KEGG   PATHWAY: pag03440Help
Entry
pag03440                    Pathway                                

Name
Homologous recombination - Pseudomonas aeruginosa LESB58
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
pag03440  Homologous recombination
pag03440

Ortholog table
Module
pag_M00260  DNA polymerase III complex, bacteria [PATH:pag03440]
Other DBs
BSID: 79113
GO: 0000724
Organism
Pseudomonas aeruginosa LESB58 [GN:pag]
Gene
PLES_12571  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
PLES_27021  Putative single-stranded DNA binding protein [KO:K03111]
PLES_06951  ssb; single-stranded DNA-binding protein [KO:K03111]
PLES_00021  recF; RecF protein [KO:K03629]
PLES_45711  recO; DNA repair protein RecO [KO:K03584]
PLES_37941  recR; recombination protein RecR [KO:K06187]
PLES_14181  recA; RecA protein [KO:K03553]
PLES_58891  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
PLES_43481  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
PLES_43471  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
PLES_43491  ruvC; Holliday junction resolvase RuvC [KO:K01159] [EC:3.1.22.4]
PLES_57401  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
PLES_46641  recB; exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
PLES_46651  recC; exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
PLES_46631  recD; exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
PLES_13951  dnaE; DNA polymerase III, alpha chain [KO:K02337] [EC:2.7.7.7]
PLES_00011  dnaN; DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
PLES_37961  dnaX; DNA polymerase subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
PLES_09861  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
PLES_21021  holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
PLES_18351  probable nuclease [KO:K02342] [EC:2.7.7.7]
PLES_35111  dnaQ; DNA polymerase III, epsilon chain [KO:K02342] [EC:2.7.7.7]
PLES_11421  holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
PLES_54401  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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