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Entry
pta02060                    Pathway                                

Name
Phosphotransferase system (PTS) - Paenibacillus terrae
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
pta02060  Phosphotransferase system (PTS)
pta02060

Ortholog table
Module
pta_M00270  PTS system, trehalose-specific II component [PATH:pta02060]
pta_M00271  PTS system, beta-glucoside-specific II component [PATH:pta02060]
pta_M00273  PTS system, fructose-specific II component [PATH:pta02060]
pta_M00274  PTS system, mannitol-specific II component [PATH:pta02060]
pta_M00275  PTS system, cellobiose-specific II component [PATH:pta02060]
pta_M00806  PTS system, maltose-specific II component [PATH:pta02060]
pta_M00809  PTS system, glucose-specific II component [PATH:pta02060]
Other DBs
BSID: 548125
GO: 0009401
TC: 4.A
Organism
Paenibacillus terrae [GN:pta]
Gene
HPL003_24655  phosphoenolpyruvate-protein phosphotransferase (phosphotransferase system, enzyme I) [KO:K08483] [EC:2.7.3.9]
HPL003_27565  phosphoenolpyruvate-protein phosphotransferase (phosphotransferase system, enzyme I) [KO:K08483] [EC:2.7.3.9]
HPL003_10680  phosphotransferase system (PTS) enzyme I [KO:K08483] [EC:2.7.3.9]
HPL003_24660  PTS system glucose-specific EIICBA component (EIICBA-Glc) [KO:K20116 K20117 K20118] [EC:2.7.1.199 2.7.1.199]
HPL003_27575  PTS system glucose-specific EIICBA component (EIICBA-Glc) [KO:K20116 K20117 K20118] [EC:2.7.1.199 2.7.1.199]
HPL003_01225  phosphotransferase system IIA component [KO:K02777] [EC:2.7.1.-]
HPL003_07985  glucose-specific phosphotransferase enzyme IIA component (PTS system glucose-specific EIIA component) [KO:K02777] [EC:2.7.1.-]
HPL003_00260  PTS system glucose-specific EIICB component (EIICB-Glc) [KO:K02803 K02804] [EC:2.7.1.193]
HPL003_08870  phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [KO:K20107 K20108] [EC:2.7.1.208]
HPL003_09055  PTS system sucrose-specific EIIBC component (EIIBC-Scr) [KO:K02809 K02810] [EC:2.7.1.211]
HPL003_13585  bc component pts system sucrose-specific enzyme ii [KO:K02809 K02810] [EC:2.7.1.211]
HPL003_10610  beta-glucosides PTS, EIIBCA [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_10835  hypothetical protein [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_00910  PTS system beta-glucoside-specific EIIBCA component (EIIBCA-Bgl) (EII-Bgl) [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_01720  PTS system beta-glucoside-specific EIIBCA component (EIIBCA-Bgl) [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_14885  beta-glucoside-specific phosphotransferase enzyme iia component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_15360  PTS system beta-glucoside-specific, IIABC component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_19765  PTS system beta-glucoside-specific IIABC component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_03530  PTS system beta-glucoside-specific EIIBCA component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_26535  PTS system beta-glucoside-specific EIIBCA component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_08735  PTS system, beta-glucoside-specific IIABC component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_00305  phosphotransferase system (pts) beta-glucoside-specific enzyme iibca component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_01945  phosphotransferase system (pts) beta-glucoside-specific enzyme iibca component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_14875  phosphotransferase system (pts) beta-glucoside-specific enzyme iibca component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
HPL003_20980  pts system, trehalose-specific iibc subunit [KO:K02818 K02819] [EC:2.7.1.201]
HPL003_27530  mannitol-specific phosphotransferase enzyme IIA component (PTS system mannitol-specific EIIA component) [KO:K02798] [EC:2.7.1.197]
HPL003_27540  phosphotransferase system mannitol-specific iibc component [KO:K02799 K02800] [EC:2.7.1.197]
HPL003_00930  Lichenan-specific phosphotransferase enzyme IIA component (PTS system lichenan-specific EIIA component) [KO:K02759] [EC:2.7.1.205 2.7.1.196]
HPL003_06310  Lichenan-specific phosphotransferase enzyme IIA component (PTS system lichenan-specific EIIA component) [KO:K02759] [EC:2.7.1.205 2.7.1.196]
HPL003_10660  phosphotransferase system PTS lactose/cellobiose-specific IIA subunit [KO:K02759] [EC:2.7.1.205 2.7.1.196]
HPL003_22160  phosphotransferase system [KO:K02759] [EC:2.7.1.205 2.7.1.196]
HPL003_01870  PTS system transporter subunit IIA [KO:K02759] [EC:2.7.1.205 2.7.1.196]
HPL003_00945  phosphotransferase system lactose/cellobiose-specific iib subunit [KO:K02760] [EC:2.7.1.205 2.7.1.196]
HPL003_01875  PTS system, lichenan-specific IIb component precursor (PTS system, lactose/cellobiose-specific family, IIB component) [KO:K02760] [EC:2.7.1.205 2.7.1.196]
HPL003_06315  cellobiose-specific phosphotransferase enzyme IIB component (PTS system cellobiose-specific EIIB component) [KO:K02760] [EC:2.7.1.205 2.7.1.196]
HPL003_10650  phosphotransferase system lactose/cellobiose-specific IIB subunit [KO:K02760] [EC:2.7.1.205 2.7.1.196]
HPL003_22165  phosphotransferase system lactose/cellobiose-specific iib subunit [KO:K02760] [EC:2.7.1.205 2.7.1.196]
HPL003_00935  phosphotransferase system cellobiose-specific component IIC [KO:K02761]
HPL003_01880  PTS system, IIC component [KO:K02761]
HPL003_06305  Lichenan permease IIC component (PTS system lichenan-specific EIIC component) [KO:K02761]
HPL003_10655  PTS system, IIC component [KO:K02761]
HPL003_22175  pts family oligomeric beta-glucoside porter component iic [KO:K02761]
HPL003_16590  PTS sysytem, mannitol-specific enzyme II, B component [KO:K02822] [EC:2.7.1.194]
HPL003_16595  ulaA; PTS system ascorbate-specific transporter subunit IIC [KO:K03475]
HPL003_16545  PTS system fructose-specific EIIBBC component (EIIBBC-Fru) [KO:K02768 K02769 K02770] [EC:2.7.1.202 2.7.1.202]
HPL003_08670  PTS system, fructose-specific, IIA component [KO:K02768] [EC:2.7.1.202]
HPL003_08675  PTS system transporter subunit IIB [KO:K02769] [EC:2.7.1.202]
HPL003_08680  PTS system, IIC component [KO:K02770]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Reference
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
DOI:10.1016/0022-2836(90)90284-S
Reference
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
DOI:10.1046/j.1365-2958.2003.03375.x
Reference
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
Reference
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
DOI:10.1093/nar/gki108
Reference
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
DOI:10.1128/JB.01737-07
Reference
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
DOI:10.1046/j.1365-2958.2000.01969.x
Reference
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
DOI:10.1016/S1389-1723(01)80308-X
KO pathway
ko02060   

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