KEGG   PATHWAY: ngr03008Help
Entry
ngr03008                    Pathway                                

Name
Ribosome biogenesis in eukaryotes - Naegleria gruberi
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ribosome biogenesis in eukaryotes
ngr03008

All organismsOrtholog table
Module
H/ACA ribonucleoprotein complex [PATH:ngr03008]
Organism
Naegleria gruberi [GN:ngr]
Gene
hypothetical protein [KO:K03115]
hypothetical protein [KO:K03097] [EC:2.7.11.1]
hypothetical protein [KO:K03097] [EC:2.7.11.1]
hypothetical protein [KO:K14544]
hypothetical protein [KO:K14545]
hypothetical protein [KO:K14546]
hypothetical protein [KO:K14548]
WD40 repeat domain-containing protein [KO:K14549]
hypothetical protein [KO:K14550]
WD40 repeat domain-containing protein [KO:K14552]
hypothetical protein [KO:K14553]
hypothetical protein [KO:K14554]
hypothetical protein [KO:K14555]
WD40 repeat domain-containing protein [KO:K14556]
hypothetical protein [KO:K14557]
hypothetical protein [KO:K14558]
U3 snoRNP protein [KO:K14559]
hypothetical protein [KO:K14560]
hypothetical protein [KO:K14561]
fibrillarin [KO:K14563] [EC:2.1.1.-]
hypothetical protein [KO:K14563] [EC:2.1.1.-]
nucleolar protein 5A [KO:K14564]
NOP58-like protein [KO:K14565]
hypothetical protein [KO:K14565]
hypothetical protein [KO:K12845]
hypothetical protein [KO:K11131] [EC:5.4.99.-]
hypothetical protein [KO:K11129]
small nucleolar RNP Gar1p [KO:K11128]
hypothetical protein [KO:K11130]
hypothetical protein [KO:K14566]
hypothetical protein [KO:K14567]
hypothetical protein [KO:K14568] [EC:2.1.1.260]
ribosome assembly protein BSM1 [KO:K14569]
hypothetical protein [KO:K14521] [EC:2.3.1.-]
hypothetical protein [KO:K11108]
AM42; hypothetical protein [KO:K01164] [EC:3.1.26.5]
hypothetical protein [KO:K03538] [EC:3.1.26.5]
exonuclease family protein [KO:K14570] [EC:3.1.-.-]
hypothetical protein [KO:K13288] [EC:3.1.-.-]
hypothetical protein [KO:K13288] [EC:3.1.-.-]
hypothetical protein [KO:K12618] [EC:3.1.13.-]
5'-3' exoribonuclease 1 [KO:K12619] [EC:3.1.13.-]
5'-3' exoribonuclease [KO:K12619] [EC:3.1.13.-]
hypothetical protein [KO:K06943]
hypothetical protein [KO:K14537]
nucleostemin family protein [KO:K14538]
hypothetical protein [KO:K14571]
midasin [KO:K14572]
RNA recognition motif-containing protein [KO:K14573]
hypothetical protein [KO:K11883]
ran family small GTPase [KO:K07936]
ran family small GTPase [KO:K07936]
ran family small GTPase [KO:K07936]
ran family small GTPase [KO:K07936]
ran family small GTPase [KO:K07936]
exportin-1 [KO:K14290]
hypothetical protein [KO:K07562]
hypothetical protein [KO:K07562]
AM44; hypothetical protein [KO:K14284]
hypothetical protein [KO:K03264]
Shwachman-Bodian-Diamond syndrome protein [KO:K14574]
hypothetical protein [KO:K14536] [EC:3.6.5.-]
large subunit GTPase 1 [KO:K14539] [EC:3.6.1.-]
hypothetical protein [KO:K14575]
hypothetical protein [KO:K18532] [EC:2.7.4.3]
hypothetical protein [KO:K07178] [EC:2.7.11.1]
tentative rio kinase [KO:K07178] [EC:2.7.11.1]
hypothetical protein [KO:K07178] [EC:2.7.11.1]
hypothetical protein [KO:K07179] [EC:2.7.11.1]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
KO pathway
 

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