KEGG   PATHWAY: oaa04140Help
Entry
oaa04140                    Pathway                                

Name
Autophagy - animal - Ornithorhynchus anatinus (platypus)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Autophagy - animal
oaa04140

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Other DBs
BSID: 
GO: 
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
MRAS; muscle RAS oncogene homolog [KO:K07831]
RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
DDIT4; DNA damage inducible transcript 4 [KO:K08270]
TSC2; tuberous sclerosis 2 [KO:K07207]
TSC1; tuberous sclerosis 1 [KO:K07206]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
RHEB; Ras homolog enriched in brain [KO:K07208]
DEPTOR; DEP domain containing MTOR interacting protein [KO:K20402]
MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
IGBP1; immunoglobulin binding protein 1 [KO:K17606]
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
ATG13; autophagy related 13 [KO:K08331]
RB1CC1; RB1 inducible coiled-coil 1 [KO:K17589]
ATG2B; autophagy related 2B [KO:K17906]
WIPI1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
WIPI2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
ATG9A; autophagy related 9A [KO:K17907]
SUPT20H; SPT20 homolog, SAGA complex component [KO:K21245]
ras-related GTP-binding protein A-like [KO:K16185]
ras-related GTP-binding protein A-like [KO:K16185]
RRAGC; Ras related GTP binding C [KO:K16186]
RRAGD; ras-related GTP-binding protein D [KO:K16186]
STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.11]
PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
protein kinase C theta type-like [KO:K06068] [EC:2.7.11.13]
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
BECN1; beclin 1 [KO:K08334]
NRBF2; nuclear receptor binding factor 2 [KO:K21246]
PIK3R4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
ATG14; autophagy related 14 [KO:K17889]
AMBRA1; autophagy and beclin 1 regulator 1 [KO:K17985]
TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
VMP1; vacuole membrane protein 1 [KO:K21248]
STX17; syntaxin 17 [KO:K08491]
UVRAG; UV radiation resistance associated [KO:K21249]
SH3GLB1; SH3 domain containing GRB2 like endophilin B1 [KO:K11248]
run domain Beclin-1-interacting and cysteine-rich domain-containing protein-like [KO:K19330]
CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:3.1.26.- 2.7.11.1]
ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
DAPK3; death associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
HMGB1; high mobility group box 1 [KO:K10802]
EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
MTMR3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
MTMR4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
MTMR14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.95 3.1.3.64]
ZFYVE1; zinc finger FYVE-type containing 1 [KO:K17603]
zinc finger FYVE domain-containing protein 1-like [KO:K17603]
zinc finger FYVE domain-containing protein 1-like [KO:K17603]
ATG5; autophagy related 5 [KO:K08339]
ATG16L1; autophagy related 16 like 1 [KO:K17890]
ATG16L2; autophagy related 16 like 2 [KO:K20868]
ATG7; autophagy related 7 [KO:K08337]
ATG10; autophagy related 10 [KO:K17888]
ATG3; autophagy related 3 [KO:K08343]
CFLAR; CASP8 and FADD like apoptosis regulator [KO:K04724]
RAB33B; RAB33B, member RAS oncogene family [KO:K07920]
PRKCQ; protein kinase C theta [KO:K18052] [EC:2.7.11.13]
GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
GABARAPL2; GABA type A receptor associated protein like 2 [KO:K08341]
ATG4C; autophagy related 4C cysteine peptidase [KO:K08342] [EC:3.4.22.-]
ATG4B; autophagy related 4B cysteine peptidase [KO:K08342] [EC:3.4.22.-]
ATG4A; autophagy related 4A cysteine peptidase [KO:K08342] [EC:3.4.22.-]
LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
SNAP29; synaptosome associated protein 29 [KO:K08509]
cathepsin D-like [KO:K01379] [EC:3.4.23.5]
cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
Compound
C00350  
Phosphatidylethanolamine
C01194  
1-Phosphatidyl-D-myo-inositol
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
Reference
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
Reference
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
Reference
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
Reference
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
Reference
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
Reference
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
Reference
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
Reference
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
Reference
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
Reference
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
Reference
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
Reference
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
Reference
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
Reference
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
KO pathway
 

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