Valine, leucine and isoleucine degradation

Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:pde00280]

2-oxoisovalerate:ferredoxin oxidoreductase [PATH:pde00280]

branched-chain amino acid aminotransferase; K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] [KO:K00826] [EC:2.6.1.42]

aminotransferase; K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] [KO:K00826] [EC:2.6.1.42]

Glu/Leu/Phe/Val dehydrogenase; K00263 leucine dehydrogenase [EC:1.4.1.9] [KO:K00263] [EC:1.4.1.9]

3-methyl-2-oxobutanoate dehydrogenase; K00166 2-oxoisovalerate dehydrogenase E1 component, alpha subunit [EC:1.2.4.4] [KO:K00166] [EC:1.2.4.4]

transketolase; K00167 2-oxoisovalerate dehydrogenase E1 component, beta subunit [EC:1.2.4.4] [KO:K00167] [EC:1.2.4.4]

transketolase; K11381 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4] [KO:K11381] [EC:1.2.4.4]

dehydrogenase catalytic domain-containing protein; K09699 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168] [KO:K09699] [EC:2.3.1.168]

dihydrolipoamide dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]

dihydrolipoamide dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]

dihydrolipoamide dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]

acyl-CoA dehydrogenase; K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] [KO:K00249] [EC:1.3.8.7]

acyl-CoA dehydrogenase; K00253 isovaleryl-CoA dehydrogenase [EC:1.3.8.4] [KO:K00253] [EC:1.3.8.4]

3-hydroxyacyl-CoA dehydrogenase; K01782 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3] [KO:K01782] [EC:5.1.2.3 4.2.1.17 1.1.1.35]

acetyl-CoA acetyltransferase; K00632 acetyl-CoA acyltransferase [EC:2.3.1.16] [KO:K00632] [EC:2.3.1.16]

carbamoyl-phosphate synthase subunit L; K01965 propionyl-CoA carboxylase alpha chain [EC:6.4.1.3] [KO:K01965] [EC:6.4.1.3]

carboxyl transferase; K01966 propionyl-CoA carboxylase beta chain [EC:6.4.1.3] [KO:K01966] [EC:6.4.1.3]

glyoxalase/bleomycin resistance protein/dioxygenase; K05606 methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] [KO:K05606] [EC:5.1.99.1]

methylmalonyl-CoA mutase; K01847 methylmalonyl-CoA mutase [EC:5.4.99.2] [KO:K01847] [EC:5.4.99.2]

3-hydroxyisobutyrate dehydrogenase; K00020 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] [KO:K00020] [EC:1.1.1.31]

3-hydroxyisobutyrate dehydrogenase; K00020 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] [KO:K00020] [EC:1.1.1.31]

3-hydroxyisobutyrate dehydrogenase; K00020 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] [KO:K00020] [EC:1.1.1.31]

3-hydroxyisobutyrate dehydrogenase; K00020 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] [KO:K00020] [EC:1.1.1.31]

methylmalonate-semialdehyde dehydrogenase; K00140 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27] [KO:K00140] [EC:1.2.1.27 1.2.1.18]

aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

propionyl-CoA carboxylase; K01969 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4] [KO:K01969] [EC:6.4.1.4]

enoyl-CoA hydratase; K13766 methylglutaconyl-CoA hydratase [EC:4.2.1.18] [KO:K13766] [EC:4.2.1.18]

hydroxymethylglutaryl-CoA lyase; K01640 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] [KO:K01640] [EC:4.1.3.4]

pyruvate carboxyltransferase; K01640 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] [KO:K01640] [EC:4.1.3.4]

3-oxoacid CoA-transferase subunit A; K01028 3-oxoacid CoA-transferase subunit A [EC:2.8.3.5] [KO:K01028] [EC:2.8.3.5]

3-oxoacid CoA-transferase subunit B; K01029 3-oxoacid CoA-transferase subunit B [EC:2.8.3.5] [KO:K01029] [EC:2.8.3.5]

beta-ketothiolase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]

acetyl-CoA acetyltransferase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]

acetyl-CoA acetyltransferase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]

beta-ketoadipyl CoA thiolase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]

beta-ketoadipyl CoA thiolase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]

acetyl-CoA acetyltransferase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]

acetyl-CoA acetyltransferase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]

Acetyl-CoA

Thiamin diphosphate

Succinyl-CoA

Propanoyl-CoA

L-Leucine

3-Methyl-2-oxobutanoic acid

Acetoacetate

L-Valine

4-Methyl-2-oxopentanoate

Acetoacetyl-CoA

(S)-3-Hydroxy-3-methylglutaryl-CoA

L-Isoleucine

2-Methylpropanoyl-CoA

(S)-3-Methyl-2-oxopentanoic acid

(S)-Methylmalonyl-CoA

(R)-Methylmalonyl-CoA

Methylmalonate

(3R)-beta-Leucine

3-Methylbutanoyl-CoA

3-Methylcrotonyl-CoA

3-Methylglutaconyl-CoA

L-3-Amino-isobutanoate

2-Methylacetoacetyl-CoA

2-Methylbut-2-enoyl-CoA

2-Methylprop-2-enoyl-CoA

beta-Ketoisocaproate

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA

Branched chain fatty acid

3-Hydroxyisovaleryl-CoA

(S)-3-Hydroxyisobutyryl-CoA

(S)-3-Hydroxyisobutyrate

(S)-Methylmalonate semialdehyde

Enzyme N6-(lipoyl)lysine

Enzyme N6-(dihydrolipoyl)lysine

3-Methyl-1-hydroxybutyl-ThPP

[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine

2-Methyl-1-hydroxypropyl-ThPP

[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine

2-Methyl-1-hydroxybutyl-ThPP

[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine

(S)-2-Methylbutanoyl-CoA