO:K06965]

Reference

PMID:15040442

Authors

Maquat LE

Title

Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.

Journal

Nat Rev Mol Cell Biol 5:89-99 (2004)

Reference

PMID:16723977

Authors

Amrani N, Sachs MS, Jacobson A

Title

Early nonsense: mRNA decay solves a translational problem.

Journal

Nat Rev Mol Cell Biol 7:415-25 (2006)

Reference

PMID:17183357

Authors

Eulalio A, Behm-Ansmant I, Izaurralde E

Title

P bodies: at the crossroads of post-transcriptional pathways.

Journal

Nat Rev Mol Cell Biol 8:9-22 (2007)

Reference

PMID:18158581

Authors

Mandel CR, Bai Y, Tong L

Title

Protein factors in pre-mRNA 3'-end processing.

Journal

Cell Mol Life Sci 65:1099-122 (2008)

Reference

PMID:16715045

Authors

Clement SL, Lykke-Andersen J

Title

No mercy for messages that mess with the ribosome.

Journal

Nat Struct Mol Biol 13:299-301 (2006)

KO pathway

ko03015

All links

Pathway (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG GENES (44)   
All databases (47)   

Download RDF

DBGET integrated database retrieval system