KEGG   PATHWAY: nmg00630Help
Entry
nmg00630                    Pathway                                

Name
Glyoxylate and dicarboxylate metabolism - Natrialba magadii
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glyoxylate and dicarboxylate metabolism
nmg00630

All organismsOrtholog table
Module
Glyoxylate cycle [PATH:nmg00630]
Methylaspartate cycle [PATH:nmg00630]
Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:nmg00630]
Organism
Natrialba magadii [GN:nmg]
Gene
isocitrate lyase and phosphorylmutase; K01637 isocitrate lyase [EC:4.1.3.1] [KO:K01637] [EC:4.1.3.1]
lactate/malate dehydrogenase; K00024 malate dehydrogenase [EC:1.1.1.37] [KO:K00024] [EC:1.1.1.37]
2-methylcitrate synthase/citrate synthase II; K01647 citrate synthase [EC:2.3.3.1] [KO:K01647] [EC:2.3.3.1]
citrate (Si)-synthase; K01647 citrate synthase [EC:2.3.3.1] [KO:K01647] [EC:2.3.3.1]
aconitate hydratase; K01681 aconitate hydratase [EC:4.2.1.3] [KO:K01681] [EC:4.2.1.3]
aconitate hydratase 1; K01681 aconitate hydratase [EC:4.2.1.3] [KO:K01681] [EC:4.2.1.3]
propanoyl-CoA C-acyltransferase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]
propanoyl-CoA C-acyltransferase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]
propanoyl-CoA C-acyltransferase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]
3-ketoacyl-CoA thiolase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]
acetyl-CoA acetyltransferase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]
methylmalonyl-CoA epimerase; K05606 methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] [KO:K05606] [EC:5.1.99.1]
MaoC domain-containing protein dehydratase; K14449 2-methylfumaryl-CoA hydratase [EC:4.2.1.148] [KO:K14449] [EC:4.2.1.148]
carbamoyl-phosphate synthaseATP-binding subunit L; K11263 acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14] [KO:K11263] [EC:6.3.4.14 6.4.1.3 6.4.1.2]
carbamoyl-phosphate synthaseATP-binding subunit L; K11263 acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14] [KO:K11263] [EC:6.3.4.14 6.4.1.3 6.4.1.2]
carboxyl transferase; K19312 acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3] [KO:K19312] [EC:6.4.1.3 6.4.1.2]
cobalamin B12-binding domain-containing protein; K01849 methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2] [KO:K01849] [EC:5.4.99.2]
methylmalonyl-CoA mutase large subunit; K01848 methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2] [KO:K01848] [EC:5.4.99.2]
methylmalonyl-CoA mutase large subunit; K01848 methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2] [KO:K01848] [EC:5.4.99.2]
methylaspartate mutase subunit E; K19268 methylaspartate mutase epsilon subunit [EC:5.4.99.1] [KO:K19268] [EC:5.4.99.1]
methylaspartate mutase; K01846 methylaspartate mutase sigma subunit [EC:5.4.99.1] [KO:K01846] [EC:5.4.99.1]
methylaspartate ammonia-lyase; K04835 methylaspartate ammonia-lyase [EC:4.3.1.2] [KO:K04835] [EC:4.3.1.2]
bile acid-inducible L-carnitine dehydratase protein F; K19280 succinyl-CoA:mesaconate CoA transferase [EC:2.8.3.-] [KO:K19280] [EC:2.8.3.-]
HpcH/HpaI aldolase; K19281 beta-methylmalyl-CoA/(S)-malyl-CoA lyase [EC:4.1.3.24] [KO:K19281] [EC:4.1.3.24]
HpcH/HpaI aldolase; K19282 bifunctional (S)-malyl-CoA lyase/thioesterase [EC:4.1.3.24 3.1.2.30] [KO:K19282] [EC:3.1.2.30 4.1.3.24]
catalase; K03781 catalase [EC:1.11.1.6] [KO:K03781] [EC:1.11.1.6]
haloacid dehalogenase; K01091 phosphoglycolate phosphatase [EC:3.1.3.18] [KO:K01091] [EC:3.1.3.18]
HAD-superfamily hydrolase; K01091 phosphoglycolate phosphatase [EC:3.1.3.18] [KO:K01091] [EC:3.1.3.18]
ribulose bisphosphate carboxylase; K01601 ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39] [KO:K01601] [EC:4.1.1.39]
class V aminotransferase; K00830 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase [EC:2.6.1.44 2.6.1.45 2.6.1.51] [KO:K00830] [EC:2.6.1.51 2.6.1.45 2.6.1.44]
glutamate--ammonia ligase; K01915 glutamine synthetase [EC:6.3.1.2] [KO:K01915] [EC:6.3.1.2]
glutamate--ammonia ligase; K01915 glutamine synthetase [EC:6.3.1.2] [KO:K01915] [EC:6.3.1.2]
glutamine synthetase; K01915 glutamine synthetase [EC:6.3.1.2] [KO:K01915] [EC:6.3.1.2]
glutamate--ammonia ligase; K01915 glutamine synthetase [EC:6.3.1.2] [KO:K01915] [EC:6.3.1.2]
glutamine synthetase; K01915 glutamine synthetase [EC:6.3.1.2] [KO:K01915] [EC:6.3.1.2]
glycine hydroxymethyltransferase; K00600 glycine hydroxymethyltransferase [EC:2.1.2.1] [KO:K00600] [EC:2.1.2.1]
glycine dehydrogenase; K00282 glycine dehydrogenase subunit 1 [EC:1.4.4.2] [KO:K00282] [EC:1.4.4.2]
class V aminotransferase; K00283 glycine dehydrogenase subunit 2 [EC:1.4.4.2] [KO:K00283] [EC:1.4.4.2]
folate-binding protein YgfZ; K00605 aminomethyltransferase [EC:2.1.2.10] [KO:K00605] [EC:2.1.2.10]
glycine cleavage system protein T; K00605 aminomethyltransferase [EC:2.1.2.10] [KO:K00605] [EC:2.1.2.10]
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
dihydrolipoamide dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
glycine cleavage system protein H; K02437 glycine cleavage system H protein [KO:K02437]
hydroxypyruvate reductase; K00050 hydroxypyruvate reductase [EC:1.1.1.81] [KO:K00050] [EC:1.1.1.81]
2-dehydro-3-deoxyphosphogluconate aldolase; K01625 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] [KO:K01625] [EC:4.1.3.42 4.1.2.14]
formyl transferase; K01433 formyltetrahydrofolate deformylase [EC:3.5.1.10] [KO:K01433] [EC:3.5.1.10]
Compound
C00007  
Oxygen
C00011  
CO2
C00014  
Ammonia
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00025  
L-Glutamate
C00026  
2-Oxoglutarate
C00027  
Hydrogen peroxide
C00036  
Oxaloacetate
C00037  
Glycine
C00042  
Succinate
C00048  
Glyoxylate
C00058  
Formate
C00064  
L-Glutamine
C00065  
L-Serine
C00091  
Succinyl-CoA
C00100  
Propanoyl-CoA
C00136  
Butanoyl-CoA
C00149  
(S)-Malate
C00158  
Citrate
C00160  
Glycolate
C00168  
Hydroxypyruvate
C00197  
3-Phospho-D-glycerate
C00209  
Oxalate
C00258  
D-Glycerate
C00266  
Glycolaldehyde
C00311  
Isocitrate
C00313  
Oxalyl-CoA
C00332  
Acetoacetyl-CoA
C00417  
cis-Aconitate
C00552  
meso-Tartaric acid
C00683  
(S)-Methylmalonyl-CoA
C00798  
Formyl-CoA
C00877  
Crotonoyl-CoA
C00888  
Pentanoyl-CoA
C00898  
(R,R)-Tartaric acid
C00975  
Dihydroxyfumarate
C00988  
2-Phosphoglycolate
C01127  
4-Hydroxy-2-oxoglutarate
C01146  
2-Hydroxy-3-oxopropanoate
C01182  
D-Ribulose 1,5-bisphosphate
C01213  
(R)-Methylmalonyl-CoA
C01380  
Ethylene glycol
C01732  
Mesaconate
C01989  
3-Ethylmalate
C01990  
3-Oxalomalate
C02123  
3-Propylmalate
C02405  
Formyl phosphate
C03217  
2-Hydroxy-3-oxoadipate
C03459  
2-Hydroxy-3-oxosuccinate
C03548  
trans-2,3-Epoxysuccinate
C03561  
(R)-3-Hydroxybutanoyl-CoA
C03618  
L-threo-3-Methylaspartate
C04348  
L-Malyl-CoA
C06027  
L-erythro-3-Methylmalyl-CoA
C06028  
2-Methylfumaryl-CoA
C06049  
N-Formylderivatives
C18026  
(2S)-Ethylmalonyl-CoA
C18324  
(2S)-Methylsuccinyl-CoA
C20238  
(2R)-Ethylmalonyl-CoA
Reference
PMID:10978349 (EC5.3.1.22)
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta -hydroxyacid dehydrogenases in Escherichia coli and Haemophilusinfluenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
Reference
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
Reference
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
Reference
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play  distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
Reference
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
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