KEGG   PATHWAY: nvi04145
Entry
nvi04145                    Pathway                                
Name
Phagosome - Nasonia vitripennis (jewel wasp)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
nvi04145  Phagosome
nvi04145

Other DBs
GO: 0045335
Organism
Nasonia vitripennis (jewel wasp) [GN:nvi]
Gene
100122560  syntaxin-12 [KO:K08488]
100116604  Arp1; actin related protein 1 [KO:K05692]
100114640  syntaxin-18 [KO:K08492]
100119676  Sec22b; vesicle-trafficking protein SEC22b [KO:K08517]
100119168  ras-related protein Rab-5C isoform X2 [KO:K07889]
100119508  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
100123769  hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
100121100  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100121759  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
100116861  V-type proton ATPase subunit B [KO:K02147]
100679877  V-type proton ATPase subunit C isoform X1 [KO:K02148]
100119832  V-type proton ATPase subunit D [KO:K02149]
100115358  V-type proton ATPase subunit E [KO:K02150]
100113561  V-type proton ATPase subunit F [KO:K02151]
100119565  V-type proton ATPase subunit G [KO:K02152]
100116059  V-type proton ATPase subunit e 2 [KO:K02153]
100116803  V-type proton ATPase 116 kDa subunit a isoform X4 [KO:K02154]
100121052  V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
100122361  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
100117789  V-type proton ATPase subunit d [KO:K02146]
100121857  V-type proton ATPase subunit H isoform X5 [KO:K02144]
100115147  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100114758  V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
103318045  V-type proton ATPase subunit S1 [KO:K03662]
100114458  ras-related protein Rab-7a [KO:K07897]
100116365  dynein heavy chain, cytoplasmic isoform X1 [KO:K10413]
100122948  cytoplasmic dynein 1 intermediate chain isoform X25 [KO:K10415]
100122511  cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
100123147  tubulin alpha-1 chain [KO:K07374]
100119612  tubulin alpha-1 chain [KO:K07374]
100116270  tubulin alpha-1 chain isoform X2 [KO:K07374]
100117239  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
100114292  tubulin beta-4 chain [KO:K07375]
100119733  tubulin beta chain [KO:K07375]
100116454  tubulin beta chain-like isoform X1 [KO:K07375]
100113958  tubulin beta chain [KO:K07375]
100116329  tubulin beta-1 chain [KO:K07375]
100122692  lysosome-associated membrane glycoprotein 1 [KO:K06528]
100122133  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2 [KO:K00921] [EC:2.7.1.150]
100313941  Nos; nitric oxide synthase [KO:K13240] [EC:1.14.13.39]
100120611  cathepsin L [KO:K01365] [EC:3.4.22.15]
100121702  cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
103316630  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100114093  protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
100114600  protein transport protein Sec61 subunit alpha [KO:K10956]
100113628  protein transport protein Sec61 subunit beta [KO:K09481]
100113939  protein transport protein Sec61 subunit gamma [KO:K07342]
100116123  Crc; calreticulin precursor [KO:K08057]
100124226  calnexin isoform X2 [KO:K08054]
100117172  integrin beta-PS [KO:K05719]
100122781  integrin beta-PS [KO:K05719]
100123927  integrin beta-PS [KO:K05719]
100114667  cartilage oligomeric matrix protein isoform X2 [KO:K04659]
100120969  protein croquemort isoform X2 [KO:K13885]
100122995  sensory neuron membrane protein 1 [KO:K13885]
100123070  sensory neuron membrane protein 1 [KO:K13885]
100115463  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100124157  ras-related protein Rac1 [KO:K04392]
100301486  rho-like [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
nvi04142  Lysosome
nvi04144  Endocytosis
KO pathway
ko04145   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (59)   
   KEGG GENES (59)   
All databases (60)   

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