KEGG PATHWAY: oaa02010

PATHWAY: oaa02010

Entry

oaa02010 Pathway

Name

ABC transporters - Ornithorhynchus anatinus (platypus)

Description

The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).

Class

Environmental Information Processing; Membrane transport

Pathway map

oaa02010

ABC transporters

Module

oaa_M00185	Sulfate transport system [PATH:oaa02010]
oaa_M00186	Tungstate transport system [PATH:oaa02010]
oaa_M00189	Molybdate transport system [PATH:oaa02010]
oaa_M00190	Iron(III) transport system [PATH:oaa02010]
oaa_M00191	Thiamine transport system [PATH:oaa02010]
oaa_M00194	Maltose/maltodextrin transport system [PATH:oaa02010]
oaa_M00195	Maltooligosaccharide transport system [PATH:oaa02010]
oaa_M00196	Multiple sugar transport system [PATH:oaa02010]
oaa_M00198	Putative sn-glycerol-phosphate transport system [PATH:oaa02010]
oaa_M00199	L-Arabinose/lactose transport system [PATH:oaa02010]
oaa_M00200	Putative sorbitol/mannitol transport system [PATH:oaa02010]
oaa_M00201	alpha-Glucoside transport system [PATH:oaa02010]
oaa_M00202	Oligogalacturonide transport system [PATH:oaa02010]
oaa_M00203	Glucose/arabinose transport system [PATH:oaa02010]
oaa_M00204	Trehalose/maltose transport system [PATH:oaa02010]
oaa_M00205	N-Acetylglucosamine transport system [PATH:oaa02010]
oaa_M00206	Cellobiose transport system [PATH:oaa02010]
oaa_M00208	Glycine betaine/proline transport system [PATH:oaa02010]
oaa_M00209	Osmoprotectant transport system [PATH:oaa02010]
oaa_M00212	Ribose transport system [PATH:oaa02010]
oaa_M00213	L-Arabinose transport system [PATH:oaa02010]
oaa_M00214	Methyl-galactoside transport system [PATH:oaa02010]
oaa_M00215	D-Xylose transport system [PATH:oaa02010]
oaa_M00216	Multiple sugar transport system [PATH:oaa02010]
oaa_M00217	D-Allose transport system [PATH:oaa02010]
oaa_M00218	Fructose transport system [PATH:oaa02010]
oaa_M00219	AI-2 transport system [PATH:oaa02010]
oaa_M00220	Rhamnose transport system [PATH:oaa02010]
oaa_M00222	Phosphate transport system [PATH:oaa02010]
oaa_M00223	Phosphonate transport system [PATH:oaa02010]
oaa_M00224	Fluoroquinolones transport system [PATH:oaa02010]
oaa_M00225	Lysine/arginine/ornithine transport system [PATH:oaa02010]
oaa_M00226	Histidine transport system [PATH:oaa02010]
oaa_M00227	Glutamine transport system [PATH:oaa02010]
oaa_M00228	Putative glutamine transport system [PATH:oaa02010]
oaa_M00229	Arginine transport system [PATH:oaa02010]
oaa_M00230	Glutamate/aspartate transport system [PATH:oaa02010]
oaa_M00231	Octopine/nopaline transport system [PATH:oaa02010]
oaa_M00232	General L-amino acid transport system [PATH:oaa02010]
oaa_M00233	Glutamate transport system [PATH:oaa02010]
oaa_M00234	Cystine transport system [PATH:oaa02010]
oaa_M00235	Arginine/ornithine transport system [PATH:oaa02010]
oaa_M00237	Branched-chain amino acid transport system [PATH:oaa02010]
oaa_M00238	D-Methionine transport system [PATH:oaa02010]
oaa_M00239	Peptides/nickel transport system [PATH:oaa02010]
oaa_M00240	Iron complex transport system [PATH:oaa02010]
oaa_M00241	Vitamin B12 transport system [PATH:oaa02010]
oaa_M00242	Zinc transport system [PATH:oaa02010]
oaa_M00245	Cobalt/nickel transport system [PATH:oaa02010]
oaa_M00246	Nickel transport system [PATH:oaa02010]
oaa_M00248	Putative antibiotic transport system [PATH:oaa02010]
oaa_M00249	Capsular polysaccharide transport system [PATH:oaa02010]
oaa_M00250	Lipopolysaccharide transport system [PATH:oaa02010]
oaa_M00251	Teichoic acid transport system [PATH:oaa02010]
oaa_M00252	Lipooligosaccharide transport system [PATH:oaa02010]
oaa_M00253	Sodium transport system [PATH:oaa02010]
oaa_M00255	Lipoprotein-releasing system [PATH:oaa02010]
oaa_M00256	Cell division transport system [PATH:oaa02010]
oaa_M00257	Hemin transport system [PATH:oaa02010]
oaa_M00259	Heme transport system [PATH:oaa02010]
oaa_M00298	Multidrug/hemolysin transport system [PATH:oaa02010]
oaa_M00299	Spermidine/putrescine transport system [PATH:oaa02010]
oaa_M00300	Putrescine transport system [PATH:oaa02010]
oaa_M00301	Mannopine transport system [PATH:oaa02010]
oaa_M00302	2-Aminoethylphosphonate transport system [PATH:oaa02010]
oaa_M00314	Bacitracin transport system [PATH:oaa02010]
oaa_M00316	Manganese transport system [PATH:oaa02010]
oaa_M00317	Manganese/iron transport system [PATH:oaa02010]
oaa_M00318	Iron/zinc/copper transport system [PATH:oaa02010]
oaa_M00319	Manganese/zinc/iron transport system [PATH:oaa02010]
oaa_M00320	Lipopolysaccharide export system [PATH:oaa02010]
oaa_M00321	Bicarbonate transport system [PATH:oaa02010]
oaa_M00322	Neutral amino acid transport system [PATH:oaa02010]
oaa_M00323	Urea transport system [PATH:oaa02010]
oaa_M00324	Dipeptide transport system [PATH:oaa02010]
oaa_M00325	alpha-Hemolysin/cyclolysin transport system [PATH:oaa02010]
oaa_M00423	Molybdate/tungstate transport system [PATH:oaa02010]
oaa_M00435	Taurine transport system [PATH:oaa02010]
oaa_M00436	Sulfonate transport system [PATH:oaa02010]
oaa_M00437	Phthalate transport system [PATH:oaa02010]
oaa_M00438	Nitrate/nitrite transport system [PATH:oaa02010]
oaa_M00439	Oligopeptide transport system [PATH:oaa02010]
oaa_M00440	Nickel transport system [PATH:oaa02010]
oaa_M00442	Putative hydroxymethylpyrimidine transport system [PATH:oaa02010]
oaa_M00491	Putative arabinogalactan oligomer transport system [PATH:oaa02010]
oaa_M00566	Dipeptide transport system, Firmicutes [PATH:oaa02010]
oaa_M00581	Biotin transport system [PATH:oaa02010]
oaa_M00582	Energy-coupling factor transport system [PATH:oaa02010]
oaa_M00583	Putative peptide transport system [PATH:oaa02010]
oaa_M00584	Acetoin utilization transport system [PATH:oaa02010]
oaa_M00585	L-Cystine transport system [PATH:oaa02010]
oaa_M00586	Putative amino-acid transport system [PATH:oaa02010]

Other DBs

BSID:

88687

GO:

0043190 0043191 0043192

TC:

3.A.1

Organism

Ornithorhynchus anatinus (platypus) [GN:oaa]

Gene

100075984	ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1 [KO:K05641]
100078007	ATP-binding cassette sub-family A member 12-like; K05646 ATP-binding cassette, subfamily A (ABC1), member 12 [KO:K05646]
100075336	ABCA13; ATP-binding cassette, sub-family A (ABC1), member 13 [KO:K05647]
100078425	ABCA5; ATP-binding cassette, sub-family A (ABC1), member 5 [KO:K05648]
100529066	TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05654]
100075497	ABCB9; ATP-binding cassette, sub-family B (MDR/TAP), member 9 [KO:K05656]
100092920	ATP-binding cassette sub-family B member 10; K05657 ATP-binding cassette, subfamily B (MDR/TAP), member 10 [KO:K05657]
100077826	multidrug resistance protein 1-like; K05658 ATP-binding cassette, subfamily B (MDR/TAP), member 1 [KO:K05658]
100077786	multidrug resistance protein 2-like; K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4 [KO:K05659]
100075231	ABCB7; ATP-binding cassette, sub-family B (MDR/TAP), member 7 [KO:K05662]
100083318	ABCB11; ATP-binding cassette, sub-family B (MDR/TAP), member 11 [KO:K05664]
100087202	multidrug resistance-associated protein 1-like; K05665 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 [KO:K05665]
100090079	canalicular multispecific organic anion transporter 1-like; K05666 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 [KO:K05666]
100073452	ABCC5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5 [KO:K05668]
100087225	ABCC6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6 [KO:K05669]
100076157	ABCC11; ATP-binding cassette, sub-family C (CFTR/MRP), member 11 [KO:K05671]
100076112	multidrug resistance-associated protein 9-like; K05672 ATP-binding cassette, subfamily C (CFTR/MRP), member 12 [KO:K05672]
100081616	ABCC4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4 [KO:K05673]
100078764	CFTR; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) [KO:K05031] [EC:3.6.3.49]
100084988	ABCC10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10 [KO:K05674]
100091377	ATP-binding cassette sub-family D member 2-like; K05676 ATP-binding cassette, subfamily D (ALD), member 2 [KO:K05676]
100080139	ABCD3; ATP-binding cassette, sub-family D (ALD), member 3 [KO:K05677]
100087502	ATP-binding cassette sub-family D member 4-like; K05678 ATP-binding cassette, subfamily D (ALD), member 4 [KO:K05678]
100080064	ATP-binding cassette sub-family D member 4-like; K05678 ATP-binding cassette, subfamily D (ALD), member 4 [KO:K05678]
100077803	ABCG1; ATP-binding cassette, sub-family G (WHITE), member 1 [KO:K05679]
100085539	ATP-binding cassette sub-family G member 2-like; K05681 ATP-binding cassette, subfamily G (WHITE), member 2 [KO:K05681]
100080045	ATP-binding cassette sub-family G member 8-like; K05684 ATP-binding cassette, subfamily G (WHITE), member 8 (sterolin 2) [KO:K05684]

Compound

C00009	Orthophosphate
C00025	L-Glutamate
C00031	D-Glucose
C00032	Heme
C00034	Manganese
C00037	Glycine
C00038	Zinc cation
C00041	L-Alanine
C00045	Amino acid
C00047	L-Lysine
C00049	L-Aspartate
C00051	Glutathione
C00059	Sulfate
C00062	L-Arginine
C00064	L-Glutamine
C00065	L-Serine
C00077	L-Ornithine
C00079	L-Phenylalanine
C00086	Urea
C00088	Nitrite
C00089	Sucrose
C00093	sn-Glycerol 3-phosphate
C00095	D-Fructose
C00098	Oligopeptide
C00107	Dipeptide
C00114	Choline
C00120	Biotin
C00121	D-Ribose
C00123	L-Leucine
C00134	Putrescine
C00135	L-Histidine
C00140	N-Acetyl-D-glucosamine
C00148	L-Proline
C00151	L-Amino acid
C00175	Cobalt ion
C00181	D-Xylose
C00183	L-Valine
C00185	Cellobiose
C00188	L-Threonine
C00208	Maltose
C00243	Lactose
C00244	Nitrate
C00245	Taurine
C00259	L-Arabinose
C00288	HCO3-
C00291	Nickel
C00315	Spermidine
C00320	Thiosulfate
C00333	D-Galacturonate
C00338	Lipopolysaccharide
C00378	Thiamine
C00392	Mannitol
C00407	L-Isoleucine
C00430	5-Aminolevulinate
C00470	Pectate
C00487	Carnitine
C00491	L-Cystine
C00719	Betaine
C00753	Tungsten
C00794	D-Sorbitol
C00855	D-Methionine
C00919	Choline sulfate
C00973	Cyclomaltodextrin
C01083	alpha,alpha-Trehalose
C01153	Orthophosphoric monoester
C01181	4-Trimethylammoniobutanoate
C01279	4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330	Sodium cation
C01417	Cyanate
C01487	D-Allose
C01606	Phthalate
C01667	Bacitracin
C01682	Nopaline
C01684	D-Rhamnose
C01834	Lipoprotein
C01835	Maltotriose
C01935	Maltodextrin
C03557	2-Aminoethylphosphonate
C03619	Methyl beta-D-galactoside
C04114	4-(Trimethylammonio)but-2-enoate
C04137	D-Octopine
C05349	Ciprofloxacin
C05776	Vitamin B12
C06227	Fe(III)hydroxamate
C06228	Ferrichrome
C06229	Fe(III)dicitrate
C06230	Fe-enterobactin
C06232	Molybdate
C06687	Norfloxacin
C06704	Iron chelate
C06705	Capsular polysaccharide
C06706	Lipo-oligosaccharide
C06707	Teichoic acid
C06767	Hemine
C07662	Sparfloxacin
C07663	Moxifloxacin
C11546	2-(beta-D-Glucosyl)-sn-glycerol
C14818	Fe2+
C14819	Fe3+
C15521	Alkanesulfonate
C16421	AI-2
C16692	Mannopine
C19609	Nickel(2+)
C19872	N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
G00457	Maltotetraose

Reference

PMID:9799792

Authors

Tomii K, Kanehisa M.

Title

A comparative analysis of ABC transporters in complete microbial genomes.

Journal

Genome Res 8:1048-59 (1998)

Reference

PMID:18424520

Authors

Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A

Title

Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.

Journal

J Bacteriol 190:4460-9 (2008)

Reference

PMID:18375759

Authors

Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ

Title

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.

Journal

Proc Natl Acad Sci U S A 105:5537-42 (2008)

Reference

PMID:10557362

Authors

Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T

Title

Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.

Journal

Proc Natl Acad Sci U S A 96:13571-6 (1999)

Reference

PMID:11731493

Authors

Quintero MJ, Montesinos ML, Herrero A, Flores E

Title

Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.

Journal

Genome Res 11:2034-40 (2001)

Reference

PMID:16135226

Authors

Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E

Title

ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.

Journal

Mol Microbiol 57:1582-92 (2005)

Reference

PMID:11929526

Authors

Valladares A, Montesinos ML, Herrero A, Flores E.

Title

An ABC-type, high-affinity urea permease identified in cyanobacteria.

Journal

Mol Microbiol 43:703-15 (2002)

Reference

PMID:18326572

Authors

Richard-Fogal CL, Frawley ER, Kranz RG

Title

Topology and function of CcmD in cytochrome c maturation.

Journal

J Bacteriol 190:3489-93 (2008)

Reference

PMID:16109926

Authors

Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H

Title

The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.

Journal

J Bacteriol 187:5861-7 (2005)

Reference

PMID:17873039

Authors

Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K

Title

The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.

Journal

J Bacteriol 189:8361-5 (2007)

Reference

PMID:17214741

Authors

Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI

Title

Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.

Journal

Mol Microbiol 63:895-910 (2007)

Reference

PMID:18805970

Authors

Yamanaka H, Kobayashi H, Takahashi E, Okamoto K

Title

MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.

Journal

J Bacteriol 190:7693-8 (2008)

KO pathway

ko02010

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG GENES (27)   
All databases (29)   

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