KEGG   PATHWAY: pad03440
Entry
pad03440                    Pathway                                
Name
Homologous recombination - Cutibacterium acnes subsp. defendens ATCC 11828
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
pad03440  Homologous recombination
pad03440

Other DBs
GO: 0000724
Organism
Cutibacterium acnes subsp. defendens ATCC 11828 [GN:pad]
Gene
TIIST44_01000  single-strand binding family protein [KO:K03111]
TIIST44_03955  single-strand binding family protein [KO:K03111]
TIIST44_04630  recF; recombination protein F [KO:K03629]
TIIST44_09930  recO; DNA repair protein RecO [KO:K03584]
TIIST44_05720  recombination protein RecR [KO:K06187]
TIIST44_09570  protein RecA [KO:K03553]
TIIST44_10565  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
TIIST44_08840  holliday junction DNA helicase RuvA [KO:K03550]
TIIST44_08835  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
TIIST44_08845  Holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
TIIST44_00310  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
TIIST44_08015  putative exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
TIIST44_08020  putative exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
TIIST44_08010  exonuclease V, alpha chain [KO:K03581] [EC:3.1.11.5]
TIIST44_08885  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
TIIST44_04620  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
TIIST44_05710  DNA polymerase III, subunit gamma and tau [KO:K02343] [EC:2.7.7.7]
TIIST44_10170  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
TIIST44_05915  DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
TIIST44_10850  hypothetical protein [KO:K02342] [EC:2.7.7.7]
TIIST44_01455  putative DNA polymerase III epsilon subunit (exonuclease) [KO:K02342] [EC:2.7.7.7]
TIIST44_08660  primosome assembly protein PriA [KO:K04066] [EC:5.6.2.4]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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