Entry |
|
Name |
Homologous recombination - Pseudomonas aeruginosa LESB58
|
Description |
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
|
Class |
Genetic Information Processing; Replication and repair
 |
Pathway map |

 |
Module |
|
Other DBs |
|
Organism |
Pseudomonas aeruginosa LESB58 [GN: pag]
|
Gene |
PLES_12571 | recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-] |
|
Reference |
|
Authors |
Maloisel L, Fabre F, Gangloff S. |
Title |
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension. |
Journal |
|
Reference |
|
Authors |
Haruta-Takahashi N, Iwasaki H. |
Title |
[Recombination mediators] Japanese |
Journal |
Seikagaku 79:449-53 (2007) |
Reference |
|
Authors |
Ouyang KJ, Woo LL, Ellis NA. |
Title |
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases. |
Journal |
|
Reference |
|
Authors |
Kawabata M, Kawabata T, Nishibori M. |
Title |
Role of recA/RAD51 family proteins in mammals. |
Journal |
Acta Med Okayama 59:1-9 (2005) |
Reference |
|
Authors |
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A. |
Title |
Mitotic recombination in Saccharomyces cerevisiae. |
Journal |
|
Reference |
|
Authors |
Heyer WD, Li X, Rolfsmeier M, Zhang XP. |
Title |
Rad54: the Swiss Army knife of homologous recombination? |
Journal |
|
Reference |
|
Authors |
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R. |
Title |
Recombination proteins and rescue of arrested replication forks. |
Journal |
|
KO pathway |
|