KEGG   PATHWAY: oaa04020Help
Entry
oaa04020                    Pathway                                
Name
Calcium signaling pathway - Ornithorhynchus anatinus (platypus)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Calcium signaling pathway
oaa04020

All organismsOrtholog table
Other DBs
BSID: 
GO: 
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
SLC8A1; solute carrier family 8 (sodium/calcium exchanger), member 1 [KO:K05849]
sodium/calcium exchanger 3-like; K05849 solute carrier family 8 (sodium/calcium exchanger) [KO:K05849]
ATP2B4; ATPase, Ca++ transporting, plasma membrane 4 [KO:K05850] [EC:3.6.3.8]
ATP2B3; ATPase, Ca++ transporting, plasma membrane 3 [KO:K05850] [EC:3.6.3.8]
ATP2B1; ATPase, Ca++ transporting, plasma membrane 1 [KO:K05850] [EC:3.6.3.8]
muscarinic acetylcholine receptor M1-like; K04129 muscarinic acetylcholine receptor M1 [KO:K04129]
muscarinic acetylcholine receptor M3-like; K04131 muscarinic acetylcholine receptor M3 [KO:K04131]
adenosine receptor A2a-like; K04266 adenosine receptor A2a [KO:K04266]
uncharacterized LOC100078270; K04267 adenosine receptor A2b [KO:K04267]
beta-1 adrenergic receptor-like; K04141 adrenergic receptor beta-1 [KO:K04141]
D(1B) dopamine receptor-like; K05840 dopamine receptor D5 [KO:K05840]
5-hydroxytryptamine receptor 4-like; K04160 5-hydroxytryptamine receptor 4 [KO:K04160]
5-hydroxytryptamine receptor 5A-like; K04161 5-hydroxytryptamine receptor 5 [KO:K04161]
5-hydroxytryptamine receptor 6-like; K04162 5-hydroxytryptamine receptor 6 [KO:K04162]
5-hydroxytryptamine receptor 7-like; K04163 5-hydroxytryptamine receptor 7 [KO:K04163]
guanine nucleotide-binding protein G(s) subunit alpha-like; K04632 guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
ADCY2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
adenylate cyclase type 7-like; K08047 adenylate cyclase 7 [EC:4.6.1.1] [KO:K08047] [EC:4.6.1.1]
ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
adenylate cyclase type 9-like; K08049 adenylate cyclase 9 [EC:4.6.1.1] [KO:K08049] [EC:4.6.1.1]
cAMP-dependent protein kinase catalytic subunit alpha-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
cAMP-dependent protein kinase catalytic subunit alpha-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
serine/threonine-protein kinase PRKX-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
cardiac phospholamban-like; K05852 phospholamban [KO:K05852]
ATP2A2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [KO:K05853] [EC:3.6.3.8]
stromal interaction molecule 1-like; K16059 stromal interaction molecule [KO:K16059]
STIM2; stromal interaction molecule 2 [KO:K16059]
calcium release-activated calcium channel protein 1-like; K16056 calcium release-activated calcium channel protein 1 [KO:K16056]
protein orai-2-like; K16057 protein Orai-2 [KO:K16057]
protein orai-3-like; K16058 protein Orai-3 [KO:K16058]
voltage-dependent L-type calcium channel subunit alpha-1F-like; K04853 voltage-dependent calcium channel L type alpha-1F [KO:K04853]
voltage-dependent L-type calcium channel subunit alpha-1S-like; K04857 voltage-dependent calcium channel L type alpha-1S [KO:K04857]
voltage-dependent P/Q-type calcium channel subunit alpha-1A-like; K04344 voltage-dependent calcium channel P/Q type alpha-1A [KO:K04344]
CACNA1B; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
voltage-dependent R-type calcium channel subunit alpha-1E-like; K04852 voltage-dependent calcium channel R type alpha-1E [KO:K04852]
CACNA1I; calcium channel, voltage-dependent, T type, alpha 1I subunit [KO:K04856]
neuronal acetylcholine receptor subunit alpha-7-like; K04809 nicotinic acetylcholine receptor alpha-7 [KO:K04809]
P2X purinoceptor 1-like; K05215 P2X purinoceptor 1 [KO:K05215]
P2X purinoceptor 2-like; K05216 P2X purinoceptor 2 [KO:K05216]
P2X purinoceptor 4-like; K05218 P2X purinoceptor 4 [KO:K05218]
P2X purinoceptor 5-like; K05219 P2X purinoceptor 5 [KO:K05219]
P2X purinoceptor 7-like; K05220 P2X purinoceptor 7 [KO:K05220]
P2X purinoceptor 6-like; K05221 P2X purinoceptor 6 [KO:K05221]
glutamate [NMDA] receptor subunit zeta-1-like; K05208 glutamate receptor ionotropic, NMDA 1 [KO:K05208]
glutamate [NMDA] receptor subunit epsilon-1-like; K05209 glutamate receptor ionotropic, NMDA 2A [KO:K05209]
ryanodine receptor 2-like; K04962 ryanodine receptor 2 [KO:K04962]
RYR3; ryanodine receptor 3 [KO:K04963]
cysteinyl leukotriene receptor 1-like; K04322 cysteinyl leukotriene receptor 1 [KO:K04322]
cysteinyl leukotriene receptor 2-like; K04323 cysteinyl leukotriene receptor 2 [KO:K04323]
muscarinic acetylcholine receptor M2-like; K04130 muscarinic acetylcholine receptor M2 [KO:K04130]
alpha-1A adrenergic receptor-like; K04135 adrenergic receptor alpha-1A [KO:K04135]
ADRA1B; adrenoceptor alpha 1B [KO:K04136]
type-1 angiotensin II receptor-like; K04166 angiotensin II receptor type 1 [KO:K04166]
EDNRA; endothelin receptor type A [KO:K04197]
endothelin B receptor-like; K04198 endothelin receptor type B [KO:K04198]
GRM1; glutamate receptor, metabotropic 1 [KO:K04603]
metabotropic glutamate receptor 5-like; K04604 metabotropic glutamate receptor 5 [KO:K04604]
gastrin-releasing peptide receptor-like; K04169 gastrin-releasing peptide receptor [KO:K04169]
histamine H1 receptor-like; K04149 histamine receptor H1 [KO:K04149]
HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled [KO:K04157]
HTR2B; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [KO:K04157]
lutropin-choriogonadotropic hormone receptor-like; K04248 luteinizing hormone/choriogonadotropin receptor [KO:K04248]
NTSR1; neurotensin receptor 1 (high affinity) [KO:K04211]
oxytocin receptor-like; K04229 oxytocin receptor [KO:K04229]
vasopressin V1a receptor-like; K04226 arginine vasopressin receptor 1A [KO:K04226]
leukotriene B4 receptor 2-like; K04297 leukotriene B4 receptor 2 [KO:K04297]
platelet-activating factor receptor-like; K04279 platelet-activating factor receptor [KO:K04279]
prostaglandin E2 receptor EP1 subtype-like; K04258 prostaglandin E receptor 1 [KO:K04258]
prostaglandin F2-alpha receptor-like; K04262 prostaglandin F receptor [KO:K04262]
B1 bradykinin receptor-like; K03915 bradykinin receptor B1 [KO:K03915]
B2 bradykinin receptor-like; K03916 bradykinin receptor B2 [KO:K03916]
substance-K receptor-like; K04223 tachykinin receptor 2 [KO:K04223]
neuromedin-K receptor-like; K04224 tachykinin receptor 3 [KO:K04224]
thromboxane A2 receptor-like; K04264 thromboxane A2 receptor [KO:K04264]
thyrotropin-releasing hormone receptor-like; K04282 thyrotropin-releasing hormone receptor [KO:K04282]
thyrotropin-releasing hormone receptor-like; K04282 thyrotropin-releasing hormone receptor [KO:K04282]
cholecystokinin receptor type A-like; K04194 cholecystokinin A receptor [KO:K04194]
EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
receptor tyrosine-protein kinase erbB-3-like; K05084 receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1] [KO:K05084] [EC:2.7.10.1]
ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) [KO:K05085] [EC:2.7.10.1]
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
guanine nucleotide-binding protein G(q) subunit alpha-like; K04634 guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
guanine nucleotide-binding protein G(q) subunit alpha-like; K04634 guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
guanine nucleotide-binding protein subunit alpha-11-like; K04635 guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
guanine nucleotide-binding protein subunit alpha-15-like; K04637 guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
uncharacterized LOC100078549; K06856 immunoglobulin heavy chain [KO:K06856]
1-phosphatidylinositol-4; K05857 phosphatidylinositol phospholipase C, delta [EC:3.1.4.11] [KO:K05857] [EC:3.1.4.11]
1-phosphatidylinositol-4; K05858 phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] [KO:K05858] [EC:3.1.4.11]
1-phosphatidylinositol-4; K01116 phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11] [KO:K01116] [EC:3.1.4.11]
1-phosphatidylinositol-4; K05859 phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11] [KO:K05859] [EC:3.1.4.11]
inositol 1; K04958 inositol 1,4,5-triphosphate receptor type 1 [KO:K04958]
ADP-ribosyl cyclase 2-like; K01242 NAD+ nucleosidase [EC:3.2.2.5] [KO:K01242] [EC:3.2.2.5]
uncharacterized LOC100074315; K01242 NAD+ nucleosidase [EC:3.2.2.5] [KO:K01242] [EC:3.2.2.5]
sphingosine kinase 2-like; K04718 sphingosine kinase [EC:2.7.1.91] [KO:K04718] [EC:2.7.1.91]
sphingosine kinase 1-like; K04718 sphingosine kinase [EC:2.7.1.91] [KO:K04718] [EC:2.7.1.91]
voltage-dependent anion-selective channel protein 1-like; K05862 voltage-dependent anion channel protein 1 [KO:K05862]
voltage-dependent anion-selective channel protein 2-like; K15040 voltage-dependent anion channel protein 2 [KO:K15040]
voltage-dependent anion-selective channel protein 3-like; K15041 voltage-dependent anion channel protein 3 [KO:K15041]
ADP/ATP translocase 2-like; K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 [KO:K05863]
peptidyl-prolyl cis-trans isomerase F; K09565 peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8] [KO:K09565] [EC:5.2.1.8]
troponin C; K05865 troponin C, slow skeletal and cardiac muscles [KO:K05865]
calmodulin-like; K02183 calmodulin [KO:K02183]
uncharacterized LOC100085924; K02183 calmodulin [KO:K02183]
phosphorylase b kinase gamma catalytic chain; K00871 phosphorylase kinase gamma subunit [EC:2.7.11.19] [KO:K00871] [EC:2.7.11.19]
PHKB; phosphorylase kinase, beta [KO:K07190]
PHKA2; phosphorylase kinase, alpha 2 (liver) [KO:K07190]
putative myosin light chain kinase 3-like; K00907 myosin-light-chain kinase [EC:2.7.11.18] [KO:K00907] [EC:2.7.11.18]
myosin light chain kinase; K00907 myosin-light-chain kinase [EC:2.7.11.18] [KO:K00907] [EC:2.7.11.18]
myosin light chain kinase family member 4-like; K00907 myosin-light-chain kinase [EC:2.7.11.18] [KO:K00907] [EC:2.7.11.18]
calcium/calmodulin-dependent protein kinase type II subunit gamma-like; K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] [KO:K04515] [EC:2.7.11.17]
calcium/calmodulin-dependent protein kinase type II subunit alpha-like; K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] [KO:K04515] [EC:2.7.11.17]
calcium/calmodulin-dependent protein kinase type IV-like; K05869 calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17] [KO:K05869] [EC:2.7.11.17]
calcium/calmodulin-dependent protein kinase type IV-like; K05869 calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17] [KO:K05869] [EC:2.7.11.17]
PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
calcineurin subunit A-like; K04348 protein phosphatase 3, catalytic subunit [EC:3.1.3.16] [KO:K04348] [EC:3.1.3.16]
calcineurin subunit A-like; K04348 protein phosphatase 3, catalytic subunit [EC:3.1.3.16] [KO:K04348] [EC:3.1.3.16]
PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
calcium-binding protein p22-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
calcineurin subunit B type 1-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
NOS1; nitric oxide synthase 1 (neuronal) [KO:K13240] [EC:1.14.13.39]
NOS2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
NOS3; nitric oxide synthase 3 (endothelial cell) [KO:K13242] [EC:1.14.13.39]
PDE1A; phosphodiesterase 1A, calmodulin-dependent [KO:K13755] [EC:3.1.4.17]
calcium/calmodulin-dependent 3'; K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] [KO:K13755] [EC:3.1.4.17]
PTK2B; PTK2B protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
inositol-trisphosphate 3-kinase B-like; K00911 1D-myo-inositol-triphosphate 3-kinase [EC:2.7.1.127] [KO:K00911] [EC:2.7.1.127]
protein kinase C alpha type-like; K02677 classical protein kinase C [EC:2.7.11.13] [KO:K02677] [EC:2.7.11.13]
Compound
C00002  
ATP
C00004  
NADH
C00076  
Calcium cation
C00165  
Diacylglycerol
C00575  
3',5'-Cyclic AMP
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C01330  
Sodium cation
C06124  
Sphingosine 1-phosphate
C13050  
Cyclic ADP-ribose
C13051  
Nicotinic acid adenine dinucleotide phosphate
Reference
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
Reference
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
Reference
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
Reference
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
Reference
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
Reference
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
Reference
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
Reference
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
Reference
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
Reference
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
Reference
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
Reference
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
Reference
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
Reference
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
Reference
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
Reference
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
KO pathway
 
DBGET integrated database retrieval system