KEGG   PATHWAY: plt03440
Entry
plt03440                    Pathway                                
Name
Homologous recombination - Pelodictyon luteolum
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
plt03440  Homologous recombination
plt03440

Other DBs
GO: 0000724
Organism
Pelodictyon luteolum [GN:plt]
Gene
Plut_0462  exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Plut_0261  single-strand binding protein [KO:K03111]
Plut_0115  single-strand binding protein [KO:K03111]
Plut_0002  RecF protein [KO:K03629]
Plut_2037  DNA replication and repair protein RecO [KO:K03584]
Plut_1284  RecR protein [KO:K06187]
Plut_0275  RecA DNA recombination protein [KO:K03553]
Plut_1645  DNA polymerase A [KO:K02335] [EC:2.7.7.7]
Plut_1758  Holliday junction DNA helicase subunit RuvA [KO:K03550]
Plut_1619  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Plut_1642  Crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Plut_0350  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Plut_0997  Exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
Plut_0996  DNA helicase/exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
Plut_0998  DNA helicase/exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
Plut_1462  Helicase RecD/TraA [KO:K03581] [EC:3.1.11.5]
Plut_1262  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Plut_0001  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Plut_1322  DNA-directed DNA polymerase [KO:K02343] [EC:2.7.7.7]
Plut_0260  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Plut_1602  DNA-directed DNA polymerase [KO:K02341] [EC:2.7.7.7]
Plut_1010  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Plut_0528  Exonuclease [KO:K02342] [EC:2.7.7.7]
Plut_0948  Primosomal protein n [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG GENES (24)   
All databases (25)   

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