KEGG PATHWAY: pon04350

PATHWAY: pon04350

Entry

pon04350 Pathway

Name

TGF-beta signaling pathway - Pongo abelii (Sumatran orangutan)

Description

The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.

Class

Environmental Information Processing; Signal transduction

Pathway map

pon04350

TGF-beta signaling pathway

Other DBs

BSID:

197709

GO:

0007179

Organism

Pongo abelii (Sumatran orangutan) [GN:pon]

Gene

100451687	CHRD; chordin [KO:K04657]
100441632	NOG; noggin [KO:K04658]
100453386	THBS1; thrombospondin 1 [KO:K16857]
100434577	DCN; decorin [KO:K04660]
100435327	LEFTY2; left-right determination factor 2 [KO:K04668]
100435934	LEFTY1; left-right determination factor 1 [KO:K04668]
100441294	FST; follistatin [KO:K04661]
100449444	BMP4; bone morphogenetic protein 4 [KO:K04662]
100460853	BMP2; bone morphogenetic protein 2 [KO:K04662]
100458055	BMP5; bone morphogenetic protein 5 [KO:K04663]
100445825	BMP6; bone morphogenetic protein 6 [KO:K16620]
100434378	BMP7; bone morphogenetic protein 7 [KO:K16621]
100445772	BMP8B; bone morphogenetic protein 8b [KO:K16622]
100440841	GDF6; growth differentiation factor 6 [KO:K04664]
100452554	GDF5; growth differentiation factor 5 [KO:K04664]
100443944	GDF7; growth differentiation factor 7 [KO:K04664]
100448030	AMH; anti-Mullerian hormone [KO:K04665]
100459982	TGFB1; transforming growth factor, beta 1 [KO:K13375]
100461291	TGFB2; transforming growth factor, beta 2 [KO:K13376]
100433208	TGFB3; transforming growth factor, beta 3 [KO:K13377]
100436309	inhibin beta C chain-like; K04667 inhibin, beta [KO:K04667]
100436690	INHBE; inhibin, beta E [KO:K04667]
100462171	INHBB; inhibin, beta B [KO:K04667]
100439592	INHBA; inhibin, beta A [KO:K04667]
100453474	NODAL; nodal homolog (mouse) [KO:K04666]
100441517	BMPR2; bone morphogenetic protein receptor, type II (serine/threonine kinase) [KO:K04671] [EC:2.7.11.30]
100441106	AMHR2; anti-Mullerian hormone receptor, type II [KO:K04672] [EC:2.7.11.30]
100459236	TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
100435220	ACVR2A; activin A receptor, type IIA [KO:K04670] [EC:2.7.11.30]
100456564	ACVR2B; activin A receptor, type IIB [KO:K13596] [EC:2.7.11.30]
100450136	BMPR1A; bone morphogenetic protein receptor, type IA [KO:K04673] [EC:2.7.11.30]
100444576	BMPR1B; bone morphogenetic protein receptor, type IB [KO:K13578] [EC:2.7.11.30]
100455728	ACVR1; activin A receptor, type I [KO:K04675] [EC:2.7.11.30]
100450864	TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
100173725	ACVR1B; activin A receptor, type IB [KO:K13567] [EC:2.7.11.30]
100449424	BAMBI; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) [KO:K10162]
100432108	SMAD1; SMAD family member 1 [KO:K04676]
100173534	SMAD5; SMAD family member 5 [KO:K16790]
100445245	SMAD9; SMAD family member 9 [KO:K16791]
100448249	SMAD3; SMAD family member 3 [KO:K04500]
100173357	SMAD2; SMAD family member 2 [KO:K04500]
100439171	SMAD4; SMAD family member 4 [KO:K04501]
100453145	SMAD6; SMAD family member 6 [KO:K04677]
100460706	SMAD7; SMAD family member 7 [KO:K04677]
100459970	SMURF2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:6.3.2.19]
100456599	SMURF1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:6.3.2.19]
100435385	ZFYVE16; zinc finger, FYVE domain containing 16 [KO:K04679]
100449092	zinc finger FYVE domain-containing protein 9-like; K04679 MAD, mothers against decapentaplegic interacting protein [KO:K04679]
100172180	ID2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein [KO:K04680]
100457642	ID3; inhibitor of DNA binding 3, dominant negative helix-loop-helix protein [KO:K04680]
100445686	ID4; inhibitor of DNA binding 4, dominant negative helix-loop-helix protein [KO:K04680]
100448405	ID1; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein [KO:K04680]
100435009	RBL1; retinoblastoma-like 1 (p107) [KO:K04681]
100438557	E2F4; E2F transcription factor 4, p107/p130-binding [KO:K04682]
100441443	transcription factor E2F5-like; K04682 E2F transcription factor 4/5 [KO:K04682]
100434418	E2F5; E2F transcription factor 5, p130-binding [KO:K04682]
100457325	TFDP1; transcription factor Dp-1 [KO:K04683]
100455260	EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
100445634	CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
100440745	SP1; Sp1 transcription factor [KO:K04684]
100456735	MYC; v-myc myelocytomatosis viral oncogene homolog (avian) [KO:K04377]
100459175	cyclin-dependent kinase 4 inhibitor B-like; K04685 cyclin-dependent kinase inhibitor 2B [KO:K04685]
100458152	PITX2; paired-like homeodomain 2 [KO:K04686]
100441665	RBX1; ring-box 1, E3 ubiquitin protein ligase [KO:K03868]
100173991	CUL1; cullin 1 [KO:K03347]
100439262	S-phase kinase-associated protein 1-like; K03094 S-phase kinase-associated protein 1 [KO:K03094]
100174716	SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100431824	MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100169740	MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100444043	interferon gamma-like; K04687 interferon gamma [KO:K04687]
100447558	TNF; tumor necrosis factor [KO:K03156]
100171605	RHOA; ras homolog family member A [KO:K04513]
100432582	rho-associated protein kinase 1-like; K04514 Rho-associated protein kinase [EC:2.7.11.1] [KO:K04514] [EC:2.7.11.1]
100461801	ROCK2; Rho-associated, coiled-coil containing protein kinase 2 [KO:K04514] [EC:2.7.11.1]
100173260	PPP2R1A; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456]
100437928	PPP2R1B; protein phosphatase 2, regulatory subunit A, beta [KO:K03456]
100437405	PPP2CB; protein phosphatase 2, catalytic subunit, beta isozyme [KO:K04382] [EC:3.1.3.16]
100461606	PPP2CA; protein phosphatase 2, catalytic subunit, alpha isozyme [KO:K04382] [EC:3.1.3.16]
100462008	RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1 [KO:K04688] [EC:2.7.11.1]
100459428	RPS6KB2; ribosomal protein S6 kinase, 70kDa, polypeptide 2 [KO:K04688] [EC:2.7.11.1]

Reference

PMID:12809600

Authors

Shi Y, Massague J.

Title

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

Journal

Cell 113:685-700 (2003)

Reference

PMID:14534577

Authors

Derynck R, Zhang YE.

Title

Smad-dependent and Smad-independent pathways in TGF-beta family signalling.

Journal

Nature 425:577-84 (2003)

Reference

PMID:11252892

Authors

Massague J.

Title

How cells read TGF-beta signals.

Journal

Nat Rev Mol Cell Biol 1:169-78 (2000)

Reference

PMID:14557817

Authors

Siegel PM, Massague J.

Title

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.

Journal

Nat Rev Cancer 3:807-21 (2003)

Reference

PMID:14769828

Authors

Shimasaki S, Moore RK, Otsuka F, Erickson GF.

Title

The bone morphogenetic protein system in mammalian reproduction.

Journal

Endocr Rev 25:72-101 (2004)

Reference

PMID:11252746

Authors

De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.

Title

The establishment of Spemann's organizer and patterning of the vertebrate embryo.

Journal

Nat Rev Genet 1:171-81 (2000)

Reference

PMID:12163231

Authors

Gumienny TL, Padgett RW.

Title

The other side of TGF-beta superfamily signal regulation: thinking outside the cell.

Journal

Trends Endocrinol Metab 13:295-9 (2002)

Reference

PMID:11836504

Authors

Hamada H, Meno C, Watanabe D, Saijoh Y.

Title

Establishment of vertebrate left-right asymmetry.

Journal

Nat Rev Genet 3:103-13 (2002)

Reference

PMID:12466190

Authors

Chang H, Brown CW, Matzuk MM.

Title

Genetic analysis of the mammalian transforming growth factor-beta superfamily.

Journal

Endocr Rev 23:787-823 (2002)

Reference

PMID:10021351

Authors

Morita K, Chow KL, Ueno N.

Title

Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.

Journal

Development 126:1337-47 (1999)

Reference

PMID:9847239

Authors

Krishna S, Maduzia LL, Padgett RW.

Title

Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.

Journal

Development 126:251-60 (1999)

Reference

PMID:15063168

Authors

Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.

Title

ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.

Journal

Dev Biol 268:280-94 (2004)

Reference

PMID:10519551

Authors

Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C

Title

Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.

Journal

Nature 401:480-5 (1999)

Reference

PMID:19758997

Authors

Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG

Title

Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.

Journal

J Biol Chem 284:30097-104 (2009)

KO pathway

ko04350

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (80)   
   KEGG GENES (80)   
All databases (82)   

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