KEGG   PATHWAY: pag03440Help
Entry
pag03440                    Pathway                                

Name
Homologous recombination - Pseudomonas aeruginosa LESB58
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
pag03440

All organismsOrtholog table
Module
DNA polymerase III complex, bacteria [PATH:pag03440]
Other DBs
BSID: 
GO: 
Organism
Pseudomonas aeruginosa LESB58 [GN:pag]
Gene
recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Putative single-stranded DNA binding protein [KO:K03111]
ssb; single-stranded DNA-binding protein [KO:K03111]
recF; RecF protein [KO:K03629]
recO; DNA repair protein RecO [KO:K03584]
recR; recombination protein RecR [KO:K06187]
recA; RecA protein [KO:K03553]
polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
ruvC; Holliday junction resolvase RuvC [KO:K01159] [EC:3.1.22.4]
recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
recB; exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
recC; exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
recD; exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
dnaE; DNA polymerase III, alpha chain [KO:K02337] [EC:2.7.7.7]
dnaN; DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
dnaX; DNA polymerase subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
probable nuclease [KO:K02342] [EC:2.7.7.7]
dnaQ; DNA polymerase III, epsilon chain [KO:K02342] [EC:2.7.7.7]
holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
 
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