KEGG   PATHWAY: opr00010
Entry
opr00010                    Pathway                                
Name
Glycolysis / Gluconeogenesis - Oceanithermus profundus
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
opr00010  Glycolysis / Gluconeogenesis
opr00010

Module
opr_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:opr00010]
opr_M00002  Glycolysis, core module involving three-carbon compounds [PATH:opr00010]
opr_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:opr00010]
opr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:opr00010]
Other DBs
GO: 0006096 0006094
Organism
Oceanithermus profundus [GN:opr]
Gene
Ocepr_1700  glucokinase [KO:K25026] [EC:2.7.1.2]
Ocepr_0148  glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
Ocepr_1695  6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
Ocepr_1301  fructose-1,6-bisphosphatase, class II [KO:K02446] [EC:3.1.3.11]
Ocepr_0454  fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
Ocepr_1141  triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
Ocepr_1139  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
Ocepr_1140  phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
Ocepr_0246  phosphoglycerate mutase [KO:K15635] [EC:5.4.2.12]
Ocepr_0003  enolase [KO:K01689] [EC:4.2.1.11]
Ocepr_0004  pyruvate kinase [KO:K00873] [EC:2.7.1.40]
Ocepr_0928  pyruvate phosphate dikinase [KO:K01006] [EC:2.7.9.1]
Ocepr_0765  phosphoenolpyruvate synthase [KO:K01007] [EC:2.7.9.2]
Ocepr_1753  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Ocepr_1062  thiamine pyrophosphate TPP-binding domain-containing protein [KO:K00170] [EC:1.2.7.1]
Ocepr_1061  pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K03737] [EC:1.2.7.1 1.2.7.-]
Ocepr_1761  pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K00174] [EC:1.2.7.3 1.2.7.11]
Ocepr_1225  pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K00174] [EC:1.2.7.3 1.2.7.11]
Ocepr_1762  pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit [KO:K00175] [EC:1.2.7.3 1.2.7.11]
Ocepr_1224  pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit [KO:K00175] [EC:1.2.7.3 1.2.7.11]
Ocepr_0923  acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
Ocepr_1473  AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
Ocepr_0290  HAD-superfamily hydrolase, subfamily IA, variant 3 [KO:K20866] [EC:3.1.3.10]
Ocepr_0495  phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
opr00020  Citrate cycle (TCA cycle)
opr00030  Pentose phosphate pathway
opr00500  Starch and sucrose metabolism
opr00620  Pyruvate metabolism
opr00640  Propanoate metabolism
KO pathway
ko00010   

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