| Entry |
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| Name |
mRNA surveillance pathway - Plasmodium berghei
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| Description |
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
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| Class |
Genetic Information Processing; Translation
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| Pathway map |
| mRNA surveillance pathway |
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| Module |
| | | Exon junction complex (EJC) [PATH: pbe03015] |
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| Other DBs |
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| Organism |
Plasmodium berghei [GN: pbe]
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| Gene |
| nuclear cap-binding protein; K12883 nuclear cap-binding protein subunit 2 [KO: K12883] | | RNA binding protein; K12876 RNA-binding protein 8A [KO: K12876] | | mago nashi protein; K12877 protein mago nashi [KO: K12877] | | | | | | hypothetical protein; K13171 serine/arginine repetitive matrix protein 1 [KO: K13171] | | RNA-binding protein; K14396 polyadenylate-binding protein 2 [KO: K14396] | | mRNA cleavage factor-like protein; K14397 cleavage and polyadenylation specificity factor subunit 5 [KO: K14397] | | | | | | cleavage and polyadenylation specifity factor protein; K14403 cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] [KO: K14403] [EC:3.1.27.-] | | hypothetical protein; K14962 COMPASS component SWD2 [KO: K14962] | | serine/threonine protein phosphatase; K06269 protein phosphatase 1, catalytic subunit [EC: 3.1.3.16] [KO: K06269] [EC: 3.1.3.16] | | mRNA processing protein; K14407 cleavage stimulation factor subunit 2 [KO: K14407] | | RNA binding protein; K14411 RNA-binding protein Musashi [KO: K14411] | | polyadenylate-binding protein; K13126 polyadenylate-binding protein [KO: K13126] | | peptide chain release factor subunit 1; K03265 peptide chain release factor subunit 1 [KO: K03265] | | translation elongation factor EF-1; K03267 peptide chain release factor subunit 3 [KO: K03267] | | regulator of nonsense transcripts; K14326 regulator of nonsense transcripts 1 [EC:3.6.4.-] [KO: K14326] [EC:3.6.4.-] | | Protein phosphatase-beta; K04382 protein phosphatase 2 (formerly 2A), catalytic subunit [EC: 3.1.3.16] [KO: K04382] [EC: 3.1.3.16] | | hypothetical protein; K11583 protein phosphatase 2 (formerly 2A), regulatory subunit B'' [KO: K11583] | | PelOta protein; K06965 protein pelota [KO: K06965] | | hypothetical protein; K06965 protein pelota [KO: K06965] |
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| Reference |
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| Authors |
Maquat LE |
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| Title |
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. |
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| Journal |
Nat Rev Mol Cell Biol 5:89-99 (2004) |
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| Reference |
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| Authors |
Amrani N, Sachs MS, Jacobson A |
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| Title |
Early nonsense: mRNA decay solves a translational problem. |
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| Journal |
Nat Rev Mol Cell Biol 7:415-25 (2006) |
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| Reference |
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| Authors |
Eulalio A, Behm-Ansmant I, Izaurralde E |
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| Title |
P bodies: at the crossroads of post-transcriptional pathways. |
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| Journal |
Nat Rev Mol Cell Biol 8:9-22 (2007) |
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| Reference |
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| Authors |
Mandel CR, Bai Y, Tong L |
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| Title |
Protein factors in pre-mRNA 3'-end processing. |
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| Journal |
Cell Mol Life Sci 65:1099-122 (2008) |
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| Reference |
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| Authors |
Clement SL, Lykke-Andersen J |
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| Title |
No mercy for messages that mess with the ribosome. |
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| Journal |
Nat Struct Mol Biol 13:299-301 (2006) |
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| KO pathway |
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