KEGG   PATHWAY: pon04664Help
pon04664                    Pathway                                

Fc epsilon RI signaling pathway - Pongo abelii (Sumatran orangutan)
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
pon04664  Fc epsilon RI signaling pathway

Ortholog table
Other DBs
BSID: 197704
GO: 0045576
Pongo abelii (Sumatran orangutan) [GN:pon]
100462604  pseudogene [KO:K06856]
100455577  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha isoform X1 [KO:K08089]
100458579  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
100461915  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma isoform X1 [KO:K07983]
100438875  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:]
100447326  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:]
100443503  BTK; tyrosine-protein kinase BTK isoform X2 [KO:K07370] [EC:]
100446045  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:]
100450941  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:]
100457650  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:]
100434355  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100452403  LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
100443271  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100431483  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112129584  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100439299  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:]
100431600  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:]
100457536  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:]
100448382  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:]
100174482  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:]
100459133  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:]
100437424  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:]
100449269  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:]
100449853  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:]
100437263  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:]
100438358  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:]
100451705  IL4; interleukin-4 isoform X1 [KO:K05430]
100451066  IL13; interleukin-13 isoform X1 [KO:K05435]
100447057  IL3; interleukin-3 [KO:K04736]
100450694  IL5; interleukin-5 [KO:K05428]
100447424  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100447558  TNF; tumor necrosis factor [KO:K03156]
100456827  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
100442703  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
100171723  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100447155  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100439712  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:]
100457376  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
100453027  LAT; linker for activation of T-cells family member 1 isoform X2 [KO:K07362]
100173972  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100434331  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100458733  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100459427  HRAS; GTPase HRas [KO:K02833]
100462513  KRAS; GTPase KRas isoform X1 [KO:K07827]
100174317  NRAS; GTPase NRas precursor [KO:K07828]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:]
100450988  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:]
100169740  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:]
100431824  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:]
100454614  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:]
100173125  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:]
100447631  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:]
100434495  PLA2G4C; cytosolic phospholipase A2 gamma isoform X3 [KO:K16342] [EC:]
100454977  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:]
100448616  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:]
100460538  ALOX5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:]
100431427  ALOX5AP; arachidonate 5-lipoxygenase-activating protein [KO:K20735]
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00374  Heparin
C00388  Histamine
C00696  Prostaglandin D2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02166  Leukotriene C4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Kawakami T, Galli SJ.
Regulation of mast-cell and basophil function and survival by IgE.
Nat Rev Immunol 2:773-86 (2002)
Siraganian RP.
Mast cell signal transduction from the high-affinity IgE receptor.
Curr Opin Immunol 15:639-46 (2003)
Janeway CA, Travers P, Walport M, Shlomchik MJ.
Immunobiology 6th edition
Garland Science Publishing (2005)
Turner H, Kinet JP.
Signalling through the high-affinity IgE receptor Fc epsilonRI.
Nature 402:B24-30 (1999)
Gilfillan AM, Tkaczyk C.
Integrated signalling pathways for mast-cell activation.
Nat Rev Immunol 6:218-30 (2006)
Nadler MJ, Matthews SA, Turner H, Kinet JP.
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
Adv Immunol 76:325-55 (2000)
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
Essential role for Gab2 in the allergic response.
Nature 412:186-90 (2001)
Nadler MJ, Kinet JP.
Uncovering new complexities in mast cell signaling.
Nat Immunol 3:707-8 (2002)
KO pathway

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