KEGG   PATHWAY: pmp03440Help
Entry
pmp03440                    Pathway                                

Name
Homologous recombination - Pasteurella multocida 36950
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
pmp03440  Homologous recombination
pmp03440

Ortholog table
Module
pmp_M00260  DNA polymerase III complex, bacteria [PATH:pmp03440]
Other DBs
BSID: 568622
GO: 0000724
Organism
Pasteurella multocida 36950 [GN:pmp]
Gene
Pmu_11210  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Pmu_03540  ssb1; single-stranded DNA-binding protein [KO:K03111]
Pmu_13950  ssb2; single-stranded DNA-binding protein [KO:K03111]
Pmu_00030  recF; DNA replication and repair protein RecF [KO:K03629]
Pmu_14670  recO; DNA repair protein RecO [KO:K03584]
Pmu_11060  recR; recombination protein RecR [KO:K06187]
Pmu_15170  recA; protein RecA [KO:K03553]
Pmu_00910  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Pmu_01910  ruvA; holliday junction ATP-dependent DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
Pmu_01920  ruvB; holliday junction ATP-dependent DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
Pmu_01900  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
Pmu_02580  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
Pmu_05780  recB; exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
Pmu_02090  recC; exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
Pmu_05790  recD; exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
Pmu_12900  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
Pmu_00020  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
Pmu_04280  dnaX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
Pmu_21680  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
Pmu_21040  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
Pmu_12100  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
Pmu_09070  holC; DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
Pmu_02110  holD; DNA polymerase III subunit psi [KO:K02344] [EC:2.7.7.7]
Pmu_00210  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Pmu_22110  priB; primosomal replication protein n [KO:K02686]
Pmu_01780  hypothetical protein [KO:K04067]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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