KEGG   PATHWAY: ppa04140Help
Entry
ppa04140                    Pathway                                

Name
Regulation of autophagy - Pichia pastoris
Class
Cellular Processes; Transport and catabolism
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Pathway map
Regulation of autophagy
ppa04140

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BSID: 
GO: 
Organism
Pichia pastoris [GN:ppa]
Gene
Protein serine/threonine kinase required for vesicle formation in autophagy; K08269 serine/threonine-protein kinase ULK/ATG1 [EC:2.7.11.1] [KO:K08269] [EC:2.7.11.1]
Scaffold protein responsible for pre-autophagosomal structure organization; K08329 autophagy-related protein 17 [KO:K08329]
Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; K08330 autophagy-related protein 11 [KO:K08330]
Regulatory subunit of the Atg1p signaling complex; K08331 autophagy-related protein 13 [KO:K08331]
Phosphorylated vacuolar membrane protein that interacts with Atg13p; K08332 vacuolar protein 8 [KO:K08332]
Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; K08333 phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1] [KO:K08333] [EC:2.7.11.1]
Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; K08334 beclin 1 [KO:K08334]
Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; K00914 phosphatidylinositol 3-kinase [EC:2.7.1.137] [KO:K00914] [EC:2.7.1.137]
Conserved ubiquitin-like modifier; K08336 ubiquitin-like protein ATG12 [KO:K08336]
Autophagy-related protein; K08337 ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
Conserved protein involved in autophagy and the Cvt pathway; K08339 autophagy-related protein 5 [KO:K08339]
Conserved protein that is a component of autophagosomes and Cvt vesicles; K08341 GABA(A) receptor-associated protein [KO:K08341]
Conserved cysteine protease required for autophagy; K08342 cysteine protease ATG4 [EC:3.4.22.-] [KO:K08342] [EC:3.4.22.-]
E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; K08343 ubiquitin-like-conjugating enzyme ATG3 [EC:6.3.2.19] [KO:K08343] [EC:6.3.2.19]
Compound
C00350  
Phosphatidylethanolamine
C00913  
3-Methyladenine
C01194  
1-Phosphatidyl-D-myo-inositol
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C15181  
Wortmannin
Reference
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
Reference
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
Reference
  Authors
Thompson AR, Vierstra RD.
  Title
Autophagic recycling: lessons from yeast help define the process in plants.
  Journal
Curr Opin Plant Biol 8:165-73 (2005)
Reference
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
Reference
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
Reference
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
Reference
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
Reference
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
Reference
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
KO pathway
 

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