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Entry
pog02010                    Pathway                                

Name
ABC transporters - Pyrobaculum oguniense
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
ABC transporters
pog02010

All organismsOrtholog table
Module
Thiamine transport system [PATH:pog02010]
alpha-Glucoside transport system [PATH:pog02010]
Glucose/arabinose transport system [PATH:pog02010]
Phosphate transport system [PATH:pog02010]
Branched-chain amino acid transport system [PATH:pog02010]
Iron complex transport system [PATH:pog02010]
Spermidine/putrescine transport system [PATH:pog02010]
Molybdate/tungstate transport system [PATH:pog02010]
arabinogalactan oligomer/maltooligosaccharide transport system [PATH:pog02010]
Other DBs
Organism
Pyrobaculum oguniense [GN:pog]
Gene
hypothetical protein; K05772 tungstate transport system substrate-binding protein [KO:K05772]
molybdate ABC transporter periplasmic protein; K15495 molybdate/tungstate transport system substrate-binding protein [KO:K15495]
ABC-type sulfate transport system permease; K15496 molybdate/tungstate transport system permease protein [KO:K15496]
sugar ABC transporter ATPase; K15497 molybdate/tungstate transport system ATP-binding protein [EC:3.6.3.- 3.6.3.55] [KO:K15497] [EC:3.6.3.55 3.6.3.-]
ABC transporter substrate-binding protein; K02064 thiamine transport system substrate-binding protein [KO:K02064]
Fe3+ ABC transporter permease; K02063 thiamine transport system permease protein [KO:K02063]
sugar ABC transporter ATPase; K02062 thiamine transport system ATP-binding protein [KO:K02062]
Spermidine/putrescine-binding periplasmic protein; K11069 spermidine/putrescine transport system substrate-binding protein [KO:K11069]
spermidine/putrescine ABC transporter permease II; K11070 spermidine/putrescine transport system permease protein [KO:K11070]
spermidine/putrescine ABC transporter permease I; K11071 spermidine/putrescine transport system permease protein [KO:K11071]
ABC-type spermidine/putrescine transport systems; K11072 spermidine/putrescine transport system ATP-binding protein [EC:3.6.3.31] [KO:K11072] [EC:3.6.3.31]
sugar ABC transporter ATPase; K10112 multiple sugar transport system ATP-binding protein [KO:K10112]
Maltose-binding periplasmic protein/domains; K15770 arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein [KO:K15770]
sugar ABC transporter permease; K15771 arabinogalactan oligomer / maltooligosaccharide transport system permease protein [KO:K15771]
ABC-type maltose transport systems; K15772 arabinogalactan oligomer / maltooligosaccharide transport system permease protein [KO:K15772]
sugar ABC transporter periplasmic protein; K10196 glucose/arabinose transport system substrate-binding protein [KO:K10196]
sugar ABC transporter permease; K10197 glucose/arabinose transport system permease protein [KO:K10197]
sugar ABC transporter permease; K10198 glucose/arabinose transport system permease protein [KO:K10198]
phosphate ABC transporter substrate-binding protein; K02040 phosphate transport system substrate-binding protein [KO:K02040]
phosphate ABC transporter permease PstC; K02037 phosphate transport system permease protein [KO:K02037]
phosphate ABC transporter permease; K02038 phosphate transport system permease protein [KO:K02038]
phosphate ABC transporter ATPase; K02036 phosphate transport system ATP-binding protein [EC:3.6.3.27] [KO:K02036] [EC:3.6.3.27]
phosphate/phosphite/phosphonate ABC transporter; K02044 phosphonate transport system substrate-binding protein [KO:K02044]
ABC-type phosphate/phosphonate transport system; K02042 phosphonate transport system permease protein [KO:K02042]
branched-chain amino acid ABC transporter periplasmic protein; K01999 branched-chain amino acid transport system substrate-binding protein [KO:K01999]
branched-chain amino acid ABC transporter periplasmic protein; K01999 branched-chain amino acid transport system substrate-binding protein [KO:K01999]
branched-chain amino acid ABC transporter periplasmic protein; K01999 branched-chain amino acid transport system substrate-binding protein [KO:K01999]
branched-chain amino acid ABC transporter periplasmic protein; K01999 branched-chain amino acid transport system substrate-binding protein [KO:K01999]
Branched-chain amino acid ABC transporter permease; K01997 branched-chain amino acid transport system permease protein [KO:K01997]
Branched-chain amino acid ABC transporter permease; K01997 branched-chain amino acid transport system permease protein [KO:K01997]
branched-chain amino acid ABC transporter permease; K01998 branched-chain amino acid transport system permease protein [KO:K01998]
branched-chain amino acid ABC transporter permease; K01998 branched-chain amino acid transport system permease protein [KO:K01998]
branched-chain amino acid ABC transporter permease; K01998 branched-chain amino acid transport system permease protein [KO:K01998]
branched-chain amino acid ABC transporter ATPase; K01995 branched-chain amino acid transport system ATP-binding protein [KO:K01995]
branched-chain amino acid ABC transporter ATPase; K01995 branched-chain amino acid transport system ATP-binding protein [KO:K01995]
ABC-type spermidine/putrescine transport systems; K01995 branched-chain amino acid transport system ATP-binding protein [KO:K01995]
branched-chain amino acid ABC transporter ATPase; K01995 branched-chain amino acid transport system ATP-binding protein [KO:K01995]
branched-chain amino acid ABC transporter ATPase; K01995 branched-chain amino acid transport system ATP-binding protein [KO:K01995]
branched-chain amino acid ABC transporter ATPase; K01996 branched-chain amino acid transport system ATP-binding protein [KO:K01996]
branched-chain amino acid ABC transporter ATPase; K01996 branched-chain amino acid transport system ATP-binding protein [KO:K01996]
branched-chain amino acid ABC transporter ATPase; K01996 branched-chain amino acid transport system ATP-binding protein [KO:K01996]
Branched-chain amino acid ABC transporter permease; K11956 neutral amino acid transport system permease protein [KO:K11956]
Fe3+-hydroxamate ABC transporter periplasmic protein; K02016 iron complex transport system substrate-binding protein [KO:K02016]
Fe3+-hydroxamate ABC transporter periplasmic protein; K02016 iron complex transport system substrate-binding protein [KO:K02016]
Fe3+-siderophore ABC transporter permease; K02015 iron complex transport system permease protein [KO:K02015]
Fe3+-siderophore ABC transporter permease; K02015 iron complex transport system permease protein [KO:K02015]
ABC-type cobalamin/Fe3+-siderophores transport systems; K02013 iron complex transport system ATP-binding protein [EC:3.6.3.34] [KO:K02013] [EC:3.6.3.34]
hypothetical protein; K02009 cobalt/nickel transport protein [KO:K02009]
Co2+ ABC transporter permease; K02007 cobalt/nickel transport system permease protein [KO:K02007]
hypothetical protein; K16785 energy-coupling factor transport system permease protein [KO:K16785]
cobalt ABC transporter ATPase; K16786 energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] K16787 energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] [KO:K16786 K16787] [EC:3.6.3.- 3.6.3.-]
cobalt ABC transporter ATPase; K16787 energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] [KO:K16787] [EC:3.6.3.-]
Compound
C00009  
Orthophosphate
C00025  
L-Glutamate
C00031  
D-Glucose
C00032  
Heme
C00034  
Manganese
C00037  
Glycine
C00038  
Zinc cation
C00041  
L-Alanine
C00045  
Amino acid
C00047  
L-Lysine
C00049  
L-Aspartate
C00051  
Glutathione
C00059  
Sulfate
C00062  
L-Arginine
C00064  
L-Glutamine
C00065  
L-Serine
C00077  
L-Ornithine
C00079  
L-Phenylalanine
C00086  
Urea
C00088  
Nitrite
C00089  
Sucrose
C00093  
sn-Glycerol 3-phosphate
C00095  
D-Fructose
C00098  
Oligopeptide
C00107  
Dipeptide
C00114  
Choline
C00116  
Glycerol
C00120  
Biotin
C00121  
D-Ribose
C00123  
L-Leucine
C00134  
Putrescine
C00135  
L-Histidine
C00137  
myo-Inositol
C00140  
N-Acetyl-D-glucosamine
C00148  
L-Proline
C00151  
L-Amino acid
C00159  
D-Mannose
C00175  
Cobalt ion
C00181  
D-Xylose
C00183  
L-Valine
C00185  
Cellobiose
C00188  
L-Threonine
C00208  
Maltose
C00243  
Lactose
C00244  
Nitrate
C00245  
Taurine
C00259  
L-Arabinose
C00288  
HCO3-
C00291  
Nickel
C00315  
Spermidine
C00320  
Thiosulfate
C00333  
D-Galacturonate
C00338  
Lipopolysaccharide
C00378  
Thiamine
C00379  
Xylitol
C00392  
Mannitol
C00407  
L-Isoleucine
C00430  
5-Aminolevulinate
C00470  
Pectate
C00487  
Carnitine
C00491  
L-Cystine
C00492  
Raffinose
C00503  
Erythritol
C00719  
Betaine
C00753  
Tungsten
C00794  
D-Sorbitol
C00855  
D-Methionine
C00919  
Choline sulfate
C00973  
Cyclomaltodextrin
C01083  
alpha,alpha-Trehalose
C01153  
Orthophosphoric monoester
C01177  
Inositol 1-phosphate
C01181  
4-Trimethylammoniobutanoate
C01279  
4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  
Sodium cation
C01417  
Cyanate
C01487  
D-Allose
C01606  
Phthalate
C01630  
Xylobiose
C01667  
Bacitracin
C01674  
Chitobiose
C01682  
Nopaline
C01684  
D-Rhamnose
C01834  
Lipoprotein
C01835  
Maltotriose
C01935  
Maltodextrin
C02160  
Isomaltotriose
C02273  
Digalacturonate
C03557  
2-Aminoethylphosphonate
C03611  
Galactose oligosaccharide
C03619  
Methyl beta-D-galactoside
C04114  
(E)-4-(Trimethylammonio)but-2-enoate
C04137  
D-Octopine
C05349  
Ciprofloxacin
C05402  
Melibiose
C05776  
Vitamin B12
C06227  
Fe(III)hydroxamate
C06228  
Ferrichrome
C06229  
Fe(III)dicitrate
C06230  
Fe-enterobactin
C06232  
Molybdate
C06687  
Norfloxacin
C06704  
Iron chelate
C06705  
Capsular polysaccharide
C06706  
Lipo-oligosaccharide
C06707  
Teichoic acid
C06767  
Hemine
C07662  
Sparfloxacin
C07663  
Moxifloxacin
C14818  
Fe2+
C14819  
Fe3+
C15521  
Alkanesulfonate
C16421  
AI-2
C16692  
Mannopine
C19609  
Nickel(2+)
C19872  
N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  
alpha-1,5-L-Arabinobiose
C20571  
alpha-1,5-L-Arabinotriose
C20572  
alpha-1,5-L-Arabinotetraose
C20573  
Aldotetraouronic acid
G00457  
Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
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