KEGG   PATHWAY: psi00030Help
psi00030                    Pathway                                

Pentose phosphate pathway - Providencia stuartii MRSN 2154
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
psi00030  Pentose phosphate pathway

Ortholog table
psi_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:psi00030]
psi_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:psi00030]
psi_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:psi00030]
psi_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:psi00030]
psi_M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:psi00030]
Other DBs
BSID: 627631
GO: 0006098
Providencia stuartii MRSN 2154 [GN:psi]
S70_08400  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:]
S70_09620  glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:]
S70_20340  glucose-6-phosphate dehydrogenase [KO:K00036] [EC:]
S70_15915  6-phosphogluconolactonase [KO:K07404] [EC:]
S70_09625  6-phosphogluconate dehydrogenase [KO:K00033] [EC:]
S70_16280  6-phosphogluconate dehydrogenase [KO:K00033] [EC:]
S70_10100  ribulose-phosphate 3-epimerase [KO:K01783] [EC:]
S70_06610  transketolase [KO:K00615] [EC:]
S70_13240  transketolase [KO:K00615] [EC:]
S70_07255  transaldolase B [KO:K00616] [EC:]
S70_03645  ribose 5-phosphate isomerase A [KO:K01807] [EC:]
S70_13245  ribose-5-phosphate isomerase B [KO:K01808] [EC:]
S70_08005  deoxyribose-phosphate aldolase [KO:K01619] [EC:]
S70_07425  deoxyribose-phosphate aldolase [KO:K01619] [EC:]
S70_08000  putative sugar kinase [KO:K00852] [EC:]
S70_10220  ribokinase [KO:K00852] [EC:]
S70_07415  phosphopentomutase [KO:K01839] [EC:]
S70_17105  phosphoglucomutase [KO:K01835] [EC:]
S70_20050  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:]
S70_08455  phosphogluconate dehydratase [KO:K01690] [EC:]
S70_08460  keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase [KO:K01625] [EC:]
S70_18445  keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase [KO:K01625] [EC:]
S70_08275  gntK; gluconate kinase 1 [KO:K00851] [EC:]
S70_18450  2-dehydro-3-deoxygluconokinase [KO:K00874] [EC:]
S70_01295  fructose-bisphosphate aldolase [KO:K11645] [EC:]
S70_06595  fructose-bisphosphate aldolase [KO:K01624] [EC:]
S70_12060  fructose-1,6-bisphosphatase [KO:K03841] [EC:]
S70_18600  glpX; fructose 1,6-bisphosphatase II [KO:K02446] [EC:]
S70_11025  6-phosphofructokinase [KO:K00850] [EC:]
C00022  Pyruvate
C00031  D-Glucose
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
(map 3)
Nishizuka Y (ed).
[Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1980)
(map 4)
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
[Cellular Functions and Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1997)
Michal G.
Biochemical Pathways
Wiley (1999)
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
J Bacteriol 185:2793-801 (2003)
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
J Bacteriol 188:4698-704 (2006)
Kato N, Yurimoto H, Thauer RK
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
Biosci Biotechnol Biochem 70:10-21 (2006)
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
FEBS J 280:1126-38 (2013)
Reher M, Schonheit P
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
FEBS Lett 580:1198-204 (2006)
Reher M, Fuhrer T, Bott M, Schonheit P
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
J Bacteriol 192:964-74 (2010)
KO pathway

DBGET integrated database retrieval system