KEGG   PATHWAY: nhe01210
Entry
nhe01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Fusarium vanettenii
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
nhe01210  2-Oxocarboxylic acid metabolism
nhe01210

Module
nhe_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:nhe01210]
nhe_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:nhe01210]
nhe_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:nhe01210]
nhe_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:nhe01210]
Organism
Fusarium vanettenii [GN:nhe]
Related
pathway
nhe00020  Citrate cycle (TCA cycle)
nhe00220  Arginine biosynthesis
nhe00250  Alanine, aspartate and glutamate metabolism
nhe00260  Glycine, serine and threonine metabolism
nhe00270  Cysteine and methionine metabolism
nhe00290  Valine, leucine and isoleucine biosynthesis
nhe00300  Lysine biosynthesis
nhe00310  Lysine degradation
nhe00620  Pyruvate metabolism
nhe00640  Propanoate metabolism
nhe00680  Methane metabolism
KO pathway
ko01210   

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