Cysteine and methionine metabolism - Ostreococcus lucimarinus

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Metabolism; Amino acid metabolism

Ostreococcus lucimarinus [GN:olu]

PMID:15102328

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BMC Microbiol 4:9 (2004)

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BMC Microbiol 2:8 (2002)

PMID:12670965

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Plant Cell Physiol 48:232-42 (2007)

PMID:17030798

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Proc Natl Acad Sci U S A 103:15687-92 (2006)

PMID:18625006

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FEBS J 275:4111-20 (2008)

PMID:18391471

Ashida H, Saito Y, Kojima C, Yokota A

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Biosci Biotechnol Biochem 72:959-67 (2008)

PMID:10613873

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J Bacteriol 182:143-5 (2000)

PMID:12644499

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Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

J Bacteriol 185:2277-84 (2003)

PMID:18520135

Tanabe S

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Yakugaku Zasshi 128:881-900 (2008)

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Tokyo Kagaku Dojin (1997)

PMID:19270684

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Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.

Nat Chem Biol 5:251-7 (2009)