KEGG   PATHWAY: pop00908Help
Entry
pop00908                    Pathway                                

Name
Zeatin biosynthesis - Populus trichocarpa (black cottonwood)
Description
Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.
Class
Metabolism; Metabolism of terpenoids and polyketides
BRITE hierarchy
Pathway map
Zeatin biosynthesis
pop00908

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BSID: 
GO: 
Organism
Populus trichocarpa (black cottonwood) [GN:pop]
Gene
POPTRDRAFT_766811; hypothetical protein [KO:K10760]
POPTRDRAFT_564538; hypothetical protein [KO:K10760]
POPTRDRAFT_566611; hypothetical protein [KO:K10760]
POPTRDRAFT_556436; hypothetical protein [KO:K10760]
POPTRDRAFT_768739; hypothetical protein [KO:K10760]
POPTRDRAFT_246143; hypothetical protein [KO:K10760]
POPTRDRAFT_563685; hypothetical protein [KO:K10760]
POPTRDRAFT_555847; cytochrome P450 family protein [KO:K10717]
POPTRDRAFT_761417; hypothetical protein [KO:K00279] [EC:1.5.99.12]
POPTRDRAFT_819456; cytokinin oxidase family protein [KO:K00279] [EC:1.5.99.12]
POPTRDRAFT_777093; hypothetical protein [KO:K00279] [EC:1.5.99.12]
POPTRDRAFT_800198; FAD-binding domain-containing family protein [KO:K00279] [EC:1.5.99.12]
POPTRDRAFT_762085; hypothetical protein [KO:K00279] [EC:1.5.99.12]
POPTRDRAFT_762685; Cytokinin dehydrogenase 3 precursor family protein [KO:K00279] [EC:1.5.99.12]
FAD-binding domain-containing family protein; K00279 cytokinin dehydrogenase [EC:1.5.99.12] [KO:K00279] [EC:1.5.99.12]
POPTRDRAFT_754101; cytokinin oxidase 6 family protein [KO:K00279] [EC:1.5.99.12]
POPTRDRAFT_562880; hypothetical protein [KO:K00279] [EC:1.5.99.12]
POPTRDRAFT_767159; TRNA ISOPENTENYLTRANSFERASE family protein [KO:K00791] [EC:2.5.1.75]
POPTRDRAFT_815805; hypothetical protein [KO:K00791] [EC:2.5.1.75]
POPTRDRAFT_560466; putative glucosyltransferase family protein [KO:K13495] [EC:2.4.1.215]
POPTRDRAFT_808453; putative glucosyltransferase family protein [KO:K13495] [EC:2.4.1.215]
POPTRDRAFT_560477; putative glucosyltransferase family protein [KO:K13495] [EC:2.4.1.215]
Compound
C00002  
ATP
C00008  
ADP
C00015  
UDP
C00019  
S-Adenosyl-L-methionine
C00020  
AMP
C00029  
UDP-glucose
C00033  
Acetate
C00066  
tRNA
C00147  
Adenine
C00170  
5'-Methylthioadenosine
C00190  
UDP-D-xylose
C00235  
Dimethylallyl diphosphate
C00371  
Zeatin
C00979  
O-Acetyl-L-serine
C01513  
Lupinate
C01804  
Discadenine
C02029  
Dihydrozeatin
C03300  
O-beta-D-Xylosylzeatin
C03423  
O-beta-D-Glucosylzeatin
C04083  
N6-(delta2-Isopentenyl)-adenine
C04432  
tRNA containing 6-isopentenyladenosine
C04713  
N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
C07330  
3-Methyl-2-butenal
C15545  
cis-Zeatin
C15546  
O-beta-D-Glucopyranosyl-cis-zeatin
C16424  
Isopentenyladenosine-5'-triphosphate
C16426  
Isopentenyladenosine-5'-diphosphate
C16427  
Isopentenyl adenosine
C16428  
trans-Zeatin riboside triphosphate
C16429  
trans-Zeatin riboside diphosphate
C16430  
trans-Zeatin riboside  monophosphate
C16431  
trans-Zeatin riboside
C16441  
cis-Zeatin riboside monophosphate
C16443  
trans-Zeatin-7-beta-D-glucoside
C16445  
Dihydrozeatin riboside monophosphate
C16447  
Dihydrozeatin riboside
C16448  
Dihydrozeatin-O-glucoside
C16449  
cis-Zeatin riboside
C16467  
cis-Prenyl-tRNA
Reference
  Authors
Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.
  Title
Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.
  Journal
J Biol Chem 279:14049-54 (2004)
Reference
  Authors
Takei K, Sakakibara H, Sugiyama T.
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J Biol Chem 276:26405-10 (2001)
Reference
  Authors
Kakimoto T.
  Title
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  Journal
Plant Cell Physiol 42:677-85 (2001)
Reference
  Authors
Takei K, Yamaya T, Sakakibara H.
  Title
Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.
  Journal
J Biol Chem 279:41866-72 (2004)
Reference
  Authors
Hou B, Lim EK, Higgins GS, Bowles DJ.
  Title
N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
  Journal
J Biol Chem 279:47822-32 (2004)
Reference
PMID:9874810
  Authors
Martin RC, Mok MC, Mok DW
  Title
Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.
  Journal
Proc Natl Acad Sci U S A 96:284-9 (1999)
Reference
  Authors
Martin RC, Mok MC, Mok DW
  Title
A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.
  Journal
Plant Physiol 120:553-8 (1999)
Reference
  Authors
Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC
  Title
O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.
  Journal
Plant Physiol 131:1374-80 (2003)
Reference
  Authors
Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T
  Title
Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.
  Journal
Plant Cell 15:2532-50 (2003)
Reference
  Authors
Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T
  Title
Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 103:16598-603 (2006)
KO pathway
 

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