KEGG PATHWAY: pba00260

PATHWAY: pba00260

Entry

pba00260 Pathway

Name

Glycine, serine and threonine metabolism - Pseudomonas brassicacearum

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

pba00260

Glycine, serine and threonine metabolism

Module

pba_M00018	Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pba00260]
pba_M00020	Serine biosynthesis, glycerate-3P => serine [PATH:pba00260]
pba_M00033	Ectoine biosynthesis, aspartate => ectoine [PATH:pba00260]
pba_M00555	Betaine biosynthesis, choline => betaine [PATH:pba00260]

Other DBs

BSID:

216784

GO:

0006544 0006563 0070178 0006566

Organism

Pseudomonas brassicacearum [GN:pba]

Gene

PSEBR_a4309	aspartate kinase; K00928 aspartate kinase [EC:2.7.2.4] [KO:K00928] [EC:2.7.2.4]
PSEBR_a3864	aspartate-semialdehyde dehydrogenase; K00133 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] [KO:K00133] [EC:1.2.1.11]
PSEBR_a5638	aspartate-semialdehyde dehydrogenase; K00133 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] [KO:K00133] [EC:1.2.1.11]
PSEBR_a996	homoserine dehydrogenase; K00003 homoserine dehydrogenase [EC:1.1.1.3] [KO:K00003] [EC:1.1.1.3]
PSEBR_a4997	homoserine dehydrogenase; K00003 homoserine dehydrogenase [EC:1.1.1.3] [KO:K00003] [EC:1.1.1.3]
PSEBR_a38	Homoserine kinase; K02204 homoserine kinase type II [EC:2.7.1.39] [KO:K02204] [EC:2.7.1.39]
PSEBR_a3964	phosphoserine phosphatase; K02203 phosphoserine / homoserine phosphotransferase [EC:3.1.3.3 2.7.1.39] [KO:K02203] [EC:2.7.1.39 3.1.3.3]
PSEBR_a997	threonine synthase; K01733 threonine synthase [EC:4.2.3.1] [KO:K01733] [EC:4.2.3.1]
PSEBR_a4690	threonine synthase; K01733 threonine synthase [EC:4.2.3.1] [KO:K01733] [EC:4.2.3.1]
PSEBR_a4999	threonine synthase; K01733 threonine synthase [EC:4.2.3.1] [KO:K01733] [EC:4.2.3.1]
PSEBR_a4311	Threonine aldolase; K01620 threonine aldolase [EC:4.1.2.5] [KO:K01620] [EC:4.1.2.5]
PSEBR_a5217	L-threonine aldolase; K01620 threonine aldolase [EC:4.1.2.5] [KO:K01620] [EC:4.1.2.5]
PSEBR_a4691	glycine hydroxymethyltransferase; K00600 glycine hydroxymethyltransferase [EC:2.1.2.1] [KO:K00600] [EC:2.1.2.1]
PSEBR_a3880	glycine hydroxymethyltransferase; K00600 glycine hydroxymethyltransferase [EC:2.1.2.1] [KO:K00600] [EC:2.1.2.1]
PSEBR_a4879	glycine hydroxymethyltransferase; K00600 glycine hydroxymethyltransferase [EC:2.1.2.1] [KO:K00600] [EC:2.1.2.1]
PSEBR_a5215	glycine hydroxymethyltransferase; K00600 glycine hydroxymethyltransferase [EC:2.1.2.1] [KO:K00600] [EC:2.1.2.1]
PSEBR_a525	phosphoserine phosphatase; K01079 phosphoserine phosphatase [EC:3.1.3.3] [KO:K01079] [EC:3.1.3.3]
PSEBR_a1549	phosphoserine aminotransferase; K00831 phosphoserine aminotransferase [EC:2.6.1.52] [KO:K00831] [EC:2.6.1.52]
PSEBR_a255	phosphoglycerate dehydrogenase; K00058 D-3-phosphoglycerate dehydrogenase [EC:1.1.1.95] [KO:K00058] [EC:1.1.1.95]
PSEBR_a3401	glycerate kinase; K00865 glycerate kinase [EC:2.7.1.31] [KO:K00865] [EC:2.7.1.31]
PSEBR_a351	phosphoglycerate mutase; K15633 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.1] [KO:K15633] [EC:5.4.2.1]
PSEBR_a4159	hydroxypyruvate reductase; K00050 hydroxypyruvate reductase [EC:1.1.1.81] [KO:K00050] [EC:1.1.1.81]
PSEBR_a3492	dehydrogenase; K12972 gyoxylate/hydroxypyruvate reductase A [EC:1.1.1.79 1.1.1.81] [KO:K12972] [EC:1.1.1.81 1.1.1.79]
PSEBR_a5290	flavin-containing amine oxidoreductase; K00274 monoamine oxidase [EC:1.4.3.4] [KO:K00274] [EC:1.4.3.4]
PSEBR_a4420	glycine dehydrogenase; K00281 glycine dehydrogenase [EC:1.4.4.2] [KO:K00281] [EC:1.4.4.2]
PSEBR_a2219	aminomethyltransferase; K00605 aminomethyltransferase [EC:2.1.2.10] [KO:K00605] [EC:2.1.2.10]
PSEBR_a2222	aminomethyltransferase; K00605 aminomethyltransferase [EC:2.1.2.10] [KO:K00605] [EC:2.1.2.10]
PSEBR_a4422	aminomethyltransferase; K00605 aminomethyltransferase [EC:2.1.2.10] [KO:K00605] [EC:2.1.2.10]
PSEBR_a5427	glycine cleavage system T protein; K00605 aminomethyltransferase [EC:2.1.2.10] [KO:K00605] [EC:2.1.2.10]
PSEBR_a3381	dihydrolipoyl dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
PSEBR_a4138	dihydrolipoyl dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
PSEBR_a5619	dihydrolipoyl dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
PSEBR_a2945	CDP-diacylglycerol-serine-O-phosphatidyltransferase; K00998 phosphatidylserine synthase [EC:2.7.8.8] [KO:K00998] [EC:2.7.8.8]
PSEBR_a4791	CDP-diacylglycerol--serine O-phosphatidyltransferase; K00998 phosphatidylserine synthase [EC:2.7.8.8] [KO:K00998] [EC:2.7.8.8]
PSEBR_a1923	choline dehydrogenase; K00108 choline dehydrogenase [EC:1.1.99.1] [KO:K00108] [EC:1.1.99.1]
PSEBR_a5248	choline dehydrogenase; K00108 choline dehydrogenase [EC:1.1.99.1] [KO:K00108] [EC:1.1.99.1]
PSEBR_a5247	betaine-aldehyde dehydrogenase; K00130 betaine-aldehyde dehydrogenase [EC:1.2.1.8] [KO:K00130] [EC:1.2.1.8]
PSEBR_a4501	dehydrogenase; K00130 betaine-aldehyde dehydrogenase [EC:1.2.1.8] [KO:K00130] [EC:1.2.1.8]
PSEBR_a2206	sarcosine oxidase subunit alpha; K00302 sarcosine oxidase, subunit alpha [EC:1.5.3.1] [KO:K00302] [EC:1.5.3.1]
PSEBR_a5212	sarcosine oxidase subunit alpha; K00302 sarcosine oxidase, subunit alpha [EC:1.5.3.1] [KO:K00302] [EC:1.5.3.1]
PSEBR_a2208	sarcosine oxidase subunit beta; K00303 sarcosine oxidase, subunit beta [EC:1.5.3.1] [KO:K00303] [EC:1.5.3.1]
PSEBR_c2g40	oxidoreductase; K00303 sarcosine oxidase, subunit beta [EC:1.5.3.1] [KO:K00303] [EC:1.5.3.1]
PSEBR_a3498	oxidoreductase; K00303 sarcosine oxidase, subunit beta [EC:1.5.3.1] [KO:K00303] [EC:1.5.3.1]
PSEBR_a3510	oxidoreductase; K00303 sarcosine oxidase, subunit beta [EC:1.5.3.1] [KO:K00303] [EC:1.5.3.1]
PSEBR_a5214	sarcosine oxidase subunit beta; K00303 sarcosine oxidase, subunit beta [EC:1.5.3.1] [KO:K00303] [EC:1.5.3.1]
PSEBR_a2205	sarcosine oxidase subunit gamma; K00305 sarcosine oxidase, subunit gamma [EC:1.5.3.1] [KO:K00305] [EC:1.5.3.1]
PSEBR_a5211	sarcosine oxidase subunit gamma; K00305 sarcosine oxidase, subunit gamma [EC:1.5.3.1] [KO:K00305] [EC:1.5.3.1]
PSEBR_a2207	sarcosine oxidase subunit delta; K00304 sarcosine oxidase, subunit delta [EC:1.5.3.1] [KO:K00304] [EC:1.5.3.1]
PSEBR_a5213	sarcosine oxidase subunit delta; K00304 sarcosine oxidase, subunit delta [EC:1.5.3.1] [KO:K00304] [EC:1.5.3.1]
PSEBR_a4421	L-serine ammonia-lyase; K01752 L-serine dehydratase [EC:4.3.1.17] [KO:K01752] [EC:4.3.1.17]
PSEBR_a5242	L-serine dehydratase; K01752 L-serine dehydratase [EC:4.3.1.17] [KO:K01752] [EC:4.3.1.17]
PSEBR_a2478	threonine dehydratase; K01754 threonine dehydratase [EC:4.3.1.19] [KO:K01754] [EC:4.3.1.19]
PSEBR_a249	threonine ammonia-lyase; K01754 threonine dehydratase [EC:4.3.1.19] [KO:K01754] [EC:4.3.1.19]
PSEBR_a3094	threonine ammonia-lyase; K01754 threonine dehydratase [EC:4.3.1.19] [KO:K01754] [EC:4.3.1.19]
PSEBR_a4655	threonine ammonia-lyase; K01754 threonine dehydratase [EC:4.3.1.19] [KO:K01754] [EC:4.3.1.19]
PSEBR_a146	Tryptophan synthase subunit alpha; K01695 tryptophan synthase alpha chain [EC:4.2.1.20] [KO:K01695] [EC:4.2.1.20]
PSEBR_a145	Tryptophan synthase subunit beta; K01696 tryptophan synthase beta chain [EC:4.2.1.20] [KO:K01696] [EC:4.2.1.20]
PSEBR_a1674	diaminobutyrate--2-oxoglutarate transaminase; K00836 diaminobutyrate-2-oxoglutarate transaminase [EC:2.6.1.76] [KO:K00836] [EC:2.6.1.76]
PSEBR_a4653	hypothetical protein; K15783 ectoine hydrolase [KO:K15783]
PSEBR_a4652	hypothetical protein; K15784 N-alpha-acetyl-L-2,4-diaminobutyrate deacetylase [EC:3.5.1.-] [KO:K15784] [EC:3.5.1.-]
PSEBR_a4649	aminotransferase; K15785 L-2,4-diaminobutyrate transaminase [EC:2.6.1.-] [KO:K15785] [EC:2.6.1.-]
PSEBR_a4650	succinate-semialdehyde dehydrogenase (NAD(P)(+)); K15786 aspartate-semialdehyde dehydrogenase [EC:1.2.1.-] [KO:K15786] [EC:1.2.1.-]

Compound

C00011	CO2
C00014	NH3
C00022	Pyruvate
C00037	Glycine
C00048	Glyoxylate
C00049	L-Aspartate
C00065	L-Serine
C00078	L-Tryptophan
C00097	L-Cysteine
C00101	Tetrahydrofolate
C00109	2-Oxobutanoate
C00114	Choline
C00143	5,10-Methylenetetrahydrofolate
C00168	Hydroxypyruvate
C00188	L-Threonine
C00197	3-Phospho-D-glycerate
C00213	Sarcosine
C00258	D-Glycerate
C00263	L-Homoserine
C00300	Creatine
C00430	5-Aminolevulinate
C00441	L-Aspartate 4-semialdehyde
C00546	Methylglyoxal
C00576	Betaine aldehyde
C00581	Guanidinoacetate
C00631	2-Phospho-D-glycerate
C00719	Betaine
C00740	D-Serine
C00986	1,3-Diaminopropane
C01005	O-Phospho-L-serine
C01026	N,N-Dimethylglycine
C01102	O-Phospho-L-homoserine
C01242	S-Aminomethyldihydrolipoylprotein
C01726	D-Lombricine
C01888	Aminoacetone
C02051	Lipoylprotein
C02291	L-Cystathionine
C02737	Phosphatidylserine
C02855	N-Phospho-D-lombricine
C02972	Dihydrolipoylprotein
C03082	4-Phospho-L-aspartate
C03194	(R)-1-Aminopropan-2-ol
C03232	3-Phosphonooxypyruvate
C03283	L-2,4-Diaminobutanoate
C03508	L-2-Amino-3-oxobutanoic acid
C05235	Hydroxyacetone
C05519	L-Allothreonine
C06231	Ectoine
C06442	N-gamma-Acetyldiaminobutyrate
C16432	5-Hydroxyectoine
C19929	N-alpha-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)

Reference

PMID:7639721

Authors

Rees WD, Hay SM

Title

The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.

Journal

Biochem J 309 ( Pt 3):999-1007 (1995)

Reference

PMID:11341914

Authors

Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD

Title

Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.

Journal

Biochim Biophys Acta 1544:28-41 (2001)

Reference

PMID:15520012

Authors

Chen X, Jhee KH, Kruger WD

Title

Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.

Journal

J Biol Chem 279:52082-6 (2004)

KO pathway

ko00260

All links

Pathway (4)   
   KEGG MODULE (3)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (62)   
   KEGG GENES (62)   
All databases (67)   

Download RDF

DBGET integrated database retrieval system