KEGG   PATHWAY: nmt00290
Entry
nmt00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Neisseria meningitidis 8013 (serogroup C)
Class
Metabolism; Amino acid metabolism
Pathway map
nmt00290  Valine, leucine and isoleucine biosynthesis
nmt00290

Module
nmt_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:nmt00290]
nmt_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:nmt00290]
nmt_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:nmt00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Neisseria meningitidis 8013 (serogroup C) [GN:nmt]
Gene
NMV_1522  ilvA; threonine dehydratase biosynthetic (threonine deaminase) [KO:K01754] [EC:4.3.1.19]
NMV_1151  leuC; 3-isopropylmalate dehydratase large subunit (isopropylmalate isomerase; alpha-IPM isomerase; IPMI) [KO:K01703] [EC:4.2.1.33 4.2.1.35]
NMV_1149  leuD; 3-isopropylmalate dehydratase small subunit (isopropylmalate isomerase; alpha-IPM isomerase; IPMI) [KO:K01704] [EC:4.2.1.33 4.2.1.35]
NMV_1147  leuB; 3-isopropylmalate dehydrogenase (beta-IPM dehydrogenase; IMDH; 3-IPM-DH) [KO:K00052] [EC:1.1.1.85]
NMV_0823  ilvI; acetolactate synthase large subunit (AHAS; acetohydroxy-acid synthase large subunit; ALS) [KO:K01652] [EC:2.2.1.6]
NMV_0824  ilvH; acetolactate synthase small subunit (AHAS; acetohydroxy-acid synthase small subunit; ALS) [KO:K01653] [EC:2.2.1.6]
NMV_0826  ilvC; ketol-acid reductoisomerase (acetohydroxy-acid isomeroreductase; alpha-keto-beta-hydroxylacil reductoisomerase) [KO:K00053] [EC:1.1.1.86]
NMV_1239  ilvD; dihydroxy-acid dehydratase (DAD) [KO:K01687] [EC:4.2.1.9]
NMV_0373  putative branched-chain amino acid aminotransferase (BCAT) [KO:K00826] [EC:2.6.1.42]
NMV_1985  avtA; valine--pyruvate aminotransferase (transaminase C; alanine--valine transaminase) [KO:K00835] [EC:2.6.1.66]
NMV_0912  putative aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
NMV_1323  leuA; 2-isopropylmalate synthase (alpha-isopropylmalate synthase; alpha-IPM synthetase) [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
nmt00260  Glycine, serine and threonine metabolism
nmt00280  Valine, leucine and isoleucine degradation
nmt00620  Pyruvate metabolism
KO pathway
ko00290   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG GENES (12)   
All databases (13)   

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