KEGG   PATHWAY: ncr03015Help
Entry
ncr03015                    Pathway                                

Name
mRNA surveillance pathway - Neurospora crassa
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These  pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
mRNA surveillance pathway
ncr03015

All organismsOrtholog table
Module
Cap binding complex [PATH:ncr03015]
Other DBs
BSID: 
GO: 
Organism
Neurospora crassa [GN:ncr]
Gene
cap binding protein [KO:K12882]
nuclear cap binding protein subunit 2 [KO:K12883]
hypothetical protein [KO:K14328]
Y14 protein [KO:K12876]
mago nashi protein [KO:K12877]
eukaryotic initiation factor 4A-12 [KO:K13025] [EC:3.6.4.13]
Sin3-associated polypeptide Sap18 [KO:K14324]
hypothetical protein [KO:K14325]
hypothetical protein [KO:K12881]
RNA binding domain-containing protein [KO:K12881]
hypothetical protein [KO:K14284]
hypothetical protein [KO:K14285]
ATP-dependent RNA helicase [KO:K12812] [EC:3.6.4.13]
RNA binding protein Pym [KO:K14294]
hypothetical protein [KO:K13171]
mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
polyadenylate-binding protein 2 [KO:K14396]
cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
un-17; unknown-17 [KO:K14376] [EC:2.7.7.19]
hypothetical protein [KO:K14399] [EC:2.7.1.78]
mRNA cleavage factor complex component Pcf11 [KO:K14400]
cft-1 [KO:K14401]
cleavage and polyadenylylation specificity factor [KO:K14402]
endoribonuclease ysh-1 [KO:K14403] [EC:3.1.27.-]
mRNA 3'-end-processing protein yth-1 [KO:K14404]
pre-mRNA polyadenylation factor fip-1 [KO:K14405]
zinc knuckle domain-containing protein [KO:K15541]
polyadenylation factor subunit 2 [KO:K15542]
WD repeat containing protein 82 [KO:K14962]
pph-3; protein phosphatase-3 [KO:K06269] [EC:3.1.3.16]
pzl-1; phosphatase-Z-like-1 [KO:K06269] [EC:3.1.3.16]
SSU72 [KO:K15544] [EC:3.1.3.16]
polyadenylation factor subunit CstF64 [KO:K14407]
mRNA 3'-end-processing protein RNA-14 [KO:K14408]
hypothetical protein [KO:K06100]
heterogeneous nuclear ribonucleoprotein HRP1 [KO:K14411]
polyadenylate-binding protein [KO:K13126]
eukaryotic release factor 1 [KO:K03265]
eukaryotic peptide chain release factor GTP-binding subunit [KO:K03267]
prd-6; period-6 [KO:K14326] [EC:3.6.4.-]
nonsense-mediated mRNA decay factor [KO:K14327]
pph-1; protein phosphatase-1 [KO:K04382] [EC:3.1.3.16]
protein phosphatase PP2A regulatory subunit A [KO:K03456]
rgb-1; B-regulatory subunit-1 [KO:K04354]
serine/threonine protein phosphatase 2A [KO:K11584]
elongation factor Tu GTP binding domain-containing protein [KO:K14416]
translation factor pelota [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
KO pathway
 

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