KEGG   PATHWAY: ncr03015Help
Entry
ncr03015                    Pathway                                

Name
mRNA surveillance pathway - Neurospora crassa
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These  pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
mRNA surveillance pathway
ncr03015

All organismsOrtholog table
Module
Cap binding complex [PATH:ncr03015]
Other DBs
BSID: 
GO: 
Organism
Neurospora crassa [GN:ncr]
Gene
similar to snRNA cap binding complex subunit; K12882 nuclear cap-binding protein subunit 1 [KO:K12882]
nuclear cap binding protein subunit 2; K12883 nuclear cap-binding protein subunit 2 [KO:K12883]
hypothetical protein; K14328 regulator of nonsense transcripts 3 [KO:K14328]
hypothetical protein; K12876 RNA-binding protein 8A [KO:K12876]
mago nashi protein; K12877 protein mago nashi [KO:K12877]
eukaryotic initiation factor 4A-12; K13025 ATP-dependent RNA helicase [EC:3.6.4.13] [KO:K13025] [EC:3.6.4.13]
hypothetical protein; K14324 histone deacetylase complex subunit SAP18 [KO:K14324]
hypothetical protein; K14325 RNA-binding protein with serine-rich domain 1 [KO:K14325]
hypothetical protein; K12881 THO complex subunit 4 [KO:K12881]
hypothetical protein; K12881 THO complex subunit 4 [KO:K12881]
hypothetical protein; K14284 nuclear RNA export factor 1/2 [KO:K14284]
hypothetical protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
ATP-dependent RNA helicase; K12812 ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13] [KO:K12812] [EC:3.6.4.13]
hypothetical protein; K14294 partner of Y14 and mago [KO:K14294]
hypothetical protein; K13171 serine/arginine repetitive matrix protein 1 [KO:K13171]
similar to mRNA cap methyltransferase; K00565 mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56] [KO:K00565] [EC:2.1.1.56]
polyadenylate-binding protein 2; K14396 polyadenylate-binding protein 2 [KO:K14396]
similar to cleavage and polyadenylation specific factor 5; K14397 cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
Poly(A) polymerase; K14376 poly(A) polymerase [EC:2.7.7.19] [KO:K14376] [EC:2.7.7.19]
hypothetical protein; K14399 polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78] [KO:K14399] [EC:2.7.1.78]
hypothetical protein; K14400 pre-mRNA cleavage complex 2 protein Pcf11 [KO:K14400]
hypothetical protein; K14401 cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
hypothetical protein; K14402 cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
similar to cleavage and polyadenylation specifity factor; K14403 cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] [KO:K14403] [EC:3.1.27.-]
similar to mRNA cleavage and polyadenylation specificity factor complex subunit; K14404 cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
hypothetical protein; K14405 pre-mRNA 3'-end-processing factor FIP1 [KO:K14405]
hypothetical protein; K15541 protein MPE1 [KO:K15541]
protein PFS2; K15542 polyadenylation factor subunit 2 [KO:K15542]
similar to WD repeat protein; K14962 COMPASS component SWD2 [KO:K14962]
PP1 Serine/threonine protein phosphatase; K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] [KO:K06269] [EC:3.1.3.16]
serine/threonine-protein phosphatase PP-Z; K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] [KO:K06269] [EC:3.1.3.16]
protein SSU72; K15544 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16] [KO:K15544] [EC:3.1.3.16]
hypothetical protein; K14407 cleavage stimulation factor subunit 2 [KO:K14407]
hypothetical protein; K14408 cleavage stimulation factor subunit 3 [KO:K14408]
hypothetical protein; K06100 symplekin [KO:K06100]
hypothetical protein; K14411 RNA-binding protein Musashi [KO:K14411]
polyadenylate-binding protein; K13126 polyadenylate-binding protein [KO:K13126]
eukaryotic peptide chain release factor subunit 1; K03265 peptide chain release factor subunit 1 [KO:K03265]
eukaryotic peptide chain release factor GTP-binding subunit; K03267 peptide chain release factor subunit 3 [KO:K03267]
ATP-dependent helicase NAM7; K14326 regulator of nonsense transcripts 1 [EC:3.6.4.-] [KO:K14326] [EC:3.6.4.-]
similar to nonsense-mediated mRNA decay factor; K14327 regulator of nonsense transcripts 2 [KO:K14327]
serine/threonine-protein phosphatase PP2A catalytic subunit; K04382 serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16] [KO:K04382] [EC:3.1.3.16]
protein phosphatase PP2A regulatory subunit A; K03456 serine/threonine-protein phosphatase 2A regulatory subunit A [KO:K03456]
protein phosphatase PP2A regulatory subunit B; K04354 serine/threonine-protein phosphatase 2A regulatory subunit B [KO:K04354]
serine/threonine protein phosphatase 2A; K11584 serine/threonine-protein phosphatase 2A regulatory subunit B' [KO:K11584]
similar to translation elongation factor EF-1 subunit; K14416 elongation factor 1 alpha-like protein [KO:K14416]
similar to translation factor pelota; K06965 protein pelota [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
KO pathway
 

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