KEGG   PATHWAY: pcs03410Help
Entry
pcs03410                    Pathway                                
Name
Base excision repair - Penicillium chrysogenum
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Base excision repair
pcs03410

All organismsOrtholog table
Module
DNA polymerase delta complex [PATH:pcs03410]
BER complex [PATH:pcs03410]
Other DBs
Organism
Penicillium chrysogenum [GN:pcs]
Gene
Pc22g05070; K10563 formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] [KO:K10563] [EC:4.2.99.18 3.2.2.23]
Pc12g05950; K03660 N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] [KO:K03660] [EC:4.2.99.18 3.2.2.-]
Pc15g00960; K10773 endonuclease III [EC:4.2.99.18] [KO:K10773] [EC:4.2.99.18]
Pc22g17880; K01247 DNA-3-methyladenine glycosylase II [EC:3.2.2.21] [KO:K01247] [EC:3.2.2.21]
Pc21g11270; K03648 uracil-DNA glycosylase [EC:3.2.2.27] [KO:K03648] [EC:3.2.2.27]
Pc22g01220; K03649 TDG/mug DNA glycosylase family protein [EC:3.2.2.-] [KO:K03649] [EC:3.2.2.-]
Pc20g07790; K10772 AP endonuclease 2 [EC:4.2.99.18] [KO:K10772] [EC:4.2.99.18]
Pc12g02720; K10798 poly [ADP-ribose] polymerase [EC:2.4.2.30] [KO:K10798] [EC:2.4.2.30]
Pc21g18060; K10798 poly [ADP-ribose] polymerase [EC:2.4.2.30] [KO:K10798] [EC:2.4.2.30]
Pc16g09710; K04802 proliferating cell nuclear antigen [KO:K04802]
Pc21g18980; K02327 DNA polymerase delta subunit 1 [EC:2.7.7.7] [KO:K02327] [EC:2.7.7.7]
Pc13g07420; K02328 DNA polymerase delta subunit 2 [KO:K02328]
Pc21g19020; K03504 DNA polymerase delta subunit 3 [KO:K03504]
Pc21g20310; K03505 DNA polymerase delta subunit 4 [KO:K03505]
Pc12g15980; K02324 DNA polymerase epsilon subunit 1 [EC:2.7.7.7] [KO:K02324] [EC:2.7.7.7]
Pc21g11310; K02325 DNA polymerase epsilon subunit 2 [EC:2.7.7.7] [KO:K02325] [EC:2.7.7.7]
Pc20g07900; K04799 flap endonuclease-1 [EC:3.-.-.-] [KO:K04799] [EC:3.-.-.-]
Pc16g13010; K10747 DNA ligase 1 [EC:6.5.1.1] [KO:K10747] [EC:6.5.1.1]
Pc13g09370; K10747 DNA ligase 1 [EC:6.5.1.1] [KO:K10747] [EC:6.5.1.1]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
 
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