KEGG   PATHWAY: psd03440Help
Entry
psd03440                    Pathway                                

Name
Homologous recombination - Pseudoxanthomonas spadix
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
psd03440  Homologous recombination
psd03440

Ortholog table
Module
psd_M00260  DNA polymerase III complex, bacteria [PATH:psd03440]
Other DBs
BSID: 538556
GO: 0000724
Organism
Pseudoxanthomonas spadix [GN:psd]
Gene
DSC_08745  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
DSC_06435  single-stranded DNA-binding protein [KO:K03111]
DSC_04255  single-stranded DNA-binding protein [KO:K03111]
DSC_01000  recF; recombination protein F [KO:K03629]
DSC_11550  recO; DNA repair protein RecO [KO:K03584]
DSC_11700  recR; recombination protein RecR [KO:K06187]
DSC_06790  recA; recombinase A [KO:K03553]
DSC_00480  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
DSC_04855  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
DSC_04865  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
DSC_04850  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
DSC_13435  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
DSC_01170  exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
DSC_01165  exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
DSC_01175  exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
DSC_10780  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
DSC_00995  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
DSC_11710  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
DSC_11300  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
DSC_11610  DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
DSC_12005  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
DSC_02640  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
DSC_04550  primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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