KEGG   PATHWAY: npp03440Help
Entry
npp03440                    Pathway                                

Name
Homologous recombination - Novosphingobium sp. PP1Y
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
npp03440  Homologous recombination
npp03440

Ortholog table
Module
npp_M00260  DNA polymerase III complex, bacteria [PATH:npp03440]
Other DBs
BSID: 219223
GO: 0000724
Organism
Novosphingobium sp. PP1Y [GN:npp]
Gene
PP1Y_AT24591  single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
PP1Y_AT12097  single-strand DNA-binding protein [KO:K03111]
PP1Y_AT14761  single-strand DNA-binding protein [KO:K03111]
PP1Y_Spl491  single-strand binding protein/primosomal replication protein N [KO:K03111]
PP1Y_AT6284  DNA replication and repair protein RecF [KO:K03629]
PP1Y_AT20160  DNA repair protein RecO (recombination protein O) [KO:K03584]
PP1Y_AT28312  recombination protein RecR [KO:K06187]
PP1Y_AT30838  recombination protein RecA [KO:K03553]
PP1Y_AT4126  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
PP1Y_AT35162  holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
PP1Y_AT35149  holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
PP1Y_AT35186  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
PP1Y_AT29160  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
PP1Y_AT30432  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
PP1Y_AT21281  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
PP1Y_AT21071  DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
PP1Y_AT826  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
PP1Y_AT25997  DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
PP1Y_AT37269  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
PP1Y_Mpl1556  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
PP1Y_AT20473  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
PP1Y_AT27810  primosomal protein N' (replication factor Y) (superfamily II helicase) [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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