KEGG   PATHWAY: psi00030Help
Entry
psi00030                    Pathway                                

Name
Pentose phosphate pathway - Providencia stuartii
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Pentose phosphate pathway
psi00030

All organismsOrtholog table
Module
Pentose phosphate pathway (Pentose phosphate cycle) [PATH:psi00030]
PRPP biosynthesis, ribose 5P => PRPP [PATH:psi00030]
Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:psi00030]
Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:psi00030]
Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:psi00030]
Other DBs
BSID: 
GO: 
Organism
Providencia stuartii [GN:psi]
Gene
pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
glucose-6-phosphate 1-dehydrogenase; K00036 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49] [KO:K00036] [EC:1.1.1.49]
glucose-6-phosphate dehydrogenase; K00036 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49] [KO:K00036] [EC:1.1.1.49]
6-phosphogluconolactonase; K07404 6-phosphogluconolactonase [EC:3.1.1.31] [KO:K07404] [EC:3.1.1.31]
6-phosphogluconate dehydrogenase; K00033 6-phosphogluconate dehydrogenase [EC:1.1.1.44] [KO:K00033] [EC:1.1.1.44]
6-phosphogluconate dehydrogenase; K00033 6-phosphogluconate dehydrogenase [EC:1.1.1.44] [KO:K00033] [EC:1.1.1.44]
ribulose-phosphate 3-epimerase; K01783 ribulose-phosphate 3-epimerase [EC:5.1.3.1] [KO:K01783] [EC:5.1.3.1]
transketolase; K00615 transketolase [EC:2.2.1.1] [KO:K00615] [EC:2.2.1.1]
transketolase; K00615 transketolase [EC:2.2.1.1] [KO:K00615] [EC:2.2.1.1]
transaldolase B; K00616 transaldolase [EC:2.2.1.2] [KO:K00616] [EC:2.2.1.2]
ribose 5-phosphate isomerase A; K01807 ribose 5-phosphate isomerase A [EC:5.3.1.6] [KO:K01807] [EC:5.3.1.6]
ribose-5-phosphate isomerase B; K01808 ribose 5-phosphate isomerase B [EC:5.3.1.6] [KO:K01808] [EC:5.3.1.6]
deoxyribose-phosphate aldolase; K01619 deoxyribose-phosphate aldolase [EC:4.1.2.4] [KO:K01619] [EC:4.1.2.4]
deoxyribose-phosphate aldolase; K01619 deoxyribose-phosphate aldolase [EC:4.1.2.4] [KO:K01619] [EC:4.1.2.4]
putative sugar kinase; K00852 ribokinase [EC:2.7.1.15] [KO:K00852] [EC:2.7.1.15]
ribokinase; K00852 ribokinase [EC:2.7.1.15] [KO:K00852] [EC:2.7.1.15]
phosphopentomutase; K01839 phosphopentomutase [EC:5.4.2.7] [KO:K01839] [EC:5.4.2.7]
phosphoglucomutase; K01835 phosphoglucomutase [EC:5.4.2.2] [KO:K01835] [EC:5.4.2.2]
ribose-phosphate pyrophosphokinase; K00948 ribose-phosphate pyrophosphokinase [EC:2.7.6.1] [KO:K00948] [EC:2.7.6.1]
phosphogluconate dehydratase; K01690 phosphogluconate dehydratase [EC:4.2.1.12] [KO:K01690] [EC:4.2.1.12]
keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; K01625 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] [KO:K01625] [EC:4.1.3.42 4.1.2.14]
keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; K01625 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] [KO:K01625] [EC:4.1.3.42 4.1.2.14]
gntK; gluconate kinase [KO:K00851] [EC:2.7.1.12]
2-dehydro-3-deoxygluconokinase; K00874 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] [KO:K00874] [EC:2.7.1.45]
fructose-bisphosphate aldolase; K11645 fructose-bisphosphate aldolase, class I [EC:4.1.2.13] [KO:K11645] [EC:4.1.2.13]
fructose-bisphosphate aldolase; K01624 fructose-bisphosphate aldolase, class II [EC:4.1.2.13] [KO:K01624] [EC:4.1.2.13]
fructose-1; K03841 fructose-1,6-bisphosphatase I [EC:3.1.3.11] [KO:K03841] [EC:3.1.3.11]
glpX; fructose 1,6-bisphosphatase II [KO:K02446] [EC:3.1.3.11]
6-phosphofructokinase; K00850 6-phosphofructokinase 1 [EC:2.7.1.11] [KO:K00850] [EC:2.7.1.11]
Compound
C00022  
Pyruvate
C00031  
D-Glucose
C00117  
D-Ribose 5-phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00119  
5-Phospho-alpha-D-ribose 1-diphosphate
C00121  
D-Ribose
C00197  
3-Phospho-D-glycerate
C00198  
D-Glucono-1,5-lactone
C00199  
D-Ribulose 5-phosphate
C00204  
2-Dehydro-3-deoxy-D-gluconate
C00221  
beta-D-Glucose
C00231  
D-Xylulose 5-phosphate
C00257  
D-Gluconic acid
C00258  
D-Glycerate
C00279  
D-Erythrose 4-phosphate
C00345  
6-Phospho-D-gluconate
C00577  
D-Glyceraldehyde
C00620  
alpha-D-Ribose 1-phosphate
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C00672  
2-Deoxy-D-ribose 1-phosphate
C00673  
2-Deoxy-D-ribose 5-phosphate
C01151  
D-Ribose 1,5-bisphosphate
C01172  
beta-D-Glucose 6-phosphate
C01218  
6-Phospho-2-dehydro-D-gluconate
C01236  
D-Glucono-1,5-lactone 6-phosphate
C01801  
Deoxyribose
C03752  
2-Amino-2-deoxy-D-gluconate
C04442  
2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C05382  
Sedoheptulose 7-phosphate
C06019  
D-arabino-Hex-3-ulose 6-phosphate
C06473  
2-Keto-D-gluconic acid
C20589  
6-Phospho-D-glucosaminate
Reference
(map 3)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 4)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate  pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
KO pathway
 

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