KEGG   PATHWAY: oaa04060Help
Entry
oaa04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Ornithorhynchus anatinus (platypus)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Cytokine-cytokine receptor interaction
oaa04060

All organismsOrtholog table
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
stromal cell-derived factor 1-like; K10031 C-X-C motif chemokine 12 [KO:K10031]
c-X-C motif chemokine 14-like; K10033 C-X-C motif chemokine 14 [KO:K10033]
fractalkine-like; K05508 C-X3-C motif chemokine 1 [KO:K05508]
c-C motif chemokine 20-like; K14625 C-C motif chemokine 20 [KO:K14625]
c-C motif chemokine 21-like; K16062 C-C motif chemokine 21 [KO:K16062]
c-C motif chemokine 27-like; K16598 C-C motif chemokine 27 [KO:K16598]
interleukin-6-like; K05405 interleukin 6 [KO:K05405]
leukemia inhibitory factor-like; K05419 leukemia inhibitory factor [KO:K05419]
ciliary neurotrophic factor-like; K05420 ciliary neurotrophic factor [KO:K05420]
cardiotrophin-like cytokine factor 1-like; K05421 B-cell stimulating factor 3 [KO:K05421]
cardiotrophin-1-like; K05422 cardiotrophin 1 [KO:K05422]
leptin-like; K05424 leptin [KO:K05424]
uncharacterized LOC100086041; K05406 interleukin 12A [KO:K05406]
interleukin-12 subunit beta-like; K05425 interleukin 12B [KO:K05425]
interleukin-23 subunit alpha-like; K05426 interleukin 23, alpha subunit p19 [KO:K05426]
uncharacterized LOC100681142; K05427 granulocyte-macrophage colony-stimulating factor [KO:K05427]
interleukin-15-like; K05433 interleukin 15 [KO:K05433]
TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
vascular endothelial growth factor A-like; K05448 vascular endothelial growth factor A [KO:K05448]
vascular endothelial growth factor D-like; K05449 vascular endothelial growth factor C/D [KO:K05449]
vascular endothelial growth factor C-like; K05449 vascular endothelial growth factor C/D [KO:K05449]
hepatocyte growth factor-like; K05460 hepatocyte growth factor [KO:K05460]
macrophage colony-stimulating factor 1-like; K05453 macrophage colony-stimulating factor 1 [KO:K05453]
kit ligand-like; K05461 KIT ligand [KO:K05461]
IFN2; type I interferon 2 [KO:K05414]
IFN1; type I interferon 1 [KO:K05414]
IFN3; type I interferon 3 [KO:K05414]
IFN6; type I interferon 6 [KO:K05415]
uncharacterized LOC100080275; K04687 interferon gamma [KO:K04687]
uncharacterized LOC100077352; K05443 interleukin 10 [KO:K05443]
interleukin-22-like; K05445 interleukin 22 [KO:K05445]
interleukin-26-like; K05446 interleukin 26 [KO:K05446]
tumor necrosis factor ligand superfamily member 15-like; K05478 tumor necrosis factor ligand superfamily member 15 [KO:K05478]
tumor necrosis factor ligand superfamily member 10-like; K04721 tumor necrosis factor ligand superfamily member 10 [KO:K04721]
tumor necrosis factor ligand superfamily member 11-like; K05473 tumor necrosis factor ligand superfamily member 11 [KO:K05473]
tumor necrosis factor-like; K03156 tumor necrosis factor superfamily, member 2 [KO:K03156]
LTB; lymphotoxin beta (TNF superfamily, member 3) [KO:K03157]
tumor necrosis factor ligand superfamily member 14-like; K05477 tumor necrosis factor ligand superfamily member 14 [KO:K05477]
tumor necrosis factor ligand superfamily member 6-like; K04389 tumor necrosis factor ligand superfamily member 6 [KO:K04389]
CD40 ligand-like; K03161 tumor necrosis factor ligand superfamily member 5 [KO:K03161]
tumor necrosis factor ligand superfamily member 8-like; K05471 tumor necrosis factor ligand superfamily member 8 [KO:K05471]
tumor necrosis factor ligand superfamily member 4-like; K05469 tumor necrosis factor ligand superfamily member 4 [KO:K05469]
tumor necrosis factor ligand superfamily member 18-like; K05479 tumor necrosis factor ligand superfamily member 18 [KO:K05479]
tumor necrosis factor ligand superfamily member 13B-like; K05476 tumor necrosis factor ligand superfamily member 13B [KO:K05476]
ectodysplasin-A-like; K05480 ectodysplasin-A [KO:K05480]
transforming growth factor beta-2-like; K13376 transforming growth factor beta-2 [KO:K13376]
transforming growth factor beta-3-like; K13377 transforming growth factor beta-3 [KO:K13377]
muellerian-inhibiting factor-like; K04665 anti-mullerian hormone [KO:K04665]
bone morphogenetic protein 7-like; K16621 bone morphogenetic protein 7 [KO:K16621]
interleukin-17A-like; K05489 interleukin 17 [KO:K05489]
interleukin-17B-like; K05490 interleukin 17B [KO:K05490]
interleukin-18-like; K05482 interleukin 18 [KO:K05482]
c-X-C chemokine receptor type 1-like; K05050 interleukin 8 receptor beta [KO:K05050]
c-X-C chemokine receptor type 1-like; K05050 interleukin 8 receptor beta [KO:K05050]
uncharacterized LOC100079713; K04189 C-X-C chemokine receptor type 4 [KO:K04189]
c-X-C chemokine receptor type 7-like; K04304 C-X-C chemokine receptor type 7 [KO:K04304]
chemokine XC receptor 1-like; K04193 XC chemokine receptor 1 [KO:K04193]
CX3C chemokine receptor 1-like; K04192 CX3C chemokine receptor 1 [KO:K04192]
c-C chemokine receptor type 6-like; K04181 C-C chemokine receptor type 6 [KO:K04181]
c-C chemokine receptor type 9-like; K04184 C-C chemokine receptor type 9 [KO:K04184]
c-C chemokine receptor type 4-like; K04179 C-C chemokine receptor type 4 [KO:K04179]
c-C chemokine receptor type 7-like; K04182 C-C chemokine receptor type 7 [KO:K04182]
c-C chemokine receptor type 5-like; K04180 C-C chemokine receptor type 5 [KO:K04180]
c-C chemokine receptor type 5-like; K04180 C-C chemokine receptor type 5 [KO:K04180]
c-C chemokine receptor type 1-like; K04176 C-C chemokine receptor type 1 [KO:K04176]
c-C chemokine receptor type 3-like; K04178 C-C chemokine receptor type 3 [KO:K04178]
IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor) [KO:K05060]
LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
granulocyte colony-stimulating factor receptor-like; K05061 granulocyte colony-stimulating factor receptor [KO:K05061]
LEPR; leptin receptor [KO:K05062]
interleukin-13 receptor subunit alpha-1-like; K05076 interleukin 13 receptor alpha-1 [KO:K05076]
interleukin-12 receptor subunit beta-1-like; K05063 interleukin 12 receptor beta-1 [KO:K05063]
interleukin-12 receptor subunit beta-2-like; K05064 interleukin 12 receptor beta-2 [KO:K05064]
interleukin-23 receptor-like; K05065 interleukin 23 receptor [KO:K05065]
interleukin-5 receptor subunit alpha-like; K05067 interleukin 5 receptor alpha [KO:K05067]
interleukin-2 receptor subunit beta-like; K05069 interleukin 2 receptor beta [KO:K05069]
interleukin-7 receptor subunit alpha-like; K05072 interleukin 7 receptor [KO:K05072]
uncharacterized LOC100085842; K05074 interleukin 15 receptor alpha [KO:K05074]
interleukin-21 receptor-like; K05075 interleukin 21 receptor [KO:K05075]
uncharacterized LOC100074584; K05078 thymic stromal-derived lymphopoietin receptor [KO:K05078]
erythropoietin receptor-like; K05079 erythropoietin receptor [KO:K05079]
growth hormone receptor-like; K05080 growth hormone receptor [KO:K05080]
prolactin receptor-like; K05081 prolactin receptor [KO:K05081]
thrombopoietin receptor-like; K05082 thrombopoietin receptor [KO:K05082]
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) [KO:K05096] [EC:2.7.10.1]
vascular endothelial growth factor receptor kdr-like; K05096 FMS-like tyrosine kinase 1 [EC:2.7.10.1] [KO:K05096] [EC:2.7.10.1]
KDR; kinase insert domain receptor (a type III receptor tyrosine kinase) [KO:K05098] [EC:2.7.10.1]
vascular endothelial growth factor receptor 3-like; K05097 FMS-like tyrosine kinase 4 [EC:2.7.10.1] [KO:K05097] [EC:2.7.10.1]
MET; met proto-oncogene (hepatocyte growth factor receptor) [KO:K05099] [EC:2.7.10.1]
EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [KO:K05091] [EC:2.7.10.1]
FLT3; fms-related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
interferon alpha/beta receptor 1-like; K05130 interferon receptor 1 [KO:K05130]
interferon gamma receptor 1-like; K05132 interferon gamma receptor 1 [KO:K05132]
interleukin-10 receptor subunit beta-like; K05135 interleukin 10 receptor beta [KO:K05135]
interleukin-20 receptor subunit alpha-like; K05136 interleukin 20 receptor alpha [KO:K05136]
interleukin-20 receptor subunit beta-like; K05137 interleukin 20 receptor beta [KO:K05137]
interleukin-22 receptor subunit alpha-1-like; K05138 interleukin 22 receptor alpha 1 [KO:K05138]
uncharacterized LOC100078608; K05139 interleukin 22 receptor alpha 2 [KO:K05139]
interleukin-28 receptor subunit alpha-like; K05140 interleukin 28 receptor alpha [KO:K05140]
tumor necrosis factor receptor superfamily member 11B-like; K05148 tumor necrosis factor receptor superfamily member 11B [KO:K05148]
tumor necrosis factor receptor superfamily member 11A-like; K05147 tumor necrosis factor receptor superfamily member 11A [KO:K05147]
tumor necrosis factor receptor superfamily member 25-like; K05160 tumor necrosis factor receptor superfamily member 25 [KO:K05160]
tumor necrosis factor receptor superfamily member 12A-like; K05149 tumor necrosis factor receptor superfamily member 12A [KO:K05149]
TNFRSF21; tumor necrosis factor receptor superfamily, member 21 [KO:K05157]
tumor necrosis factor receptor superfamily member 16-like; K02583 nerve growth factor receptor (TNFR superfamily member 16) [KO:K02583]
tumor necrosis factor receptor superfamily member 6B-like; K05143 tumor necrosis factor receptor superfamily member 6B [KO:K05143]
tumor necrosis factor receptor superfamily member 6-like; K04390 tumor necrosis factor receptor superfamily member 6 [KO:K04390]
tumor necrosis factor receptor superfamily member 9-like; K05146 tumor necrosis factor receptor superfamily member 9 [KO:K05146]
tumor necrosis factor receptor superfamily member 17-like; K05153 tumor necrosis factor receptor superfamily member 17 [KO:K05153]
tumor necrosis factor receptor superfamily member 13B-like; K05150 tumor necrosis factor receptor superfamily member 13B [KO:K05150]
tumor necrosis factor receptor superfamily member EDAR-like; K05162 tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
TGF-beta receptor type-1-like; K04674 TGF-beta receptor type-1 [EC:2.7.11.30] [KO:K04674] [EC:2.7.11.30]
uncharacterized LOC100089503; K04670 activin receptor type-2A [EC:2.7.11.30] [KO:K04670] [EC:2.7.11.30]
ACVR1; activin A receptor, type I [KO:K04675] [EC:2.7.11.30]
bone morphogenetic protein receptor type-2-like; K04671 bone morphogenetic protein receptor type-2 [EC:2.7.11.30] [KO:K04671] [EC:2.7.11.30]
BMPR1A; bone morphogenetic protein receptor, type IA [KO:K04673] [EC:2.7.11.30]
bone morphogenetic protein receptor type-1B-like; K13578 bone morphogenetic protein receptor type-1B [EC:2.7.11.30] [KO:K13578] [EC:2.7.11.30]
interleukin-17 receptor B-like; K05165 interleukin 17 receptor B [KO:K05165]
interleukin-1 receptor type 1-like; K04386 interleukin 1 receptor type I [KO:K04386]
interleukin-1 receptor accessory protein-like; K04723 interleukin 1 receptor accessory protein [KO:K04723]
interleukin-1 receptor type 2-like; K04387 interleukin 1 receptor type II [KO:K04387]
interleukin-18 receptor accessory protein-like; K05174 interleukin 18 receptor accessory protein [KO:K05174]
Reference
  Authors
Oppenheim JJ, Feldman M (ed).
  Title
Cytokine Reference
  Journal
Academic Press (2001)
Reference
  Authors
Thomson AW, Lotze MT (ed).
  Title
The Cytokine Handbook (Fourth edition)
  Journal
Academic Press (2003)
Reference
  Authors
Zlotnik A, Yoshie O.
  Title
Chemokines: a new classification system and their role in immunity.
  Journal
Immunity 12:121-7 (2000)
Reference
  Authors
Ozaki K, Leonard WJ.
  Title
Cytokine and cytokine receptor pleiotropy and redundancy.
  Journal
J Biol Chem 277:29355-8 (2002)
Reference
  Authors
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW.
  Title
Signaling through the JAK/STAT pathway, recent advances and future challenges.
  Journal
Gene 285:1-24 (2002)
Reference
  Authors
Li X, Eriksson U.
  Title
Novel PDGF family members: PDGF-C and PDGF-D.
  Journal
Cytokine Growth Factor Rev 14:91-8 (2003)
Reference
  Authors
Li X, Eriksson U.
  Title
Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D.
  Journal
Int J Biochem Cell Biol 33:421-6 (2001)
Reference
  Authors
Zachary I, Gliki G.
  Title
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.
  Journal
Cardiovasc Res 49:568-81 (2001)
Reference
  Authors
Dey A, She H, Kim L, Boruch A, Guris DL, Carlberg K, Sebti SM, Woodley DT, Imamoto A, Li W.
  Title
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.
  Journal
Mol Biol Cell 11:3835-48 (2000)
Reference
  Authors
Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB.
  Title
Interleukin-10 and related cytokines and receptors.
  Journal
Annu Rev Immunol 22:929-79 (2004)
Reference
  Authors
Bodmer JL, Schneider P, Tschopp J.
  Title
The molecular architecture of the TNF superfamily.
  Journal
Trends Biochem Sci 27:19-26 (2002)
Reference
PMID:9395284
  Authors
Derynck R, Feng XH.
  Title
TGF-beta receptor signaling.
  Journal
Biochim Biophys Acta 1333:F105-50 (1997)
Reference
PMID:7791754
  Authors
Liu F, Ventura F, Doody J, Massague J.
  Title
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
  Journal
Mol Cell Biol 15:3479-86 (1995)
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)
Reference
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
Reference
  Authors
Moseley TA, Haudenschild DR, Rose L, Reddi AH.
  Title
Interleukin-17 family and IL-17 receptors.
  Journal
Cytokine Growth Factor Rev 14:155-74 (2003)
Reference
  Authors
Martin MU, Wesche H.
  Title
Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family.
  Journal
Biochim Biophys Acta 1592:265-80 (2002)
Reference
PMID:9862719
  Authors
Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU.
  Title
The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.
  Journal
J Immunol 161:6871-7 (1998)
KO pathway
 
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