KEGG   PATHWAY: pon04664Help
Entry
pon04664                    Pathway                                
Name
Fc epsilon RI signaling pathway - Pongo abelii (Sumatran orangutan)
Description
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Fc epsilon RI signaling pathway
pon04664

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BSID: 
GO: 
Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
uncharacterized LOC100936047; K06856 immunoglobulin heavy chain [KO:K06856]
FCER1A; Fc fragment of IgE, high affinity I, receptor for [KO:K08089]
MS4A2; membrane-spanning 4-domains, subfamily A, member 2 [KO:K08090]
FCER1G; Fc fragment of IgE, high affinity I, receptor for [KO:K07983]
SYK; spleen tyrosine kinase [KO:K05855] [EC:2.7.10.2]
LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [KO:K05854] [EC:2.7.10.2]
BTK; Bruton agammaglobulinemia tyrosine kinase [KO:K07370] [EC:2.7.10.2]
INPP5D; inositol polyphosphate-5-phosphatase, 145kDa [KO:K03084] [EC:3.1.3.86]
PLCG1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
1-phosphatidylinositol 4; K05859 phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11] [KO:K05859] [EC:3.1.4.11]
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
DKFZP459B1536 protein; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
PDK1; pyruvate dehydrogenase kinase, isozyme 1 [KO:K12077] [EC:2.7.11.2]
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
rho-related protein rac1B-like; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
dual specificity mitogen-activated protein kinase kinase 4-like; K04430 mitogen-activated protein kinase kinase 4 [EC:2.7.12.2] [KO:K04430] [EC:2.7.12.2]
MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
IL4; interleukin 4 [KO:K05430]
IL13; interleukin 13 [KO:K05435]
IL3; interleukin 3 (colony-stimulating factor, multiple) [KO:K04736]
IL5; interleukin 5 (colony-stimulating factor, eosinophil) [KO:K05428]
CSF2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
TNF; tumor necrosis factor [KO:K03156]
LCP2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) [KO:K07361]
VAV3; vav 3 guanine nucleotide exchange factor [KO:K05730]
VAV2; vav 2 guanine nucleotide exchange factor [KO:K05730]
VAV1; vav 1 guanine nucleotide exchange factor [KO:K05730]
FYN; FYN oncogene related to SRC, FGR, YES [KO:K05703] [EC:2.7.10.2]
GAB2; GRB2-associated binding protein 2 [KO:K08091]
LAT; linker for activation of T cells [KO:K07362]
GRB2; growth factor receptor-bound protein 2 [KO:K04364]
SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
SOS1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO:K02833]
GTPase KRas-like; K07827 GTPase KRas [KO:K07827]
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [KO:K04366] [EC:2.7.11.1]
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
dual specificity mitogen-activated protein kinase kinase 2-like; K04369 mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] [KO:K04369] [EC:2.7.12.2]
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
PLA2G4E; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
PLA2G4B; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
PLA2G4C; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
PLA2G4D; phospholipase A2, group IVD (cytosolic) [KO:K16342] [EC:3.1.1.4]
PLA2G4F; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00219  
Arachidonate
C00374  
Heparin
C00388  
Histamine
C00696  
Prostaglandin D2
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C02166  
Leukotriene C4
C05951  
Leukotriene D4
C05952  
Leukotriene E4
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kawakami T, Galli SJ.
  Title
Regulation of mast-cell and basophil function and survival by IgE.
  Journal
Nat Rev Immunol 2:773-86 (2002)
Reference
  Authors
Siraganian RP.
  Title
Mast cell signal transduction from the high-affinity IgE receptor.
  Journal
Curr Opin Immunol 15:639-46 (2003)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Turner H, Kinet JP.
  Title
Signalling through the high-affinity IgE receptor Fc epsilonRI.
  Journal
Nature 402:B24-30 (1999)
Reference
  Authors
Gilfillan AM, Tkaczyk C.
  Title
Integrated signalling pathways for mast-cell activation.
  Journal
Nat Rev Immunol 6:218-30 (2006)
Reference
  Authors
Nadler MJ, Matthews SA, Turner H, Kinet JP.
  Title
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
  Journal
Adv Immunol 76:325-55 (2000)
Reference
  Authors
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
  Title
Essential role for Gab2 in the allergic response.
  Journal
Nature 412:186-90 (2001)
Reference
  Authors
Nadler MJ, Kinet JP.
  Title
Uncovering new complexities in mast cell signaling.
  Journal
Nat Immunol 3:707-8 (2002)
KO pathway
 
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