KEGG   PATHWAY: ncr03015Help
Entry
ncr03015                    Pathway                                

Name
mRNA surveillance pathway - Neurospora crassa
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These  pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
ncr03015  mRNA surveillance pathway
ncr03015

Ortholog table
Module
ncr_M00399  Cap binding complex [PATH:ncr03015]
Other DBs
BSID: 193338
GO: 0071028
Organism
Neurospora crassa [GN:ncr]
Gene
NCU04187  cap binding protein [KO:K12882]
NCU00210  nuclear cap binding protein subunit 2 [KO:K12883]
NCU03435  hypothetical protein [KO:K14328]
NCU03226  Y14 protein [KO:K12876]
NCU04405  mago nashi protein [KO:K12877]
NCU01234  eukaryotic initiation factor 4A-12 [KO:K13025] [EC:3.6.4.13]
NCU00159  Sin3-associated polypeptide Sap18 [KO:K14324]
NCU09901  hypothetical protein [KO:K14325]
NCU07421  hypothetical protein [KO:K12881]
NCU01793  RNA binding domain-containing protein [KO:K12881]
NCU09317  hypothetical protein [KO:K14284]
NCU03631  hypothetical protein [KO:K14285]
NCU09076  ATP-dependent RNA helicase [KO:K12812] [EC:3.6.4.13]
NCU03232  RNA binding protein Pym [KO:K14294]
NCU03285  hypothetical protein [KO:K13171]
NCU03971  mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
NCU03946  polyadenylate-binding protein 2 [KO:K14396]
NCU09014  cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
NCU08983  un-17; unknown-17 [KO:K14376] [EC:2.7.7.19]
NCU06314  hypothetical protein [KO:K14399] [EC:2.7.1.78]
NCU01696  mRNA cleavage factor complex component Pcf11 [KO:K14400]
NCU02082  cft-1 [KO:K14401]
NCU06869  cleavage and polyadenylylation specificity factor [KO:K14402]
NCU03479  endoribonuclease ysh-1 [KO:K14403] [EC:3.1.27.-]
NCU08353  mRNA 3'-end-processing protein yth-1 [KO:K14404]
NCU07654  pre-mRNA polyadenylation factor fip-1 [KO:K14405]
NCU06718  zinc knuckle domain-containing protein [KO:K15541]
NCU00037  polyadenylation factor subunit 2 [KO:K15542]
NCU07885  WD repeat containing protein 82 [KO:K14962]
NCU00043  pph-3; protein phosphatase-3 [KO:K06269] [EC:3.1.3.16]
NCU07489  pzl-1; phosphatase-Z-like-1 [KO:K06269] [EC:3.1.3.16]
NCU03114  SSU72 [KO:K15544] [EC:3.1.3.16]
NCU03311  polyadenylation factor subunit CstF64 [KO:K14407]
NCU09435  mRNA 3'-end-processing protein RNA-14 [KO:K14408]
NCU09128  hypothetical protein [KO:K06100]
NCU17030  heterogeneous nuclear ribonucleoprotein HRP1 [KO:K14411]
NCU04799  polyadenylate-binding protein [KO:K13126]
NCU00410  eukaryotic release factor 1 [KO:K03265]
NCU04790  eukaryotic peptide chain release factor GTP-binding subunit [KO:K03267]
NCU04242  prd-6; period-6 [KO:K14326] [EC:3.6.4.-]
NCU05267  nonsense-mediated mRNA decay factor [KO:K14327]
NCU06630  pph-1; protein phosphatase-1 [KO:K04382] [EC:3.1.3.16]
NCU00488  protein phosphatase PP2A regulatory subunit A [KO:K03456]
NCU09377  rgb-1; B-regulatory subunit-1 [KO:K04354]
NCU03786  serine/threonine protein phosphatase 2A [KO:K11584]
NCU03981  elongation factor Tu GTP binding domain-containing protein [KO:K14416]
NCU09161  translation factor pelota [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
KO pathway
ko03015   

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