KEGG   PATHWAY: pic00900Help
Entry
pic00900                    Pathway                                

Name
Terpenoid backbone biosynthesis - Scheffersomyces stipitis
Description
Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:M00096], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil monoterpenes and linalyl acetate, some sesquiterpenes, diterpenes, and carotenoids and phytol. The mevalonate pathway, operating in the cytosol, gives rise to triterpenes, sterols, and most sesquiterpenes.
Class
Metabolism; Metabolism of terpenoids and polyketides
BRITE hierarchy
Pathway map
pic00900  Terpenoid backbone biosynthesis
pic00900

Ortholog table
Module
pic_M00095  C5 isoprenoid biosynthesis, mevalonate pathway [PATH:pic00900]
pic_M00367  C10-C20 isoprenoid biosynthesis, non-plant eukaryotes [PATH:pic00900]
Other DBs
BSID: 86118
GO: 0009240 0016091
Organism
Scheffersomyces stipitis [GN:pic]
Gene
PICST_31707  ERG10; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
PICST_83020  predicted protein [KO:K01641] [EC:2.3.3.10]
PICST_72872  HMG1; 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoA) [KO:K00021] [EC:1.1.1.34]
PICST_40742  ERG12; mevalonate kinase [KO:K00869] [EC:2.7.1.36]
PICST_52257  ERG8; Phosphomevalonate kinase [KO:K00938] [EC:2.7.4.2]
PICST_90752  predicted protein [KO:K01597] [EC:4.1.1.33]
PICST_68990  IDI1; isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase) [KO:K01823] [EC:5.3.3.2]
PICST_89338  ERG20; arnesyl diphosphate synthetase (FPP synthetase) [KO:K00787] [EC:2.5.1.10 2.5.1.1]
PICST_46658  BTS1; geranylgeranyl diphosphate synthase [KO:K00804] [EC:2.5.1.29 2.5.1.10 2.5.1.1]
PICST_86778  COQ1; hexaprenyl pyrophosphate synthetase, mitochondrial precursor (HPS) [KO:K05355] [EC:2.5.1.83 2.5.1.82]
PICST_41956  cis-prenyltransferase [KO:K11778] [EC:2.5.1.87]
PICST_29164  SRT1; cis-prenyltransferase involved in dolichol synthesis [KO:K11778] [EC:2.5.1.87]
PICST_63927  predicted protein [KO:K19177] [EC:2.5.1.87]
PICST_55783  RAM2; protein farnesyltransferase / geranylgeranyltransferase type I alpha subunit [KO:K05955] [EC:2.5.1.59 2.5.1.58]
PICST_82404  RAM1; protein farnesyltransferase, beta subunit [KO:K05954] [EC:2.5.1.58]
PICST_35752  STE24; zinc metalloprotease [KO:K06013] [EC:3.4.24.84]
PICST_60928  predicted protein [KO:K00587] [EC:2.1.1.100]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00118  D-Glyceraldehyde 3-phosphate
C00129  Isopentenyl diphosphate
C00235  Dimethylallyl diphosphate
C00332  Acetoacetyl-CoA
C00341  Geranyl diphosphate
C00353  Geranylgeranyl diphosphate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00418  (R)-Mevalonate
C00448  trans,trans-Farnesyl diphosphate
C00621  Dolichyl diphosphate
C01107  (R)-5-Phosphomevalonate
C01126  (2E,6E)-Farnesol
C01143  (R)-5-Diphosphomevalonate
C01230  all-trans-Hexaprenyl diphosphate
C02321  Rubber particle
C03461  2-trans,6-trans-Farnesal
C04145  all-trans-Nonaprenyl diphosphate
C04146  all-trans-Octaprenyl diphosphate
C04216  all-trans-Heptaprenyl diphosphate
C04506  Protein C-terminal S-farnesyl-L-cysteine
C04574  di-trans,poly-cis-Undecaprenyl diphosphate
C04748  Protein C-terminal S-farnesyl-L-cysteine methyl ester
C05427  Phytyl diphosphate
C05859  Dehydrodolichol diphosphate
C11434  2-C-Methyl-D-erythritol 4-phosphate
C11435  4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol
C11436  2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
C11437  1-Deoxy-D-xylulose 5-phosphate
C11453  2-C-Methyl-D-erythritol 2,4-cyclodiphosphate
C11811  1-Hydroxy-2-methyl-2-butenyl 4-diphosphate
C16521  Isoprene
C16826  2-cis,6-trans-Farnesyl diphosphate
C17432  all-trans-Decaprenyl diphosphate
C18321  (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-Decaprenyl diphosphate
C19691  Farnesylcysteine
C19760  (2Z,6Z)-Farnesyl diphosphate
C19852  tritrans,heptacis-Undecaprenyl diphosphate
C19853  trans,polycis-Polyprenyl diphosphate
C20120  S-Farnesyl protein
C20121  trans,trans-Farnesyl phosphate
C20345  Isopentenyl phosphate
C20847  (R)-Mevalonate 3-phosphate
C20848  (R)-Mevalonate 3,5-bisphosphate
Reference
  Authors
Lange BM, Ghassemian M.
  Title
Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.
  Journal
Plant Mol Biol 51:925-48 (2003)
DOI:10.1023/A:1023005504702
Reference
  Authors
Saiki R, Nagata A, Kainou T, Matsuda H, Kawamukai M
  Title
Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.
  Journal
FEBS J 272:5606-22 (2005)
DOI:10.1111/j.1742-4658.2005.04956.x
Reference
PMID:9858571
  Authors
Sato M, Sato K, Nishikawa S, Hirata A, Kato J, Nakano A
  Title
The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.
  Journal
Mol Cell Biol 19:471-83 (1999)
DOI:10.1128/MCB.19.1.471
Reference
  Authors
Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM
  Title
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an  archaeal alternate mevalonate pathway.
  Journal
J Bacteriol 196:1055-63 (2014)
DOI:10.1128/JB.01230-13
KO pathway
ko00900   

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