KEGG   PATHWAY: pbl03440
Entry
pbl03440                    Pathway                                
Name
Homologous recombination - Paracoccidioides lutzii Pb01
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
pbl03440  Homologous recombination
pbl03440

Other DBs
GO: 0000724
Organism
Paracoccidioides lutzii Pb01 [GN:pbl]
Gene
PAAG_12326  PAAG_07058; hypothetical protein [KO:K10866] [EC:3.6.-.-]
PAAG_05247  double-strand break repair protein mus-23 [KO:K10865]
PAAG_02532  ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
PAAG_02875  hypothetical protein [KO:K10881]
PAAG_08657  hypothetical protein [KO:K10958]
PAAG_00294  replication factor-A protein [KO:K07466]
PAAG_03970  replication factor-A protein [KO:K10739]
PAAG_02879  DNA repair protein RAD51 [KO:K04482]
PAAG_07572  RAD52 DNA repair protein RADC [KO:K10873]
PAAG_05045  SNF2 family N-terminal domain containing protein [KO:K10875] [EC:5.6.2.-]
PAAG_02129  hypothetical protein [KO:K10877] [EC:5.6.2.-]
PAAG_06601  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
PAAG_00711  DNA polymerase subunit delta-2 [KO:K02328]
PAAG_05160  hypothetical protein [KO:K03505]
PAAG_01087  ATP-dependent DNA helicase Q1 [KO:K10901] [EC:5.6.2.4]
PAAG_05109  DNA topoisomerase [KO:K03165] [EC:5.6.2.1]
PAAG_07155  crossover junction endonuclease mus81 [KO:K08991] [EC:3.1.22.-]
PAAG_05193  hypothetical protein [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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