KEGG   PATHWAY: ncr03015Help
ncr03015                    Pathway                                

mRNA surveillance pathway - Neurospora crassa
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These  pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Genetic Information Processing; Translation
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mRNA surveillance pathway

All organismsOrtholog table
Cap binding complex [PATH:ncr03015]
Other DBs
Neurospora crassa [GN:ncr]
cap binding protein; K12882 nuclear cap-binding protein subunit 1 [KO:K12882]
nuclear cap binding protein subunit 2; K12883 nuclear cap-binding protein subunit 2 [KO:K12883]
hypothetical protein; K14328 regulator of nonsense transcripts 3 [KO:K14328]
Y14 protein; K12876 RNA-binding protein 8A [KO:K12876]
mago nashi protein; K12877 protein mago nashi [KO:K12877]
eukaryotic initiation factor 4A-12; K13025 ATP-dependent RNA helicase [EC:] [KO:K13025] [EC:]
Sin3-associated polypeptide Sap18; K14324 histone deacetylase complex subunit SAP18 [KO:K14324]
hypothetical protein; K14325 RNA-binding protein with serine-rich domain 1 [KO:K14325]
hypothetical protein; K12881 THO complex subunit 4 [KO:K12881]
RNA binding domain-containing protein; K12881 THO complex subunit 4 [KO:K12881]
hypothetical protein; K14284 nuclear RNA export factor [KO:K14284]
hypothetical protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
ATP-dependent RNA helicase; K12812 ATP-dependent RNA helicase UAP56/SUB2 [EC:] [KO:K12812] [EC:]
RNA binding protein Pym; K14294 partner of Y14 and mago [KO:K14294]
hypothetical protein; K13171 serine/arginine repetitive matrix protein 1 [KO:K13171]
mRNA cap guanine-N7 methyltransferase; K00565 mRNA (guanine-N7-)-methyltransferase [EC:] [KO:K00565] [EC:]
polyadenylate-binding protein 2; K14396 polyadenylate-binding protein 2 [KO:K14396]
cleavage and polyadenylation specificity factor subunit 5; K14397 cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
un-17; unknown-17 [KO:K14376] [EC:]
hypothetical protein; K14399 polyribonucleotide 5'-hydroxyl-kinase [EC:] [KO:K14399] [EC:]
mRNA cleavage factor complex component Pcf11; K14400 pre-mRNA cleavage complex 2 protein Pcf11 [KO:K14400]
cft-1; K14401 cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
cleavage and polyadenylylation specificity factor; K14402 cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
endoribonuclease ysh-1; K14403 cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] [KO:K14403] [EC:3.1.27.-]
mRNA 3'-end-processing protein yth-1; K14404 cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
pre-mRNA polyadenylation factor fip-1; K14405 pre-mRNA 3'-end-processing factor FIP1 [KO:K14405]
zinc knuckle domain-containing protein; K15541 protein MPE1 [KO:K15541]
polyadenylation factor subunit 2; K15542 polyadenylation factor subunit 2 [KO:K15542]
WD repeat containing protein 82; K14962 COMPASS component SWD2 [KO:K14962]
pph-3; protein phosphatase-3 [KO:K06269] [EC:]
pzl-1; phosphatase-Z-like-1 [KO:K06269] [EC:]
SSU72; K15544 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:] [KO:K15544] [EC:]
polyadenylation factor subunit CstF64; K14407 cleavage stimulation factor subunit 2 [KO:K14407]
mRNA 3'-end-processing protein RNA-14; K14408 cleavage stimulation factor subunit 3 [KO:K14408]
polyadenylate-binding protein; K13126 polyadenylate-binding protein [KO:K13126]
eukaryotic release factor 1; K03265 peptide chain release factor subunit 1 [KO:K03265]
eukaryotic peptide chain release factor GTP-binding subunit; K03267 peptide chain release factor subunit 3 [KO:K03267]
prd-6; period-6 [KO:K14326] [EC:3.6.4.-]
nonsense-mediated mRNA decay factor; K14327 regulator of nonsense transcripts 2 [KO:K14327]
pph-1; protein phosphatase-1 [KO:K04382] [EC:]
protein phosphatase PP2A regulatory subunit A; K03456 serine/threonine-protein phosphatase 2A regulatory subunit A [KO:K03456]
rgb-1; B-regulatory subunit-1 [KO:K04354]
serine/threonine protein phosphatase 2A; K11584 serine/threonine-protein phosphatase 2A regulatory subunit B' [KO:K11584]
elongation factor Tu GTP binding domain-containing protein; K14416 elongation factor 1 alpha-like protein [KO:K14416]
translation factor pelota; K06965 protein pelota [KO:K06965]
Maquat LE
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
Nat Rev Mol Cell Biol 5:89-99 (2004)
Amrani N, Sachs MS, Jacobson A
Early nonsense: mRNA decay solves a translational problem.
Nat Rev Mol Cell Biol 7:415-25 (2006)
Eulalio A, Behm-Ansmant I, Izaurralde E
P bodies: at the crossroads of post-transcriptional pathways.
Nat Rev Mol Cell Biol 8:9-22 (2007)
Mandel CR, Bai Y, Tong L
Protein factors in pre-mRNA 3'-end processing.
Cell Mol Life Sci 65:1099-122 (2008)
Clement SL, Lykke-Andersen J
No mercy for messages that mess with the ribosome.
Nat Struct Mol Biol 13:299-301 (2006)
KO pathway

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