KEGG   PATHWAY: pbl04146
Entry
pbl04146                    Pathway                                
Name
Peroxisome - Paracoccidioides lutzii Pb01
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
pbl04146  Peroxisome
pbl04146

Other DBs
GO: 0005777
Organism
Paracoccidioides lutzii Pb01 [GN:pbl]
Gene
PAAG_08421  peroxisomal membrane protein PEX16 [KO:K13335]
PAAG_00484  peroxin 3 [KO:K13336]
PAAG_02064  hypothetical protein [KO:K13337]
PAAG_06723  peroxisome biosynthesis protein PAS1 [KO:K13338]
PAAG_11349  PAAG_01716; hypothetical protein [KO:K13339]
PAAG_02155  peroxisomal targeting signal 2 receptor [KO:K13341]
PAAG_01896  peroxin 14 [KO:K13343]
PAAG_04809  hypothetical protein [KO:K13344]
PAAG_06581  peroxisome assembly protein [KO:K13345]
PAAG_08678  peroxisome assembly protein [KO:K13346]
PAAG_05772  peroxisomal biogenesis factor 2 [KO:K06664]
PAAG_09044  hypothetical protein [KO:K13348]
PAAG_04749  hypothetical protein [KO:K13350]
PAAG_08209  peroxin-11 [KO:K13352]
PAAG_08029  peroxisomal membrane protein PMP34 [KO:K13354]
PAAG_11932  PAAG_04811; hypothetical protein [KO:K12261] [EC:4.1.2.63]
PAAG_04266  alpha-methylacyl-CoA racemase [KO:K01796] [EC:5.1.99.4]
PAAG_03366  phytanoyl-CoA dioxygenase family protein [KO:K00477] [EC:1.14.11.18]
PAAG_07421  acyl-coenzyme A oxidase [KO:K00232] [EC:1.3.3.6]
PAAG_07422  acyl-coenzyme A oxidase [KO:K00232] [EC:1.3.3.6]
PAAG_03116  acyl-coenzyme A oxidase [KO:K00232] [EC:1.3.3.6]
PAAG_11860  PAAG_04374; hypothetical protein [KO:K08764] [EC:2.3.1.176]
PAAG_01387  3-ketoacyl-CoA thiolase B [KO:K07513] [EC:2.3.1.16]
PAAG_02664  3-ketoacyl-CoA thiolase [KO:K07513] [EC:2.3.1.16]
PAAG_07746  3-ketoacyl-CoA thiolase [KO:K07513] [EC:2.3.1.16]
PAAG_03689  3-ketoacyl-CoA thiolase B [KO:K07513] [EC:2.3.1.16]
PAAG_04894  sporulation protein SPS19 [KO:K13237] [EC:1.3.1.124]
PAAG_03407  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase [KO:K12663] [EC:5.3.3.21]
PAAG_00546  ATP-binding cassette [KO:K15628] [EC:7.6.2.4]
PAAG_00938  peroxisomal long-chain fatty acid import protein [KO:K15628] [EC:7.6.2.4]
PAAG_01336  long-chain-fatty-acid-CoA ligase [KO:K01897] [EC:6.2.1.3]
PAAG_03481  long-chain-fatty-acid-CoA ligase [KO:K01897] [EC:6.2.1.3]
PAAG_08052  long-chain-fatty-acid-CoA ligase [KO:K01897] [EC:6.2.1.3]
PAAG_04615  3,2-trans-enoyl-CoA isomerase ,Delta(2)-enoyl-CoA isomerase [KO:K13239] [EC:5.3.3.8]
PAAG_04340  peroxisomal NADH pyrophosphatase NUDT12 [KO:K03426] [EC:3.6.1.22]
PAAG_06224  carnitine O-acetyltransferase [KO:K00624] [EC:2.3.1.7]
PAAG_03062  carnitine O-palmitoyltransferase [KO:K00624] [EC:2.3.1.7]
PAAG_00718  mevalonate kinase [KO:K00869] [EC:2.7.1.36]
PAAG_03138  alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
PAAG_02361  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
PAAG_08351  mitochondrial NADP-specific isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
PAAG_01906  sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PAAG_06215  hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
PAAG_07725  peroxisomal (S)-2-hydroxy-acid oxidase [KO:K11517] [EC:1.1.3.15]
PAAG_01454  catalase [KO:K03781] [EC:1.11.1.6]
PAAG_01553  catalase B [KO:K03781] [EC:1.11.1.6]
PAAG_04580  catalase A [KO:K03781] [EC:1.11.1.6]
PAAG_05061  AhpC/TSA family protein [KO:K11187] [EC:1.11.1.24]
PAAG_04164  superoxide dismutase [KO:K04565] [EC:1.15.1.1]
PAAG_06363  superoxide dismutase [KO:K04564] [EC:1.15.1.1]
PAAG_02926  superoxide dismutase [KO:K04564] [EC:1.15.1.1]
PAAG_02725  superoxide dismutase [KO:K04564] [EC:1.15.1.1]
PAAG_06941  hypothetical protein [KO:K08726] [EC:3.3.2.10 3.1.3.76]
PAAG_03629  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
PAAG_02640  aldehyde oxidoreductase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
pbl00071  Fatty acid degradation
pbl00230  Purine metabolism
pbl00564  Glycerophospholipid metabolism
pbl00565  Ether lipid metabolism
pbl00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (55)   
   KEGG GENES (55)   
All databases (56)   

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